Integrin expression and IgA nephropathy: In vitro modulation by IgA with altered glycosylation and macromolecular IgA

Kidney International

Volumn 58, Issue 6, 2000, Pages 2331-2340

  Peruzzi, Licia ^a,b,c,d   Amore, Alessandro ^a,b,c,d   Cirina, Paola ^a,b,c,d   Trusolino, Livio ^a,b,c,d   Basso, Giuseppe ^a,b,c,d   Ricotti, Emanuela ^a,b,c,d   Emancipator, Steven Noel ^a,b,c,d   Marchisio, Pier Carlo ^a,b,c,d   Coppo, Rosanna ^a,b,c,d  

^a REGINA MARGHERITA CHILDREN S HOSPITAL   (Italy)

^b SAN RAFFAELE HOSPITAL   (Italy)

^c UNIVERSITY OF TURIN   (Italy)

^d CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Cell matrix interaction; Degalactosylated IgA; Extracellular matrix; Glomerular hemodynamics; Mesangial matrix; Transmembrane proteins

Indexed keywords

GALACTOSE; GLYCAN; IMMUNOGLOBULIN A; INTEGRIN; MANNOSE;

ARTICLE; CELL INTERACTION; CONTROLLED STUDY; EXTRACELLULAR MATRIX; GLYCATION; GLYCOSYLATION; HUMAN; HUMAN CELL; IMMUNOGLOBULIN A NEPHROPATHY; MESANGIUM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ASSAY; SIGNAL TRANSDUCTION;

EID: 0033671640     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.2000.00417.x     Document Type: Article

References (47)

1. Pathogenesis of IgA nephropathy: Established observations, new insight and perspectives in treatment
2. Cellular receptors for matrix proteins in normal human kidney and human MC
3. Integrins: Versatility, modulation, and signaling in cell adhesion
4. Integrins
5. Integrins and signal transduction pathways: The road taken
6. Integrin mediated activation of MAPK or MEK is independent of Ras
7. Dependence of cyclin E-cdk2 kinase activity on cell anchorage
8. Modulation of cell proliferation by the integrin cytoplasmic domain
9. Interactions between glomerular mesangial cells, cytokines, and extracellular matrix
10. Transforming growth factor-β and the glomerular extracellular matrix in renal pathology
11. The role of integrins in IgA nephropathy
12. Distribution of extracellular matrix receptors in various forms of glomerulonephritis
13. Adhesion molecules in the glomerular mesangium
14. Functional role of N-glycosylation in alpha5 beta 1 integrin receptor: De-N-glycosylation induces dissociation or altered association on alpha5 and beta 1 subunits and concomitant loss of fibronectin binding activity
15. Effects of matrix glycation on mesangial cell adhesion, spreading and proliferation
16. The structure and function of human IgA
17. O-linked oligosaccharide from human serum immunoglobulin A
18. IgA antibodies to dietary antigens and lectin-binding IgA in sera from Italian, Australian and Japanese IgA nephropathy patients
19. Serum IgA and macromolecular IgA reacting with mesangial matrix components
20. IgA serology in recurrent and non-recurrent IgA nephropathy after renal transplantation
21. Galactosylation of N- and O-linked carbohydrate moieties of IgA1 and IgG in IgA nephropathy
22. Association of asialo-galactosyl β1-3N-acetylgalactosamine on the hinge with a conformational instability of jacalin-reactive immunoglobulin A1 in immunoglobulin A nephropathy
23. Galactose-deficient IgA1 in sera of IgA nephropathy patients is present in complexes with IgG
24. Leukocyte β1,3 galactosyltrasferase activity in IgA nephropathy
25. Inhibition of cell cycle progression by the alternatively spliced integrin β1C
26. Macromolecular properties that promote mesangial binding and mesangiopathic nephritis
27. The sialic acids: VI purification and properties sialidase from Clostridium perfringens
28. The purification and properties of β galactosidase from bovine testes
29. Cytokine mRNA expression by cultured rat mesangial cells after contact with environmental lectins
30. 5 integrin
31. Flow cytometric detection and quantitative analysis of the GM-CSF receptor in human granulocytes and comparison with the radioligand binding assay
32. Expression of β1 integrins in IgA nephropathy
33. Vitronectin receptor mediated phagocytosis of cells undergoing apoptosis
34. Alpha1 beta1 integrin-mediated collagen matrix remodeling by rat mesangial cells is differentially regulated by transforming growth factor beta and platelet growth factor BB
35. Mesangial cells and their adhesive properties
36. The pathogenic role of immunoglobulin A polymers in immunoglobulin A nephropathy
37. Characteristics of nephritogenic IgA immune complexes
38. Interaction of mesangial cells with IgA and IgG immune complexes: A possible mechanism of glomerular injury in IgA nephropathy
39. Binding of dimeric and polymeric IgA to rat renal mesangial cells enhances the release of interleukin 6
40. Interaction of IgA with Fc alpha receptors of human mesangial cells activates transcription factor nuclear factor-kappa B and induces expression and synthesis of monocyte chemoattractant protein-1, IL-8, and IFN-inducible protein 10
41. Protective role of IgA1 glycans against IgA1 self-aggregation and adhesion to extracellular matrix proteins
42. The role of the carbohydrate chains in complement (C3) fixation by solid-phase-bound human IgA
43. Mesangial cells possess an asialoglycoprotein receptor with affinity for human immunoglobulin A
44. Absence of CD89, polymeric immunoglobulin receptor, and asialoglycoprotein receptor on human mesangial cells
45. Evidence that the interaction between circulating IgA and fibronectin is a normal process enhanced in primary IgA nephropathy
46. On the specificity of assays to detect circulating immunoglobulin Afibronectin complexes: Implications for the study of serology phenomena in patients with immunoglobulin A nephropathy
47. Induction of beta 1 integrin synthesis by recombinant platelet derived growth factor (PDGF-AB) correlates with an enhanced migratory response of human dermal fibroblasts to various extracellular matrix proteins