NMR structure of biosynthetic engineered human insulin monomer B31Lys-B32Arg in water/acetonitrile solution. Comparison with the solution structure of native human insulin monomer

Biopolymers

Volumn 89, Issue 10, 2008, Pages 820-830

  Bocian, Wojciech ^a,b   Borowicz, Piotr ^c   Mikołajczyk, Jerzy ^c   Sitkowski, Jerzy ^a,b   Tarnowska, Anna ^b   Bednarek, Elzbieta ^a   Głabski, Tadeusz ^c   Tejchman Malecka, Bozena ^c   Bogiel, Monika ^c   Kozerski, Lech ^a,b  

^a NATIONAL MEDICINES INSTITUTE   (Poland)

^b INSTITUTE OF ORGANIC CHEMISTRY   (Poland)

^c INDUSTRIAL CHEMISTRY RESEARCH INSTITUTE   (Poland)

Author keywords

MD in water; Modified human insulin B31Lys B32Arg monomer; NMR structure; Water acetonitrile solvent

Indexed keywords

ACETONITRILE; AGGLOMERATION; ALUMINUM; AMBER; ANNEALING; CARBON NITRIDE; CONCENTRATION (PROCESS); DYNAMICS; HORMONES; INSULIN; MODEL STRUCTURES; MOLECULAR DYNAMICS; MONOMERS; NETWORK PROTOCOLS; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OLIGOMERS; ORGANIC SOLVENTS; POLYMERS; QUANTUM CHEMISTRY; SIMULATED ANNEALING; SOLVENTS;

CONCENTRATION RANGES; DYNAMIC INFORMATIONS; GENERALIZED BORN; HEXAMER; IN VACUUMS; INSULIN MONOMERS; LONG-RANGE; MD IN WATER; MODIFIED HUMAN INSULIN B31LYS-B32ARG MONOMER; NATIVE CONFORMATIONS; NMR STRUCTURE; NMR STRUCTURES; PULSED FIELD GRADIENT SPIN ECHOES; SOLUTION NMR; SOLUTION STRUCTURES; SOLVENT MODELS; SOLVENT SYSTEMS; STRUCTURE ELUCIDATIONS; TERTIARY STRUCTURES; X-RAY STRUCTURES;

CRYSTAL STRUCTURE;

ACETONITRILE; ARGININE; HUMAN INSULIN; LYSINE; MONOMER; SOLVENT; WATER; ACETONITRILE DERIVATIVE; INSULIN; RECOMBINANT PROTEIN;

ACIDITY; ARTICLE; BIOSYNTHESIS; CHEMICAL STRUCTURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG STRUCTURE; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE; NUCLEAR OVERHAUSER EFFECT; PHYSICAL CHEMISTRY; SOLVENT EFFECT; STRUCTURE ANALYSIS; X RAY ANALYSIS; CHEMISTRY; COMPARATIVE STUDY; HUMAN; MECHANICAL TORSION; METABOLISM; PROTEIN MOTIF; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SOLUTION AND SOLUBILITY; X RAY CRYSTALLOGRAPHY;

ACETONITRILES; AMINO ACID MOTIFS; ARGININE; CRYSTALLOGRAPHY, X-RAY; HUMANS; INSULIN; LYSINE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SOLUTIONS; TORSION, MECHANICAL; WATER;

EID: 52449106156     PISSN: 00063525     EISSN: 10970282     Source Type: Journal    
DOI: 10.1002/bip.21018     Document Type: Article

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