CD40 expression on antigen presenting cells and correlation with disease severity in atopic dermatitis

European Journal of Dermatology

Volumn 18, Issue 5, 2008, Pages 527-533

  Oflazoglu, Ezogelin ^a   Simpson, Eric L ^b   Takiguchi, Rodd ^b   Hanifin, Jon M ^b   Grewal, Iqbal S ^a   Gerber, Hans Peter ^a  

^a SEATTLE GENETICS INC   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

APCs; Atopic dematitis; CD1a+; CD40; PARC

Indexed keywords

CD1 ANTIGEN; CD11B ANTIGEN; CD40 ANTIGEN; CHEMOKINE; IMMUNOGLOBULIN E; PROTEIN PARC;

ANTIBODY PRODUCTION; ANTIGEN DETECTION; ANTIGEN EXPRESSION; ANTIGEN FUNCTION; ANTIGEN PRESENTING CELL; ARTICLE; ATOPIC DERMATITIS; CELL INFILTRATION; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATIONAL STUDY; DISEASE ASSOCIATION; DISEASE MARKER; DISEASE SEVERITY; HUMAN; HUMAN CELL; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOHISTOCHEMISTRY; INFLAMMATORY CELL; PROTEIN BLOOD LEVEL; SKIN DEFECT; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; UPREGULATION;

ANTIGEN-PRESENTING CELLS; ANTIGENS, CD40; DERMATITIS, ATOPIC; HUMANS; SEVERITY OF ILLNESS INDEX;

EID: 52649178408     PISSN: 11671122     EISSN: None     Source Type: Journal    
DOI: 10.1684/ejd.2008.0495     Document Type: Article

References (32)

1. Grewal IS, Flavell RA. CD40 and CD154 in cell-mediated immunity. Annu Rev Immunol 1998; 16: 111-35.
2. van Kooten C, Banchereau J. CD40-CD40 ligand. J Leukoc Biol 2000; 67: 2-17.
3. Novak N, Bieber T, Leung DY. Immune mechanisms leading to atopic dermatitis. J Allergy Clin Immunol 2003; 112: S128-S139.
4. Leung DY, Boguniewicz M, Howell MD, Nomura I, Hamid QA. New insights into atopic dermatitis. J Clin Invest 2004; 113: 651-7.
5. Galli G, Chantry D, Annunziato F, Romagnani P, Cosmi L, Lazzeri E, Manetti R, Maggi E, Gray PW, Romagnani S. Macrophage-derived chemokine production by activated human T cells in vitro and in vivo: preferential association with the production of type 2 cytokines. Eur J Immunol 2000; 30: 204-10.
6. Lin L, Nonoyama S, Oshiba A, Kabasawa Y, Mizutani S. TARC and MDC are produced by CD40 activated human B cells and are elevated in the sera of infantile atopic dermatitis patients. J Med Dent Sci 2003; 50: 27-33.
7. Leung DY, Bieber T. Atopic dermatitis. Lancet 2003; 361: 151-60.
8. Mihm Jr. MC, Soter NA, Dvorak HF, Austen KF. The structure normal skin and the morphology of atopic eczema. J Invest Dermatol 1976; 67: 305-12.
9. Braathen LR, Forre O, Natvig JB, Eeg-Larsen T. Predominance of T lymphocytes in the dermal infiltrate of atopic dermatitis. Br J Dermatol 1979; 100: 511-9.
10. Leung DY, Bhan AK, Schneeberger EE, Geho RS. Characterization of the mononuclear cell infiltrate in atopic dermatitis using monoclonal antibodies. J Allergy Clin Immunol 1983; 71: 47-56.
11. Uno H, Hanifin JM. Langerhans cells in acute and chronic epidermal lesions of atopic dermatitis, observed by L-dopa histofluorescence, glycol methacrylate thin secretion, and electron microscopy. J Invest Dermatol 1980; 75: 52-60.
12. Zachary CB, Poulter LW, MacDonald DM. Cell-mediated immune responses in atopic dermatitis: the relevance of antigen-presenting cells. Br J Dermatol 1985; 113(Suppl 28): 10-6.
13. Watanabe K, Kondo N, Fukutomi O, Takami T, Agata H, Orii T. Characterization of infiltrating CD4+ cells in atopic dermatitis using CD45R and CD29 monoclonal antibodies. Ann Allergy 1994; 72: 39-44.
14. Hermes B, Worm M, Nowak F, Kroczek RA, Stein H, Henz BM. Upregulation of CD40 and CD40 ligand expression in IgE-associated cutaneous diseases. Acta Derm Venereol 1997; 77: 441-5.
15. Simpson EL, Hanifin JM. Atopic dermatitis. Med Clin North Am 2006; 90: 149-67; (ix).
16. Rajka G, Langeland T. Grading of the severity of atopic dermatitis. Acta Derm Venereol Suppl (Stockh) 1989; 144: 13-4.
17. Hanifin JM, Thurston M, Omoto M, Cherill R, Tofte SJ, Graeber M. The eczema area and severity index (EASI): assessment of reliability in atopic dermatitis. EASI Evaluator Group. Exp Dermatol 2001; 10: 11-8.
18. Bieber T. Atopic dermatitis. N Engl J Med 2008; 358: 1483-94.
19. Barbee RA, Halonen M, Lebowitz M, Burrows B. Distribution of IgE in a community population sample: correlations with age, sex, and allergen skin test reactivity. J Allergy Clin Immunol 1981; 68: 106-11.
20. Leung DY, Harbeck R, Bina P, Reiser RF, Yang E, Norris DA, Hanifin JM, Sampson HA. Presence of IgE antibodies to staphylococcal exotoxins on the skin of patients with atopic dermatitis. Evidence for a new group of allergens. J Clin Invest 1993; 92: 1374-80.
21. Pivarcsi A, Gombert M, Dieu-Nosjean MC, Lauerma A, Kubitza R, Meller S, Rieker J, Muller A, Da Cunha L, Haahtela A, Sonkoly E, Fridman WH, Alenius H, Kemeny L, Ruzicka T, Zlotnik A, Homey B. CC chemokine ligand 18, an atopic dermatitis-associated and dendritic cell-derived chemokine, is regulated by staphylococcal products and allergen exposure. J Immunol 2004; 173: 5810-7.
22. Gunther C, Bello-Fernandez C, Kopp T, Kund J, Carballido-Perrig N, Hinteregger S, Fassl S, Schwarzler C, Lametschwandtner G, Stingl G, Biedermann T, Carballido JM. CCL18 is expressed in atopic dermatitis and mediates skin homing of human memory T cells. J Immunol 2005; 174: 1723-8.
23. Kakinuma T, Nakamura K, Wakugawa M, Mitsui H, Tada Y, Saeki H, Torii H, Komine M, Asahina A, Tomaki K. Serum macrophage-derived chemokine (MDC) levels are closely related with the disease activity of atopic dermatitis. Clin Exp Immunol 2002; 127: 270-3.
24. Fujisawa T, Fujisawa R, Kato Y, Nakayama T, Morita A, Katsumata H, Nishimori H, Iguchi K, Kamiya H, Gray PW, Chantry D, Suzuki R, Yoshie O. Presence of high contents of thymus and activation-regulated chemokine in platelets and elevated plasma levels of thymus and activation-regulated chemokine and macrophage-derived chemokine in patients with atopic dermatitis. J Allergy Clin Immunol 2002; 110: 139-46.
25. Shimada Y, Takehara K, Sato S. Both Th2 and Th1 chemokines (TARC/CCL17, MDC/CCL22, and Mig/CXCL9) are elevated in sera from patients with atopic dermatitis. J Dermatol Sci 2004; 34: 201-8.
26. Jahnz-Rozyk K, Targowski T, Paluchowska E, Owczarek W, Kuchorczyk A. Serum thymus and activation-regulated chemokine, macrophage-derived chemokine and eotaxin as markers of severity of atopic dermatitis. Allergy 2005; 60: 685-8.
27. Pivarcsi A, Homey B. Chemokine networks in atopic dermatitis: traffic signals of disease. Curr Allergy Asthma Rep 2005; 5: 284-90.
28. Nomura I, Gao B, Boguniewicz M, Darst MA, Travers JB, Leung DY. Distinct patterns of gene expression in the skin lesions of atopic dermatitis and psoriasis: a gene microarray analysis. J Allergy Clin Immunol 2003; 112: 1195-202.
29. Hon KL, Leung TF, Ma KC, Li AM, Wong Y, Fok TF. Serum levels of cutaneous T-cell attracting chemokine (CTACK as a laboratory marker of the severity of atopic dermatitis in children. Clin Exp Dermatol 2004; 29: 293-6.
30. Kagami S, Kakinuma T, Saeki H, Tsunemi Y, Fujita H, Nakamura K, Takekoshi T, Kishimoto M, Mitsui H, Torii H, Komine M, Asahino A, Tamaki K. Significant elevation of serum levels of eotaxin-3/CCL26, but not of eotaxin-2/CCL24, in patients with atopic dermatitis: serum eotaxin-3/ CCL26 levels reflect the disease activity of atopic dermatitis. Clin Exp Immunol 2003; 134: 309-13.
31. Gould HJ, Takhar P, Harries HE, Chevretton E, Sutton BJ. The allergic march from Staphylococcus aureus superantigens to immunoglobulin E. Chem Immunol Allergy 2007; 93: 106-36.
32. Howard LM, Kohm AP, Castaneda CL, Miller SD. Therapeutic blockade of TCR signal transduction and co-stimulation in autoimmune disease. Curr Drug Targets Inflamm Allergy 2005; 4: 205-16.