Differences in serum GH cut-off values for pharmacological tests of GH secretion depend on the serum GH method: Clinical validation from the growth velocity score during the first year of treatment

Hormone Research

Volumn 66, Issue 5, 2006, Pages 231-235

  Chaler, Eduardo A ^a,c   Rivarola, M A ^a   Guerci, B ^b   Ciaccio, M ^a   Costanzo, M ^a   Travaglino, P ^b   Maceiras, M ^a   Pagani, S ^b   Meazza, C ^b   Bozzola, E ^b   Barberi, S ^b   Bozzola, M ^b   Belgorosky, A ^a  

^a HOSPITAL DE PEDIATRÍA PROF DR JUAN P GARRAHAN   (Argentina)

^b UNIVERSITY OF PAVIA   (Italy)

^c NONE   (Argentina)

Author keywords

GH deficiency; GH pharmacological tests; Idiopathic short stature; Serum GH cut off; Serum growth hormone

Indexed keywords

ARGININE; CLONIDINE; GROWTH HORMONE; HUMAN GROWTH HORMONE; SOMATOMEDIN C;

ADOLESCENT; ARTICLE; BODY HEIGHT; CHILD; CLINICAL ARTICLE; CORRELATION ANALYSIS; FEMALE; GROWTH HORMONE BLOOD LEVEL; GROWTH HORMONE DEFICIENCY; GROWTH HORMONE RELEASE; GROWTH RATE; HORMONAL THERAPY; HORMONE DETERMINATION; HORMONE RESPONSE; HUMAN; INTERMETHOD COMPARISON; MALE; PREPUBERTY; PRIORITY JOURNAL; ROC CURVE; SCORING SYSTEM; SHORT STATURE; TREATMENT OUTCOME; VALIDATION STUDY;

ADOLESCENT; BIOLOGICAL ASSAY; BODY HEIGHT; CHILD; DWARFISM, PITUITARY; FEMALE; GROWTH DISORDERS; HUMAN GROWTH HORMONE; HUMANS; MALE; PEPTIDE FRAGMENTS; SENSITIVITY AND SPECIFICITY;

EID: 33750195104     PISSN: 03010163     EISSN: None     Source Type: Journal    
DOI: 10.1159/000095005     Document Type: Article

References (17)

1. Baumann G: Growth hormone heterogeneity: genes, iso-hormones, variants, and binding proteins. Endocr Rev 1991;12:424-449.
2. Popii V, Baumann G: Laboratory measurement of growth hormone. Clin Chim Acta 2004;350:1-16.
3. Wood P: Growth hormone: its measurement and the need for assay harmonization. Ann Clin Biochem 2001;38:471-482.
4. Chaler E, Belgorosky A, Maceiras M, Mendioroz M, Rivarola MA: Between-assay differences in serum GH measurements: importance in the diagnosis of GH deficiency in childhood. Clin Chem 2001;47:1735-1738.
5. GH Research Society: 2000 Consensus guidelines for the diagnosis and treatment of growth hormone (GH) deficiency in childhood and adolescence: summary statement of the GH Research Society. J Clin Endocrinol Metab 2000;85:3990-3993.
6. Boquete HR, Sobrado PG, Fideleff HL, Sequeira AM, Giaccio AV, Suarez MG, Rubial G, Miras M: Evaluation of diagnostic accuracy of insulin-like growth factor (IGF)-I and IGF-binding protein-3 in growth hormone-deficient children and adults using ROC plot analysis. J Clin Endocrinol Metab 2003;88:4702-4708.
7. Ranke MB, Lindberg A, Chatelain P, Wilton P, Cutfield W, Albertsson-Wickland W, Price DA: Derivation and validation of a mathematical model for predicting the response to exogenous recombinant growth hormone (GH) in prepubertal children with idiopathic GH deficiency. J Clin Endocrinol Metab 1999;84:1174-1183.
8. Lejarraga H, Orfila G: Estándares de peso y estatura para niñas y niños argentinos desde el nacimiento hasta la madurez. Arch Argent Pediatr 1987;85:209-222.
9. Tanner JM, Whitehouse RH: Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty. Arch Dis Child 1976;51:170-179.
10. Greulich WW, Pile SI (Eds): Radiographic Atlas of Skeletal Development of the Hand and Wrist. Standford, Standford University Press, 1959.
11. Albertsson-Wickland K, Jansson C, Rosberg S, Novamo A: Time-resolved immunofluorometric assay of human growth hormone. Clin Chem 1993;39:1620-1625.
12. Rivarola MA, Mendilaharzu H, Warman M, Belgorosky A, Iorcansky, Castellano, Caresana A, Chaler E, Maceiras M: Endocrine disorders in 66 suprasellar and pineal tumors of patients with prepubertal and pubertal ages. Horm Res 1992;37:1-6.
13. Bozzola M, Zecca M, Locatelli F, Radetti G, Pagani S, Aurelli M, Tato L, Chatelain P: Evaluation of Growth hormone bioactivity using the Nb2 cell bioassay in children with growth disorders. J Endocrinol Invest 1998;21:765-770.
14. Chaler E, Travaglino P, Pagani S, Bozzola E, Marino R, Berensztein E, Maceiras M, Tauber M, Rivarola MA, Belgorosky A, Bozzola M: Dose dependency of the serum Bio/Immuno GH ratio in children during pharmacological secretion tests. J Endocrinol Invest 2006;29:109-114.
15. Marino R, Chaler EA, Warman M, Ciaccio M, Berensztein E, Rivarola MA, Belgorosky A: The serum growth hormone (GH) response to provocative tests is dependent on type of assay inautosomal dominant isolated GH deficiency because an ARG(183)HIS (R183H) GH-1 gene mutation. Clin Chem 2003;49:1002-1005.
16. Ciaccio M, Belgorosky A, Rivarola MA: Differences in serum insulin-like growth factor I and sex-hormone-binding globulin levels between late and early prepuberty in patients with idiopathic and organic growth hormone deficiency. Acta Endocrinol (Copenh) 1993;129:419-423.
17. Belgorosky A, Rivarola MA: Insulin-like growth factor binding protein (IGFBP)-3 bound IGF-I and IGFBP-3 bound IGF-II in growth hormone deficiency. Horm Res 1999;52:60-65.