cis-Δ2,3-double bond of phoslactomycins is generated by a post-PKS tailoring enzyme

Journal of the American Chemical Society

Volumn 130, Issue 37, 2008, Pages 12236-12237

  Palaniappan, Nadaraj ^a   Alhamadsheh, Mamoun M ^a   Reynolds, Kevin A ^a  

^a PORTLAND STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSLACTOMYCIN DERIVATIVE; POLYKETIDE SYNTHASE;

ARTICLE; BIOSYNTHESIS; CARBON NUCLEAR MAGNETIC RESONANCE; CATALYSIS; CHEMICAL BOND; DECARBOXYLATION; FERMENTATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROXYLATION; PROTEIN DOMAIN; PROTON NUCLEAR MAGNETIC RESONANCE;

ALKENES; HYDRO-LYASES; LACTONES; MULTIGENE FAMILY; OPEN READING FRAMES; ORGANOPHOSPHORUS COMPOUNDS; POLYKETIDE SYNTHASES; PROTEIN STRUCTURE, TERTIARY; PYRONES; STREPTOMYCES;

EID: 51949093833     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja8044162     Document Type: Article

References (19)

1. Staunton, J.; Weissman, K. J. Nat. Prod. Rep. 2001, 18, 380-416.
2. Wu, J.; Zaleski, T. J.; Valenzano, C.; Khosla, C.; Cane, D. E. J. Am. Chem. Soc. 2005, 127, 17393-404.
3. Caffrey, P. ChemBioChem 2003, 4, 654-7.
4. Reid, R.; Piagentini, M.; Rodriguez, E.; Ashley, G.; Viswanathan, N.; Carney, J.; Santi, D. V.; Hutchinson, C. R.; McDaniel, R. Biochemistry 2003, 42, 72-9.
5. Alhamadsheh, M. M.; Palaniappan, N.; Daschouduri, S.; Reynolds, K. A. J. Am. Chem. Soc. 2007, 129, 1910-1.
6. Stampwala, S. S.; Bunge, R. H.; Hurley, T. R.; Willmer, N. E.; Brankiewicz, A. J.; Steinman, C. E.; Smitka, T. A.; French, J. C. J. Antibiot. 1983, 36, 1601-5.
7. Fushimi, S.; Furihata, K.; Seto, H. J. Antibiot. (Tokyo) 1989, 42, 1026-36.
8. Fushimi, S.; Nishikawa, S.; Shimazu, A.; Seto, H. J. Antibiot. (Tokyo) 1989, 42, 1019-25.
9. Palaniappan, N.; Kim, B. S.; Sekiyama, Y.; Osada, H.; Reynolds, K. A. J. Biol. Chem. 2003, 278, 35552-7.
10. Hu, Z.; Reid, R.; Gramajo, H. J. Antibiot. (Tokyo) 2005, 58, 625-33.
11. Ghatge, M.; Palaniappan, N.; Das Choudhuri, S.; Reynolds, K. J. Ind. Microbiol. Biotechnol. 2006, 33, 589-99.
12. Choudhuri, S. D.; Ayers, S.; Soine, W. H.; Reynolds, K. A. J. Antibiot. (Tokyo) 2005, 58, 573-82.
13. Kim, B. S.; Cropp, T. A.; Florova, G.; Lindsay, Y.; Sherman, D. H.; Reynolds, K. A. Biochemistry 2002, 41, 10827-33.
14. Chandra, A.; Nair, M. G. J. Antibiot. (Tokyo) 1995, 48, 896-8.
15. Kobinata, K.; Koshino, H.; Kusakabe, H.; Kobayashi, Y.; Yamaguchi, I.; Isono, K.; Osada, H. J. Antibiot. (Tokyo) 1993, 46, 1912-5.
16. Kumazawa, S.; Asami, Y.; Awane, K.; Ohtani, H.; Fukuchi, C.; Mikawa, T.; Hayase, T. J. Antibiot. (Tokyo) 1994, 47, 688-96.
17. Ghatge, M. S.; Reynolds, K. A. J. Bacteriol. 2005, 187, 7970-7976.
18. Lawhorn, B. G.; Boga, S. B.; Wolkenberg, S. E.; Colby, D. A.; Gauss, C. M.; Swingle, M. R.; Amable, L.; Honkanen, R. E.; Boger, D. L. J. Am. Chem. Soc. 2006, 128, 16720-32.
19. Teruya, T.; Simizu, S.; Kanoh, N.; Osada, H. FEBS Lett. 2005, 579, 2463-8.