The acid-labile subunit of human ternary insulin-like growth factor binding protein complex in serum: Hepatosplanchnic release, diurnal variation, circulating concentrations in healthy subjects, and diagnostic use in patients with growth hormone deficiency

Journal of Clinical Endocrinology and Metabolism

Volumn 83, Issue 12, 1998, Pages 4408-4415

  Juul, Anders ^a   Møller, Søren ^b   Mosfeldt Laursen, Eva ^a   Højby Rasmussen, Michael ^b   Scheike, Thomas ^f   Pedersen, Søren A ^a   Kastrup, Knud W ^c   Yu, Herbert ^f   Mistry, Jehangir ^a,d   Rasmussen, Susanne ^e   Müller, Jørn ^a,d   Henriksen, Jens ^b   Skakkebæk, Niels E ^a  

^a Rigshospitalet   (Denmark)

^b HVIDOVRE HOSPITAL   (Denmark)

^c GLOSTRUP UNIVERSITY HOSPITAL   (Denmark)

^d Diagnostic Systems Laboratories Inc   (United States)

^e UNIVERSITY OF COPENHAGEN   (Denmark)

^f Rigshospitalet Section 5064 ^*

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN; GROWTH HORMONE; PROTEIN SUBUNIT; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C;

ADOLESCENT; ADULT; ARTICLE; CHILD; CIRCADIAN RHYTHM; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST; DIAGNOSTIC VALUE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GROWTH HORMONE DEFICIENCY; GROWTH HORMONE RELEASE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION; PROTEIN SYNTHESIS;

EID: 0032461089     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jcem.83.12.5311     Document Type: Article

References (46)

1. 1. Furlanetto RW. 1980 The somatomedin C binding protein: evidence for a heterologous subunit structure. J Clin Endocrinol Metab. 51:12-19.
2. 2. Liu F, Hintz R, Khare A, Diagustine RP, Powell DR, Lee PDK. 1994 Immunoblot studies of the IGF-related acid-labile subunit. J Clin Endocrinol Metab. 79:1883-1886.
3. 3. Arany E, Afford S, Strain AJ, Winwood PJ, Arthur MJP, Hill DJ. 1994 Differential cellular synthesis of insulin-like growth factor binding protein-1 (IGFBP-1) and IGFBF-3 within human liver. J Clin Endocrinol Metab. 79:1871-1876.
4. 4. Chin E, Zhou J, Dai J, Baxter RC, Bondy CA. 1994 Cellular localization and regulation of gene expression for components of the insulin-like growth factor ternary binding protein complex. Endocrinology. 134:2498-2504.
5. 5. Baxter RC. 1988 Characterization of the acid-labile subunit of the growth hormone-dependent insulin-like growth factor binding protein complex. J Clin Endocrinol Metab. 67:265-272.
6. 6. Baxter RC, Martin JL, Beniac VA. 1989 High molecular weight insulin-like growth factor binding protein complex. Purification and properties of the acid-labile subunit from human serum. J Biol Chem 264:11843-11848.
7. 7. Baxter RC. 1990 Circulating levels and molecular distribution of the acid-labile (α) subunit of the high molecular weights insulin-like growth factor-binding protein complex. J Clin Endocrinol Metab. 70:1347-1353.
8. 8. Labarta JI, Gargosky SE, Simpson DM, et al. 1997 Immunoblot studies of the acid-labile subunit (ALS) in biological fluids, normal human serum and in children with GH deficiency and GH receptor deficiency before and after long-term therapy with GH or IGF-I respectively. Clin Endocrinol (Oxf) 47:657-666.
9. 9. Bereket A, WIlson TA, Blethen SL, et al. 1996 Regulation of the acid-labile subunit of the insulin-like growth factor ternary complex in patients with insulin-dependent diabetes mellitus and severe burns. Clin Endocrinol (Oxf) 44:525-532.
10. 10. De Boer H, Blok GJ, Popp-Snijders C, Stuurman L, Baxter RC, van der Veen E. 1996 Monitoring of growth hormone replacement therapy in adults, based on measurement of serum markers. J Clin Endocrinol Metab. 81:1371-1377.
11. 11. Thorén M, Hildling A, Baxter RC, Degerblad M, Wivall-Helleryd I-L, Hall K. 1997 Serum insulin-like growth factor I (IGF-I), IGE-binding proreins-1 and -3, and the acid-labile subunit as serum markers of body composition during growth hormone (GH) therapy in adults with GH deficiency. J Clin Endocrinol Metab. 82:223-228.
12. 12. Juul A, Andersson A-M, Pedersen SA, et al., Effects of growth hormone (GH) replacement therapy on IGF-related parameters and on the pituitary-gonadal axis in GH-deficient males: a double-blind, placebo-controlled cross-over study. Horm Res, in press.
13. 13. Khosravi MJ, Diamandi A, Mistry J, Krishna RG, Khare A. 1997 Acid-labile subunit of human insulin-like growth factor-binding protein complex: measurement, molecular, and clinical evaluation. J Clin Endocrinol Metab. 82:3944-3951.
14. 14. Juul A, Bang P, Hertel NT, et al. 1994 Serum insulin-like growth factor-1 in 1030 healthy children, adolescents and adults; relation to age, sex, stage of puberty, testicular size and body mass index. J Clin Endocrinol Metab. 78:744-752.
15. 15. Juul A, Dalgaard P, Blum WF, et al. 1995 Serum levels of insulin-like growth factor (IGF) binding protein-3 in healthy infants, children and adolescents: the relation to IGF-I, IGF-II, IGFBP-1, IGFBP-2, age, sex, body mass index and pubertal maturation. J Clin Endocrinol Metab. 80:2534-2542.
16. 16. Juul A, Holm K, Kastrup KW, et al. 1997 Free insulin-like growth factor (IGF)-I serum levels in 1430 healthy children and adults, and its diagnostic value in patients suspected of Growth Hormone-deficiency. J Clin Endocrinol Metab. 82:2497-2502.
17. 17. Henriksen JH, Ring-Larsen H, Kanstrup I-L, Christensen NJ. 1984 Splanchnic and renal elimination and release of catecholamines in cirrhoses. Evidence of enhanced sympathetic nervous activity in patients with cirrhosis. Gut. 25:1034-1043.
18. 18. Henriksen JH, Winkler W. 1987 Hepatic blood flow determination. A comparison of 99-Tc-diethyl-IDA and indocyanine green as hepatic blood flow indicators in man. J Hepatol. 4:66-70.
19. 19. Juul A, Kastrup KW, Pedersen SA, Skakkebæk NE. 1997 Growth hormone (GH) provocative retesting of 108 young adults with childhood-onset GH deficiency and the diagnostic value of insulin-like growth factor (IGF)-I and IGF binding protein-3. J Clin Endocrinol Metab. 82:1195-1201.
20. 20. Blum WF, Ranke MB, Kietzmann K, Gauggel E, Zeisel HJ, Bierich JR. 1990 A specific radioimmunoassay for the growth hormone (GH)-dependent somatomedin-binding protein: its use for diagnosis of GH deficiency. J Clin Endocrinol Metab. 70:1292-1298.
21. 21. Venables WN, Ripley BD. 1994 Modern applied statistics with S-Plus. New York: Springer-Verlag; .
22. 22. Rose SR, Municchi G, Barnes KM, et al. 1991 Spontaneous growth hormone secretion increases during puberty in normal girls and boys. J Clin Endocrinol Metab. 73:428-435.
23. 23. Albertsson-Wikland K, Rosberg S, Karlberg J, Groth T. 1994 Analysis of 24-hour growth hormone profiles in healthy boys and girls of normal stature: relation to puberty. J Clin Endocrinol Metab. 78:1195-1201.
24. 24. Holman SR, Baxter RC. 1996 Insulin-like growth factor binding protein-3: factors affecting binary and ternary complex formation. Growth Regul. 6:42-47.
25. 25. Baxter RC 1990 Glycosaminoglycans inhibit formation of the 140 kDa insulin-like growth factor-binding protein complex. Biochem J. 271:773-777.
26. 26. Guler H-P, Zapf J, Schmid C, Froesch ER. 1989 Insulin-like growth factors I and II in healthy man. Estimations of half-lives and production rates. Acta Endocrinol. 121:753-758.
27. 27. Wilton P, Sietnieks A, Gunnarsson R, Berger L, Grahnén A. 1991 Pharmacokinetic profile of recombinant human insulin-like growth factor I given subcutaneously in normal subjects. Acta Paediatr. [Suppl] 377:111-114.
28. 28. Fouque D, Pneg SC, Kopple JD. 1995 Pharmacokinetics of recombinant human insulin-like growth factor-I in dialysis patients. Kidney Int. 47:869-875.
29. 29. Rabkin R, Fervenza FC, Maidment H, et al. 1996 Pharmacokinetics of insulin-like growth factor-1 in advances chronic renal failure. Kidney Int. 49:1134-1140.
30. 30. Blum WF. 1991 Insulin-like growth factors (IGFs) and IGF binding proteins in chronic renal failure: evidence for reduced secretion of IGFs. Acta Paediatr. [Suppl] 379:24-31.
31. 31. Boroujerdi MA, Sonksen PH, Jones RH. 1994 A compartmental model for simulation of IGF-I kinetics and metabolism. Methods Inf Med. 33:514-521.
32. 32. Dahn MS, Lange P, Jacobs LA. 1988 Insulin-like growth factor 1 production is inhibited in human sepsis. Arch Surg. 123:1409-1414.
33. 33. Brismar K, Fernquist-Forbes E, Wahren J, Hall K. 1994 Effect of insulin on the hepatic production of insulin-like growth factor binding protein-1 (IGFBP-1), IGFBP-3, and IGF-I in insulin-dependent diabetes. J Clin Endocrinol Metab. 79:872-878.
34. 34. Ooi GT, Cohen FJ, Tseng LY-H, Rechler MM, Boisclair YR. 1997 Growth hormone stimulates transcription of the gene encoding the acid-labile subunit (ALS) of the circulating insulin-like growth factor binding protein complex and ALS promotor activity in rat liver. Mol Endocrinol. 11:997-1007.
35. 35. Scharf J, Ramadori G, Braulke T, Hartman H. 1996 Synthesis of insulin-like growth factor binding proteins and of the acid-labile subunit in primary cultures of rat hepatocytes, of Kuppfer cell, and in cocultures: regulation by insulin, insulin-like growth factor, and growth hormone. Hepatology. 23: 818-827.
36. 36. Barreca AM, Voci A, Lee PDK, et al. 1997 Effect of the somatostatin analog, octreotide, and of other hormones on the release of the acid-labile subunit of the 150 kDa complex by rat hepatocytee in primary culture. Eur J Endocrinol. 137:193-199.
37. 37. Kupfer SR, Underwood LE, Baxter RC, Clemmons DR. 1993 Enhancement of the anabolic effects of growth hormone and insulin-like growth factor I by use of both agents simultaneously. J Clin Invest. 91:391-396.
38. 38. Minuto F, Underwood LE, Grimaldi P, Furlanetto RW, van Wyk JJ, Giordano G. 1981 Decreased somatomedin C concentrations during sleep: temporal relationship to the nocturnal surges of growth hormone and prolactin. J Clin Endocrinol Metab. 52:399-403.
39. 39. Stratakis CA, Mastorakos G, Magiakou MA, et al. 1996 24-hour secretion of growth hormone (GH), insulin-like growth factors-I and -II (IGF-I,-II), prolactin (PRL) and thyrotropin (TSH) in young adults of normal and tall stature. Endocr Res. 22:261-276.
40. 40. Jørgensen JOL, Blum WF, Møller N, Ranke MB, Christiansen JS. 1990 Circadian patterns of serum insulin-like growth factor (IGF) II and IGF binding protein 3 in growth hormone-deficient patients and age-and sex-matched normal subjects. Acta Endocrinol. 123:257-262.
41. 41. Baxter RC, Cowell CT. 1987 Diurnal rhythm of growth hormone-independent binding protein for insulin-like growth factors in human plasma. J Clin Endocrinol Metab. 65:432-440.
42. 42. Vahl N, Jørgensen JOL, Jurik AG, Christiansen JS. 1996 Abdominal adiposity and physical fitness are major determinants of the age associated decline in stimulated GH secretion in healthy adults. J Clin Endocrinol Metab. 81:2209-2215.
43. 43. Hoeck HC, Vestergaard P, Jakobsen PE, Laurberg P. 1995 Test of growth hormone secretion in adults: poor reproducibility of the insulin tolerance test. Eur J Endocrinol. 133:305-312.
44. 44. Thorner MO, Bengtsson B-Å, Ho KKY, et al. 1995. The diagnosis of growth hormone deficiency (GHD) in adults [letter to the editor]. J Clin Endocrinol Metab. 80:3097-3098.
45. 45. Hoffman DM, O'sullivan AJ, Baxter RC, Ho KKY. 1994 Diagnosis of growth hormone deficiency in adults. Lancet. 343:1064-1068.
46. 46. De Boer H, Blok G-J, Popp-Snijders C, Van der Veen EA. 1994 Diagnosis of growth hormone deficiency in adults. Lancet. 343:1645-1646.