Separation of the four stereoisomers of a potent inhibitor (L-694,458) of human leukocyte elastase and its determination in human plasma using achiral/chiral chromatography with column switching

Journal of Pharmaceutical and Biomedical Analysis

Volumn 17, Issue 6-7, 1998, Pages 1057-1064

  Zagrobelny, J ^a   Matuszewski, B K ^a   Kline, W F ^a   Vincent, S H ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Achiral chiral chromatography; Column switching; Human leukocyte elastase; L 694,458; Potent inhibitor

Indexed keywords

ELASTASE INHIBITOR; N [1 (1,3 BENZODIOXOL 5 YL)BUTYL] 3,3 DIETHYL 2 [4 [(4 METHYL 1 PIPERAZINYL)CARBONYL]PHENOXY] 4 OXO 1 AZETIDINECARBOXAMIDE;

ARTICLE; CHIRAL CHROMATOGRAPHY; DRUG DETERMINATION; HUMAN; MONKEY; NONHUMAN; PRIORITY JOURNAL; STEREOISOMERISM; STEREOSPECIFICITY;

ANIMALS; AZETIDINES; CHEMISTRY, ANALYTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; HYDROGEN-ION CONCENTRATION; LEUKOCYTE ELASTASE; MACACA MULATTA; PIPERAZINES; SPECTROPHOTOMETRY, ULTRAVIOLET; STEREOISOMERISM;

EID: 0032444407     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0731-7085(98)00071-5     Document Type: Article

References (13)

1. [1] R.J. Cvetovich, M. Chartrain, F.W. Hartner Jr., C. Roberge, J.S. Amato, E.J.J. Grabowski, J. Org. Chem. 61 (1996) 6575-6580.
2. [2] P.E. Finke, C.P Dorn, Jr, A.L. Kissinger et al., Orally active intracellular inhibitors of human leukocyte elastase (HLE), 22nd Natl. Meet. of the American Chemical Society, Chicago, 1995, MEDI 083.
3. [3] L-694,458 has been licensed to DuPont Merck Pharmaceutical Company (DMP-777).
4. [4] S.H. Vincent, S.K. Painter, D. Luffer-Atlas, et al., Drug Metab. Dispos. 25 (1997) 932-939.
5. [5] B.K. Matuszewski, M.L. Constanzen, G.A. Hessey II, W.F. Bayne, Anal. Chem. 62 (1990) 1308-1315.
6. [6] B.K. Matuszewski, M.L. Constanzer, Chirality 4 (1992) 515-519.
7. [7] B.K. Matuszewski, M.L. Constanzer, M. Kiganda, Pharm. Res. 11 (1994) 449-454.
8. [8] B.K. Matuszewski, M.L. Constanzer, G.A. Hessey II, W.F. Bayne, J. Chromatogr. 526 (1990) 461-473.
9. [9] J. Zagrobelny, B.K. Matuszewski, Enantiomer 2 (1997) 37-43.
10. [10] I. Fu, E.J. Woolf, B.K. Matuszewski, J. Pharm. Biomed. Anal. (in press).
11. [11] B.K. Matuszewski, M.L. Constanzer, C.M. Chavez-Eng, Anal. Chem. 70 (1998) 882-889.
12. [12] B.K. Matuszewski, Pharmaceutical and Biomedical Analysis 8th Int. Symp., Orlando, FL, 4-8 May, 1997, abstract no. M/P-A9.
13. [13] J. Stewart, M. Silveru, W. Bachman, T. Venkateschwaran, D. Delinky, B.K. Matuszewski, Methodological surveys in bioanalysis of drugs, R. Soc. Chem. (in press).