The roles of Kupffer cells in the development and regression of liver fibrosis

Yaoxue Xuebao

Volumn 43, Issue 9, 2008, Pages 884-889

  Wu, Jun Yu ^a   Liu, Geng Tao ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Hepatic stellate cell; Kupffer cell; Liver fibrosis

Indexed keywords

MATRIX METALLOPROTEINASE; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL; APOPTOSIS; HUMAN; ITO CELL; KUPFFER CELL; LIVER CELL; LIVER CIRRHOSIS; LIVER REGENERATION; METABOLISM; PATHOLOGY; PHYSIOLOGY; REVIEW; SECRETION;

ANIMALS; APOPTOSIS; HEPATIC STELLATE CELLS; HEPATOCYTES; HUMANS; KUPFFER CELLS; LIVER CIRRHOSIS; LIVER REGENERATION; MATRIX METALLOPROTEINASES, SECRETED; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 52149123663     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (35)

1. Wallace K, Burt AD, Wright MC. Liver fibrosis [J]. Biochem J, 2008,411:1-18.
2. Gines P, Cardenas A, Arroyo V, et al. Management of cirrhosis and ascites [J]. N Engl J Med, 2004,350:1646-1654.
3. Schuppan D, Afdhal NH. Liver cirrhosis [J]. Lancet, 2008,371:838-851.
4. Gershwin ME, Mackay IR. The causes of primary biliary cirrhosis: convenient and inconvenient truths [J]. Hepatology, 2008,47:737-745.
5. Brunt EM. Nonalcoholic steatohepatitis [J]. Semin Liver Dis, 2004,24:3-20.
6. Muriel P, Escobar Y. Kupffer cells are responsible for liver cirrhosis induced by carbontetrachloride [J]. J Appl Toxicol, 2003,23:103-108.
7. Fukuda M, Yokoyama H, Mizukami T, et al. Kupffer cell depletionattenuates superoxide anion release into the hepatic sinusoids after lipopolysaccharide treatment [J]. J Gastroenterol Hepatol, 2004,19:1155-1162.
8. Atsukawa K, Saito H, Tsukada N, et al. Th1 and Th2 cytokines differentially regulate the transformation of Kupffer cells into multinucleated giant cells but similarly enhance the Kupffer cell-induced hepatic stellate cell proliferation [J]. Hepatol Res, 2001,20:193-206.
9. Ogasawara J, Watanabe-Fukunaga R, Adachi M, et al. Lethal effect of the anti-Fas antibody in mice [J]. Nature, 1993,364:806-809.
10. Jaeschke H. Inflammation in response to hepatocellular apoptosis [J]. Hepatology, 2002,35:964-966.
11. Canbay A, Guicciardi ME, Higuchi H, et al. Cathepsin B inactivation attenuates hepatic injury and fibrosis during cholestasis [J]. J Clin Invest, 2003,112:152-159.
12. Canbay A, Feldstein AE, Higuchi H, et al. Kupffer cellengulfment of apoptotic bodies stimulates death ligand and cytokine expression [J]. Hepatology, 2003,38:1188-1198.
13. Pinzani M, Abboud HE, Gesualdo L, et al. Regulation of macrophage colony-stimulating factor in liver fat-storing cells by peptide growth factors [J]. Am J Physiol, 1992,262:C876-881.
14. Xiong S, She H, Sung CK, et al. Iron-dependent activation of NF-kappaB in Kupffer cells: a priming mechanism for alcoholic liver disease [J]. Alcohol, 2003,30:107-113.
15. Lieber CS. Alcoholic fatty liver: its pathogenesis and mechanism of progression to inflammation and fibrosis [J]. Alcohol, 2004,34:9-19.
16. Nieto N, Cederbaum AI. Cross talk between Kupffer cells and stellate cells and fibrogenic response [J]. J Hepatol, 2005,42:120.
17. Arias M, Lahme B, Van de Leur E, et al. Adenoviral delivery of an antisense RNA complementary to the 30 coding sequence of transforming growth factor-β1 inhibits fibrogenic activities of hepatic stellate cells [J]. Cell Growth Differ, 2002,13:265-273.
18. Liu X, Hu H, Yin JQ. Therapeutic strategies against TGF-beta signaling pathway in hepatic fibrosis [J]. Liver Int, 2006,26:8-22.
19. Gobejishvili L, Barve S, Joshi-Barve S, et al. Chronic ethanol-mediated decrease in cAMP primes macrophages to enhanced LPS-inducible NF-kappaB activity and TNF expression: relevance to alcoholic liver disease [J]. Am J Physiol Gastrointest Liver Physiol, 2006, 291:681-688.
20. Shen J, Sakaida I, Uchida K, et al. Leptin enhances TNF-alpha production via p38 and JNK MAPK in LPS-stimulated Kupffer cells [J]. Life Sci, 2005,77:1502-1515.
21. Thirunavukkarasu C, Watkins SC, Gandhi CR. Mechanisms of endotoxin-induced NO, IL-6, and TNF-alpha production in activated rat hepatic stellate cells: role of p38 MAPK [J]. Hepatology, 2006,44:389-398.
22. Sudo K, Yamada Y, Moriwaki H, et al. Lack of tumor necrosis factor receptor type 1 inhibits liver fibrosis induced by carbon tetrachloride in mice [J]. Cytokine, 2005,29:236-244.
23. Svegliati-Baroni G, Inagaki Y, Rincon-Sanchez AR, et al. Early response of alpha2 (I) collagen to acetaldehyde in human hepatic stellate cells is TGF-beta independent [J]. Hepatology, 2005,42:343-352.
24. Parola M, Pinzani M, Casini A, et al. Induction of procollagen type I gene expression and synthesis in human hepatic stellate cells by 4-hydroxy-2,3-nonenal and other 4-hydroxy-2, 3-alkenals is related to their molecular structure [J]. Biochem Biophys Res Commun, 1996,222:261-264.
25. Schneiderhan W, Schmid-Kotsas A, Zhao J, et al. Oxidized low-density lipoproteins bind to the scavenger receptor, CD36, of hepatic stellate cells and stimulate extracellular matrix synthesis [J]. Hepatology, 2001,34:729-737.
26. Lee KS, Buck M, Houglum K, et al. Activation of hepatic stellate cells by TGF alpha and collagen type I is mediated by oxidative stress through c-myb expression [J]. J Clin Invest, 1995,96:2461-2468.
27. Parola M, Robino G. Oxidative stress-related molecules and liver fibrosis [J]. J Hepatol, 2001,35:297-306.
28. Hemmann S, Graf J, Roderfeld M, et al. Expression of MMPs and TIMPs in liver fibrosis - a systematic review with special emphasis on anti-fibrotic strategies [J]. J Hepatol, 2007,46:955-975.
29. Chavez-Tapia NC, Torre-Delgadillo A, Tellez-Avila FI, et al. The molecular basis of susceptibility to infection in liver cirrhosis [J]. Curr Med Chem, 2007,14:2954-2958.
30. Duffield JS, Forbes SJ, Constandinou CM, et al. Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair [J]. J Clin Invest, 2005,115:56-65.
31. Panasiuk A, Wysocka J, Maciorkowska E, et al. Phagocytic and oxidative burst activity of neutrophils in the end stage of liver cirrhosis [J]. World J Gastroenterol, 2005,11:7661-7665.
32. Fischer R, Cariers A, Reinehr R, et al. Caspase 9 dependent killing of hepatic stellate cells by activated Kupffer cells [J]. Gastroenterology, 2002,123:845-861.
33. Issa R, Zhou X, Trim N, et al. Mutation in collagen-1 that confers resistance to the action of collagenase results in failure of recovery from CCl4-induced liver fibrosis, persistence of activated hepatic stellate cells, and diminished hepatocyte regeneration [J]. FASEB J, 2003,17:47-49.
34. Sakaida I, Hironaka K, Terai S, et al. Gadolinium chloride reverses dimethylnitrosamine (DMN)-induced rat liver fibrosis with increased matrix metalloproteinases (MMPs) of Kupffer cells [J]. Life Sci, 2003,72:943-959.
35. Hu QW, Liu GT. Adrances in the research of anti-hepatic fibrosis drugs [J]. Acta Pharm Sin, 2006,41:7-11.