Chromatin structure and expression of synapsin I and synaptophysin in retinal precursor cells

Neurochemistry International

Volumn 53, Issue 5, 2008, Pages 165-172

  Ekici, Myriam ^a   Schmitz, Frank ^a   Hohl, Mathias ^a   Seigel, Gail M ^b   Thiel, Gerald ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b UNIVERSITY AT BUFFALO   (United States)

Author keywords

Histone deacetylase; Histone methylation; NRSF (neuron restrictive silencer factor); REST (RE 1 silencing transcription factor); Retinal precursor cells; Synapsin I; Synaptophysin

Indexed keywords

CYCLIC AMP; HISTONE; HISTONE DEACETYLASE; PROTEIN RIBEYE; RE 1 SILENCING TRANSCRIPTION FACTOR; STRUCTURAL PROTEIN; SYNAPSIN I; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ACETYLATION; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL TYPE; CHROMATIN IMMUNOPRECIPITATION; CHROMATIN STRUCTURE; CONTROLLED STUDY; DEACETYLATION; ENZYME INHIBITION; EPIGENETICS; FIBROBLAST; GENE CONTROL; GENE EXPRESSION; GENE SILENCING; GENETIC TRANSCRIPTION; NONHUMAN; NUCLEOSOME; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; RETINA CELL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEM CELL;

ANIMALS; CELL LINE; CHROMATIN; CHROMATIN IMMUNOPRECIPITATION; EPIGENESIS, GENETIC; EYE PROTEINS; FIBROBLASTS; GENES, REPORTER; HISTONE DEACETYLASES; LUCIFERASES; MUTATION; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; RATS; REPRESSOR PROTEINS; RETINA; STEM CELLS; SYNAPSINS; SYNAPTOPHYSIN; TAMOXIFEN; TRANSCRIPTIONAL ACTIVATION;

EID: 52049124010     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2008.07.006     Document Type: Article

References (26)

1. Barber A.J., Nakamura M., Wolpert E.B., Reiter C.E.N., Seigel G.M., Antonetti D.A., and Gardner T.W. Insulin rescues retinal neurons from apoptosis by a phosphatidylinositol 3-kinase/Akt-mediated mechanism that reduces the activation of caspase-3. J. Biological Chem. 276 (2001) 32814-32821
2. Bauer I., Al Sarraj J., Vinson C., Larsen R., and Thiel G. Interleukin 1β and tetradecanoylphorbol acetate-induced biosynthesis of tumor necrosis factor α in human hepatoma cells involves the transcription factors ATF2 and c-Jun and stress-activated protein kinases. J. Cellular Biochem. 100 (2007) 242-255
3. Brandstätter J.H., Löhrke S., Morgans C.W., and Wässle H. Distributions of two homologous synaptic vesicle proteins, synaptoporin and synaptophysin, in the mammalian retina. J. Comparative Neurol. 370 (1996) 1-10
4. Ekici M., Hohl M., Schuit F., Martínez-Serrano A., and Thiel G. Transcription of genes encoding synaptic vesicle proteins in human neural stem cells: chromatin accessibility, histone methylation pattern, and the essential role of REST. J. Biological Chem. 283 (2008) 9257-9268
5. Hohl M., and Thiel G. Cell type-specific regulation of RE-1 silencing transcription factor (REST) target genes. Eur. J. Neurosci. 22 (2005) 2216-2230
6. Kaufmann K., and Thiel G. Epidermal growth factor and thrombin induced proliferation of immortalized human keratinocytes is coupled to the synthesis of Egr-1, a zinc finger transcriptional regulator. J. Cellular Biochem. 85 (2002) 381-391
7. Lietz M., Hohl M., and Thiel G. RE-1 silencing transcription factor (REST) regulates human synaptophysin gene transcription through an intronic sequence-specific DNA-binding site. Eur. J. Biochem. 270 (2003) 2-9
8. Lois C., Hong E.J., Pease S., Brown E.J., and Baltimore D. Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors. Science 295 (2002) 868-872
9. Myers S.J., Peters J., Huang Y., Comer M.B., Barthel F., and Dingledine R. Transcriptional regulation of the GluR2 gene: neural-specific expression, multiple promoters, and regulatory elements. J. Neurosci. 18 (1998) 6723-6739
10. Ooi L., and Wood I.C. Chromatin crosstalk in development and disease: lessons from REST. Nat. Rev. Genet. 8 (2007) 544-554
11. Palm K., Belluardo N., Metsis M., and Timmusk T. Neuronal expression of zinc finger transcription factor REST/NRSF/XBR gene. J. Neurosci. 18 (1998) 1280-1296
12. Rea S., Eisenhaber F., O'Carroll D., Strahl B.D., Sun Z.-W., Schmid M., Opravil S., Mechtler K., Ponting C.P., Allis C.D., and Jenuwein T. Regulation of chromatin structure by site-specific histone H3 methyltransferases. Nature 406 (2000) 593-599
13. Rössler O.G., and Thiel G. Brain-derived neurotrophic factor, epidermal growth factor, or A-Raf induced growth of HaCaT keratinocytes requires extracellular signal-regulated kinase. Am. J. Physiology-Cell Physiology 286 (2004) C1118-C1129
14. Rössler O.G., Henβ I., and Thiel G. Transcriptional response to muscarinic acetylcholine receptor stimulation: regulation of Egr-1 biosynthesis by ERK, Elk-1, MKP-1, and calcineurin in carbachol-stimulated human neuroblastoma cells. Arch. Biochem. Biophysics 470 (2008) 93-102
15. Santos-Rosa H., Schneider R., Bannister A.J., Sherriff J., Bernstein B.E., Emre N.C.T., Schreiber S.L., Mellor J., and Kouzarides T. Active genes are tri-methylated at K4 of histone H3. Nature 419 (2002) 407-411
16. Schmitz F., Königstorfer A., and Südhof T.C. RIBEYE, a component of synaptic ribbons: a protein's journey through evolution provides insight into synaptic ribbon function. Neuron 28 (2000) 857-872
17. Seigel G.M. Establishment of an E1A-immortalized retinal cell culture. In Vitro Cell. Developmental Biology-Animal 32 (1996) 66-68
18. Seigel G.M., Sun W., Wang J., Hershberger D.H., Campbell L.M., and Salvi R.J. Neuronal gene expression and function in the growth-stimulated R28 retinal precursor cell line. Curr. Eye Res. 28 (2004) 257-269
19. Schoch S., Cibelli G., and Thiel G. Neuron-specific gene expression of synapsin I. Major role of a negative regulatory mechanism. J. Biol. Chem. 271 (1996) 3317-3323
20. Stefano L., Al Sarraj J., Rössler O.G., Vinson C., and Thiel G. Up-regulation of tyrosine hydroxylase gene transcription by tetradecanoylphorbol acetate is mediated by the transcription factors Ets-like protein-1 (Elk-1) and Egr-1. J. Neurochem. 97 (2006) 92-104
21. Thiel G., and Hohl M. RE-1 silencing transcription factor (REST)-regulation of neuronal gene expression via modification of the chromatin structure. In: Thiel G. (Ed). Transcription Factors in the Nervous System-Development, Brain Function and Disease Wiley-VCH (2006), Weinheim, Germany 113-128
22. Thiel G., Kaufmann K., Magin A., Lietz M., Bach K., and Cramer M. The human transcriptional repressor protein NAB1: expression and biological activity. Biochimica et Biophysica Acta 1493 (2000) 289-301
23. Thiel G., Lietz M., and Cramer M. Biological activity and modular structure of RE-1 silencing transcription factor (REST), a repressor of neuronal genes. J. Biological Chem. 273 (1998) 26891-26899
24. Thiel G., Lietz M., and Hohl H. How mammalian transcriptional repressors work. Eur. J. Biochem. 271 (2004) 2855-2862
25. Timmusk T., Palm K., Lendahl U., and Metsis M. Brain-derived neurotrophic factor expression in vivo is under the control of neuron-restrictive silencer element. J. Biological Chem. 274 (1999) 1078-1084
26. von Kriegstein K., Schmitz F., Link E., and Südhof T.C. Distribution of synaptic vesicle proteins in the mammalian retina identifies obligatory and facultative components of ribbon synapses. Eur. J. Neurosci. 11 (1999) 1335-1348