The use of a high-throughput luminescent method to assess CYP3A enzyme induction in cultured rat hepatocytes

In Vitro Cellular and Developmental Biology - Animal

Volumn 44, Issue 5-6, 2008, Pages 129-134

  Garcia, Martha C ^a   Ma, Dongping ^b   Dicioccio, A Thomas ^a   Cali, James ^b  

^a The Institute for Diabetes Discovery   (United States)

^b PROMEGA CORPORATION   (United States)

Author keywords

CYP induction; Drug metabolism; High throughput screening

Indexed keywords

16ALPHA CYANOPREGNENOLONE; CYTOCHROME P450 3A; DEXAMETHASONE; ETHER DERIVATIVE; LUCIFERIN; PHENOBARBITAL;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; BENZYLATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INDUCTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH THROUGHPUT SCREENING; HYDROXYLATION; LIVER CELL; MALE; MASS SPECTROMETRY; NONHUMAN; RAT;

ANIMALS; CELLS, CULTURED; CYTOCHROME P-450 CYP3A; ENZYME INDUCTION; FIREFLY LUCIFERIN; HEPATOCYTES; LUMINESCENT MEASUREMENTS; RATS; REPRODUCIBILITY OF RESULTS; SUBSTRATE SPECIFICITY;

RATTUS;

EID: 51749108655     PISSN: 10712690     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11626-008-9085-1     Document Type: Article

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