메뉴 건너뛰기




Volumn 7, Issue 9, 2008, Pages 1492-1497

Downregulation of KSR1 in pancreatic cancer xenografts by antisense oligonucleotide correlates with tumor drug uptake

Author keywords

Antisense oligonucleotide; Drug uptake; ELISA; KSR1; Pancreatic cancer

Indexed keywords

ANTIINFECTIVE AGENT; ANTISENSE OLIGONUCLEOTIDE; KINASE SUPPRESSOR OF RAS1; UNCLASSIFIED DRUG; KSR 1 PROTEIN KINASE; KSR-1 PROTEIN KINASE; PROTEIN KINASE;

EID: 52149087172     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (14)

References (26)
  • 1
    • 0028947528 scopus 로고
    • The Caenorhabditis elegans gene mek-2 is required for vulval induction and encodes a protein similar to the protein kinase MEK
    • Kornfeld K, Guan KL, Horvitz HR. The Caenorhabditis elegans gene mek-2 is required for vulval induction and encodes a protein similar to the protein kinase MEK. Genes Dev 1995; 9:756-68.
    • (1995) Genes Dev , vol.9 , pp. 756-768
    • Kornfeld, K.1    Guan, K.L.2    Horvitz, H.R.3
  • 2
    • 0029588204 scopus 로고
    • The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans
    • Kornfeld K, Hom DB, Horvitz HR. The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans. Cell 1995; 83:903-13.
    • (1995) Cell , vol.83 , pp. 903-913
    • Kornfeld, K.1    Hom, D.B.2    Horvitz, H.R.3
  • 3
    • 0029559183 scopus 로고
    • The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction
    • Sundaram M, Han M. The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction. Cell 1995; 83:889-901.
    • (1995) Cell , vol.83 , pp. 889-901
    • Sundaram, M.1    Han, M.2
  • 4
    • 0029584327 scopus 로고    scopus 로고
    • Therrien M, Chang HC, Solomon NM, Karim FD, Wassarman DA, Rubin GM. KSR, a novel protein kinase required for RAS signal transduction. Cell 1995; 83:879-88.
    • Therrien M, Chang HC, Solomon NM, Karim FD, Wassarman DA, Rubin GM. KSR, a novel protein kinase required for RAS signal transduction. Cell 1995; 83:879-88.
  • 6
    • 34248576576 scopus 로고    scopus 로고
    • KSR and CNK: Two scaffolds regulating RAS-mediated RAF activation
    • Clapèron A and Therrien M. KSR and CNK: Two scaffolds regulating RAS-mediated RAF activation. Oncogene 2007; 26:3143-58.
    • (2007) Oncogene , vol.26 , pp. 3143-3158
    • Clapèron, A.1    Therrien, M.2
  • 7
    • 0142137239 scopus 로고    scopus 로고
    • Pharmacologic inactivation of kinase suppressor of ras-1 abrogates Ras-mediated pancreatic cancer
    • Xing HR, Cordon-Cardo C, Deng X, Tong W, Campodonico L, Fuks Z, Kolesnick R. Pharmacologic inactivation of kinase suppressor of ras-1 abrogates Ras-mediated pancreatic cancer. Nat Med 2003; 9:1266-8.
    • (2003) Nat Med , vol.9 , pp. 1266-1268
    • Xing, H.R.1    Cordon-Cardo, C.2    Deng, X.3    Tong, W.4    Campodonico, L.5    Fuks, Z.6    Kolesnick, R.7
  • 8
    • 14544270277 scopus 로고    scopus 로고
    • Does anyone survive pancreatic ductal adenocarcinoma? A nationwide study re-evaluating the data of the Finnish Cancer Registry
    • Carpelan-Holmstrom M, Nordling S, Pukkala E, Sankila R, Luttges J, Kloppel G, Haglund C. Does anyone survive pancreatic ductal adenocarcinoma? A nationwide study re-evaluating the data of the Finnish Cancer Registry. Gut 2005; 54:385-7.
    • (2005) Gut , vol.54 , pp. 385-387
    • Carpelan-Holmstrom, M.1    Nordling, S.2    Pukkala, E.3    Sankila, R.4    Luttges, J.5    Kloppel, G.6    Haglund, C.7
  • 9
    • 34447260521 scopus 로고    scopus 로고
    • Parris GE. Why G3139 works poorly in cancer trials but might work well against HIV. Med Hypotheses 2007; 69:537-40.
    • Parris GE. Why G3139 works poorly in cancer trials but might work well against HIV. Med Hypotheses 2007; 69:537-40.
  • 11
    • 0035845318 scopus 로고    scopus 로고
    • Antisense therapy in oncology: New hope for an old idea?
    • Tamm I, Dorken B, Hartmann G. Antisense therapy in oncology: new hope for an old idea? Lancet 2001; 358:489-97.
    • (2001) Lancet , vol.358 , pp. 489-497
    • Tamm, I.1    Dorken, B.2    Hartmann, G.3
  • 12
    • 3142607812 scopus 로고    scopus 로고
    • Potential roles of antisense therapy in the molecular targeting of genes involved in cancer (review)
    • Kim R, Tanabe K, Emi M, Uchida Y, Toge T. Potential roles of antisense therapy in the molecular targeting of genes involved in cancer (review). Int J Oncol 2004; 24:5-17.
    • (2004) Int J Oncol , vol.24 , pp. 5-17
    • Kim, R.1    Tanabe, K.2    Emi, M.3    Uchida, Y.4    Toge, T.5
  • 13
    • 0032833451 scopus 로고    scopus 로고
    • Antisense therapy of hematologic malignancies
    • Cotter FE. Antisense therapy of hematologic malignancies. Semin Hematol 1999; 36:9-1
    • (1999) Semin Hematol , vol.36 , pp. 9-1
    • Cotter, F.E.1
  • 14
    • 0034015672 scopus 로고    scopus 로고
    • Phase I clinical and pharmacokinetic study of bcl-2 antisense oligonucleotide therapy in patients with non-Hodgkin's lymphoma
    • Waters JS, Webb A, Cunningham D, Clarke PA, Raynaud F, di Stefano F, Cotter FE. Phase I clinical and pharmacokinetic study of bcl-2 antisense oligonucleotide therapy in patients with non-Hodgkin's lymphoma. J Clin Oncol 2000; 18:1812-23.
    • (2000) J Clin Oncol , vol.18 , pp. 1812-1823
    • Waters, J.S.1    Webb, A.2    Cunningham, D.3    Clarke, P.A.4    Raynaud, F.5    di Stefano, F.6    Cotter, F.E.7
  • 15
    • 33748342736 scopus 로고    scopus 로고
    • Antisense therapy in clinical oncology: Preclinical and clinical experiences
    • Tamm I, Wagner M. Antisense therapy in clinical oncology: preclinical and clinical experiences. Mol Biotechnol 2006; 33:221-38.
    • (2006) Mol Biotechnol , vol.33 , pp. 221-238
    • Tamm, I.1    Wagner, M.2
  • 16
    • 0025223297 scopus 로고
    • High-performance liquid chromatographic analysis of phosphorothioate analogues of oligodeoxynucleotides in biological fluids
    • Bigelow JC, Chrin LR, Mathews LA, McCormick JJ. High-performance liquid chromatographic analysis of phosphorothioate analogues of oligodeoxynucleotides in biological fluids. J Chromatogr 1990; 533:133-40.
    • (1990) J Chromatogr , vol.533 , pp. 133-140
    • Bigelow, J.C.1    Chrin, L.R.2    Mathews, L.A.3    McCormick, J.J.4
  • 17
    • 0030963933 scopus 로고    scopus 로고
    • Determination of antisense phosphorothioate oligonucleotides and catabolites in biological fluids and tissue extracts using anion-exchange high-performance liquid chromatography and capillary gel electrophoresis
    • Chen SH, Qian M, Brennan JM, Gallo JM. Determination of antisense phosphorothioate oligonucleotides and catabolites in biological fluids and tissue extracts using anion-exchange high-performance liquid chromatography and capillary gel electrophoresis. J Chromatogr B Biomed Sci Appl 1997; 692:43-51.
    • (1997) J Chromatogr B Biomed Sci Appl , vol.692 , pp. 43-51
    • Chen, S.H.1    Qian, M.2    Brennan, J.M.3    Gallo, J.M.4
  • 18
    • 0030065059 scopus 로고    scopus 로고
    • Quantitation of phosphorothioate oligonucleotides in human plasma
    • Leeds JM, Graham MJ, Truong L, Cummins LL. Quantitation of phosphorothioate oligonucleotides in human plasma. Anal Biochem 1996; 235:36-43.
    • (1996) Anal Biochem , vol.235 , pp. 36-43
    • Leeds, J.M.1    Graham, M.J.2    Truong, L.3    Cummins, L.L.4
  • 19
    • 0030573018 scopus 로고    scopus 로고
    • Determination of single-stranded oligodeoxynucleotides by capillary gel electrophoresis with laser induced fluorescence and on column derivatization
    • Reyderman L, Stavchansky S. Determination of single-stranded oligodeoxynucleotides by capillary gel electrophoresis with laser induced fluorescence and on column derivatization. J Chromatogr A 1996; 755:271-80.
    • (1996) J Chromatogr A , vol.755 , pp. 271-280
    • Reyderman, L.1    Stavchansky, S.2
  • 20
    • 0030466760 scopus 로고    scopus 로고
    • Quantitative analysis of oligonucleotides by matrix-assisted laser desorption/ionization mass spectrometry
    • Bruenner BA, Yip TT, Hutchens TW. Quantitative analysis of oligonucleotides by matrix-assisted laser desorption/ionization mass spectrometry. Rapid Commun Mass Spectrom 1996; 10:1797-801.
    • (1996) Rapid Commun Mass Spectrom , vol.10 , pp. 1797-1801
    • Bruenner, B.A.1    Yip, T.T.2    Hutchens, T.W.3
  • 21
    • 0030026790 scopus 로고    scopus 로고
    • Development of a novel scintillation proximity competitive hybridization assay for the determination of phosphorothioate antisense oligonucleotide plasma concentrations in a toxicokinetic study
    • de Serres M, McNulty MJ, Christensen L, Zon G, Findlay JW. Development of a novel scintillation proximity competitive hybridization assay for the determination of phosphorothioate antisense oligonucleotide plasma concentrations in a toxicokinetic study. Anal Biochem 1996; 233:228-33.
    • (1996) Anal Biochem , vol.233 , pp. 228-233
    • de Serres, M.1    McNulty, M.J.2    Christensen, L.3    Zon, G.4    Findlay, J.W.5
  • 22
    • 0030863191 scopus 로고    scopus 로고
    • A competitive enzyme hybridization assay for plasma determination of phosphodiester and phosphorothioate antisense oligonucleotides
    • Deverre JR, Boutet V, Boquet D, Ezan E, Grassi J, Grognet JM. A competitive enzyme hybridization assay for plasma determination of phosphodiester and phosphorothioate antisense oligonucleotides. Nucleic Acids Res 1997; 25:3584-9.
    • (1997) Nucleic Acids Res , vol.25 , pp. 3584-3589
    • Deverre, J.R.1    Boutet, V.2    Boquet, D.3    Ezan, E.4    Grassi, J.5    Grognet, J.M.6
  • 24
    • 0036570927 scopus 로고    scopus 로고
    • Development of an ultrasensitive noncompetitive hybridization-ligation enzyme-linked immunosorbent assay for the determination of phosphorothioate oligodeoxynucleotide in plasma
    • Yu RZ, Baker B, Chappell A, Geary RS, Cheung E, Levin AA. Development of an ultrasensitive noncompetitive hybridization-ligation enzyme-linked immunosorbent assay for the determination of phosphorothioate oligodeoxynucleotide in plasma. Anal Biochem 2002; 304:19-25.
    • (2002) Anal Biochem , vol.304 , pp. 19-25
    • Yu, R.Z.1    Baker, B.2    Chappell, A.3    Geary, R.S.4    Cheung, E.5    Levin, A.A.6
  • 25
    • 33745329502 scopus 로고    scopus 로고
    • A specific picomolar hybridization-based ELISA assay for the determination of phosphorothioate oligonucleotides in plasma and cellular matrices
    • Wei X, Dai G, Marcucci G, Liu Z, Hoyt D, Blum W, Chan KK. A specific picomolar hybridization-based ELISA assay for the determination of phosphorothioate oligonucleotides in plasma and cellular matrices. Pharm Res 2006; 23:1251-64.
    • (2006) Pharm Res , vol.23 , pp. 1251-1264
    • Wei, X.1    Dai, G.2    Marcucci, G.3    Liu, Z.4    Hoyt, D.5    Blum, W.6    Chan, K.K.7
  • 26
    • 33745213356 scopus 로고    scopus 로고
    • Plasma protein binding of an antisense oligonucleotide targeting human ICAM-1 (ISIS 2302)
    • Watanabe TA, Geary RS, Levin AA. Plasma protein binding of an antisense oligonucleotide targeting human ICAM-1 (ISIS 2302). Oligonucleotides 2006; 16:169-80.
    • (2006) Oligonucleotides , vol.16 , pp. 169-180
    • Watanabe, T.A.1    Geary, R.S.2    Levin, A.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.