Cyclic AMP inhibits JNK activation by CREB-mediated induction of c-FLIPL and MKP-1, thereby antagonizing UV-induced apoptosis

Cell Death and Differentiation

Volumn 15, Issue 10, 2008, Pages 1654-1662

  Zhang, J ^a,b   Wang, Q ^a   Zhu, N ^a   Yu, M ^a   Shen, B ^a   Xiang, J ^c   Lin, A ^b  

^a INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

^b UNIVERSITY OF CHICAGO   (United States)

^c ILLINOIS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DYNEIN ADENOSINE TRIPHOSPHATASE; DYNEIN LIGHT CHAIN; FLICE INHIBITORY PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 1; PROTEIN P21; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL CELL CULTURE; APOPTOSIS; ARTICLE; CELL PROTECTION; CELL STRAIN 3T3; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; MOLECULAR MECHANICS; MOUSE; NONHUMAN; NUCLEIC ACID ANALYSIS; NUCLEOTIDE METABOLISM; PRIORITY JOURNAL; PROTEIN NUCLEIC ACID INTERACTION; RADIATION PROTECTION; RAT; ULTRAVIOLET RADIATION;

ANIMALS; APOPTOSIS; CASP8 AND FADD-LIKE APOPTOSIS REGULATING PROTEIN; CYCLIC AMP; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DUAL SPECIFICITY PHOSPHATASE 1; ENZYME ACTIVATION; ENZYME INDUCTION; GTPASE-ACTIVATING PROTEINS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICE; NIH 3T3 CELLS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RATS; RNA, SMALL INTERFERING; SECOND MESSENGER SYSTEMS; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEINS; ULTRAVIOLET RAYS;

RATTUS;

EID: 52149091686     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2008.87     Document Type: Article

References (40)

1. Hibi M, Lin A, Smeal T, Minden A, Karin M. Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes Dev 1993; 7: 2135-2148.
2. Chang L, Karin M. Mammalian MAP kinase signaling cascades. Nature 2001; 410: 37-40.
3. Lin A. Activation of the JNK signaling pathway: Breaking the brake on apoptosis. Bioessays 2003; 25: 1-8.
4. Yu C, Minemoto Y, Zhang J, Liu J, Tang F, Bui TN et al. JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD. Mol Cell 2004; 13: 329-340.
5. Sunahara RK, Taussig R. Isoforms of mammalian adenylyl cyclase: multiplicities of signaling. Mol Interv 2002; 2: 168-184.
6. Seamon KB, Padgett W, Daly JW. Forskolin: Unique diterpene activator of adenylate cyclase in membranes and in intact cells. Proc Natl Acad Sci USA 1981; 78: 3363-3367.
7. Birnbaumer L. Receptor-to-effector signaling through G proteins: Roles for βγ dimers as well as α-subunits. Cell 1992; 71: 1069-1072.
8. Lubran MM. Bacterial toxins. Ann Clin Lab Sci 1988; 18: 58-71.
9. de Rooij J, Zwartkruis FJ, Verheijen MH, Cool RH, Nijman SM, Wittinghofer A et al. Epac is a Rap1 guanine-nucleotide exchange factor directly activated by cyclic AMP. Nature 1998; 396: 474-477.
10. Feliciello A, Gottesman ME, Avvedimento EV. cAMP-PKA signaling to the mitochondria: Protein scaffolds, mRNA and phosphatases. Cell Signal 2005; 17: 279-287.
11. Mayr B, Montminy M. Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat Rev Mol Cell Biol 2001; 2: 599-609.
12. Impey S, McCorkle SR, Cha-Molstad H, Dwyer JM, Yochum GS, Boss JM et al. Defining the CREB regulon: A genome-wide analysis of transcription factor regulatory regions. Cell 2004; 119: 1041-1054.
13. Zhang X, Odom DT, Koo SH, Conkright MD, Canettieri G, Best J et al Genomewide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues. Proc Natl Acad Sci USA 2005; 102: 4459-4464.
14. + double-positive thymocytes. J Immunol 2000; 164: 1689-1694.
15. Kostylina G, Simon D, Fey MF, Yousefi S, Simon HU. Neutrophil apoptosis mediated by nicotinic acid receptors (GPR109A). Cell Death Differ 2008; 15: 134-142.
16. Negrotto S, Pacienza N, D'Atri LP, Pozner RG, Malaver E, Torres O et al. Activation of cyclic AMP pathway prevents CD34(+) cell apoptosis. Exp Hematol 2006; 34: 1420-1428.
17. Zhang J, Bui TN, Xiang J, Lin A. Cyclic AMP inhibits p38 activation via CREB-induced dynein light chain. Mol Cell Biol 2006; 26: 1223-1234.
18. Stork PJ, Schmitt JM. Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation. Trends Cell Biol 2002; 12 258-266.
19. Li J, Zhou Y, Wang C. p38 MAPK in regulating cellular responses to ultraviolet radiation. J Biomed Sci 2007; 14: 303-312.
20. Brancho D, Tanaka N, Jaeschke A, Ventura JJ, Kelkar N, Tanaka Y et al Mechanism of p38 MAP kinase activation in vivo. Genes Dev 2003; 17: 1969-1978.
21. Cuenda A, Rouse J, Doza YN, Meier R, Cohen P, Gallagher TF et al. SB203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett 1995; 364: 229-233.
22. Hsueh YP, Lai MZ. c-Jun N-terminal kinase but not mitogen-activated protein kinase is sensitive to cAMP inhibition in T lymphocytes. J Biol Chem 1995; 270: 18094-18098.
23. Rao GN, Runge MS. Cyclic AMP inhibition of thrombin-induced growth in vascular smooth muscle cells correlates with decreased JNK1 activity and c-Jun expression. J Biol Chem 1996; 271: 20805-20810.
24. Tournier C, Hess P, Yang DD, Xu J, Turner TK, Nimnual A et al. Requirement of JNK for stress-induced activation of the cytochrome c mediated death pathway. Science 2000; 288: 870-874.
25. Borsello T, Clarke PG, Hirt L, Vercelli A, Repici M, Schorderet DF et al. A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia. Nat Med 2003; 9: 1180-1186.
26. Ahn S, Olive M, Aggarwal S, Krylov D, Ginty DD, Vinson C. A dominant-negative inhibitor of CREB reveals that it is a general mediator of stimulus-dependent transcription of c-fos. Mol Cell Biol 1998; 18: 967-977.
27. Huang S, Shu L, Dilling MB, Easton J, Harwood FC, Ichijo H et al. Sustained activation of the JNK cascade and rapamycin-induced apoptosis are suppressed by p53/p21(Cip1). Mol Cell 2003; 11: 1491-1501.
28. ARF and p53 levels and an alteration of the Bax/Bcl-2 ratio. J Biol Chem 2002; 277: 37949-37954.
29. Sewer MB, Waterman MR. cAMP-dependent protein kinase enhances CYP17 transcription via MKP-1 activation in H295R human adrenocortical cells. J Biol Chem 2003; 278: 8106-8111.
30. Burgun C, Esteve L, Humblot N, Aunis D, Zwiller J. Cyclic AMP-elevating agents induce the expression of MAP kinase phosphatase-1 in PC12 cells. FEBS Lett 2000; 484: 189-193.
31. Chiou SH, Chen SJ, Peng CH, Chang YL, Ku HH, Hsu WM et al. Fluoxetine up-regulates expression of cellular FLICE-inhibitory protein and inhibits LPS-induced apoptosis in hippocampus-derived neural stem cell. Biochem Biophys Res Commun 2006; 343: 391-400.
32. Qiao L, Han SI, Fang Y, Park JS, Gupta S, Gilfor D et al. Bile acid regulation of C/EBPbeta, CREB, and c-Jun function, via the extracellular signal-regulated kinase and c-Jun NH2-terminal kinase pathways, modulates the apoptotic response of hepatocytes. Mol Cell Biol 2003; 23: 3052-3066.
33. Karin M, Lin A. NF-κB at the crossroads of life and death. Nat Immunol 2002; 3: 221-227.
34. Kamata H, Honda S, Maeda S, Chang L, Hirata H, Karin M. Reactive oxygen species promote TNF-α-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell 2005; 120: 649-661.
35. Liu J, Yang D, Minemoto Y, Leitges M, Rosner MR, Lin A. NF-κB is required for UV-induced JNK activation via induction of PKCδ. Mol Cell 2006; 21: 467-480.
36. Laderoute KR, Mendonca HL, Calaoagan JM, Knapp AM, Giaccia AJ, Stork PJ. Mitogen-activated protein kinase phosphatase-1 (MKP-1) expression is induced by low oxygen conditions found in solid tumor microenvironments. A candidate MKP for the inactivation of hypoxiainducible stress-activated protein kinase/c-Jun N-terminal protein kinase activity. J Biol Chem 1999; 274: 12890-12897.
37. Bhattacharyya S, Brown DE, Brewer JA, Vogt SK, Muglia LJ. Macrophage glucocorticoid receptors regulate Toll-like receptor 4-mediated inflammatory response by selective inhibition of p38 MAP kinase. Blood 2007; 109: 4313-4319.
38. Franklin CC, Srikanth S, Kraft AS. Conditional expression of mitogen-activated protein kinase phosphatase-1, MKP-1, is cytoprotective against UV-induced apoptosis. Proc Natl Acad Sci USA 1998; 95 3014-3019.
39. Irmler M, Thome M, Hahne M, Schneider P, Hofmann K, Steiner V et al Inhibition of death receptor signals by cellular FLIP. Nature 1997; 388: 190-195.
40. L, directly binds to MKK7 and inhibits the JNK pathway. EMBO J 2006; 25: 5549-5559.