Amino-alkyl-cyclohexanes are novel uncompetitive NMDA receptor antagonists with strong voltage-dependency and fast blocking kinetics: In vitro and in vivo characterization

Neuropharmacology

Volumn 38, Issue 1, 1999, Pages 85-108

  Parsons, Chris G ^a   Danysz, Wojciech ^a   Bartmann, Annette ^a   Spielmanns, Peter ^a   Frankiewicz, Tadeusz ^a   Hesselink, Mayke ^a   Eilbacher, Bernd ^a   Quack, Günter ^a  

^a Merz+Co Eckenheimer L ^*  (Germany)

Author keywords

Amino alkyl cyclohexane; Cortical cultures; Excitotoxicity; Hipppocampal slices; Hypoglycaemia; Hypoxia; MES convulsions; Microdialysis; Patch clamp; Subtypes; Uncompetitive N methyl D aspartate receptor antagonist; Xenopus oocytes

Indexed keywords

AMANTADINE; CYCLOHEXANE; DIZOCILPINE; GLUTAMIC ACID; MEMANTINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; RECEPTOR SUBTYPE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; CONVULSION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG HALF LIFE; DRUG POTENCY; ELECTRIC POTENTIAL; EXCITATORY POSTSYNAPTIC POTENTIAL; FEMALE; FETUS; HIPPOCAMPUS; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NERVE CELL CULTURE; NEWBORN; NONHUMAN; OOCYTE; ORAL DRUG ADMINISTRATION; PATCH CLAMP; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; RECEPTOR BLOCKING; XENOPUS;

ALKYLATION; AMINES; ANIMALS; BINDING, COMPETITIVE; CELLS, CULTURED; CYCLOHEXANES; EXCITATORY AMINO ACID ANTAGONISTS; KINETICS; MALE; MICE; NEURONS; PATCH-CLAMP TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE; TIME FACTORS; XENOPUS LAEVIS;

EID: 0032968779     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(98)00161-0     Document Type: Article

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