Pre-operative inflammatory markers and the risk of postoperative delirium in elderly patients

International Journal of Geriatric Psychiatry

Volumn 23, Issue 9, 2008, Pages 943-948

  Lemstra, Afina W ^a   Kalisvaart, Kees J ^b   Vreeswijk, Ralph ^b   van Gool, Willem A ^a   Eikelenboom, Piet ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b Location Alkmaar   (Netherlands)

Author keywords

Cytokines; Delirium; Hip surgery; Risk markers

Indexed keywords

BIOLOGICAL MARKER; C REACTIVE PROTEIN; INTERLEUKIN 6; SOMATOMEDIN C RECEPTOR;

AGED; APACHE; ARTICLE; CASE CONTROL STUDY; CLINICAL ARTICLE; CLINICAL TRIAL; COGNITIVE DEFECT; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTOKINE RELEASE; DELIRIUM; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; GERIATRIC PATIENT; GERONTOPSYCHIATRY; HIP SURGERY; HUMAN; MALE; PATHOPHYSIOLOGY; POSTOPERATIVE COMPLICATION; PREOPERATIVE EVALUATION; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; RISK ASSESSMENT;

AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; CASE-CONTROL STUDIES; COGNITION DISORDERS; DELIRIUM; FEMALE; HIP FRACTURES; HUMANS; INFLAMMATION; INSULIN-LIKE GROWTH FACTOR I; INTERLEUKIN-6; MALE; NETHERLANDS; POSTOPERATIVE COMPLICATIONS; PROSPECTIVE STUDIES;

EID: 52649128411     PISSN: 08856230     EISSN: 10991166     Source Type: Journal    
DOI: 10.1002/gps.2015     Document Type: Article

References (30)

1. Adamis D, Treloar A, Martin FC, et al. 2007. APOE and cytokines as biological markers for recovery of prevalent delirium in elderly medical inpatients. Int J Geriatr Psychiatry 22(7): 688-094.
2. Beloosesky Y, Grinblat J, Pirotsky A, et al. 2004. Different c-reactive protein kinetics in post-operative hip-fractured geriatric patients with and without complications. Gerontology 50(4): 216-222.
3. Beloosesky Y, Hendel D, Weiss A, et al. 2007. Cytokines and c-reactive protein production in hip-fracture-operated elderly patients. J. Gerontol A Biol Sci Med Sci 62(4): 420-426.
4. De Martinis M, Franceschi C, Monti D, Ginaldi L. 2006. Inflammation markers predicting frailty and mortality in the elderly. Exp Mol Pathol 80(3): 219-227.
5. De Rooij SE, Van Munster BC, Korevaar JC, Levi M. 2007. Cytokines and acute phase response in delirium. J. Psychosom Res 62(5): 521-525.
6. Eikelenboom P, Hoogendijk WJ, Jonker C, Van Tilburg W. 2002. Immunological mechanisms and the spectrum of psychiatric syndromes in Alzheimer's disease. J. Psychiatr Res 36(5): 269-280.
7. Folstein MF, Folstein SE, Mchugh PR. 1975. 'Mini-Mental State'. A. practical method for grading the cognitive state of patients for the clinician. J. Psychiatr Res 12(3): 189-198.
8. Godbout JP, Chen J, Abraham J, et al. 2005. Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system. FASEB J 19(10): 1329-1331.
9. Godbout JP, Johnson RW. 2006. Age and neuroinflammation: a lifetime of psychoneuroimmune consequences. Neurol Clin 24(3): 521-538.
10. Inouye SK. 2006. Delirium in older persons. N. Engl J Med 354(11): 1157-1165.
11. Inouye SK, Van Dyck CH, Alessi CA, et al. 1990. Clarifying confusion: the confusion assessment method. a new method for detection of delirium. Ann Intern Med 113(12): 941-948.
12. Inouye SK, Viscoli CM, Horwitz RI, et al. 1993. A predictive model for delirium in hospitalized elderly medical patients based on admission characteristics. Ann Intern Med 119(6): 474-481.
13. Kalisvaart KJ, De Jonghe JF, Bogaards MJ, et al. 2005. Haloperidol prophylaxis for elderly hip-surgery patients at risk for delirium: a randomized placebo-controlled study. J. Am Geriatr Soc 53(10): 1658-1666.
14. Knaus WA, Draper EA, Wagner DP, Zimmerman JE. 1985. APACHE II: a severity of disease classification system. Crit Care Med 13(10): 818-829.
15. Krabbe KS, Pedersen M, Bruunsgaard H. 2004. Inflammatory mediators in the elderly. Exp Gerontol 39(5): 687-699.
16. Kudoh A, Takase H, Katagai H, Takazawa T. 2005. Postoperative interleukin-6 and cortisol concentrations in elderly patients with postoperative confusion. Neuroimmunomodulation 12(1): 60-66.
17. Lemstra AW, Groen INT, Woud JC, et al. 2007. Microglia activation in sepsis: a case-control study. J. Neuroinflammation 4(1): 4.
18. Licastro F, Candore G, Lio D, et al. 2005. Innate immunity and inflammation in ageing: a key for understanding age-related diseases. Immun Ageing 2: 8.
19. Macdonald A, Adamis D, Treloar A, Martin F. 2006. C-reactive protein levels predict the incidence of delirium and recovery from it. Age Ageing 36: 222-225.
20. Malek-Ahmadi P, Hilsabeck RC. 2007. Neuropsychiatric complications of interferons: classification, neurochemical bases, and management. Ann ClinPsychiatry 19(2): 113-123.
21. Marcantonio ER, Rudolph JL, Culley D, et al. 2006. Serum biomarkers for delirium. J. Gerontol A Biol Sci Med Sci 61(12): 1281-1286.
22. Marcantonio ER, Simon SE, Bergmann MA, et al. 2003. Delirium symptoms in post-acute care: prevalent, persistent, and associated with poor functional recovery. J. AmGeriatr Soc 51(1): 4-9.
23. Perry VH, Cunningham C, Holmes C. 2007. Systemic infections and inflammation affect chronic neurodegeneration. Nat Rev Immunol 7(2): 161-167.
24. Schalkwijk CG, Poland DC, Van DW, et al. 1999. Plasma concentration of C-reactive protein is increased in Type I diabetic patients without clinical macroangiopathy and correlates with markers of endothelial dysfunction: evidence for chronic inflammation. Diabetologia 42(3): 351-357.
25. Trzepacz PT, Mittal D, Torres R, et al. 2001. Validation of the Delirium Rating Scale - Revised - 98: comparison with the Delirium Rating Scale and the Cognitive Test For Delirium. J. Neuropsychiatry Clin Neurosci 13(2): 229-242.
26. Van Steijn JH, Nieboer P, Hospers GA, et al. 2001. Delirium after interleukin-2 and alpha-interferon therapy for renal cell carcinoma. Anticancer Res 21(5): 3699-3700.
27. Vasto S, Candore G, Balistreri CR, et al. 2007. Inflammatory networks in ageing, age-related diseases and longevity. Mech-Ageing Dev 128(1): 83-91.
28. Weaver JD, Huang MH, Albert M, et al. 2002. Interleukin-6 and risk of cognitive decline: Macarthur studies of successful aging. Neurology 59(3): 371-378.
29. Wilson K, Broadhurst C, Diver M, et al. 2005. Plasma insulin growth factor-1 and incident delirium in older people. Int J Geriatr Psychiatry 20(2): 154-159.
30. Yaffe K, Lindquist K, Penninx BW, et al. 2003. Inflammatory markers and cognition in well-functioning African-American and white elders. Neurology 61(1): 76-80.