The effect of shape on the margination dynamics of non-neutrally buoyant particles in two-dimensional shear flows

Journal of Biomechanics

Volumn 41, Issue 10, 2008, Pages 2312-2318

  Gentile, F ^a,b   Chiappini, C ^d   Fine, D ^d   Bhavane, R C ^b   Peluccio, M S ^b,e   Cheng, M Ming Cheng ^b   Liu, X ^b   Ferrari, M ^b,f   Decuzzi, P ^a,b,c  

^a UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^b UNIVERSITY OF TEXAS   (United States)

^c POLITECNICO DI BARI   (Italy)

^d UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^e POLITECNICO DI TORINO   (Italy)

^f UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Drug delivery; Fluidic chamber; Particle dynamics; Sedimentation

Indexed keywords

BLOOD VESSELS; BUOYANCY; DRUG DELIVERY; DYNAMICS; LAMINAR FLOW; MICROCIRCULATION; PARALLEL FLOW; SEDIMENTATION; SHEAR DEFORMATION; SPHERES;

BUOYANT PARTICLES; DISCOIDAL PARTICLES; FLUIDIC CHAMBER; HYDRODYNAMIC CONDITIONS; PARALLEL PLATE FLOW CHAMBER; PARTICLE DYNAMICS; SILICON PARTICLES; SPHERICAL PARTICLE;

SHEAR FLOW;

SILICON DIOXIDE; GLASS;

ARTICLE; DENSITY; DRUG DELIVERY SYSTEM; HEMISPHERE; HYDRODYNAMICS; IMAGE ANALYSIS; LAMINAR FLOW; MEMBRANE MICROPARTICLE; MICROCIRCULATION; NONHUMAN; PARTICLE IMAGE VELOCIMETRY; PARTICLE MARGINATION DYNAMICS; PARTICLE SIZE; PRIORITY JOURNAL; SEDIMENTATION; SHEAR FLOW; SHEAR RATE; BIOLOGICAL MODEL; BIOMECHANICS; BLOOD FLOW VELOCITY; CHEMISTRY; COMPUTER PROGRAM; COMPUTER SIMULATION; ELASTICITY; EQUIPMENT DESIGN; MECHANICAL STRESS; METHODOLOGY; PHYSIOLOGY; POROSITY; SHEAR STRENGTH; TIME;

BIOMECHANICS; BLOOD FLOW VELOCITY; COMPUTER SIMULATION; DRUG DELIVERY SYSTEMS; ELASTICITY; EQUIPMENT DESIGN; GLASS; MODELS, CARDIOVASCULAR; PARTICLE SIZE; POROSITY; SHEAR STRENGTH; SILICON DIOXIDE; SOFTWARE; STRESS, MECHANICAL; TIME FACTORS;

EID: 52649118065     PISSN: 00219290     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiomech.2008.03.021     Document Type: Article

References (23)

1. Choi, Y.S., Thomas, T., Kotlyar, A., Islam, M.T., Baker, J.R., 2005. Synthesis and functional evaluation of DNA-assembled polyamidoamine dendrimer clusters for cancer cell-specific targeting. Chemistry & Biology 12.
2. Cohen, M.H., Melnik, K., Boiarski, A.A., Ferrari, M., Martin, F.J., 2003. Microfabrication of silicon-based nanoporous particulates for medical applications. Biomedical Microdevices 5, 253-259.
3. Crommelin, D.J.A., Schreier, H., 1994. Liposomes. In: Kreuter, J. (Ed.), Colloidal Drug Delivery Systems. Marcel Dekker Inc., New York.
4. Decuzzi, P., Ferrari, M., 2006. The adhesive strength of non-spherical particles mediated by specific interactions. Biomaterials 27 (30), 5307-5314.
5. Decuzzi, P., Lee, S., Bhushan, B., Ferrari, M., 2005. Theoretical model for the margination of particles within blood vessels. Annals of Biomedical Engineering 32 (6), 793-802.
6. di Tomaso, E., Capen, D., Haskell, A., Hart, J., Logie, J.J., Jain, R.K., et al., 2005. Mosaic tumor vessels: cellular basis and ultrastructure of focal regions lacking endothelial cell markers. Cancer Research 65 (13), 5740-5749.
7. Duncan, R., 2003. The dawning era of polymer therapeutics. Nature Reviews: Drug Discovery 2, 347-360.
8. Ferrari, M., 2005a. Nanovector therapeutics. Current Opinion in Chemical Biology 9 (4), 343-346.
9. Ferrari, M., 2005b. Cancer nanotechnology: opportunities and challenges. Nature Reviews: Cancer 5 (3), 161-171.
10. Gavze, E., Shapiro, M., 1998. Motion of inertial spheroidal particles in a shear flow near a solid wall with special application to aerosol transport in microgravity. Journal of Fluid Mechanics 371, 59-79.
11. Goldman, A.J., Cox, R.G., Brenner, H., 1967. Slow viscous motion of a sphere parallel to a plane wall. II. Couette flow. Chemical Engineering Science 22, 653.
12. Goldsmith, H.L., Spain, S., 1984. Margination of leukocytes in blood flow through small tubes. Microvascular Research 27 (2), 204-222.
13. Gopalan, P.K., Smith, C.W., Lu, H., Berg, E.L., McIntire, L.V., Simon, S.I., 1997. Neutrophil CD18-dependent arrest on intercellular adhesion molecule 1 (ICAM-1) in shear flow can be activated through L-selectin. Journal of Immunology 158 (1), 367-375.
14. Hogg, A.J., 1994. Inertial migration of a non-neutrally buoyant particle in a two-dimensional shear flow. Journal of Fluid Mechanics 272, 285-318.
15. LaVan, D.A., Mcguire, T., Langer, R., 2003. Small-scale systems for in vivo drug delivery. Nature Biotechnology 21 (10), 1184-1191.
16. Lee, S.Y., Decuzzi, P., 2008. Analysis of the hydrodynamics forces on non-spherical particles within a capillary flow, internal communication.
17. MatLab 6.5, 2002. Image Processing Toolbox, The MAthWorks, Inc., Copyright 1984-2002.
18. Neri, D., Bicknell, R., 2005. Tumour vascular targeting. Nature Reviews Cancer 5, 436-446.
19. Pozrikidis, C., 2006. Flipping of an adherent blood platelet over a substrate. Journal of Fluid Mechanics 568, 161-172.
20. Rolland, J.P., Maynor, B.W., Euliss, L.E., Exner, A.E., Denison, G.M., DeSimone, J.M., 2005. Direct fabrication and harvesting of monodisperse, shape specific nano-biomaterials. Journal of American Chemical Society 127, 10096-10100.
21. Shinde Patil, V.R., Campbell, C.J., Yun, Y.H., Slack, S.M., Goetz, D.J., 2001. Particle diameter influences adhesion under flow. Biophysical Journal 80 (4), 1733-1743.
22. van Dillen, T., van Blaaderen, A., Polman, A., 2004. Ion beam shaping of colloidal assemblies. Materials Today, 40-46.
23. Wolfram, S., 2003. The Mathematica Book, fifth ed. Wolfram Media, Cambridge University Press, Cambrid