Emdogain stimulates matrix degradation by osteoblasts

Journal of Dental Research

Volumn 87, Issue 8, 2008, Pages 782-787

  Goda, S ^a   Inoue, H ^a   Kaneshita, Y ^a   Nagano, Y ^a   Ikeo, Y T ^a   Iida, J ^b   Domae, N ^a  

^a OSAKA DENTAL UNIVERSITY   (Japan)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

Emdogain; Matrix metallo proteinases; Osteoblasts

Indexed keywords

COLLAGEN TYPE 1; ENAMEL MATRIX PROTEINS; ENAMEL PROTEIN; INTERSTITIAL COLLAGENASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE 2; NEUTROPHIL COLLAGENASE;

ARTICLE; BONE REGENERATION; CELL LINE; ENZYMOLOGY; EXTRACELLULAR MATRIX; HUMAN; METABOLISM; OSTEOBLAST; PERIODONTAL DISEASE; PHYSIOLOGY;

BONE REGENERATION; CELL LINE; COLLAGEN TYPE I; DENTAL ENAMEL PROTEINS; EXTRACELLULAR MATRIX; HUMANS; MAP KINASE KINASE 1; MAP KINASE KINASE KINASE 2; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 8; OSTEOBLASTS; PERIODONTAL DISEASES;

EID: 52049084800     PISSN: 00220345     EISSN: None     Source Type: Journal    
DOI: 10.1177/154405910808700805     Document Type: Article

References (34)

1. Benbow U, Buttice G, Nagase H, Kurkinen M (1996). Characterization of the 46-kDa intermediates of matrix metalloproteinase 3 (stromelysin 1) obtained by site-directed mutation of phenylalanine 83. J Biol Chem 271:10715-10722.
2. Boyan BD, Weesner TC, Lohmann CH, Andreacchio D, Carnes DL, Dean DD, et al. (2000). Porcine fetal enamel matrix derivative enhances bone formation induced by demineralized freeze dried bone allograft in vivo. J Periodontol 71:1278-1286.
3. Cochran DL, Jones A, Heijl L, Mellonig JT, Schoolfield J, King GN (2003). Periodontal regeneration with a combination of enamel matrix proteins and autogenous bone grafting. J Periodontol 74:1269-1281.
4. Fujisaki K, Tanabe N, Suzuki N, Mitsui N, Oka H, Ito K, et al. (2006). The effect of IL-1 alpha on the expression of matrix metalloproteinases, plasminogen activators, and their inhibitors in osteoblastic ROS 17/2.8 cells. Life Sci 78:1975-1982.
5. Gestrelius S, Andersson C, Lidström D, Hammarström L, Somerman M (1997). In vitro studies on periodontal ligament cells and enamel matrix derivative. J Clin Periodontol 24:685-692.
6. Goda S, Inoue H, Umehara H, Miyaji M, Nagano Y, Harakawa N, et al. (2006). Matrix metalloproteinase-1 produced by human CXCL12-stimulated natural killer cells. Am J Pathol 169:445-458.
7. Hammarström L, Heijl L, Gestrelius S (1997). Periodontal regeneration in a buccal dehiscence model in monkeys after application of enamel matrix proteins. J Clin Periodontol 24:669-677.
8. Heijl L (1997). Periodontal regeneration with enamel matrix derivative in one human experimental defect. A case report. J Clin Periodontol 24:693-696.
9. Heijl L, Heden G, Svardström G, Ostgren A (1997). Enamel matrix derivative (EMDOGAIN) in the treatment of intrabony periodontal defects. J Clin Periodontol 24:705-714.
10. Hoberg M, Rudert M, Pap T, Klein G, Gay S, Aicher WK (2007). Attachment to laminin-111 facilitates transforming growth factor beta-induced expression of matrix metalloproteinase-3 in synovial fibroblasts. Ann Rheum Dis 66:446-451.
11. Holmbeck K, Bianco P, Caterina J, Yamada S, Kromer M, Kuznetsov SA, et al. (1999). MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover. Cell 99:81-92.
12. Itoh N, Kasai H, Ariyoshi W, Harada E, Yokota M, Nishihara T (2006). Mechanisms involved in the enhancement of osteoclast formation by enamel matrix derivative. J Periodontal Res 41:273-279.
13. Kajanne R, Miettinen P, Mehlem A, Leivonen SK, Birrer M, Foschi M, et al. (2007). EGF-R regulates MMP function in fibroblasts through MAPK and AP-1 pathways. J Cell Physiol 212:489-497.
14. Krane SM (1995). Is collagenase (matrix metalloproteinase-1) necessary for bone and other connective tissue remodeling? Clin Orthop Relat Res 313:47-53.
15. Matsuda N, Horikawa M, Watanabe M, Kitagawa S, Kudo Y, Takata T (2002). Possible involvement of extracellular signal-regulated kinases 1/2 in mitogenic response of periodontal ligament cells to enamel matrix derivative. Eur J Oral Sci 110:439-444.
16. McCawley LJ, Matrisian LM (2001). Matrix metalloproteinases: they're not just for matrix anymore! Curr Opin Cell Biol 13:534-540.
17. McQuibban GA, Gong JH, Wong JP, Wallace JL, Clark-Lewis I, Overall CM (2002). Matrix metalloproteinase processing of monocyte chemoattractant proteins generates CC chemokine receptor antagonists with anti-inflammatory properties in vivo. Blood 100:1160-1167.
18. Nagase H, Woessner JF Jr (1999). Matrix metalloproteinases. J Biol Chem 274:21491-21494.
19. Nagase H, Suzuki K, Morodomi T, Enghild JJ, Salvesen G (1992). Activation mechanisms of the precursors of matrix metalloproteinases 1, 2 and 3. Matrix Suppl 1:237-244.
20. Ohuchi E, Imai K, Fujii Y, Sato H, Seiki M, Okada Y (1997). Membrane type 1 matrix metalloproteinase digests interstitial collagens and other extracellular matrix macromolecules. J Biol Chem 272:2446-2451.
21. Okuda K, Miyazaki A, Momose M, Murata M, Nomura T, Kubota T, et al. (2001). Levels of tissue inhibitor of metalloproteinases-1 and matrix metalloproteinases-1 and-8 in gingival crevicular fluid following treatment with enamel matrix derivative (EMDOGAIN). J Periodontal Res 36:309-316.
22. Opdenakker G, Van den Steen PE, Dubois B, Nelissen I, Van Coillie E, Masure S, et al. (2001 ). Gelatinase B functions as regulator and effector in leukocyte biology. J Leukoc Biol 69:851-859.
23. Sasaki K, Takagi M, Konttinen YT, Sasaki A, Tamaki Y, Ogino T, et al. (2007). Upregulation of matrix metalloproteinase (MMP)-1 and its activator MMP-3 of human osteoblast by uniaxial cyclic stimulation. J Biomed Mater Res B Appl Biomater 80:491-498.
24. Sculean A, Blaes A, Arweiler N, Reich E, Donos N, Brecx M (2001). The effect of postsurgical antibiotics on the healing of intrabony defects following treatment with enamel matrix proteins. J Periodontol 72:190-195.
25. Seiki M (2003). Membrane-type 1 matrix metalloproteinase: a key enzyme for tumor invasion. Cancer Lett 194:1-11.
26. Suzuki S, Nagano T, Yamakoshi Y, Gomi K, Arai T, Fukae M, et al. (2005). Enamel matrix derivative gel stimulates signal transduction of BMP and TGF-{beta}. J Dent Res 84:510-514.
27. Takiguchi T, Kobayashi M, Suzuki R, Yamaguchi A, Isatsu K, Nishihara T, et al. (1998). Recombinant human bone morphogenetic protein-2 stimulates osteoblast differentiation and suppresses matrix metalloproteinase-1 production in human bone cells isolated from mandibulae. J Periodontal Res 33:476-485.
28. Tanimura S, Asato K, Fujishiro SH, Kohno M (2003). Specific blockade of the ERK pathway inhibits the invasiveness of tumor cells: down-regulation of matrix metalloproteinase-3/-9/-14 and CD44. Biochem Biophys Res Commun 304:801-806.
29. Visse R, Nagase H (2003). Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. Cire Res 92:827-839.
30. Vu TH, Werb Z (2000). Matrix metalloproteinases: effectors of development and normal physiology. Genes Dev 14:2123-2133.
31. Vu TH, Shipley JM, Bergers G, Berger JE, Helms JA, Hanahan D, et al. (1998). MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes. Cell 93:411-422.
32. Wang EA, Rosen V, D'Alessandro JS, Bauduy M, Cordes P, Harada T, et al. (1990). Recombinant human bone morphogenetic protein induces bone formation. Proc Natl Acad Sci USA 87:2220-2224.
33. Yoneda S, Itoh D, Kuroda S, Kondo H, Umezawa A, Ohya K, et al. (2003). The effects of enamel matrix derivative (EMD) on osteoblastic cells in culture and bone regeneration in a rat skull defect. J Periodontal Res 38:333-342.
34. Zhou Z, Apte SS, Soininen R, Cao R, Baaklini GY, Rauser RW, et al. (2000). Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I. Proc Natl Acad Sci USA 97:4052-4057.