Pharmacokinetic/pharmacodynamic modeling of corticosterone suppression and lymphocytopenia by methylprednisolone in rats

Journal of Pharmaceutical Sciences

Volumn 97, Issue 7, 2008, Pages 2820-2832

  Yao, Zhenling ^a   Dubois, Debra C ^a   Almon, Richard R ^a   Jusko, William J ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

Cell trafficking; Circadian rhythm; Corticosteroid; Hormones; Indirect response model; Lymphocyte; Mathematical model; Pharmacodynamics; Pharmacokinetic pharmacodynamic models; Pharmacokinetics

Indexed keywords

METHYLPREDNISOLONE SODIUM SUCCINATE;

ADRENAL SUPPRESSION; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CIRCADIAN RHYTHM; CONTROLLED STUDY; DRUG ABSORPTION; DRUG MECHANISM; EXPERIMENTAL MODEL; HORMONE BLOOD LEVEL; LYMPHOCYTE; LYMPHOCYTOPENIA; MALE; NONHUMAN; QUANTITATIVE ANALYSIS; RAT; STRESS; TREATMENT RESPONSE;

EID: 52449084182     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21167     Document Type: Article

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