α1-Proteinase Inhibitor Forms Initial Non-covalent and Final Covalent Complexes with Elastase Analogously to Other Serpin-Proteinase Pairs, Suggesting a Common Mechanism of Inhibition

Journal of Biological Chemistry

Volumn 279, Issue 10, 2004, Pages 9264-9269

  Dobó, József ^a   Gettins, Peter G W ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENERGY TRANSFER; ENZYME INHIBITION; ESTERS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; QUANTUM THEORY; X RAY CRYSTALLOGRAPHY;

COVALENT COMPLEX; HETERONUCLEAR SINGLE QUANTUM CORRELATION SPECTROSCOPY (HSQC);

BIOCHEMISTRY;

ALPHA 1 ANTITRYPSIN; ELASTASE; SERINE PROTEINASE INHIBITOR; ANHYDROELASTASE; PANCREATIC ELASTASE;

ARTICLE; BASE PAIRING; BETA SHEET; COMPLEX FORMATION; COVALENT BOND; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME PURIFICATION; ENZYME SPECIFICITY; HETERONUCLEAR SINGLE QUANTUM CORRELATION SPECTROSCOPY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN STRUCTURE; SPECTROSCOPY; SWINE; BINDING COMPETITION; CHEMISTRY; DRUG ANTAGONISM; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN BINDING; PROTEIN CONFORMATION;

INSERTION SEQUENCES; SUS SCROFA;

ALPHA 1-ANTITRYPSIN; BINDING, COMPETITIVE; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; PANCREATIC ELASTASE; PROTEIN BINDING; PROTEIN CONFORMATION; SERINE PROTEINASE INHIBITORS;

EID: 1542305364     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M311731200     Document Type: Article

References (30)

1. Gettins, P. G. W. (2002) Chem. Rev. 102, 4751-4804
2. Patston, P. A., Gettins, P., Beechem, J., and Schapira, M. (1991) Biochemistry 30, 8876-8882
3. Cooperman, B. S., Stavridi, E., Nickbarg, E., Rescorla, E., Schechter, N. M., and Rubin, H. (1993) J. Biol. Chem. 268, 23616-23625
4. Lawrence, D. A., Olson, S. T., Palaniappan, S., and Ginsburg, D. (1994) J. Biol. Chem. 269, 27657-27662
5. Lawrence, D. A., Ginsburg, D., Day, D. E., Berkenpas, M. B., Verhamme, I. M., Kvassman, J.-O., and Shore, J. D. (1995) J. Biol. Chem. 270, 25309-25312
6. Olson, S. T., Bock, P. E., Kvassman, J., Shore, J. D., Lawrence, D. A., Ginsburg, D., and Björk, I. (1995) J. Biol. Chem. 270, 30007-30017
7. Hood, D. B., Huntington, J. A., and Gettins, P. G. W. (1994) Biochemistry 33, 8538-8547
8. Wright, H. T., and Scarsdale, J. N. (1995) Proteins 22, 210-225
9. Stratikos, E., and Gettins, P. G. W. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 4808-4813
10. Stratikos, E., and Gettins, P. G. W. (1998) J. Biol. Chem. 273, 15582-15589
11. Stratikos, E., and Gettins, P. G. W. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 453-458
12. Huntington, J. A., Read, R. J., and Carrell, R. W. (2000) Nature 407, 923-926
13. Baglin, T. P., Carrell, R. W., Church, F. C., Esmon, C. T., and Huntington, J. A. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 11079-11084
14. Ye, S., Cech, A. L., Belmares, R., Bergstrom, R. C., Tong, Y., Corey, D. R., Kanost, M. R., and Goldsmith, E. J. (2001) Nat. Struct. Biol. 8, 979-983
15. Fa, M., Bergstrom, F., Hagglof, P., Wilczynska, M., Johansson, L., and Ny, T. (2000) Structure 8, 397-405
16. Boudier, C., and Bieth, J. G. (2001) Biochemistry 40, 9962-9967
17. Kaslik, G., Kardos, J., Szabó, L., Závodszky, P., Westler, W. M., Markley, J. L., and Gráf, L. (1997) Biochemistry 36, 5455-5474
18. Gettins, P. G. W. (2002) FEBS Lett. 523, 2-6
19. Backovic, M., Stratikos, E., Lawrence, D. A., and Gettins, P. G. W. (2002) Protein Sci. 11, 1182-1191
20. Peterson, F. C., and Gettins, P. G. W. (2001) Biochemistry 40, 6284-6292
21. Peterson, F. C., Gordon, N. C., and Gettins, P. G. W. (2000) Biochemistry 39, 11884-11892
22. Dementiev, A., Simonovic, M., Volz, K., and Gettins, P. G. W. (2003) J. Biol. Chem. 278, 37881-37887
23. O'Malley, K. M., and Cooperman, B. S. (2001) J. Biol. Chem. 276, 6631-6637
24. Mellet, P., and Bieth, J. G. (2000) J. Biol. Chem. 275, 10788-10795
25. Im, H., Seo, E. J., and Yu, M. H. (1999) J. Biol. Chem. 274, 11072-11077
26. Ako, H., Foster, R. J., and Ryan, C. A. (1972) Biochem. Biophys. Res. Commun. 47, 1402-1407
27. Ako, H., Foster, R. J., and Ryan, C. A. (1974) Biochemistry 13, 132-139
28. Olson, S. T., Swanson, R., Day, D., Verhamme, I., Kvassman, J., and Shore, J. D. (2001) Biochemistry 40, 11742-11756
29. Delaglio, F., Grzesiak, A., Vuister, G. W., Zhu, G., Pfeifer, J., and Bax, A. (1995) J. Biomol. NMR 6, 277-293
30. Futamura, A., Stratikos, E., Olson, S. T., and Gettins, P. G. W. (1998) Biochemistry 37, 13110-13119