Testing the hypothesis that amphiphilic antineoplastic lipid analogues act through reduction of membrane curvature elastic stress

Journal of the Royal Society Interface

Volumn 5, Issue 28, 2008, Pages 1371-1386

  Dymond, Marcus ^a   Attard, George ^a   Postle, Anthony D ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

Alkyllysophospholipids; Alkylphosphocholines; Anticancer; CTP: phosphocholine cytidylyltransferase; Curvature elastic stress; Type I lipids

Indexed keywords

ARSENIC COMPOUNDS; BIOCHEMISTRY; CELL DEATH; CHEMOTHERAPY; CHLORINE COMPOUNDS; COLLOIDS; CONCENTRATION (PROCESS); CRITICAL MICELLE CONCENTRATION; DRUG DELIVERY; DRUG DOSAGE; MEMBRANES; MICELLES;

ALKYLLYSOPHOSPHOLIPIDS; ALKYLPHOSPHOCHOLINES; AMPHIPHILIC; ANTI-CANCER DRUGS; ANTICANCER; ANTINEOPLASTIC; APOPTOSIS; CELLULAR MEMBRANES; CTP: PHOSPHOCHOLINE CYTIDYLYLTRANSFERASE; CURVATURE ELASTIC STRESS; CYTIDYLYLTRANSFERASE; ELASTIC STRESSES; EXPERIMENTAL DATA; LITERATURE DATA; MEMBRANE CURVATURE; MICELLE CONCENTRATIONS; MODE OF ACTION; PHOSPHOCHOLINE; PROTEIN ACTIVITIES; STRUCTURE-ACTIVITY RELATIONSHIPS; TYPE I LIPIDS;

CELL MEMBRANES;

ALKYLLYSOPHOSPHOLIPID; AMPHOPHILE; ANTINEOPLASTIC AGENT; CHOLINE PHOSPHATE CYTIDYLYLTRANSFERASE; EDELFOSINE; MILTEFOSINE; PHOSPHORAMIDIC ACID DERIVATIVE; PHOSPHORYLCHOLINE;

APOPTOSIS; ARTICLE; CELL MEMBRANE; CRITICAL MICELLE CONCENTRATION; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; ELASTICITY; HUMAN; HUMAN CELL; LIPID MEMBRANE; MEMBRANE STRUCTURE; NONHUMAN; PROTEIN TARGETING; STRUCTURE ACTIVITY RELATION;

EID: 52749098089     PISSN: 17425689     EISSN: 17425662     Source Type: Journal    
DOI: 10.1098/rsif.2008.0041     Document Type: Article

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