Ki-ras proto-oncogene mutations in sporadic colorectal adenomas: Relationship to histologic and clinical characteristics

Gastroenterology

Volumn 121, Issue 2, 2001, Pages 302-309

  Maltzman, Terese ^a,b   Knoll, Kirsten ^a   Martinez, Maria Elena ^c   Byers, Tim ^b   Stevens, Beth R ^d   Marshall, James R ^c   Reid, Mary E ^c   Einspahr, Janine ^c   Hart, Nancy ^c   Bhattacharyya, Achyut K ^c   Kramer, Cheryl B ^c   Sampliner, Richard ^c,e,f   Alberts, David S ^c,f   Ahnen, Dennis J ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF ARIZONA   (United States)

^d Colorado Foundation for Medical Care ^*  (United States)

^e SOUTHERN ARIZONA VA HEALTH CARE SYSTEM   (United States)

^f UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; KI RAS PROTEIN; RAS PROTEIN; UNCLASSIFIED DRUG;

ADENOMATOUS POLYP; ADULT; AGED; ARTICLE; CANCER GRADING; CANCER GROWTH; COLON ADENOMA; COLON TUMOR; CONTROLLED STUDY; DEMOGRAPHY; DYSPLASIA; FEMALE; GENE MUTATION; GENE SEQUENCE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; ONCOGENE RAS; PRIORITY JOURNAL; PROTO ONCOGENE; RECTUM ADENOMA; TUMOR GROWTH; TUMOR LOCALIZATION; TUMOR VOLUME;

EID: 0034910649     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/gast.2001.26278     Document Type: Article

References (37)

1. Cancer Statistics, 2000
2. Prevention of colorectal cancer by colonoscopic polypectomy. The National Polyp Workshop
3. A genetic model for colorectal tumorigenesis
4. Altered expression of hMSH2 and hMLH1 in tumors with microsatellite instability and genetic alterations in mismatch repair genes
5. Molecular genetics of colorectal carcinoma
6. Genetic alteration during colorectal-tumor development
7. Getting a handle on ras activity
8. The ras gene family and human carcinogenesis
9. Epidemiology of colorectal adenomas
10. Lack of effect of a high-fiber cereal supplement on the recurrence of colorectal adenomas
11. Risk factors for Ki-ras protooncogene mutation in sporadic colorectal adenomas
12. Prevalence of ras gene mutations in human colorectal cancers
13. Detection of high incidence of K-ras oncogenes during human colon carcinogenesis
14. Prognostic value of TP53 and K-ras-2 mutational analysis in stage III carcinoma of the colon
15. Ki-ras mutation and p53 overexpression predict the clinical behavior of colorectal cancer: A southwest oncology study
16. K-ras gene mutation is a useful predictor of the survival of early stage colorectal cancers
17. Mutant K-ras oncogenes in colon cancers do not predict patient's chemotherapy or response to survival
18. Genetic heterogeneity in sporadic colorectal adenomas
19. K-RAS-2 gene mutations as predictors of metachronous colorectal adenomas
20. Microsatellite instability in cancer of the proximal colon
21. Higher frequency of point mutations in the c-K-ras 2 gene in human colorectal adenomas with severe atypia than in carcinomas
22. K-ras mutations and HLA-DR expression in large bowel adenomas
23. Effect of K-ras mutation on morphogenesis of colorectal adenomas and early cancers: Relationship to distribution of proliferating cells
24. Ki-ras mutations in adenomas: A characteristic of cancer-bearing colorectal mucosa
25. Adenoma-carcinoma sequence of colorectum. Prevalence of K-ras gene mutation in adenomas with increasing degree of dysplasia and aneuploidy
26. Infrequent K-ras codon 12 mutation in serrated adenomas of human colorectum
27. A detailed analysis of the role of K-ras gene mutation in the progression of colorectal adenoma
28. High frequency of K-ras mutations in sporadic colorectal adenomas
29. Genetic epidemiology of mutated K-ras proto-oncogene, altered suppressor genes, and microsatellite instability in colorectal adenomas
30. K-ras gene mutation related to histological atypias in human colorectal adenomas
31. K-ras gene mutations in normal colorectal tissues from K-ras mutation-positive colorectal cancer patients
32. Activation of c-K-ras mutation in human gastrointestinal tumors
33. Ki-ras mutation in colorectal cancer: Relations to patient age, sex and tumor location
34. Intervention studies in adenoma patients
35. The national polyp study
36. The incidence and significance of villous change in adenomatous polyps
37. Univariate and multivariate analyses of the relationship between adenocarcinoma and solitary and multiple adenomas in colorectal adenoma patients