Regulation of the voltage-gated K+ channels KCNQ2/3 and KCNQ3/5 by serum- and glucocorticoid-regulated kinase-1

American Journal of Physiology - Cell Physiology

Volumn 295, Issue 1, 2008, Pages

  Schuetz, Friderike ^a   Kumar, Sharad ^b   Poronnik, Philip ^a   Adams, David J ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b INSTITUTE OF MEDICAL AND VETERINARY SCIENCE   (Australia)

Author keywords

KCNQ channel; M current; Potassium channel; Ubiquitin ligase; Xenopus oocyte

Indexed keywords

CASPASE 2; HEMAGGLUTININ; POTASSIUM CHANNEL KCNQ 5; POTASSIUM CHANNEL KCNQ2; POTASSIUM CHANNEL KCNQ3; SERUM AND GLUCOCORTICOID REGULATED KINASE 1; UBIQUITIN PROTEIN LIGASE NEDD4; UNCLASSIFIED DRUG; IMMEDIATE EARLY PROTEIN; KCNQ2 PROTEIN, RAT; KCNQ3 PROTEIN, RAT; KCNQ5 PROTEIN, RAT; NEDD4 UBIQUITIN PROTEIN LIGASES; POTASSIUM CHANNEL KCNQ; PROTEIN SERINE THREONINE KINASE; RECOMBINANT PROTEIN; SERUM GLUCOCORTICOID REGULATED KINASE; SERUM-GLUCOCORTICOID REGULATED KINASE; UBIQUITIN PROTEIN LIGASE;

AMPLITUDE MODULATION; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL SURFACE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION; XENOPUS; ANIMAL; CHANNEL GATING; DRUG EFFECT; FEMALE; METABOLISM; PHYSIOLOGY; RAT; SERUM; XENOPUS LAEVIS;

ANIMALS; DOWN-REGULATION; FEMALE; IMMEDIATE-EARLY PROTEINS; ION CHANNEL GATING; KCNQ POTASSIUM CHANNELS; KCNQ2 POTASSIUM CHANNEL; KCNQ3 POTASSIUM CHANNEL; OOCYTES; PROTEIN-SERINE-THREONINE KINASES; RATS; RECOMBINANT PROTEINS; SERUM; UBIQUITIN-PROTEIN LIGASES; XENOPUS LAEVIS;

EID: 52749089159     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00146.2008     Document Type: Article

References (48)

1. Bhalla V, Daidié D, Li H, Pao AC, LaGrange LP, Wang J, Vandewalle A, Stockand JD, Staub O, Pearce D. Serum- and glucocorticoid-regulated kinase 1 regulates ubiquitin ligase neural precursor cell-expressed, developmentally down-regulated protein 4-2 by interacting with 14-3-3. Mol Endocrinol 19: 3073-3084, 2005.
2. Boehmer C, Wilhelm V, Palmada M, Wallisch S, Henke G, Brinkmeier H, Cohen P, Pieske B, Lang F. Serum and glucocorticoid inducible kinases in the regulation of the cardiac sodium channel SCN5A. Cardiovasc Res 57: 1079-1084, 2003.
3. Cooper E, Harrington E, Jan Y, Jan L. M channel KCNQ2 subunits are localized to key sites for control of neuronal network oscillations and synchronization in mouse brain. J Neurosci 21: 9529-9540, 2001.
4. Cooper EC, Aldape KD, Abosch A, Barbaro NM, Berger MS, Peacock WS, Jan YN, Jan LY. Co-localization and co-assembly of two human brain M-type potassium channel subunits that are mutated in epilepsy. Proc Natl Acad Sci USA 97: 4914-4919, 2000.
5. Crozier RA, Ajit SK, Kaftan EJ, Pausch MH. MrgD activation inhibits KCNQ/M-currents and contributes to enhanced neuronal excitability. J Neurosci 27: 4492-4496, 2007.
6. + channel cell surface expression. EMBO J 20: 7052-7059, 2001.
7. Delmas P, Brown DA. Pathways modulating neural KCNQ/M (Kv7) potassium channels. Nat Rev Neurosci 6: 850-862, 2005.
8. Dibbens LM, Ekberg J, Taylor I, Hodgson BL, Conroy SJ, Lensink IL, Kumar S, Zielinski MA, Harkin LA, Sutherland GR, Adams DJ, Berkovic SF, Scheffer IE, Mulley JC, Poronnik P. NEDD4-2 as a potential candidate susceptibility gene for epileptic photosensitivity. Genes Brain Behav 6: 750-755, 2007.
9. + channels KCNQ2/3 and KCNQ3/5 by ubiquitination: novel role for Nedd4-2. J Biol Chem 282: 12135-12142, 2007.
10. Etxeberria A, Aivar P, Rodriguez-Alfaro JA, Alaimo A, Villacé P, Gómez-Posada JC, Areso P, Villarroel A. Calmodulin regulates the trafficking of KCNQ2 potassium channels. FASEB J 22: 1135-1143, 2007.
11. Fonatana DJ, Inouye GT, Johnson RM. Linopirdine (DuP 966) improves performance in several tests of learning and memory by modulation of cholinergic neurotransmission. Pharmacol Biochem Behav 49: 1075-1082, 1994.
12. Fotia AB, Ekberg J, Adams DJ, Cook DI, Poronnik P, Kumar S. Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2. J Biol Chem 279: 28930-28935, 2004.
13. + channels as a mechanism of cytoprotective neuronal silencing. EMBO J 25: 4996-5004, 2006.
14. Haitin Y, Attali B. The C-terminus of Kv7 channels: a multifunctional module. J Physiol 586: 1803-1810, 2008.
15. Hamilton SE, Hardouin SN, Anagnostaras SG, Murphy GG, Richmond KN, Silva AJ, Feigl EO, Nathanson NM. Alteration of cardiovascular and neuronal function in M1 knockout mice. Life Sci 68: 2489-2493, 2001.
16. Hanada M, Feng J, Hemmings BA. Structure, regulation and function of PKB/AKT - a major therapeutic target. Biochim Biophys Acta 1697: 3-16, 2004.
17. + channel Kv1.3 by the ubiquitin ligase Nedd4-2 and the serum and glucocorticoid inducible kinase SGK1. J Cell Physiol 199: 194-199, 2004.
18. Hernandez CC, Zaika O, Tolstykh GP, Shapiro MS. Regulation of neural KCNQ channels: signalling pathways, structural motifs and functional implications. J Physiol 586: 1811-1821, 2008.
19. Hollister RD, Page KJ, Hyman BT. Distribution of the messenger RNA for the extracellularly regulated kinases 1, 2 and 3 in rat brain: effects of excitotoxic hippocampal lesions. Neuroscience 79: 1111-1119, 1997.
20. Hryciw DH, Ekberg J, Lee A, Lensink IL, Kumar S, Guggino WB, Cook DI, Pollock CA, Poronnik P. Nedd4-2 functionally interacts with ClC-5: involvement in constitutive albumin endocytosis in proximal tubule cells. J Biol Chem 279: 54996-55007, 2004.
21. + channels by phosphorylation-dependent interaction with Nedd4-2 ubiquitin ligase. J Biol Chem 280: 13187-13194, 2005.
22. Jensen HS, Grunnet M, Olesen SP. Inactivation as a new regulatory mechanism for neuronal Kv7 channels. Biophys J 92: 2747-2756, 2007.
23. Jentsch TJ. Neuronal KCNQ potassium channels: physiology and role in disease. Nat Rev Neurosci 1: 21-30, 2000.
24. Lang F, Böhmer C, Palmada M, Seebohm G, Strutz-Seebohm N, Vallon V. (Patho)physiological significance of the serum- and glucocorticoid- inducible kinase isoforms. Physiol Rev 86: 1151-1178, 2006.
25. Lee IH, Dinudom A, Sanchez-Perez A, Kumar S, Cook DI. Akt mediates the effect of insulin on epithelial sodium channels by inhibiting Nedd4-2. J Biol Chem 282: 29866-29873, 2007.
26. Ma YL, Tsai MC, Hsu WL, Lee EH. SGK protein kinase facilitates the expression of long-term potentiation in hippocampal neurons. Learn Mem 13: 114-118, 2006.
27. Nishida Y, Nagata T, Takahashi Y, Sugahara-Kobayashi M, Murata A, Asai S. Alteration of serum/glucocorticoid regulated kinase-1 (sgk-1) gene expression in rat hippocampus after transient global ischemia. Brain Res Mol Brain Res 123: 121-125, 2004.
28. + channel ROMK1 by the serum- and glucocorticoid-inducible kinase SGK1. Biochem Biophys Res Commun 311: 629-634, 2003.
29. Passmore GM, Selyanko AA, Mistry M, Al-Qatari M, Marsh SJ, Matthews EA, Dickenson AH, Brown TA, Burbidge SA, Main M, Brown DA. KCNQ/M currents in sensory neurons: significance for pain therapy. J Neurosci 23: 7227-7236, 2003.
30. Peretz A, Degani N, Nachman R, Uziyel Y, Gibor G, Shabat D, Attali B. Meclofenamic acid and diclofenac, novel templates of KCNQ2/Q3 potassium channel openers, depress cortical neuron activity and exhibit anticonvulsant properties. Mol Pharmacol 67: 1053-1066, 2005.
31. Peters HC, Hu H, Pongs O, Storm JF, Isbrandt D. Conditional transgenic suppression of M channels in mouse brain reveals functions in neuronal excitability, resonance and behavior. Nat Neurosci 8: 51-60, 2005.
32. Romero M, Reboreda A, Sánchez E, Lamas JA. Newly developed blockers of the M-current do not reduce spike frequency adaptation in cultured mouse sympathetic neurons. Eur J Neurosci 19: 2693-2702, 2004.
33. Sale EM, Sale GJ. Protein kinase B: signalling roles and therapeutic targeting. Cell Mol Life Sci 65: 113-127, 2008.
34. Schnee ME, Brown BS. Selectivity of linopirdine (DuP 996), a neurotransmitter release enhancer, in blocking voltage-dependent and calcium-activated potassium currents in hippocampal neurons. J Pharmacol Exp Ther 286: 709-717, 1998.
35. Seebohm G, Strutz-Seebohm N, Baltaev R, Korniychuk G, Knirsch M, Engel J, Lang F. Regulation of KCNQ4 potassium channel prepulse dependence and current amplitude by SGK1 in Xenopus oocytes. Cell Physiol Biochem 16: 255-262, 2005.
36. + channels. J Physiol 563: 359-368, 2005.
37. Shah MM, Mistry M, Marsh SJ, Brown DA, Delmas P. Molecular correlates of the M-current in cultured rat hippocampal neurons. J Physiol 544: 29-37, 2002.
38. + channel. J Biol Chem 277: 5-8, 2002.
39. Tatulian L, Delmas P, Abogadie FC, Brown DA. Activation of expressed KCNQ potassium currents and native neuronal M-type potassium currents by the anti-convulsant drug retigabine. J Neurosci 21: 5535-5545, 2001.
40. Tessier M, Woodgett JR. Serum and glucocorticoid-regulated protein kinases: variations on a theme. J Cell Biochem 98: 1391-1407, 2006.
41. Wang HS, Pan Z, Shi W, Brown BS, Wymore RS, Cohen IS, Dixon JE, McKinnon D. KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel. Science 282: 1890-1893, 1998.
42. Webster MK, Goya L, Ge Y, Maiyar AC, Firestone GL. Characterization of sgk, a novel member of the serine/threonine protein kinase gene family which is transcriptionally induced by glucocorticoids and serum. Mol Cell Biol 13: 2031-2040, 1993.
43. Wickenden AD, Zou A, Wagoner PK, Jegla T. Characterization of KCNQ5/Q3 potassium channels expressed in mammalian cells. Br J Pharmacol 132: 381-384, 2001.
44. Xia S, Lampe PA, Deshmukh M, Yang A, Brown BS, Rothman SM, Johnson EMJ, Yu SP. Multiple channel interactions explain the protection of sympathetic neurons from apoptosis induced by nerve growth factor deprivation. J Neurosci 22: 114-122, 2002.
45. Yoo D, Kim BY, Campo C, Nance L, King A, Maouyo D, Welling PA. Cell surface expression of the ROMK (Kir 1.1) channel is regulated by the aldosterone-induced kinase, SGK-1, and protein kinase A. J Biol Chem 278: 23066-23075, 2003.
46. Yus-Nájera E, Muñoz A, Salvador N, Jensen BS, Rasmussen HB, Defelipe J, Villarroel A. Localization of KCNQ5 in the normal and epileptic human temporal neocortex and hippocampal formation. Neuroscience 120: 353-364, 2003.
47. + channels. J Physiol 575: 49-67, 2006.
48. ATP channels. Neuron 22: 537-548, 1999.