Kaempferol: A new immunosuppressant of calcineurin

IUBMB Life

Volumn 60, Issue 8, 2008, Pages 549-554

  Wang, Hu ^a   Zhou, Chun Lei ^a   Lei, Hong ^a   Zhang, Song Dong ^a   Zheng, Jianquan ^b   Wei, Qun ^a  

^a BEIJING NORMAL UNIVERSITY   (China)

^b BEIJING UNION UNIVERSITY   (China)

Author keywords

Calcineurin; Inhibitor; Kaempferol; RT PCR; Truncated mutants

Indexed keywords

ALKALINE PHOSPHATASE; CALCINEURIN; CALMODULIN; INTERLEUKIN 2; KAEMPFEROL; MESSENGER RNA; MUTANT PROTEIN; PHOSPHOPROTEIN PHOSPHATASE 1; PROTEIN SUBUNIT; IMMUNOSUPPRESSIVE AGENT; KAEMPFEROL DERIVATIVE; PRIMER DNA;

ARTICLE; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PURIFICATION; ENZYME SUBSTRATE; GENE EXPRESSION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; DRUG ANTAGONISM; GENETICS; IMMUNOLOGY; METABOLISM;

CALCINEURIN; DNA PRIMERS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-2; JURKAT CELLS; KAEMPFEROLS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 52049122868     PISSN: 15216543     EISSN: 15216551     Source Type: Journal    
DOI: 10.1002/iub.94     Document Type: Article

References (25)

1. Klee, C. B., Crouch, T. H., and Krinks, M. H. (1979) Calcineurin: a calcium- and calmodulin-binding protein of the nervous system. Proc. Natl. Acad. Sci. USA 76, 6270-6273.
2. Klee, C. B., Draetta, G. F., and Hubbard, M. J. (1988) Calcineurin. Adv. Enzymol. Relat. Areas Mol. Biol. 61, 149-200.
3. Klee, C. B., Ren, H., and Wang, X. T. (1998) Regulation of the calmodulin- stimulated protein phosphatase, calcineurin. J. Biol. Chem. 273, 13367-13370.
4. Perrino, B. A., Ng, Y. L., and Soderling, T. R. (1995) Calcium regulation of calcineurin phosphatase activity by its B subunit and calmodulin. J. Biol. Chem. 270, 340-346.
5. Hubbard, M. J. and Klee, C. B. (1989) Functional domain structure of calcineurin A: mapping by limited proteolysis. Biochemistry 28, 1868-1874.
6. 2+/calcineurin-NFAT-mediated signaling. Mol. Cell 18, 1-9.
7. Macian, F. (2005) NFAT proteins: key regulator of T-cell development and function. Nat. Rev. Immunol. 5, 472-484.
8. Rusnak, F. and Mertz, P. (2000) Calcineurin: Form and Function. Physiol. Rev. 4, 1483-1521.
9. Baumgrass, R., Weiwad, M., Erdmann, F., Liu, J. O., Wunderlich, D., Grabley, S., and Fischer, G. (2001) Reversible inhibition of calcineurin by the polyphenolic aldehyde gossypol. J. Biochem. 276, 47914-47921. (Pubitemid 37370689)
10. Liu, J., Farmer, J. D., Lane, W. S., Friedman, J., Weissman, I., and Schreiber, S. L. (1991) Calcineurin is a common target of cyclophilin- cyclosporin A and FKBP-PK506 complexes. Cell 66, 807-815. (Pubitemid 121001714)
11. Wallemacq, P. E. and Reding, R. (1993) FK506(Tacrolimus), a novel immunosuppressant in organ transplantation: clinical, biomedical, and analytical aspects. Clin. Chem. 39, 2219-2228.
12. Wang, H.-L., Du, Y.-W., Xiang, B.-Q., Lin, W.-L., and Wei, Q. (2007) The regulatory domains of CAN have different effects on the inhibition of CN activity by FK506 and CsA. IUBMB Life 6, 388-393.
13. Tong, L., Song, Y., Jia, Z.-G., Zhang, W., and Wei, Q. (2007) Calmodulin-dependent activation of calcineurin by chlorogenic acid. IUBMB Life 6, 402-407. (Pubitemid 47027110)
14. Takai, A. and Mieskes, G. (1991) Inhibitory effect of okadaic acid on the p-nitrophenyl phosphates. Biochem. J. 275, 233-239.
15. Garen, A. and Leyinthal, C. (1960) A fine-structure genetic and chemical study of the enzyme alkaline phosphatase of E. coli. Biochem. Biophys. Acta. 38, 470-483.
16. Fruman, D. A., Klee, C. B., Bierer, B. E., and Burakoff, S. J. (1992) Calcineurin phosphatase activity in T lymphocytes is inhibited by FK506 and cyclosporin A. PNAS 89, 3686-3690.
17. Yu, D.-Y., Luo, J., Bu, F., Zhang, W., and Wei, Q. (2006) Effects of cyclosporin A, FK506 and rapamycin on calcineurin phosphatase activity in mouse brain. IUBMB Life 58, 429-433.
18. Huang, X.-X., Yamashiki, M., Nakatani, K., Nobori, T., and Mase, A. (2001) Semi-quantitative analysis of cytokine mRNA expression induced by the herbal medicine sho-saiko-to (TJ-9) using a gel doc system. J. Clin. Lab. Anal. 15, 199-209.
19. Xiang, B. Q., Liu, P., Jiang, G. H., Zou, K., Yi, F., Yang, S. J., and Wei, Q. (2003) The catalytically active domain in the A subunit of calcineurin. Biol. Chem. 384, 1429-1434.
20. Kissinger, C. R., Parge, H. E., Knighton, D. R., Lewis, C. T., Pelletier, L. A., Tempczyk, A., Kalish, V. J., Tucker, K. D., Showalter, R. E., Moomaw, E. W., Gastinel, L.N., Habuka, N., Chen, X., and Maldonado, F. (1995) Crystal structure of human calcineurin and the human FKBP12-FK506-calcineurin complex. Nature 378, 641-644. (Pubitemid 3005789)
21. Li, H.-C. (1982). Phosphoprotein phosphatases. Curr. Top. Cell. Regul. 21, 129-174.
22. Sommer, D., Fakata, K. L., Swanson, S. A., and Stemmer, P. M. (2000) Modulation of the phosphatase activity of calcineurin by oxidants and antioxidants in vitro. Eur. J. Biochem. 267, 2312-2322.
23. Robb, R. J., Greene, W. C., and Rusk, C. M. (1984) Low and high affinity cellular receptors for interleukin 2 implications for the level of Tac antigen. J. Exp. Med. 160, 1126-1146.
24. Birt, D. F., Hendrich, S., and Wang, W. Q. (2001) Dietary agents in cancer prevention: flavonoids and isoflavonoids. Pharmacol. Ther. 90, 157-177.
25. + T cell engraftment. Clin. Immunol., 2, 132-144.