Comparison of human T cell repertoire generated in xenogeneic porcine and human thymus grafts

Transplantation

Volumn 86, Issue 4, 2008, Pages 601-610

  Shimizu, Ichiro ^a,b   Fudaba, Yasuhiro ^a   Shimizu, Akira ^a   Yang, Yong Guang ^a   Sykes, Megan ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

Spectratyping; T cell repertoire; Thymopoiesis; Thymus; Xenotransplantation

Indexed keywords

CD34 ANTIGEN; T LYMPHOCYTE RECEPTOR BETA CHAIN; LYMPHOCYTE ANTIGEN RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL MATURATION; CONTROLLED STUDY; FETUS; HUMAN; HUMAN CELL; HUMAN TISSUE; KIDNEY CAPSULE; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; SWINE; T LYMPHOCYTE; THYMUS GRAFT; XENOGRAFT; ANIMAL; DRUG SCREENING; GENETICS; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; METHODOLOGY; MINIPIG; MIXED LYMPHOCYTE CULTURE; MOUSE MUTANT; NONOBESE DIABETIC MOUSE; THYMUS; TRANSPLANTATION;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; FETUS; HUMANS; IMMUNE TOLERANCE; LYMPHOCYTE CULTURE TEST, MIXED; MAJOR HISTOCOMPATIBILITY COMPLEX; MICE; MICE, INBRED NOD; MICE, SCID; RECEPTORS, ANTIGEN, T-CELL; SUBRENAL CAPSULE ASSAY; SWINE; SWINE, MINIATURE; T-LYMPHOCYTES; THYMUS GLAND; TRANSPLANTATION, HETEROLOGOUS;

EID: 52449135124     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e318182d47a     Document Type: Article

References (49)

1. Sachs DH, Sykes M, Greenstein JL, et al. Tolerance and xenograft survival. Nat Med 1995; 1: 969.
2. Dor FJ, Tseng YL, Cheng J, et al. alpha1,3-Galactosyltransferase geneknockout miniature swine produce natural cytotoxic anti-Gal antibodies. Transplantation 2004; 78: 15.
3. Yamada K, Yazawa K, Shimizu A, et al. Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3- galactosyltransferase gene-knockout donors and the co-transplantation of vascularized thymic tissue. Nat Med 2005; 11: 32.
4. Kuwaki K, Tseng YL, Dor FJ, et al. Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: Initial experience. Nat Med 2005; 11: 29.
5. Chen G, Qian H, Starzl T, et al. Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys. Nat Med 2005; 11: 1295.
6. Khan A, Sergio JJ, Zhao Y, et al. Discordant xenogeneic neonatal thymic transplantation can induce donor-specific tolerance. Transplantation 1997; 63: 124.
7. Lee LA, Gritsch HA, Sergio JJ, et al. Specific tolerance across a discordant xenogeneic transplantation barrier. Proc Natl Acad Sci USA 1994; 91: 10864.
8. Zhao Y, Swenson K, Sergio JJ, et al. Skin graft tolerance across a discordant xenogeneic barrier. Nat Med 1996; 2: 1211.
9. Zhao Y, Fishman JA, Sergio JJ, et al. Immune restoration by fetal pig thymus graftsinT cell-depleted, thymectomized mice. J Immunol 1997; 158: 1641.
10. Nikolic B, Gardner JP, Scadden DT, et al. Normal development in porcine thymus grafts and specific tolerance of human T cells to porcine donor MHC. J Immunol 1999; 162: 3402.
11. Kamano C, Vagefi PA, Kumagai N, et al. Vascularized thymic lobe transplantation in miniature swine: Thymopoiesis and tolerance induction across fully MHC-mismatched barriers. Proc Natl Acad Sci USA 2004; 101: 3827.
12. Barth RN, Yamamoto S, LaMattina JC, et al. Xenogeneic thymokidney and thymic tissue transplantation in a pig-to-baboon model: I. Evi- dence for pig-specific T-cell unresponsiveness. Transplantation 2003; 75: 1615.
13. Wu A, Yamada K, Neville DM, et al. Xenogeneic thymus transplantation in a pig-to-baboon model. Transplantation 2003; 75: 282.
14. Yamamoto S, Lavelle JM, Vagefi PA, et al. Vascularized thymic lobe transplantation in a pig-to-baboon model: A novel strategy for xenogeneic tolerance induction and T-cell reconstitution. Transplantation 2005; 80: 1783.
15. Toyonaga B, Yoshikai Y, Vadasz V, et al. Organization and sequences of the diversity, joining, and constant region genes of the human T-cell receptor beta chain. Proc Natl Acad Sci USA 1985; 82: 8624.
16. Garcia KC, Degano M, Stanfield RL, et al. An alphabeta T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex. Science 1996; 274: 209.
17. Genevee C, Diu A, Nierat J, et al. An experimentally validated panel of subfamily-specific oligonucleotide primers (V alpha 1-w29/V beta 1-w24) for the study of human T cell receptor variable V gene segment usage by polymerase chain reaction. Eur J Immunol 1992; 22: 1261.
18. Gorski J, Yassai M, Zhu X, et al. Circulating T cell repertoire complexity in normal individuals and bone marrow recipients analyzed by CDR3 size spectratyping. Correlation with immune status. J Immunol 1994; 152: 5109.
19. Dietrich PY, Caignard A, Lim A, et al. In vivo T-cell clonal amplification at time of acute graft-versus-host disease. Blood 1994; 84: 2815.
20. Douillard P, Josien R, Pannetier C, et al. Selection of T cell clones with restricted TCR-CDR3 lengths during in vitro and in vivo alloresponses. Int Immunol 1998; 10: 71.
21. Leight GS, Sachs DH, Rosenberg SA. Transplantation in miniature swine. II. In vitro parameters of histocompatibility in MSLA homozygous minipigs. Transplantation 1977; 23: 271.
22. Haller GW, EsnaolaN, Yamada K, et al. Thymic transplantation across an MHC class I barrier in swine. J Immunol 1999; 163: 3785.
23. Lan P, Wang L, Diouf B, et al. Induction of human T-cell tolerance to porcine xenoantigens through mixed hematopoietic chimerism. Blood 2004; 103: 3964.
24. + T cell receptor repertoire. J Infect Dis 1998; 177: 579.
25. Zhao Y, Sergio JJ, Swenson K, et al. Positive and negative selection of functional mouse CD4 cells by porcine MHC in pig thymus grafts. J Immunol 1997; 159: 2100.
26. Zhao Y, Rodriguez-Barbosa JI, Zhao G, et al. Maturation and function of mouse T-cells with a transgenic TCR positively selected by highly disparate xenogeneic porcine MHC. Cell Mol Biol (Noisy-le-grand) 2001; 47: 217.
27. Zhao Y, Rodriguez-Barbosa JI, Shimizu A, et al. Despite efficient intrathymic negative selection of host-reactive T cells, autoimmune disease may develop in porcine thymus-grafted athymic mice: Evidence for failure of regulatory mechanisms suppressing autoimmunity. Transplantation 2003; 75: 1832.
28. + T cells with a mouse MHC-restricted TCR in pig thymus grafts. J Immunol 1998; 161: 1320.
29. Renard C, Vaiman M, Chiannilkulchai N, et al. Sequence of the pig major histocompatibility region containing the classical class I genes. Immunogenetics 2001; 53: 490.
30. Chardon P, Rogel-Gaillard C, Cattolico L, et al. Sequence of the swine major histocompatibility complex region containing all non-classical class I genes. Tissue Antigens 2001; 57: 55.
31. Gustafsson K, Germana S, Hirsch F, et al. Structure of miniature swine class IIDRB genes: Conservation of hypervariable amino acid residues between distantly related mammalian species. Proc Natl Acad Sci USA 1990; 87: 9798.
32. Hirsch F, Sachs DH, Gustafsson K, et al. Class II genes of miniature swine. III. Characterization of an expressed pig class II gene homologous to HLA-DQA. Immunogenetics 1990; 31: 52.
33. HusebyES, Crawford F, White J, et al. Interface-disrupting amino acids establish specificity between T cell receptors and complexes of major histocompatibility complex and peptide. Nat Immunol 2006; 7: 1191.
34. Huseby E, Kappler J, Marrack P. TCR-MHC/peptide interactions: Kissing-cousins or a shotgun wedding? Eur J Immunol 2004; 34: 1243.
35. Zerrahn J, Held W, Raulet DH. The MHC reactivity of the T cell repertoire prior to positive and negative selection. Cell 1997; 88: 627.
36. Yamada K, Shimizu A, Utsugi R, et al. Thymic transplantation in miniature swine. II. Induction of tolerance by transplantation of composite thymokidneys to thymectomized recipients. J Immunol 2000; 164: 3079.
37. + T cells via a CD30-dependent mechanism. J Clin Invest 2004; 113: 310.
38. Maloy KJ, Powrie F. Regulatory T cells in the control of immune pathology. Nat Immunol 2001; 2: 816.
39. Kingsley CI, Karim M, Bushell AR, et al. CD25+CD4+ regulatory T cells prevent graft rejection: CTLA-4- and IL-10-dependent immuno-regulation of alloresponses. J Immunol 2002; 168: 1080.
40. Kim JM, Rasmussen JP, Rudensky AY. Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat Immunol 2007; 8: 191.
41. Modigliani Y, Thomas-Vaslin V, Bandeira A, et al. Lymphocytes selected in allogeneic thymic epithelium mediate dominant tolerance toward tissue grafts of the thymic epithelium haplotype. Proc Natl Acad Sci USA 1995; 92: 7555.
42. Zamoyska R, Waldmann H, Matzinger P. Peripheral tolerance mecha- nisms prevent the development of autoreactive T cells in chimeras grafted with two minor incompatible thymuses. Eur J Immunol 1989; 19: 111.
43. Lan P, Wang L, Diouf B, et al. Induction of human T-cell tolerance to porcine xenoantigens through mixed hematopoietic chimerism. Blood 2004; 103: 3964.
44. + cell transplantation. Blood 2006; 108: 487.
45. TonomuraN, Habiro K, Shimizu A, et al. Antigen specific human T cell responses and T cell-dependent production of human antibodies in a humanized mouse model. Blood 2008; 111: 4293.
46. Jung S. Good, bad and beautiful - the role of dendritic cells in autoimmunity. Autoimmun Rev 2004; 3: 54.
47. Taguchi O, Takahashi T, Seto M, et al. Development of multiple organ-localized autoimmune diseases in nude mice after reconstitution of T cell function by rat fetal thymus graft. J Exp Med 1986; 164: 60.
48. Yan Y, Devos T, Yu L, et al. Pathogenesis of autoimmunity after xenogeneic thymus transplantation. J Immunol 2003; 170: 5936.
49. Devos T, Sprangers B, Lin Y, et al. Occurrence of autoimmunity after xenothymus transplantation in T-cell-deficient mice depends on the thymus transplant technique. Transplantation 2008; 85: 640.