Image-based evaluation of the molecular events underlying HC11 mammary epithelial cell differentiation

Analytical Biochemistry

Volumn 382, Issue 2, 2008, Pages 122-128

  Shan, Liang ^a   Zhang, Renshu ^a   Zhang, Wanghai ^a   Lee, Edward ^a   Sridhar, Rajagopalan ^a   Snyderwine, Elizabeth G ^b   Wang, Paul C ^a  

^a HOWARD UNIVERSITY   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Differentiation; Mammary epithelial cells; Optical imaging; Signal pathways

Indexed keywords

CASEIN; CELL CULTURE; CELL PROLIFERATION; DIFFERENTIATION (CALCULUS); GENES; IMAGING TECHNIQUES; OPTICAL IMAGE STORAGE; PROTEINS; RNA;

DOSE-DEPENDENT MANNER; EPIDERMAL GROWTH FACTORS; HIGH THROUGHPUT SCREENING; IMAGE-BASED TECHNIQUES; MAMMARY EPITHELIAL CELLS; MESSENGER RNAS (MRNA); OPTICAL IMAGING; SIGNAL PATHWAYS;

LUTETIUM COMPOUNDS;

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; BETA CASEIN; EPIDERMAL GROWTH FACTOR; JANUS KINASE 2; LUCIFERASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; PROTEIN KINASE B; RAF PROTEIN; STAT5A PROTEIN;

ANIMAL CELL; ARTICLE; BREAST EPITHELIUM; CARCINOGENESIS; CELL DIFFERENTIATION; CORRELATION ANALYSIS; DOSE RESPONSE; GENETIC TRANSFECTION; HIGH THROUGHPUT SCREENING; IMAGE ANALYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN INDUCTION; SIGNAL TRANSDUCTION;

EID: 52049115629     PISSN: 00032697     EISSN: 10960309     Source Type: Journal    
DOI: 10.1016/j.ab.2008.08.004     Document Type: Article

References (28)

1. Brisken C. Hormonal control of alveolar development and its implications for breast carcinogenesis. J. Mammary Gland Biol. Neoplasia 7 (2002) 39-48
2. Goffin V., Binart N., Touraine P., and Kelly P.A. Prolactin: The new biology of an old hormone. Annu. Rev. Physiol. 64 (2002) 47-67
3. Binart N., Ormandy C.J., and Kelly P.A. Mammary gland development and the prolactin receptor. Adv. Exp. Med. Biol. 480 (2000) 85-92
4. Cavalieri E., Chakravarti D., Guttenplan J., Hart E., Ingel J., Jankowiak R., Muti P., Rogan E., Russo J., Santen R., and Sutter T. Catechol estrogen quinones as initiators of breast and other human cancers: Implications for biomarkers of susceptibility and cancer prevention. Biochim. Biophys. Acta 1766 (2006) 63-78
5. Russo J., Hasan L.M., Balogh G., Guo S., and Russo I.H. Estrogen and its metabolites are carcinogenic agents in human breast epithelial cells. J. Steroid Biochem. Mol. Biol. 87 (2003) 1-25
6. Shan L., Rouhani S.A., Schut H.A.J., and Snyderwine E.G. 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) modulates lactogenic hormone-mediated differentiation and gene expression in HC11 mouse mammary epithelial cells. Cell Growth Differ. 12 (2001) 649-656
7. Shan L., Yu M., and Snyderwine E.G. Gene expression profiling of chemically-induced rat mammary gland cancer. Carcinogenesis 26 (2005) 503-509
8. Fenton S.E. Endocrine-disrupting compounds and mammary gland development: Early exposure and later life consequences. Endocrinology 147 Suppl. 6 (2006) S18-S24
9. Clemons P.A. Complex phenotypic assays in high-throughput screening. Curr. Opin. Chem. Biol. 8 (2004) 334-338
10. Sundberg S.A. High-throughput and ultra-high-throughput screening: Solution- and cell-based approaches. Curr. Opin. Biotechnol. 11 (2000) 47-53
11. Shan L., Yu M., Qiu C., and Snyderwine E.G. Id4 regulates mammary epithelial cell growth and differentiation and is overexpressed in rat mammary gland carcinomas. Am. J. Pathol. 163 (2003) 2495-2502
12. Raafat A., Zoltan-Jones A., Strizzi L., Bargo S., Kimura K., Salomon D., and Callahan R. Kit and PDGFR- activities are necessary for Notch4/Int3-induced tumorigenesis. Oncogene 26 (2007) 662-672
13. Chughtai N., Schimchowitsch S., Lebrun J.J., and Ali S. Prolactin induces SHP-2 association with Stat5 nuclear translocation and binding to the -casein gene promoter in mammary cells. J. Biol. Chem. 277 (2002) 31107-31114
14. Galbaugh T., Cerrito M.G., Jose C.C., and Cutler M.L. EGF-induced activation of Akt results in mTOR-dependent p70S6 kinase phosphorylation and inhibition of HC11 cell lactogenic differentiation. BMC Cell Biol. 7 (2006) 34
15. Marte B.M., Meyer T., Stabel S., Standke G.J., Jaken S., Fabbro D., and Hynes N.E. Protein kinase C and mammary cell differentiation: Involvement of protein kinase C alpha in the induction of -casein expression. Cell Growth Differ. 5 (1994) 239-247
16. Cerrito M.G., Galbaugh T., Wang W., Chopp T., Salomon D., and Cutler M.L. Dominant negative Ras enhances lactogenic hormone-induced differentiation by blocking activation of the Raf-Mek-Erk signal transduction pathway. J. Cell Physiol. 201 (2004) 244-258
17. Xie J., LeBaron M.J., Nevalainen M.T., and Rui H. Role of tyrosine kinase Jak2 in prolactin-induced differentiation and growth of mammary epithelial cells. J. Biol. Chem. 277 (2002) 14020-14030
18. Dillon R.L., White D.E., and Muller W.J. The phosphatidyl inositol 3-kinase signaling network: Implications for human breast cancer. Oncogene 26 (2007) 1338-1345
19. Brisken C., Ayyanan A., and Doppler W. Prolactin signaling and Stat5: Going their own separate ways?. Breast Cancer Res. 4 (2002) 209-212
20. Shan L., Yu M., Clark B., and Snyderwine E.G. Possible role of Stat5a in rat mammary gland carcinogenesis. Breast Cancer Res. Treat. 88 (2004) 263-272
21. Wagner K.U., and Rui H. Jak2/Stat5 signaling in mammogenesis, breast cancer initiation, and progression. J. Mammary Gland Biol. Neoplasia 13 (2008) 93-103
22. McCubrey J.A., Steelman L.S., Chappell W.H., Abrams S.L., Wong E.W., Chang F., Lehmann B., Terrian D.M., Milella M., Tafuri A., Stivala F., Libra M., Basecke J., Evangelisti C., Martelli A.M., and Franklin R.A. Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation, and drug resistance. Biochim. Biophys. Acta 1773 (2007) 1263-1284
23. Evans M.J., Saghatelian A., Sorensen E.J., and Cravatt B.F. Target discovery in small-molecule cell-based screens by in situ proteome reactivity profiling. Nat. Biotechnol. 23 (2005) 1303-1307
24. Cali J.J., Niles A., Valley M.P., O'Brien M.A., Riss T.L., and Schultz J. Bioluminescent assays for ADMET. Expert Opin. Drug Metab. Toxicol. 4 (2008) 103-120
25. Korn K., and Krausz E. Cell-based high-content screening of small-molecule libraries. Curr. Opin. Chem. Biol. 11 (2007) 503-510
26. Ding S., Wu T.Y., Brinker A., Peters E.C., Hur W., Gray N.S., and Schultz P.G. Synthetic small molecules that control stem cell fate. Proc. Natl. Acad. Sci. USA 100 (2003) 7632-7637
27. Valley M.P., Zhou W., Hawkins E.M., Shultz J., Cali J.J., Worzella T., Bernad L., Good T., Good D., Riss T.L., Klaubert D.H., and Wood K.V. A bioluminescent assay for monoamine oxidase activity. Anal. Biochem. 359 (2006) 238-346
28. Li Z., Yan Y., Powers E.A., Ying X., Janjua K., Garyantes T., and Baron B. Identification of gap junction blockers using automated fluorescence microscopy imaging. J. Biomol. Screen. 8 (2003) 489-499