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Volumn 186, Issue 2, 2002, Pages 137-150

Squamous cell carcinoma of the tongue: The prevalence and prognostic roles of p53, Bcl-2, c-erbB-2 and apoptotic rate as related to clinical and pathological characteristics in a retrospective study

Author keywords

Bcl 2; C erbB 2; P53; Squamous cell carcinoma; Terminal dUTP nick end labelling; Tongue

Indexed keywords

BIOLOGICAL MARKER; PROTEIN BCL 2; PROTEIN P53; TUMOR MARKER;

EID: 0037027750     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(02)00265-3     Document Type: Article
Times cited : (50)

References (60)
  • 1
    • 0033883429 scopus 로고    scopus 로고
    • Prognostic factors in tongue cancer - relative importance of demographic, clinical and histopathological factors
    • Kantola S., Parikka M., Jokinen K., Hyrynkangs K., Soini Y., Alho O.P., Salo T. Prognostic factors in tongue cancer - relative importance of demographic, clinical and histopathological factors. Br. J. Cancer. 83:2000;614-619.
    • (2000) Br. J. Cancer , vol.83 , pp. 614-619
    • Kantola, S.1    Parikka, M.2    Jokinen, K.3    Hyrynkangs, K.4    Soini, Y.5    Alho, O.P.6    Salo, T.7
  • 2
    • 0033976581 scopus 로고    scopus 로고
    • Squamous cell carcinoma of the tongue in young adults: Increasing incidence and factors that predict treatment outcomes
    • Myers J.N., Elkins T., Roberts D., Byers R.M. Squamous cell carcinoma of the tongue in young adults: increasing incidence and factors that predict treatment outcomes. Otolaryngol. Head Neck Surg. 122:2000;44-51.
    • (2000) Otolaryngol. Head Neck Surg. , vol.122 , pp. 44-51
    • Myers, J.N.1    Elkins, T.2    Roberts, D.3    Byers, R.M.4
  • 3
    • 0033403787 scopus 로고    scopus 로고
    • Cancer of the mobile tongue in Finland - increasing incidence, but improved survival
    • Alho O.P., Kantola S., Pirkola U., Laara E., Jokinen K., Pukkala E. Cancer of the mobile tongue in Finland - increasing incidence, but improved survival. Acta Oncol. 38:1999;1021-1024.
    • (1999) Acta Oncol. , vol.38 , pp. 1021-1024
    • Alho, O.P.1    Kantola, S.2    Pirkola, U.3    Laara, E.4    Jokinen, K.5    Pukkala, E.6
  • 4
    • 0030695402 scopus 로고    scopus 로고
    • Spiral CT angiography - an alternative vascular evaluation technique for head and neck microvascular reconstruction: A preliminary experience
    • Nagler R.M., Braun Y., Daitzchman M., Laufer D. Spiral CT angiography - an alternative vascular evaluation technique for head and neck microvascular reconstruction: a preliminary experience. Plast. Reconst. Surg. 100:1997;1697-1703.
    • (1997) Plast. Reconst. Surg. , vol.100 , pp. 1697-1703
    • Nagler, R.M.1    Braun, Y.2    Daitzchman, M.3    Laufer, D.4
  • 5
    • 0033820863 scopus 로고    scopus 로고
    • Impact of comorbidity, symptoms, and patients' characteristics on the prognosis of oral carcinomas
    • Ribeiro K.C., Kowalski L.P., Latorre M.R. Impact of comorbidity, symptoms, and patients' characteristics on the prognosis of oral carcinomas. Arch. Otolaryngol. Head Neck Surg. 126:2000;1079-1085.
    • (2000) Arch. Otolaryngol. Head Neck Surg. , vol.126 , pp. 1079-1085
    • Ribeiro, K.C.1    Kowalski, L.P.2    Latorre, M.R.3
  • 7
    • 0028893993 scopus 로고
    • Upper aerodigestive tract cancers
    • Muir C., Weiland L. Upper aerodigestive tract cancers. Cancer. 75:1995;147-153.
    • (1995) Cancer , vol.75 , pp. 147-153
    • Muir, C.1    Weiland, L.2
  • 9
    • 0033006427 scopus 로고    scopus 로고
    • Early diagnostic and treatment monitoring role of Cyfra, 21-1 and TPS in oral squamous cell carcinoma
    • Nagler R.M., Barak M., Ben-Aryeh H., Peled M., Filatov M., Laufer D. Early diagnostic and treatment monitoring role of Cyfra, 21-1 and TPS in oral squamous cell carcinoma. Cancer. 35:1999;1018-1025.
    • (1999) Cancer , vol.35 , pp. 1018-1025
    • Nagler, R.M.1    Barak, M.2    Ben-Aryeh, H.3    Peled, M.4    Filatov, M.5    Laufer, D.6
  • 11
    • 0033567933 scopus 로고    scopus 로고
    • The prognostic value of spontaneous apoptosis, Bax, Bcl-2, and p53 in oral squamous cell carcinoma of the tongue
    • Xie X., Clausen O.P.F., De Angelis P., Boysen M. The prognostic value of spontaneous apoptosis, Bax, Bcl-2, and p53 in oral squamous cell carcinoma of the tongue. Cancer. 86:1999;913-920.
    • (1999) Cancer , vol.86 , pp. 913-920
    • Xie, X.1    Clausen, O.P.F.2    De Angelis, P.3    Boysen, M.4
  • 13
    • 0030013337 scopus 로고    scopus 로고
    • Transcriptional activation by p53, but not induction of the p21 gene, is essential for oncogene-mediated apoptosis
    • Attardi L.D., Lowe S.W., Brugarolas J., Jacks T. Transcriptional activation by p53, but not induction of the p21 gene, is essential for oncogene-mediated apoptosis. EMBO J. 15:1996;3693-3701.
    • (1996) EMBO J. , vol.15 , pp. 3693-3701
    • Attardi, L.D.1    Lowe, S.W.2    Brugarolas, J.3    Jacks, T.4
  • 14
    • 84872639295 scopus 로고
    • Significance tests for 2x2 tables
    • Barnard G.A. Significance tests for 2x2 tables. Biometrika. 34:1947;123-138.
    • (1947) Biometrika , vol.34 , pp. 123-138
    • Barnard, G.A.1
  • 15
    • 0002679321 scopus 로고
    • Tests of significance for differences between percentages based on small numbers
    • Irwin J.O. Tests of significance for differences between percentages based on small numbers. Merton. 12:1935;83-94.
    • (1935) Merton , vol.12 , pp. 83-94
    • Irwin, J.O.1
  • 16
    • 33845382806 scopus 로고
    • Nonparametric estimation from incomplete observations
    • Kaplan E.L., Meier P. Nonparametric estimation from incomplete observations. J. Am. Stat. Assoc. 53:1958;457-481.
    • (1958) J. Am. Stat. Assoc. , vol.53 , pp. 457-481
    • Kaplan, E.L.1    Meier, P.2
  • 17
    • 0013886333 scopus 로고
    • Evaluation of survival data and two new rank order statistics arising in its consideration
    • Mantel M. Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chemother. Rep. 50:1966;457-481.
    • (1966) Cancer Chemother. Rep. , vol.50 , pp. 457-481
    • Mantel, M.1
  • 18
    • 0024999649 scopus 로고
    • Significance of positive margins in oral cavity squamous carcinoma
    • Loree T.R., Strong E.W. Significance of positive margins in oral cavity squamous carcinoma. Am. J. Surg. 160:1990;410-414.
    • (1990) Am. J. Surg. , vol.160 , pp. 410-414
    • Loree, T.R.1    Strong, E.W.2
  • 19
    • 0029245137 scopus 로고
    • Correlation of histopathological findings with clinical and radiologic assessments of cervical lymph-node metastases in oral cancer
    • Woolgar J.A., Birne J.C., Vaughan E.D., Lewis-Jones H.G., Scott J., Brown J.S. Correlation of histopathological findings with clinical and radiologic assessments of cervical lymph-node metastases in oral cancer. Int. J. Oral Maxillofac. Surg. 24:1995;30-37.
    • (1995) Int. J. Oral Maxillofac. Surg. , vol.24 , pp. 30-37
    • Woolgar, J.A.1    Birne, J.C.2    Vaughan, E.D.3    Lewis-Jones, H.G.4    Scott, J.5    Brown, J.S.6
  • 20
    • 0344766118 scopus 로고    scopus 로고
    • Clinicopathological analysis of elective neck dissection for N0 neck of early oral tongue carcinoma
    • Yuen A.P., Lam K., Chan A.C., Wei W.I., Lam L.K., Ho W.K., Ho C.M. Clinicopathological analysis of elective neck dissection for N0 neck of early oral tongue carcinoma. Am. J. Surg. 177:1999;90-92.
    • (1999) Am. J. Surg. , vol.177 , pp. 90-92
    • Yuen, A.P.1    Lam, K.2    Chan, A.C.3    Wei, W.I.4    Lam, L.K.5    Ho, W.K.6    Ho, C.M.7
  • 21
    • 0032878325 scopus 로고    scopus 로고
    • Improved survival for patients with clinically T1/T2, N0 tongue tumors undergoing a prophylactic neck dissection
    • Haddadin K.J., Soutar D.S., Oliver R.J., Webster M.H., Robertson A.G., Macdonald D.G. Improved survival for patients with clinically T1/T2, N0 tongue tumors undergoing a prophylactic neck dissection. Head Neck. 12:1999;517-525.
    • (1999) Head Neck , vol.12 , pp. 517-525
    • Haddadin, K.J.1    Soutar, D.S.2    Oliver, R.J.3    Webster, M.H.4    Robertson, A.G.5    Macdonald, D.G.6
  • 22
    • 0033787982 scopus 로고    scopus 로고
    • Advanced squamous cell carcinoma of the base of the tongue treated with surgery and post-operative radiotherapy
    • Tiwari R.M., Van Ardenne A., Leemans C.R., Quak J.J., Tobi H., Mehta D.M., Snow G.B. Advanced squamous cell carcinoma of the base of the tongue treated with surgery and post-operative radiotherapy. Eur. J. Surg. Oncol. 26:2000;556-560.
    • (2000) Eur. J. Surg. Oncol. , vol.26 , pp. 556-560
    • Tiwari, R.M.1    Van Ardenne, A.2    Leemans, C.R.3    Quak, J.J.4    Tobi, H.5    Mehta, D.M.6    Snow, G.B.7
  • 24
    • 0031574637 scopus 로고    scopus 로고
    • Facial trauma - characteristics and therapy
    • Nagler R.M., Peled M., Laufer D. Facial trauma - characteristics and therapy. Harefuah. 132:1997;6-10.
    • (1997) Harefuah , vol.132 , pp. 6-10
    • Nagler, R.M.1    Peled, M.2    Laufer, D.3
  • 26
    • 0032833964 scopus 로고    scopus 로고
    • Head and neck cancer in nonsmokers: A distinct clinical and molecular entity
    • Koch W.M., Lango M., Sewell D., Zahurak M., Sidransky D. Head and neck cancer in nonsmokers: a distinct clinical and molecular entity. Laryngoscope. 109:1999;1544-1551.
    • (1999) Laryngoscope , vol.109 , pp. 1544-1551
    • Koch, W.M.1    Lango, M.2    Sewell, D.3    Zahurak, M.4    Sidransky, D.5
  • 27
    • 0032856620 scopus 로고    scopus 로고
    • Pattern of invasion and margin assessment in patients with oral tongue cancer
    • Spiro R.H., Guillamondegui O. Jr., Paulino A.F., Huvos A.G. Pattern of invasion and margin assessment in patients with oral tongue cancer. Head Neck. 21:1999;408-413.
    • (1999) Head Neck , vol.21 , pp. 408-413
    • Spiro, R.H.1    Guillamondegui O., Jr.2    Paulino, A.F.3    Huvos, A.G.4
  • 29
    • 0028874706 scopus 로고
    • Are the new staging rules better for t4 oral cancer?
    • Virag M., Uglesic V., Aljinovic N., Jurlina M. Are the new staging rules better for t4 oral cancer? Am. J. Surg. 170:1995;432-435.
    • (1995) Am. J. Surg. , vol.170 , pp. 432-435
    • Virag, M.1    Uglesic, V.2    Aljinovic, N.3    Jurlina, M.4
  • 30
    • 0017346245 scopus 로고    scopus 로고
    • STNMP: A new system for the clinico-pathological classification and identification of intra-oral cancer
    • Rapidis A.D., Langdon J.D., Patel M.F., Harvey P.W. STNMP: a new system for the clinico-pathological classification and identification of intra-oral cancer. Cancer. 39:1997;204-209.
    • (1997) Cancer , vol.39 , pp. 204-209
    • Rapidis, A.D.1    Langdon, J.D.2    Patel, M.F.3    Harvey, P.W.4
  • 34
    • 0026636412 scopus 로고
    • Oncogenes and tumour-suppressor genes in squamous cell carcinoma of the head and neck
    • Field J.K. Oncogenes and tumour-suppressor genes in squamous cell carcinoma of the head and neck. Eur. J. Cancer B Oral Oncol. 28B:1992;67-76.
    • (1992) Eur. J. Cancer B Oral Oncol. , vol.28 B , pp. 67-76
    • Field, J.K.1
  • 36
  • 37
    • 0033990714 scopus 로고    scopus 로고
    • Clinical relevance of erbB-1 and -2 oncogenes in oral carcinomas
    • Werkmeister R., Brandt B., Joos U. Clinical relevance of erbB-1 and -2 oncogenes in oral carcinomas. Oral Oncol. 31:(6):2000;100-105.
    • (2000) Oral Oncol. , vol.31 , Issue.6 , pp. 100-105
    • Werkmeister, R.1    Brandt, B.2    Joos, U.3
  • 38
    • 0004893334 scopus 로고
    • Sequential expression and cooperative interaction of c-ha-ras and c-erbB genes in in vivo chemical carcinogenesis
    • Husain Z., Fei Y., Roy S., Solt D.B., Polverini P.J., Biswas D.K. Sequential expression and cooperative interaction of c-ha-ras and c-erbB genes in in vivo chemical carcinogenesis. Proc. Natl. Acad. Sci. USA. 86:1989;1264-1268.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 1264-1268
    • Husain, Z.1    Fei, Y.2    Roy, S.3    Solt, D.B.4    Polverini, P.J.5    Biswas, D.K.6
  • 39
    • 0023637043 scopus 로고
    • Expression of c-erbB proto-oncogene during dimethylbenzanthracene-induced tumorigenesis in hamster cheek pouch
    • Wong D.T.W., Biswas D.K. Expression of c-erbB proto-oncogene during dimethylbenzanthracene-induced tumorigenesis in hamster cheek pouch. Oncogene. 2:1987;67-72.
    • (1987) Oncogene , vol.2 , pp. 67-72
    • Wong, D.T.W.1    Biswas, D.K.2
  • 40
    • 0023620171 scopus 로고
    • Amplification of the c-erbB1 oncogene in chemically-induced oral carcinomas
    • Wong D.T.W. Amplification of the c-erbB1 oncogene in chemically-induced oral carcinomas. Carcinogenesis. 8:1987;1963-1965.
    • (1987) Carcinogenesis , vol.8 , pp. 1963-1965
    • Wong, D.T.W.1
  • 42
    • 0026693306 scopus 로고
    • Immunohistochemical study of c-erbB-2 oncoprotein overexpression in human major salivary gland carcinoma: An indicator of aggressiveness
    • Sugano S., Mukai K., Tsuda H., Hirohashi S., Furuya S., Shimosato Y. Immunohistochemical study of c-erbB-2 oncoprotein overexpression in human major salivary gland carcinoma: an indicator of aggressiveness. Laryngoscope. 102:1992;923-927.
    • (1992) Laryngoscope , vol.102 , pp. 923-927
    • Sugano, S.1    Mukai, K.2    Tsuda, H.3    Hirohashi, S.4    Furuya, S.5    Shimosato, Y.6
  • 43
    • 0034264397 scopus 로고    scopus 로고
    • Objective biologic parameters and their clinical relevance in assessing salivary gland neoplasms
    • Pinto A.E., Fonseca I., Martins C., Soares J. Objective biologic parameters and their clinical relevance in assessing salivary gland neoplasms. Adv. Anat. Pathol. 7:2000;294-306.
    • (2000) Adv. Anat. Pathol. , vol.7 , pp. 294-306
    • Pinto, A.E.1    Fonseca, I.2    Martins, C.3    Soares, J.4
  • 44
    • 0032887214 scopus 로고    scopus 로고
    • Oral squamous cell carcinoma is associated with decreased Bcl-2/Bax expression ratio and increased apoptosis
    • Loro L.L., Vintermyr O.K., Liavaag P.G., Jonsson R., Johannessen A.C. Oral squamous cell carcinoma is associated with decreased Bcl-2/Bax expression ratio and increased apoptosis. Hum. Pathol. 30:1999;1097-1105.
    • (1999) Hum. Pathol. , vol.30 , pp. 1097-1105
    • Loro, L.L.1    Vintermyr, O.K.2    Liavaag, P.G.3    Jonsson, R.4    Johannessen, A.C.5
  • 45
    • 0345131690 scopus 로고    scopus 로고
    • Angiogenesis during tumour progression in the oral cavity is related to reduced apoptosis and high tumor cell proliferation
    • Ravi D., Ramadas K., Mathew B.S., Nalinakumari K.R., Nair M.K., Pillai M.R. Angiogenesis during tumour progression in the oral cavity is related to reduced apoptosis and high tumor cell proliferation. Oral Oncol. 34:1998;543-548.
    • (1998) Oral Oncol. , vol.34 , pp. 543-548
    • Ravi, D.1    Ramadas, K.2    Mathew, B.S.3    Nalinakumari, K.R.4    Nair, M.K.5    Pillai, M.R.6
  • 46
    • 0032768021 scopus 로고    scopus 로고
    • Prognostic significance of proliferative and apoptotic markers in oral tongue squamous cell carcinomas
    • Xie X., De Angelis P., Clausen O.P.F., Boysen M. Prognostic significance of proliferative and apoptotic markers in oral tongue squamous cell carcinomas. Oral Oncol. 35:1999;502-509.
    • (1999) Oral Oncol. , vol.35 , pp. 502-509
    • Xie, X.1    De Angelis, P.2    Clausen, O.P.F.3    Boysen, M.4
  • 47
    • 0034213853 scopus 로고    scopus 로고
    • Apoptosis and p53 are associated with effect of preoperative radiation in oral squamous cell carcinomas
    • Shintani S., Mihara M., Nakahara Y., Terakado N., Yoshihama Y., Kiyota A. Apoptosis and p53 are associated with effect of preoperative radiation in oral squamous cell carcinomas. Cancer Lett. 154:2000;71-77.
    • (2000) Cancer Lett. , vol.154 , pp. 71-77
    • Shintani, S.1    Mihara, M.2    Nakahara, Y.3    Terakado, N.4    Yoshihama, Y.5    Kiyota, A.6
  • 49
    • 0023959795 scopus 로고
    • Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life
    • Finlay C.A., Hinds P.W., Tan T.H., Eliyahu D., Oren M., Levine A.J. Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life. Mol. Cell. Biol. 8:1988;531-539.
    • (1988) Mol. Cell. Biol. , vol.8 , pp. 531-539
    • Finlay, C.A.1    Hinds, P.W.2    Tan, T.H.3    Eliyahu, D.4    Oren, M.5    Levine, A.J.6
  • 50
    • 0029294613 scopus 로고
    • In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: A cautionary note
    • Grasl-Kraupp B., Ruttkay-Nedecky B., Koudelka H., Bukowska K., Bursch W., Schulte-Hermann R. In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: a cautionary note. Hepatology. 21:1995;1465-1468.
    • (1995) Hepatology , vol.21 , pp. 1465-1468
    • Grasl-Kraupp, B.1    Ruttkay-Nedecky, B.2    Koudelka, H.3    Bukowska, K.4    Bursch, W.5    Schulte-Hermann, R.6
  • 51
    • 0032890023 scopus 로고    scopus 로고
    • Correlations of Bcl-2 and p53 expression with the clinicopathological features in tongue squamous cell carcinomas
    • Yao L., Iwai M., Furuta L. Correlations of Bcl-2 and p53 expression with the clinicopathological features in tongue squamous cell carcinomas. Oral Oncol. 35:1999;56-62.
    • (1999) Oral Oncol. , vol.35 , pp. 56-62
    • Yao, L.1    Iwai, M.2    Furuta, L.3
  • 52
    • 0033278052 scopus 로고    scopus 로고
    • Changes in Bcl-2 and Bax expression in rat tongue during 4-nitroquinoline 1-oxide-induced carcinogenesis
    • Nishimura A. Changes in Bcl-2 and Bax expression in rat tongue during 4-nitroquinoline 1-oxide-induced carcinogenesis. J. Dent. Responsibility. 78:1999;1264-1269.
    • (1999) J. Dent. Responsibility , vol.78 , pp. 1264-1269
    • Nishimura, A.1
  • 53
    • 0034045448 scopus 로고    scopus 로고
    • Overexpression of p53 in squamous cell carcinoma of the tongue in young patients with no known risk factors is not associated with mutations in exons 5-9
    • Lingen M.W., Chang K.W., McMurray S.J., Solt D.B., Kies M.S., Mittal B.B. Overexpression of p53 in squamous cell carcinoma of the tongue in young patients with no known risk factors is not associated with mutations in exons 5-9. Head Neck. 22:2000;328-335.
    • (2000) Head Neck , vol.22 , pp. 328-335
    • Lingen, M.W.1    Chang, K.W.2    McMurray, S.J.3    Solt, D.B.4    Kies, M.S.5    Mittal, B.B.6
  • 54
    • 0032922471 scopus 로고    scopus 로고
    • Predictive value of malignancy grading systems, DNA content, p53, and angiogenesis for Stage I tongue carcinomas
    • Hogmo A., Kuylenstierna R., Lindholm J., Munck-Wikland E. Predictive value of malignancy grading systems, DNA content, p53, and angiogenesis for Stage I tongue carcinomas. J. Clin. Pathol. 52:1999;35-40.
    • (1999) J. Clin. Pathol. , vol.52 , pp. 35-40
    • Hogmo, A.1    Kuylenstierna, R.2    Lindholm, J.3    Munck-Wikland, E.4
  • 55
    • 0032914274 scopus 로고    scopus 로고
    • Prognostic value of p53 expression and histopathological parameters in squamous cell carcinoma of oral tongue
    • Unal O.F., Ayhan A., Hosal A.S. Prognostic value of p53 expression and histopathological parameters in squamous cell carcinoma of oral tongue. J. Laryngol. Otol. 113:1999;446-450.
    • (1999) J. Laryngol. Otol. , vol.113 , pp. 446-450
    • Unal, O.F.1    Ayhan, A.2    Hosal, A.S.3
  • 56
    • 0030941458 scopus 로고    scopus 로고
    • P53, the cellular gatekeeper for growth and division
    • Levine A.I. P53, the cellular gatekeeper for growth and division. Cell. 88:1997;323-331.
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.I.1
  • 57
    • 0031607505 scopus 로고    scopus 로고
    • Molecular assessment of p53 abnormalities at the invasive front of oral squamous cell carcinomas
    • Piffko J., Bankfalvi A., Tory K., Fuzesi L., Bryne M., Ofner D. Molecular assessment of p53 abnormalities at the invasive front of oral squamous cell carcinomas. Head Neck. 12:1998;8-15.
    • (1998) Head Neck , vol.12 , pp. 8-15
    • Piffko, J.1    Bankfalvi, A.2    Tory, K.3    Fuzesi, L.4    Bryne, M.5    Ofner, D.6
  • 58
    • 0033889662 scopus 로고    scopus 로고
    • Oncogenes and male breast carcinoma: C-erbB-2 and p53 coexpression predicts a poor survival
    • Pich A., Margaria E., Chiusa L. Oncogenes and male breast carcinoma: c-erbB-2 and p53 coexpression predicts a poor survival. J. Clin. Oncol. 18:2000;2948-2956.
    • (2000) J. Clin. Oncol. , vol.18 , pp. 2948-2956
    • Pich, A.1    Margaria, E.2    Chiusa, L.3
  • 59
    • 0030565001 scopus 로고    scopus 로고
    • Expression of programmed cell death regulatory p53 and Bcl-2 proteins in oral lesions
    • Ravi D., Nalinakumari K.R., Rajaram R.S., Nair M.K., Pillai M.R. Expression of programmed cell death regulatory p53 and Bcl-2 proteins in oral lesions. Cancer Lett. 105:1996;139-146.
    • (1996) Cancer Lett. , vol.105 , pp. 139-146
    • Ravi, D.1    Nalinakumari, K.R.2    Rajaram, R.S.3    Nair, M.K.4    Pillai, M.R.5


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