Enhanced gastric IL-18 mRNA expression in Helicobacter pylori-infected children is associated with macrophage infiltration, IL-8, and IL-1β mRNA expression

European Journal of Gastroenterology and Hepatology

Volumn 20, Issue 4, 2008, Pages 314-319

  Dzierzanowska Fangrat, Katarzyna ^b   Michalkiewicz, Jacek ^b,c   Cielecka Kuszyk, Joanna ^b   Nowak, Magdalena ^b   Celinska Cedro, Danuta ^b   Rozynek, Elzbieta ^b   Dzierzanowska, Danuta ^b   Crabtree, Jean E ^a  

^a ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

^b CHILDREN'S MEMORIAL HEALTH INSTITUTE   (Poland)

^c NICOLAUS COPERNICUS UNIVERSITY   (Poland)

Author keywords

Helicobacter pylori; Interleukin 18; Macrophages; Paediatrics

Indexed keywords

CD14 ANTIGEN; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 8; MESSENGER RNA;

ADOLESCENT; ADULT; ARTICLE; CHILD; CHILDHOOD DISEASE; CLINICAL ARTICLE; CYTOKINE PRODUCTION; DNA POLYMORPHISM; FEMALE; GENE EXPRESSION; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MACROPHAGE ACTIVATION; MALE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH ANTRUM; STOMACH BIOPSY;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; FEMALE; GASTRIC MUCOSA; GASTRITIS; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-18; INTERLEUKIN-1BETA; MACROPHAGES; MALE; STOMACH NEOPLASMS;

EID: 40649095046     PISSN: 0954691X     EISSN: None     Source Type: Journal    
DOI: 10.1097/MEG.0b013e3282f340da     Document Type: Article

References (46)

1. Peek RM, Crabtree JE. Helicobacter infection and gastric neoplasia. J Pathol 2006; 208:233-248.
2. Wilson KT, Crabtree JE. Immunology of Helicobacter pylori: insights into the failure of the immune response and perspectives on vaccine studies. Gastroenterol 2007; 133:288-308.
3. Suzuki T, Kato K, Ohara S, Noguchi K, Sekine H, Nagura H, et al. Localization of antigen-presenting cells in Helicobacter pylori-infected gastric mucosa. Pathol Int 2002; 52:265-271.
4. Harris PR, Mobley HL, Perez-Perez GI, Blaser MJ, Smith PD. Helicobacter pylori urease is a potent stimulus of mononuclear phagocyte activation and inflammatory cytokine production. Gastroenterology 1996; 111:419-425.
5. Mai UEH, Perez-Perez GI, Wahl LM, Wahl SM, Blaser MJ, Smith PD. Soluble surface proteins from Helicobacter pylori activate monocytes/macrophages by lipopolysaccharide-independent mechanism. J Clin Invest 1991; 87:894-900.
6. Harris PR, Ernst PB, Kawabata S, Kiyono H, Graham MF, Smith PD. Recombinant Helicobacter pylori urease activates primary mucosal macrophages. J Infect Dis 1998; 178:1516-1520.
7. Puren AJ, Fantuzzi G, Gu Y, Su MS, Dinarello CA. Interleukin-18 (IFN gamma-inducing factor) induces IL-8 and IL-1beta via TNF alpha production from non-CD14+ human blood mononuclear cells. J Clin Invest 1998; 101:711-721.
8. Okamura H, Tsutsui H, Komatsu T, Yutsudo M, Hakura A, Tanimoto T, et al. Cloning of a new cytokine that induces IFN-gamma production by T cells. Nature 1995; 378:88-91.
9. Takeda K, Tsutsui H, Yoshimoto T, Adachi O, Yoshida N, Kishimoto T, et al. Defective NK cell activity and Th1 response in IL-18-deficient mice. Immunity 1998; 8:383-390.
10. Pizzaro TT, Michie MH, Bentz M, Woraratanadharm J, Smith MF, Foley Y, et al. IL-18, a novel immunoregulatory cytokine, is up-regulated in Crohn's disease: expression and localization in intestinal mucosal cells. J Immunol 1999; 162:6829-6835.
11. Tanaka M, Harigai M, Kawaguchi Y, Ohta S, Sugiura T, Takagi K, et al. Mature form of interleukin 18 is expressed in rheumatoid arthritis synovial tissue and contributes to interferon-gamma production by synovial T cells. J Rheumatol 2001; 28:1779-1787.
12. Tucci M, Quatraro C, Dammacco F, Silvestris F. Interleukin-18 overexpression as a hallmark of the activity of autoimmune inflammatory myopathies. Clin Exp Immunol 2006; 146:21-31.
13. Tomita T, Jackson AM, Hida N, Hayat M, Dixon MF, Shimoyama T, et al. Expression of Interleukin-18, a Th1 cytokine, in human gastric mucosa is increased in Helicobacter pylori infection. J Infect Dis 2001; 183:620-627.
14. Kawakami K. Interleukin-18 and host defense against infectious pathogens. J Immunother 2002; 25 (Suppl 1):12-19.
15. Akhiani AA, Schon K, Lycke N. Vaccine-induced immunity against Helicobacter pylori infection is impaired in IL-18-deficient mice. J Immunol 2004; 173:3348-3356.
16. Dzierzanowska-Fangrat K, Raeiszadeh M, Dzierzanowska D, Gladkowska-Dura M, Celinska-Cedro D, Crabtree JE. IgG subclass response to Helicobacter pylori and CagA antigens in children. Clin Exp Immunol 2003; 134:442-446.
17. Shimoyama T, Everett SM, Dixon MF, Axon AT, Crabtree JE. Chemokine mRNA expression in gastric mucosa is associated with Helicobacter pylori cagA positivity and severity of gastritis. J Clin Pathol 1998; 51:765-770.
18. Sugimoto M, Furuta T, Shirai N, Nakamura A, Xiao F, Kajimura M, et al. Different effects of polymorphisms of tumor necrosis factor-alpha and interleukin-1 beta on development of peptic ulcer and gastric cancer. J Gastroenterol Hepatol 2007; 22:51-59.
19. Wang M, Furuta T, Takashima M, Futami H, Shirai N, Hanai H, et al. Relation between interleukin-1beta messenger RNA in gastric fundic mucosa and gastric juice pH in patients infected with Helicobacter pylori. J Gastroenterol 1999; 34 (Suppl 11):10-17.
20. Fera MT, Carbone M, Buda C, Aragona M, Panetta S, Gianonne M, et al. Correlation between Helicobacter pylori infection and IL-18 mRNA expression in human gastric biopsy specimens. Ann N Y Acad Sci 2002; 963:326-328.
21. Yamaoka Y, Kita M, Kodama T, Sawai N, Kashima K, Imanishi J. Induction of various cytokines and development of severe mucosal inflammation by cagA gene positive Helicobacter pylori strains. Gut 1997; 41:442-451.
22. Bamford KB, Fan X, Crowe SE, Leary JF, Gourley WK, Luthra GK, et al. Lymphocytes in the human gastric mucosa during Helicobacter pylori have a T helper cell 1 phenotype. Gastroenterology 1998; 114:482-492.
23. Shimizu T, Haruna H, Ohtsuka Y, Kaneko K, Gupta R, Yamashiro Y. Cytokines in the gastric mucosa of children with Helicobacter pylori infection. Acta Paediatr 2004; 93:322-326.
24. Day AS, Su B, Ceponis PJ, Jones ML, Yau E, Sieveking D, et al. Helicobacter pylori infection induces interleukin-18 production in gastric epithelial (AGS) cells. Dig Dis Sci 2004; 49:1830-1835.
25. Crabtree JE, Wyatt JI, Trejdosiewicz LK, Peichl P, Nichols PH, Ramsay N, et al. IL-8 expression in Helicobacter pylori infected, normal and neoplastic gastroduodenal mucosa. J Clin Pathol 1994; 47:61-66.
26. Yoshida N, Granger DN, Evans DJ Jr, Evans DG, Graham DY, Anderson DC, et al. Mechanisms involved in Helicobacter pylori-induced inflammation. Gastroenterology 1993; 105:1431-1440.
27. Wolfe MM, Nompleggi DJ. Cytokine inhibition of gastric acid secretion - a little goes a long way. Gastroenterology 1992; 102:2177-2178.
28. Hwang IR, Kodama T, Kikuchi S, Sakai K, Peterson LE, Graham DY, et al. Effect of interleukin 1 polymorphisms on gastric mucosal interleukin 1beta production in Helicobacter pylori infection. Gastroenterology 2002; 123:1793-1803.
29. Rad R, Prinz C, Neu B, Neuhofer M, Zeitner M, Voland P, et al. Synergistic effect of Helicobacter pylori virulence factors and interleukin-1 polymorphisms for the development of severe histological changes in the gastric mucosa. J Infect Dis 2003; 188:272-281.
30. El-Omar EM, Carrington M, Chow WH, McColl KE, Bream JH, Young HA, et al. Interleukin-1 polymorphisms associated with increased risk of gastric cancer. Nature 2000; 404:398-402.
31. Bedoya A, Garay J, Sanzon F, Bravo LE, Bravo JC, Correa H, et al. Histopathology of gastritis in Helicobacter pylori-infected children from populations at high and low gastric cancer risk. Hum Pathol 2003; 34:206-213.
32. Maciorkowska E, Kondej-Muszynska K, Kasacka I, Kaczmarski M, Kemona A. Macrophages of the antral mucosa in children with Helicobacter pylori infection and after eradication. Rocz Akad Med Bialymst 2004; 49 (Suppl 1):228-230.
33. Whitney AE, Emory TS, Marty AM, O'Shea PA, Newman GW, Gold BD. Increased macrophage infiltration of gastric mucosa in Helicobacter pylori-infected children. Dig Dis Sci 2000; 45:1337-1342.
34. Krauss-Etschmann S, Gruber R, Plikat K, Antoni I, Demmelmair H, Reinhardt D, et al. Increase of antigen-presenting cells in the gastric mucosa of Helicobacter pylori-infected children. Helicobacter 2005; 10:214-222.
35. Andersen LP, Holck S, Janulaityte-Gunther D, Kupcinskas L, Kiudelis G, Jonaitis L, et al. Gastric inflammatory markers and interleukins in patients with functional dyspepsia, with and without Helicobacter pylori infection. FEMS Immunol Med Microbiol 2005; 44:233-238.
36. Wright SD, Ramos RA, Tobias PS, Ulevitch RJ, Mathison JC. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 1990; 249:1431-1433.
37. Haziot A, Chen S, Ferrero E, Low MG, Silber R, Goyert SM. The monocyte differentiation antigen, CD14, is anchored to the cell membrane by a phosphatidylinositol linkage. J Immunol 1988; 141:547-552.
38. Bliss CM, Golenbock DT, Keates S, Linevsky JK, Kelly CP. Helicobacter pylori lipopolysaccharide binds to CD14 and stimulates release of interleukin-8, epithelial neutrophil-activating peptide 78, and monocyte chemotactic protein 1 by human monocytes. Infect Immun 1998; 66:5357-5363.
39. Duncan L, Yoshioka M, Chandad F, Grenier D. Loss of lipopolysaccharide receptor CD14 from the surface of human macrophage-like cells mediated by Porphyromonas gingivalis outer membrane vesicles. Microb Pathog 2004; 36:319-325.
40. Juffermans NP, Verbon A, van Deventer SJ, Buurman WA, van Deutekom H, Speelman P, et al. Serum concentrations of lipopolysaccharide activity-modulating proteins during tuberculosis. J Infect Dis 1998; 178:1839-1842.
41. Lin B, Noring R, Steere AC, Klempner MS, Hu LT. Soluble CD14 levels in the serum, synovial fluid, and cerebrospinal fluid of patients with various stages of Lyme disease. J Infect Dis 2000; 181:1185-1188.
42. Karhukorpi J, Yan Y, Niemela S, Valtonen J, Koistinen P, Joensuu T, et al. Effect of CD14 promoter polymorphism and H. pylori infection and its clinical outcomes on circulating CD14. Clin Exp Immunol 2002; 128:326-332.
43. Viala J, Chaput C, Boneca IG, Cardona A, Girardin SE, Moran AP, et al. Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island. Nat Immunol 2004; 5:1166-1174.
44. Hofner P, Gyulai Z, Kiss ZF, Tiszai A, Tiszlavicz L, Toth G, et al. Genetic polymorphisms of NOD1 and IL-8, but not polymorphisms of TLR4 genes, are associated with Helicobacter pylori-induced duodenal ulcer and gastritis. Helicobacter 2007; 12:124-131.
45. Fritz JH, Girardin SE, Fitting C, Werts C, Mengin-Lecreulx D, Cardoff M, et al. Synergistic stimulation of human monocytes and dendritic cells by Toll-like receptor 4 and NOD1-activating and NOD2-activating agonists. Eur J Immunol 2005; 35:2459-2470.
46. Takada H, Uehara A. Enhancement of TLR-mediated innate immune responses by peptidoglycans through NOD signaling. Curr Pharm Des 2006; 12:4163-4172.