Anticonvulsant mood stabilizers in the treatment of behavioral and psychological symptoms of dementia (BPSD);Les antiépileptiques thymorégulateurs dans le traitement des symptômes comportementaux et psychologiques de la démence (SCPD)

Encephale

Volumn 34, Issue 4, 2008, Pages 409-415

  Pinheiro, D ^a  

^a Service de Psychiatrie Adulte   (France)

Author keywords

Anticonvulsants; Behavioral and psychological symptoms; BPSD; Dementia; Mood stabilizers

Indexed keywords

4 AMINOBUTYRIC ACID; ANTICONVULSIVE AGENT; CARBAMAZEPINE; GABAPENTIN; GLUTAMIC ACID; LAMOTRIGINE; MOOD STABILIZER; OXCARBAZEPINE; TOPIRAMATE; VALPROATE SEMISODIUM; VALPROIC ACID;

ARTICLE; ATAXIA; BEHAVIOR DISORDER; BEHAVIORAL AND PSYCHOLOGICAL SYMPTOMS OF DEMENTIA; BIPOLAR DISORDER; BLOOD TOXICITY; CARDIOTOXICITY; COGNITIVE DEFECT; DISEASE SEVERITY; DRUG EFFICACY; DRUG INDICATION; DRUG TOLERABILITY; HUMAN; HYPONATREMIA; INFECTION; LIVER TOXICITY; MENTAL DISEASE; NEUROPROTECTION; RATING SCALE; SEDATION; SIDE EFFECT; SKIN TOXICITY; SYMPTOMATOLOGY; SYNAPTIC TRANSMISSION; THROMBOEMBOLISM; TREATMENT RESPONSE;

AGED; AMINES; ANTICONVULSANTS; CARBAMAZEPINE; CYCLOHEXANECARBOXYLIC ACIDS; DEMENTIA; FRUCTOSE; GAMMA-AMINOBUTYRIC ACID; HUMANS; PSYCHOMOTOR AGITATION; TREATMENT OUTCOME; TRIAZINES; VALPROIC ACID;

EID: 52049122145     PISSN: 00137006     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.encep.2007.10.006     Document Type: Article

References (48)

1. Chambers C.A., Bain J., Rosbottom R., et al. Carbamazepine in senile dementia and overactivity - a placebo-controlled double blind trial. IRCS J Med Sci 10 (1982) 505-506
2. Dallocchio C., Buffa C., and Mazzarello P. Combination of donepezil and gabapentin for behavioral disorders in Alzheimer's disease. J Clin Psychiatry 61 (2000) 64
3. De León O.A. Treatment of psychotic symptoms with lamotrigine in Alzheimer disease. J Clin Psychopharmacol 24 2 (2004) 232-233
4. Devarajan S., and Dursun S.M. Aggression in dementia with lamotrigine treatment. Am J Psychiatry 157 7 (2000) 1178 [letter]
5. Essa M. Carbamazepine in dementia. J Clin Psychopharmacol 6 4 (1986) 234-236
6. Feely M. Fortnightly review: drug treatment of epilepsy. BMJ 318 (1999) 106-109
7. Fhager B., Meiri I.M., Sjögren M., et al. Treatment of aggressive behaviour in dementia with the anticonvulsant topiramate: a retrospective pilot study. Int Psychogeriatr 15 3 (2003) 307-309
8. Gleason R.P., and Schneider L.S. Carbamazepine treatment of agitation in Alzheimer's outpatients refractory to neuroleptics. J Clin Psychiatry 51 3 (1990) 115-118
9. Haas S., Vincent K., Holt J., et al. Divalproex: a possible alternative for demented, elderly aggressive patients. Ann Clin Psychiatry 9 (1997) 145-147
10. Hawkins J.W., Tincklenberg J.R., Sheikh J.I., et al. A retrospective chart review of gabapentin for the treatment of aggressive and agitated behavior in patients with dementias. Am J Geriatr Psychiatry 8 3 (2000) 221-225
11. Herment N., Germain M.L., Herlem E., et al. Hyponatremia due to sodium valproate. Fundam Clin Pharmacol 19 2 (2005) 229
12. Herrmann N. Valproic acid treatment of agitation in dementia. Can J Psychiatry 43 1 (1998) 69-72
13. Herrmann N., Lanctôt K., and Myszak M. Effectiveness of gabapentin for the treatment of behavioral disorders in dementia. J Clin Psychopharmacol 20 1 (2000) 90-93
14. Herrmann N., Lanctôt K.L., Rothenburg L.S., et al. A placebo-controlled trial of valproate for agitation and aggression in Alzheimer's disease. Dement Geriatr Cogn Disord 23 (2007) 116-119
15. Iijima M. Valproate-induced parkinsonism in a demented elderly patient. J Clin Psychiatry 63 1 (2002) 75
16. Kunik M.E., Puryear L., Orengo C.A., et al. The efficacy and tolerability of divalproex sodium in elderly demented patients with behavioral disturbances. Int J Geriatr Psychiatry 13 1 (1998) 29-34
17. Lanctôt K.L., Herrmann N., Mazzotta P., et al. GABAergic function in Alzheimer's disease: evidence for dysfunction and potential as a therapeutic target fot the treatment of behavioural and psychological symptoms of dementia. Can J Psychiatry 49 7 (2004) 439-453
18. Lebert F., Robert P., and Rigaud A.S. Prise en charge des troubles du comportement dans les démences. Rev Neurol 156 (2000) 767-772
19. Lee P.E., Gill S.S., Freedman M., et al. Atypical antipsychotic drugs in the treatment of behavioural and psychological symptoms of dementia: systematic review. BMJ 329 (2004) 75
20. Leibovici A., and Tariot P.N. Carbamazepine treatment of agitation associated with dementia. J Geriatr Psychiatry Neurol 1 2 (1988) 110-112
21. Lemke M.R. Effect of carbamazepine on agitation in Alzheimer's inpatients refractory to neuroleptics. J Clin Psychiatry 56 8 (1995) 354-357
22. Lonergan ET, Luxenberg J. Valproate preparations for agitation in dementia. Cochrane review. In: The Cochrane Library, Oxford: 2004: issue 4.
23. Lott A.D., McElroy S.L., and Keys M.A. Valproate in the treatment of behavioral agitation in elderly patients with dementia. J Neuropsychiatr Clin Neurosci 7 3 (1995) 314-319
24. Low R., and Brandes M. Gabapentin for the management of agitation. J Clin Psychopharmacol 19 5 (1999) 482-483
25. Loy R., and Tariot P.N. Neuroprotective properties of valproate: potential benefit for AD and tauopathies. J Mol Neurosci 19 3 (2002) 303-307
26. Martin R., Kuzniecky R., Ho S., et al. Cognitive effects of topiramate, gabapentin, and lamotrigine in healthy young adults. Neurology 52 (1999) 321-327
27. Mellow A.M., Solano-Lopez C., and Davis S. Sodium valproate in the treatment of behavioral disturbance in dementia. J Geriatr Psychiatry Neurol 6 4 (1993) 205-209
28. Miller L.J. Gabapentin for treatment of behavioral and psychological symptoms of dementia. Ann Pharmacother 35 4 (2001) 427-431
29. Moretti R., Torre P., Antonello R.M., et al. Gabapentin for the treatment of behavioural alterations in dementia: preliminary 15-month investigation. Drugs Aging 20 14 (2003) 1035-1040
30. Narayan M., and Nelson J.C. Treatment of dementia with behavioral disturbance using valproex or a combination of divalproex and a neuroleptic. J Clin Psychiatry 58 (1997) 351-354
31. Olin J.T., Fox L.S., Pawluczyk S., et al. A pilot randomized trial of carbamazepine for behavioral symptoms in treatment-resistant outpatients with Alzheimer disease. Am J Geriatr Psychiatry 9 4 (2001) 400-405
32. Patterson J.F. A preliminary study of carbamazepine in the treatment of assaultive patients with dementia. J Geriatr Psychiatry Neurol 1 1 (1988) 21-23
33. Porsteinsson A.P., Tariot P.N., Erb R., et al. An open trial of valproate for agitation in geriatric neuropsychiatric disorders. Am J Geriatr Psychiatry 5 4 (1997) 344-351
34. Porsteinsson A.P., Tariot P.N., Erb R., et al. Placebo-controlled study of divalproex sodium for agitation in dementia. Am J Geriatr Psychiatry 9 1 (2001) 58-66
35. Porsteinsson A.P., Tariot P.N., Jakimovitch L.J., et al. Valproate therapy for agitation in dementia: extension of a double-blind trial. Am J Geriatr Psychiatry 11 4 (2003) 434-440
36. Profenno L.A., Jakimovich L., Holt C.J., et al. A randomized, double-blind, placebo-controlled pilot trial of safety and tolerability of two doses of divalproex sodium in outpatients with probable Alzheimer's disease. Curr Alzheimer Res 2 5 (2005) 553-558
37. Raudino F., Mascalzi M.G., and Zagami A. Gabapentin and behavioral disorders in severe Alzheimer disease. J Clin Psychopharmacol 24 4 (2004) 459-460
38. Regan W., and Gordon S. Gabapentin for behavioral agitation in Alzheimer's disease. J Clin Psychopharmacol 17 1 (1997) 59-60
39. Roane D.M., Feinberg T.E., Meckler L., et al. Treatment of dementia-associated agitation with gabapentin. J Neuropsychiatry Clin Neurosci 12 1 (2000) 40-43
40. Sival R.C., Haffmans P.M.J., van Gent P.P., et al. The effects of sodium valproate on disturbed behaviour in dementia. J Am Geriatr Soc 42 (1994) 906-907
41. Sival R.C., Haffmans P.M., Jansen P.A., et al. Sodium valproate in the treatment of aggressive behaviour in patients with dementia - a randomized placebo-controlled clinical trial. Int J Geriatr Psychiatry 17 (2002) 579-585
42. Southam E., Kirkby D., Higgins G., et al. Lamotrigin inhibits monoamin uptake in vitro and modulates 5-hydroxytryptamine uptake in rats. Eur J Pharmacol 358 (1998) 19-24
43. Tariot P.N., Erb R., Leibovici A., et al. Carbamazepine treatment of agitation in nursing home patients with dementia: a preliminary study. J Am Geriatr Soc 42 11 (1994) 1160-1166
44. Tariot P.N., Erb R., Podgorski C.A., et al. Efficacy and tolerability of carbamazepine for agitation and aggression in dementia. Am J Psychiatry 155 1 (1998) 54-61
45. Tariot P.N., Schneider L., Mintzer J., et al. Safety and tolerability of divalproex sodium for the treatment of symptoms of mania in elderly patients with dementia: results of a double-blind, placebo-controlled trial. Curr Ther Res 62 (2001) 51-67
46. Tariot P.N., Loy R., Ryan J.M., et al. Mood stabilizers in Alzheimer's disease: symptomatic and neuroprotective rationales. Adv Drug Deliv Rev 54 12 (2002) 1567-1577
47. Tariot P.N., Raman R., Jakimovich L., et al. Divalproex sodium in nursing home residents with possible or probable Alzheimer disease complicated by agitation: a randomized, controlled trial. Am J Geriatr Psychiatry 13 11 (2005) 942-949
48. Thompson P.J., Baxendale S.A., Duncan J.S., et al. Effects of topiramate on cognitive function. J Neurol Neurosurg Psychiatry 69 (2000) 636-641