Apoptin induces apoptosis in an oral cancer mouse model

Cancer Biology and Therapy

Volumn 7, Issue 9, 2008, Pages 1368-1373

  Schoop, Remilio A L ^a   Baatenburg De Jong, Robert J ^b   Noteborn, Mathieu H M ^c  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c LEIDEN UNIVERSITY   (Netherlands)

Author keywords

4 nitroquinoline 1 oxide; Apoptin; Apoptosis; Caspase 3; Head and neck squamous cell carcinoma; Immunocompetent mice; Recombinant adenovirus

Indexed keywords

4 NITROQUINOLINE 1 OXIDE; APOPTIN; BETA GALACTOSIDASE; CASPASE 3; RECOMBINANT PROTEIN; CAPSID PROTEIN; CARCINOGEN; FLUORESCEIN ISOTHIOCYANATE; FLUORESCENT DYE; UNCLASSIFIED DRUG; VP3 PROTEIN, CHICKEN ANEMIA VIRUS;

ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; GENETIC CODE; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; MOUSE; MOUTH CANCER; NONHUMAN; PROTEIN EXPRESSION; ADENOVIRUS; ANIMAL; CBA MOUSE; CELL DEATH; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; DRUG EFFECT; ENZYME ACTIVATION; FLUORESCENT ANTIBODY TECHNIQUE; GENE VECTOR; GENETIC TRANSFECTION; GENETICS; IMMUNOHISTOCHEMISTRY; MALE; METABOLISM; MOUTH TUMOR; PATHOLOGY; PILOT STUDY; PLASMID; RANDOMIZATION; SQUAMOUS CELL CARCINOMA; TUMOR CELL CULTURE; TUMOR VOLUME;

4-NITROQUINOLINE-1-OXIDE; ADENOVIRIDAE; ANIMALS; APOPTOSIS; CAPSID PROTEINS; CARCINOGENS; CARCINOMA, SQUAMOUS CELL; CASPASE 3; CELL DEATH; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; FLUORESCEIN-5-ISOTHIOCYANATE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; FLUORESCENT DYES; GENETIC VECTORS; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED CBA; MOUTH NEOPLASMS; PILOT PROJECTS; PLASMIDS; RANDOM ALLOCATION; TRANSFECTION; TUMOR BURDEN; TUMOR CELLS, CULTURED;

EID: 52149101748     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.7.9.6419     Document Type: Article

References (27)

1. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin 2005; 55:74-108.
2. Sjogren EV. Epidemiology of head and neck squamous cell carcinoma. In: Baatenburg de Jong RJ, ed. Prognosis in head and neck cancer, Oxford: Taylor & Francis Group 2007; 2006:3-21.
3. Chen C, Ricks S, Doody DR, Fitzgibbons ED, Porter PL, Schwartz SM. N-Acetyltransferase 2 polymorphisms, cigarette smoking and alcohol consumption, and oral squamous cell cancer risk. Carcinogenesis 2001; 22:1993-9.
4. Ha PK, Benoit NE, Yochem R, Sciubba J, Zahurak M, Sidransky D, Pevsner J, Westra WH, Califano J. A transcriptional progression model for head and neck cancer. Clin Cancer Res 2003; 9:3058-64.
5. Kunkel M, Forster GJ, Reichert TE, Jeong JH, Benz P, Bartenstein P, Wagner W, Whiteside TL. Detection of recurrent oral squamous cell carcinoma by [18F]-2-fluorodeoxyglucose-positron emission tomography: implications for prognosis and patient management. Cancer 2003; 98:2257-65.
6. Nagler RM, Kerner H, Laufer D, Ben Eliezer S, Minkov I, Ben Itzhak O. Squamous cell carcinoma of the tongue: the prevalence and prognostic roles of p53, Bcl-2, c-erbB-2 and apoptotic rate as related to clinical and pathological characteristics in a retrospective study. Cancer Lett 2002; 186:137-50.
7. Chin D, Boyle GM, Porceddu S, Theile DR, Parsons PG, Coman WB. Head and neck cancer: past, present and future. Expert Rev Anticancer Ther 2006; 6:1111-8.
8. Moon C, Oh Y, Roth JA. Current status of gene therapy for lung cancer and head and neck cancer. Clin Cancer Res 2003; 9:5055-67.
9. Reed JC. Apoptosis-targeted therapies for cancer. Cancer Cell 2003; 3:17-22.
10. Rohn JL, Noteborn MH. The viral death effector Apoptin reveals tumor-specific processes. Apoptosis 2004; 9:315-22.
11. L inhibits p53-but not apoptin-induced apoptosis in head and neck squamous cell carcinoma cell line. Int J Cancer 2004; 109:38-42.
12. Liu X, Elojeimy S, El Zawahry AM, Holman DH, Bielawska A, Bielawski J, Rubinchik S, Guo GW, Dong JY, Keane T, Hannun YA, Tavassoli M, Norris JS. Modulation of ceramide metabolism enhances viral protein apoptin's cytotoxicity in prostate cancer. Mol Ther 2006; 14:637-46.
13. Danen-van Oorschot AA, DER Eb AJ, Noteborn MH. The chicken anemia virus-derived protein apoptin requires activation of caspases for induction of apoptosis in human tumor cells. J Virol 2000; 74:7072-8.
14. van der Eb MM, Pietersen AM, Speetjens FM, Kuppen PJ, Van De Velde CJ, Noteborn MH, Hoeben RC. Gene therapy with apoptin induces regression of xenografted human hepatomas. Cancer Gene Ther 2002; 9:53-61.
15. Peng DJ, Sun J, Wang YZ, Tian J, Zhang YH, Noteborn MH, Qu S. Inhibition of hepatocarcinoma by systemic delivery of Apoptin gene via the hepatic asialoglycoprotein receptor. Cancer Gene Ther 2007; 14:66-73.
16. Maddika S, Mendoza FJ, Hauff K, Zamzow CR, Paranjothy T, Los M. Cancer-selective therapy of the future: apoptin and its mechanism of action. Cancer Biol Ther 2006; 5:10-9.
17. Submitted for publication. R.A.L. Schoop R.J. Baatenburg de Jong M.H. M. Noteborn. A mouse model for squamous cell carcinoma 2007. Ref Type: Unpublished Work.
18. Pietersen AM, van der Eb MM, Rademaker HJ, van den Wollenberg DJ, Rabelink MJ, Kuppen PJ, van Dierendonck JH, van Ormondt H, Masman D, Van De Velde CJ, van der Eb AJ, Hoeben RC, Noteborn MH. Specific tumor-cell killing with adenovirus vectors containing the apoptin gene. Gene Ther 1999; 6:882-92.
19. Fallaux FJ, Kranenburg O, Cramer SJ, Houweling A, van Ormondt H, Hoeben RC, van der Eb AJ. Characterization of 911: a new helper cell line for the titration and propagation of early region 1-deleted adenoviral vectors. Hum Gene Ther 1996; 7:215-22.
20. Danen-Van Oorschot AA, DER Eb AJ, Noteborn MH. The chicken anemia virus-derived protein apoptin requires activation of caspases for induction of apoptosis in human tumor cells. J Virol 2000; 74:7072-8.
21. Zheng G, Chen A, Sterner RE, Zhang PJ, Pan T, Kiyatkin N, Tykocinski ML. Induction of antitumor immunity via intratumoral tetra-costimulator protein transfer. Cancer Res 2001; 61:8127-34.
22. Wildner O, Morris JC. The role of the E1B 55 kDa gene product in oncolytic adenoviral vectors expressing herpes simplex virus-tk: assessment of antitumor efficacy and toxicity. Cancer Res 2000; 60:4167-74.
23. Kip1 induces cell migration. Nat Med 1998; 4:1449-52.
24. Prochiantz A. Messenger proteins: homeoproteins, TAT and others. Curr Opin Cell Biol 2000; 12:400-6.
25. Jeang KT, Xiao H, Rich EA. Multifaceted activities of the HIV-1 transactivator of transcription, Tat. J Biol Chem 1999; 274:28837-40.
26. Schwarze SR, Ho A, Vocero-Akbani A, Dowdy SF. In vivo protein transduction: delivery of a biologically active protein into the mouse. Science 1999; 285:1569-72.
27. Guelen L, Paterson H, Gaken J, Meyers M, Farzaneh F, Tavassoli M. TAT-apoptin is efficiently delivered and induces apoptosis in cancer cells. Oncogene 2004; 23:1153-65.