Fermentation filtrates of Rubus coreanus relax the corpus cavernosum and increase sperm count and motility

Journal of Medicinal Food

Volumn 11, Issue 3, 2008, Pages 474-478

  Jeon, Jeong Hee ^a   Shin, Sunhee ^a   Park, Dongsun ^a   Jang, Ja Young ^a   Choi, Byong Il ^a   Kang, Jong Koo ^a   Joo, Seong Soo ^a   Hwang, Seock Yeon ^b   Kim, Jong Choon ^c   Kim, Byung Yul ^d   Kim, Mee Ree ^e   Kim, Yun Bae ^a  

^a Chungbuk National University   (South Korea)

^b Juseong College   (South Korea)

^c Chonnam National University   (South Korea)

^d Dongyangbiopia Inc   (South Korea)

^e Chungnam National University   (South Korea)

Author keywords

Corpus cavernosum; Male reproductive function; Rubus coreanus; Sperm counts; Testosterone

Indexed keywords

PHENYLEPHRINE; PLANT EXTRACT; RUBUS COREANUS EXTRACT; SILDENAFIL; TESTOSTERONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORPUS CAVERNOSUM; EPIDIDYMIS TAIL; EX VIVO STUDY; FERMENTATION; GENITAL SYSTEM; HORMONE DETERMINATION; LOW DRUG DOSE; MALE; MALE GENITAL SYSTEM; MOUSE; MUSCLE RELAXATION; NONHUMAN; ORGAN WEIGHT; PENIS ERECTION; PRIORITY JOURNAL; RABBIT; SPERMATOZOON COUNT; SPERMATOZOON MOTILITY; TESTOSTERONE BLOOD LEVEL; TREATMENT DURATION;

ANIMALS; DRUGS, CHINESE HERBAL; ERECTILE DYSFUNCTION; FERMENTATION; MALE; MICE; MICE, INBRED ICR; ORGAN SIZE; PENIS; PHENYLEPHRINE; PHYTOTHERAPY; PLANT PREPARATIONS; RABBITS; ROSACEAE; SPERM COUNT; SPERM MOTILITY; TESTIS; TESTOSTERONE;

MUS; ORYCTOLAGUS CUNICULUS; RUBUS COREANUS;

EID: 52149085732     PISSN: 1096620X     EISSN: None     Source Type: Journal    
DOI: 10.1089/jmf.2007.0070     Document Type: Article

References (31)

1. Kolodny RC, Masters WH, Johnson VE: Sexual anatomy and physiology. In: Textbook of Sexual Medicine. Little, Brown and Co., Boston, 1979, pp. 1-28.
2. Johannes CB, Araujo AB, Feldman HA, Derby CA, Kleinman KP, McKinlay JB: Incidence of erectile dysfunction in men 40 to 69 years old; longitudinal results from the Massachusetts male aging study. J Urol 2000;163:460-463.
3. Felman HA, Johannes CB, Derby CA, Kleinman KP, Mohr BA, Araujo AB, McKinlay JB: Erectile dysfunction and coronary risk factors: protective results from the Massachusetts male aging study. Prev Med 2000;30:328-338.
4. McCulloch DK, Campbell IW, Wu FC, Prescott RJ, Clarke BF: The prevalence of diabetic importance. Diabetologia 1980;18:279-283.
5. Kaufman JM, Hatzichristou DG, Mulhall JP, Fitch WP, Goldstein I: Impotence and chronic renal failure: a study of the hemodynamic pathphysiology. J Urol 1994;151:612-618.
6. Sullivan ME, Miller MA, Bell CR, Jagroop IA, Thompson CS, Khan MA, Morgan RJ, Mikhailidis DP: Fibrinogens, lipoprotein (a) and lipids in patients with erectile dysfunction. A preliminary study. Int Angiol 2001;20:195-199.
7. Bortollotti A, Fedele D, Chatenoud L, Colli E, Cosecelli C, Landoni M, Laverzzari M, Santeusanio F, Parazzini F: Cigarette smoking: a risk factor for erectile dysfunction in diabetics. Eur Urol 2001;40:392-396.
8. McCulloch DK, Young RJ, Prescott RJ, Cambell IW, Clarke BF: The natural history of impotence in diabetic men. Diabetologia 1984;26:437-440.
9. Fouad R, Vivien K, Ronald S: Male sexual function and its disorders: physiology, pathophysiology, clinical investigation, and treatment. Endocr Rev 2001;22:342-388.
10. NIH Consensus Conference: Impotence. JAMA 1993;270:83-90.
11. Sinclair S: Male fertility: nutritional and environmental considerations. Altern Med Rev 2000;5:28-38.
12. Jouannet P, Wang C, Eustache F, Kold-Jensen T, Auger J: Semen quality and male reproductive health: the controversy about human sperm concentration decline. Acta Pathol Microbiol Immunol Scand 2001;109:333-344.
13. Gruenewald DA, Matsumoto AM: Testosterone supplementation therapy for older men: potential benefits and risks. J Am Geriatr Soc 2003;51:101-115.
14. Padama-Nathan H, Eardly I, Kloner RA, Laties AM, Montorsi F: A 4 year update on the safety of sildenafil citrate (Viagra). Urology 2002;60(Suppl 2B):67-90.
15. Abel B, Carswell G, Elton R, Hargreave T, Kyle K, Orr S, Rogers A, Baxby K, Yates A: Randomised trial of clomiphene citrate treatment and vitamin C for male infertility. Br J Urol 1982;54:780-784.
16. Lee SJ: Korean Folk Medicine. Publishing Center of Seoul National University, Seoul, 1966, p. 75.
17. Perry LM: Medicinal Plants of East and Southeast Asia, Attributed Properties and Uses. MIT Press, Cambridge, 1980, p. 346.
18. Kimura T, Guo JX, Han BH: International Collection of Traditional and Folk Medicine, Vol. 2. World Scientific, Hackensack, NJ, 1997, pp. 68-69.
19. Cha HS, Park MS, Park MS: Physiological activities of Rubus coreanus Miquel. J Food Sci Nutr 2001;11:5-12.
20. Shin TY, Kim SH, Lee ES, Eom DO, Kim HM: Action of Rubus coreanus extract on systemic and local anaphylaxis. Phytother Res 2002;16:508-513.
21. Choi JW, Lee KT, Ha JH, Yun SY, Ko CD, Jung HJ, Park HJ: Antinociceptive and antiinflammatory effects of niga-ichigoside F1 and 23-hydroxytormentic acid obtained from Rubus coreanus. Biol Pharm Bull 2003;26:1436-1441.
22. Maatta-Riihinen KR, Kamal-Eldin A, Torronen AR: Identification and quantification of phenolic compounds in berries of Fragaria and Rubus species (Family Rosaceae). J Agric Food Chem 2004;52:6178-6187.
23. Bell DR, Gochenaur K: Direct vasoactive and vasoprotective properties of anthocyanin-rich extract. J Appl Physiol 2006;100:1164-1168.
24. Fumagalli F, Rossoni M, Iriti M, Gennaro A, Faoro F, Borroni E, Scienza A, Sala A, Folco G: From field to health: a simple way to increase the nutraceutical content of grape as shown by NO-dependent vascular relaxation. J Agric Food Chem 2006;54:5344-5349.
25. Andersson KE, Wagner G: Physiology of penile erection. Physiol Rev 1995;75:191-236.
26. Das DK, Sato M, Ray PS, Maulik G, Engelman RM, Bertelli AAE, Bertelli A: Cardioprotection of red wine: role of polyphenolic antioxidants. Drugs Exp Clin Res 1999;25:115-120.
27. Wallerath T, Poleo D, Li H, Forstermann U: Red wine increase the expression of human endothelial nitric oxide synthase: a mechanism that may contribute to its beneficial cardiovascular effects. J Am College Cardiol 2003;41:479-478.
28. Arthur C: Reproductive and hormonal functions of the male (and function of the pineal gland). In: Textbook of Medical Physiology (Guyton MD, Hall JE, eds.). W.B. Saunders, Philadelphia, 2000, pp. 922-924.
29. Holdcraft RW, Braun RE: Hormonal regulation of spermatogenesis. Int J Androl 2004;27:335-342.
30. Rowley MJ, Teshima F, Heller CB: Duration of transit of spermatozoa through the human male ductular system. Fertil Steril 1070;21:390-395.
31. Hinrichsen MJ, Blagaier JA: Evidence supporting the existence of sperm maturation in the human epididymis. J Reprod Fertil 1980;60:291-294.