Evaluating diagnosis methods on childhood GH (DGH) deficiency: IGFs, IGFBPs, releasing tests, GH rhythm and image exams;Avaliação dos métodos diagnósticos para deficiência de GH (DGH) na infância: IGFs, IGFBPs, testes de liberação, ritmo de GH e exames de imagem

Arquivos Brasileiros de Endocrinologia e Metabologia

Volumn 52, Issue 5, 2008, Pages 734-744

  De Paula, Leila Pedroso ^a,b   Czepielewski, Mauro A ^a  

^a HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

^b NONE   (Brazil)

Author keywords

GH; GH clonidine stimulation test; Gh stimulation test; Growth hormone deficiency; IGF 1; IGFBP 3; ROC curve for GH test

Indexed keywords

EID: 51949094557     PISSN: 00042730     EISSN: 16779487     Source Type: Journal    
DOI: 10.1590/s0004-27302008000500004     Document Type: Review

References (33)

1. Roith D L, Bondy C, Yakar S, Liu J L, and Butler A. The somatomedin hypothesis: 2001. Endocr Rev. 2001;22(1):53-74.
2. Bussières L, Souberbielle JC, Pinto G, Adan L, Noel M, Brauner R. The use of insulin-like growth factor 1 reference values for the diagnosis of growth hormone deficiency in prepubertal children. Clin Endocrinol. (Oxf) 2000;52:735-9.
3. Juul A, Bang P, Hertel NT, Main K, Dalgaard P, Jorgensen K, et al. Serum insulin-like growth factor-i in 1030 healthy children, adolescents, and adults: relation to age, sex, stage of puberty, testicular size, and body mass index. J Clin Endocrinol Metab 1994;78(3):744-52.
4. Juul A, Holm K, Kastrup KW, Pedersen SA, Michaelsen KM, Scheike T, et al. Free insulin-like growth factor I serum levels in 1430 healthy children and adults, and its diagnostic value in patients suspected of growth hormone deficiency. J Clin Endocrinol Metab. 1997;82:2497-502.
5. Reiter EO, Rosenfeld RG. Normal and aberrant growth. In: Kronenberg HM, Melmed S, Polonsky KS, Larsen PR, editors. Williams textbook of endocrinology. 11th ed. Saunders Elsevier; 2008. p 849-968.
6. Juul A, Moller S, Mosfeldt-Laursen E, Rasmussen MH, Scheike T, Pedersen SA, et al. The acid-labile subunit of human ternary insulin-like growth factor binding protein complex in serum: hepatosplanchnic release, diurnal variation, circulating concentrations in healthy subjects, and diagnostic use in patients with growth hormone deficiency. J Clin Endocrinol Metab. 1998;83:4408-15.
7. Growth Hormone Research Society. Consensus guidelines for the diagnosis and treatment of growth hormone (GH) deficiency in childhood and adolescence: summary statement of the GH Research Society. J Clin Endocrinol Metab. 2000;85(11):3990-3.
8. Saenger P. Editorials. Growth hormone in growth hormone deficiency. Start treatment early and give it for long enough. Br Med J. 2002;325:58-9.
9. Darzy KH, Pezzoli SS, Thorner MO, Shalet SM. Cranial irradiation and growth hormone neurosecretory dysfunction: a critical appraisal. J Clin Endocrinol Metab. 2007;92:1666-72.
10. Darzy KH, Aimaretti G, Wieringa G, Rao Gattamaneni H, Ghigo E, Shalet SM. The usefulness of the combined growth hormone (GH)-releasing hormone and arginine stimulation test in the diagnosis of radiation-induced GH deficiency is dependent on the post-irradiation time interval. J Clin Endocrinol Metab. 2003;88:95-102.
11. De Paula LP. Estudos Prospectivos no diagnóstico diferencial da baixa estatura e da deficiência de hormônio de crescimento em crianças. Orientador: Mauro A Czepielewski. [Tese: doutorado] Faculdade de Medicina, UFRGS, 2007. p. 103.
12. Nunez SB, Municchi G, Barnes KM, Rose SR. Insulin-like growth factor I (IGF-1) and IGF-binding protein-3 concentrations compared to stimulated and night growth hormone in the evaluation of short children - a clinical research center study. J Clin Endocrinol Metab. 1996;81:1927-32.
13. Juul A, Kastrup KW, Pedersen SA, Skakkebaek NE. Growth hormone (GH) provocative retesting of 108 young adults with childhood-onset GH deficiency and the diagnostic value of insulin-like growth factor I (IGF-1) and IGF-binding protein-3. J Clin Endocrinol Metab. 1997;82:1195-201.
14. Kawai N, Kanzaki S, Takano-Watou S, Tada C, Yamanaka Y, Miyata T, et al. Serum free insulin-like growth factor I (IGF-I), total IGF-I, and IGF-binding protein-3 concentrations in normal children and children with growth hormone deficiency. J Clin Endocrinol Metab. 1999;84(1):82-9.
15. Rosenfeld RG, Wilson DM, Lee PD, Hintz RL. Insulin-like growth factors I and II in evaluation of growth retardation. J Pediatr 1986;109:428-33.
16. Ranke MB, Schweizer R, Elmlinger MW, Weber K, Binder G, Schwarze CP, Wollmann HA. Significance of basal IGF-1, IGFBP-3 and IGFBP-2 measurements in the diagnostics of short stature in children. Horm Res. 2000;54:60-68.
17. Mitchell H, Dattani MT, Nanduri V, Hinmarsh PC, Preece MA, Brook CG. Failure of IGF-1 and IGFBP-3 to diagnose growth hormone insufficiency. Arch Dis Child. 1999;80:443-7.
18. Tassoni P, Cacciari E, Cau M, Colli C, Tosi M, Zucchini S, et al. Variability of growth hormone response to pharmacological and sleep tests performed twice in short children. J Clin Endocrinol Metab. 1990;71:230-4.
19. Zadik Z, Chalew SA, Gilula Z, Kowarski A. Reproducibility of growth hormone testing procedures: A comparison between 24-hour integrated concentration and pharmacological stimulation. J Clin Endocrinol Metab. 1990;71:1127-30.
20. Marin G, Domené HM, Barnes KM, Blackwell BJ, Cassorla FG, Cutler Jr GB. The effects of estrogen priming and puberty on the growth hormone response to standardized treadmill exercise and arginine-insulin in normal girls and boys. J Clin Endocrinol Metab. 1994;79(2):537-41.
21. Rosenfeld RG, Albertsson-Wikland K, Cassorla F, Frasier SD, Hasegawa Y, Hintz RL, et al. Diagnostic controversy: the diagnosis of childhood growth hormone deficiency revisited. J Clin Endocrinol Metab. 1995;80(5):1532-40.
22. Chanoine JP, Rebuffat E, Kahn A, Bergmann P, Van Vliet G. Glucose, growth hormone, cortisol, and insulin responses to glucagon injection in normal infants, aged 0.5- 12 months. J Clin Endocrinol Metab. 1995;80:30-2.
23. Ghigo E, Bellone J, Aimaretti S, Bellone S, Loche S, Cappa M, et al. Reliability of provocative tests to assess growth hormone secretory status. Study in 472 normally growing children. J Clin Endocrinol Metab. 1996;81:3323-7.
24. Celniker AC, Chen AB, Wert Jr RM, Sherman BM. Variability in the quantitation of circulating growth hormone using commercial immunoassays. J Clin Endocrinol Metab. 1989;68(2):469-76.
25. Tauber M. Growth hormone testing in KIGS. In: Ranke MB, Price DA, Reiter EO, editors. Growth hormone therapy in pediatrics - 20 years of KIGS. Basel, Karger, 2007: 54-85.
26. Cacciari E, Tassoni P, Cicognani A, Pirazzoli P, Salardi S, Balsamo A, et al. Value and limits of pharmacological and physiological tests to diagnose growth hormone (GH) deficiency and predict therapy response: first and second retesting during replacement therapy of patients defined as GH deficient. J Clin Endocrinol Metab. 1994;79(6):1663-9.
27. Silva EGP, Slhessarenko N, Arnhold IJP, Batista MC, Estefan V, Osório MGF, et al. GH values after clonidine stimulation measured by immunofluorometric assay in normal prepubertal children and GH-deficient patients. Horm Res. 2003;59:229-33.
28. Martínez AS, Domené HM, Ropelato G, Jasper HG, Pennisi Pa, Escobar ME, Heinrich JJ. Estrogen priming effect on growth hormone (GH) provocative test: A useful tool for the diagnosis of GH deficiency. J Clin Endocrinol Metab 2000; 85: 4168-72.
29. Chaler EA, Rivarola MA, Guerci B, Ciaccio M, Costanzo M, Travaglino P, et al. Differences in serum GH cut-off values for pharmacological tests of GH secretion depend on the serum GH method. Clinical validation from the growth velocity score during the first year of treatment. Horm Res. 2006; 6:231-5.
30. Maghnie M, di Lorgi N, Rossi A, Gastaldi R, Tortori-Donati P, Lorini R. Neuroimaging in growth hormone deficiency. In: Ranke MB, Price DA, Reiter EO (eds): Growth hormone therapy in pediatrics - 20 years of KIGS. Basel, Karger, 2007: 93-107.
31. Osório MGF, Marui S, Jorge AAL, Latronico AC, Lo LS, Leite CC, et al. Pituitary magnetic resonance imaging and function in patients with growth hormone deficiency with and without mutations in GHRH-R, GH-1, or PROP-1 genes. J Clin Endocrinol Metab. 2002;87:5076-84.
32. Coutant R, Rouleau S, Despert F, Magontier N, Loisel D, Limal JM. Growth and adult height in GH-treated children with nonacquired GH deficiency and idiopathic short stature: The influence of pituitary magnetic resonance imaging findings. J Clin Endocrinol Metab. 2001;86:4649-54.
33. Gelwane G, Garel C, Chevenne D, Armoogum P, Simon D, Czernichow P, Léger J. Subnormal serum insulin-like growth factor-1 levels in young adults with childhood-onset nonacquired growth hormone (GH) deficiency who recover normal GH secretion may indicate less severe but persistent pituitary failure. J Clin Endocrinol Metab. 2007;92:3788-95.