Efficacy of laser capture microdissection plus RT-PCR technique in analyzing gene expression levels in human gastric cancer and colon cancer

BMC Cancer

Volumn 8, Issue , 2008, Pages

  Makino, Hiroshi ^a   Uetake, Hiroyuki ^a   Danenberg, Kathleen ^b   Danenberg, Peter V ^b   Sugihara, Kenichi ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROPYRIMIDINE DEHYDROGENASE; MESSENGER RNA; OROTATE PHOSPHORIBOSYLTRANSFERASE; THYMIDINE PHOSPHORYLASE; THYMIDYLATE SYNTHASE; PRIMER DNA;

ACCURACY; ARTICLE; CANCER CELL CULTURE; COLON CANCER; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; LASER CAPTURE MICRODISSECTION; MAJOR CLINICAL STUDY; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH CANCER; STROMA CELL; UPREGULATION; BIOSYNTHESIS; CHEMISTRY; COLON TUMOR; LASER; METABOLISM; METHODOLOGY; MICRODISSECTION; STOMACH TUMOR; TUMOR CELL LINE;

CELL LINE, TUMOR; COLONIC NEOPLASMS; DIHYDROURACIL DEHYDROGENASE (NADP); DNA PRIMERS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LASERS; MICRODISSECTION; OROTATE PHOSPHORIBOSYLTRANSFERASE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STOMACH NEOPLASMS; THYMIDINE PHOSPHORYLASE; THYMIDYLATE SYNTHASE;

EID: 51649129059     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-8-210     Document Type: Article

References (44)

1. Jemal A Murray T Ward E Samuels A Tiwari RC Ghafoor A Feuer EJ Thun MJ Cancer Statistics, 2005 CA Cancer J Clin 2005, 55:10-30. 15661684
2. Ajamni JA Evolving chemotherapy for advanced gastric cancer Oncologist 2005, 10(Suppl 3):49-58. 16368871
3. Saltz LB Cox JV Blanke C Irinotecanplus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan Study Group N Engl J Med 2000, 343:905-914. 11006366
4. Douillard JY Cunningham D Roth AD Iriniotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: A multicentre randomized trial Lancet 2000, 355:1041-1047. 10744089
5. Goldberg RM Sargent DJ Morton RF A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer J Clin Oncol 2004, 22:23-30. 14665611
6. de Gramont A Figer A Seymour M Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer J Clin Oncol 2000, 18:2938-2947. 10944126
7. Grothey A Deschler B Kroening H Phase III study of bolus 5-fluorouracil (5-FU)/folinic acid (FA) (Mayo) vs weekly high-dose 24 h 5-FU infusion/ FA + oxaliplatin in advanced colorectalcancer Proc Am Soc Clin Oncol 2002, 21:129a. (abstr 512)
8. Ohtsu A Current status and future prospects of chemotherapy for metastatis gastric cancer:a review Gastric Cancer 2005, 8:95-102. 15864716
9. Danenberg PV Thymidylate synthase - a target enzyme in cancer chemotherapy Biochem Biophys Acta 1977, 473:73-92. 145246
10. Peters GJ Wilt van der CL van Triest B Codacci-Pisanelli G Johnston PG van Groeningen CJ Pinedo HM Thymidylate syntase and drug resistance Eur J Cancer 1995, 31A:1299-1305. 7577040
11. Salonga D Danenberg KD Johnson M Metzger R Groshen S Tsao-Wei DD Lenz HJ Leichman L Diasio RB Danenberg PV Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate syntase, and thymidine phosphorylase Clin Cancer Res 2000, 6:1322-1327. 10778957
12. Ichikawa W Uetake H Shirota Y Yamada H Nishi N Nihei Z Sugihara K Hirayama R Combination of dihydropyrimidine dehydrogenase and thymidylate syntase gene expressions in primary tumors as predictive parameters for the efficacy of fluoropyrimidine-based chemotherapy for metastatic colorectal cancer Clin Cancer Res 2003, 9:786-789. 12576451
13. Peters GJ Laurensse E Leyva A Lankelma J Pinedo HM Sensitivity of human, murine, and rat cells to 5-fluorouraci and 5′-deoxy-5-fluorouracil in relation to drug-metabolizing enzymes Caner Res 1986, 46:20-28.
14. Koizumi W Saigenji K Nakamaru N Okayasu I Kurihara M Prediction of response to 5′-deoxy-5-fluorouridine (5′-DFUR) in patients with inoperable advanced gastric cancer by immunostaining of thymidine phosphorylase/platelet-derived endotherial cell growth factor Oncology 1999, 56:215-222. 10202277
15. Sawada N Ishikawa T Fukase Y Nishida M Yoshikubo T Ishitsuka H Induction of thymidine phosphorylase activity and enhancement of capecitabine efficacy by taxil/taxotere in human cancer xenografts Clin Cancer Res 1998, 4:1013-1019. 9563897
16. Peters GJ Braakhuis BJ Bruijin EA Laurensse EJ Walsum M Pinedo HM Enhanced therapeutic efficacy of 5′-deoxy - 5-fluorouridine in 5-fluorouracil-ressistant head and neck tumours in relation to 5-fluorouracil metabolizing enzymes Br J Cancer 1989, 59:327-334. 2522792
17. Ma T Zhu ZC Ji YB Zhang Y Yu YY Liu BY Yin HR Lin YZ Correlation of thymidylate synthase, thymidine phosphorylase and dihydropyrimidine dehydrogenase with sensitivity of gastrointestinal cancer cells to 5-fluorouracil and 5-fluoro-2′-deoxyuridine World J Gastroenterol 2004, 10:172-176. 14716816
18. Toriumi F Kubota T Saikawa Y Yoshida M Otani Y Watanabe M Kumai K Kitajima M Thymidylate synthase(TS)genotype and TS/dihydropyrimidine dehydrogenase mRNA levels as am indicator in determining chemosensitivity to 5-fluorouracil in advanced gastric carcinoma Anticancer Res 2004, 24:2455-2463. 15330198
19. Ishikawa Y Kubota T Otani Y Watanabe M Teramoto T Kumai K Takechi T Okabe H Fukushima M Kitajima M Dihydropyrimidine dehydrogenase and messenger RNA levels in gastric cancer possible predictor for sensetivity to 5-fluorouracil Jpn J Cancer Res 2000, 91:105-112. 10744051
20. Ichikawa W Uetake H Shirota Y Yamada H Takahashi T Nihei Z Sugihara K Sasaki Y Hirayama R Both gene expression for orotate phosphoribosyl transferase and its ratio to dihydropyrimidine dehydrogenase influence outcome following fluoropyrimidine-based chemotherapy for metastatic colorectal cancer Br J Cancer 2003, 89:1486-1492. 14562021
21. Ochiai T Nishimura K Noguchi H Kitajima M Tsukada A Watanabe E Nagaoka I Futagawa S Prognostic impact of orotate phosphoribosyl transferase among 5-fluorouracil metabolic enzymes ie respectable colorectal cancers treated by oral 5-fluorouracil based adjuvant chemotherapy Int J Cancer 2006, 118:3084-3088. 16425285
22. Adlard JW Richman SD Seymour MT Quirke P Prediction of the response of colorectal cancer to systemic therapy Lancet Oncol 2002, 3:75-82. 11902527
23. Isshi K Sakuyama T Gen T Nakamura Y Kuroda T Katsuyama T Maekawa Y Predicting 5-FU sensitivity using human colorectal cancer specimens: comparison of tumor dihydropyrimidine dehydrogenase and orotate phosphoribosyl transferase activities with in vitro chemosensitivity to 5-FU Int J Clin Oncol 2002, 7:335-342. 12494248
24. Kakimoto M Uetake H Osanai T Shirota Y Sugihara K Thymidine synthasae and dihydropyrimidine dehydrogenase gene expression in breast cancer predicts 5-FU sensitivity by a histocultural drug sensitivity test Cancer Letters 2005, 223:103-111. 15890242
25. Lord RV Salonga D Danenberg KD Peters JH DeMeester TR Park JM Johansson J Skinner KA Chandrasoma P DeMeester SR Bremner CG Tsai PI Danenberg PV Teromerase reverse transcriptase, expression in increased early in the Barrett's metaplasia, dysplasia, carcinoma sequence J Gastrointest Surg 2000, 4:135-142. 10675236
26. Heid CA Stevens J Livak KJ Williams PM Real time quantitative RT-PCR Gemome Res 1996, 10:986-994.
27. Gibson UE Heid CA Williams PM A novel method for real time quantitative RT-PCR Gemome Res 1996, 10:995-1011.
28. Sakamoto K Sugimoto Y Miyadera K Oka T Fukushima M Preparation of anti-orotate phosphoribosyltransferase antibody and its application to immunohistochemical detection in human tumor cells Int J Mol Med 2005, 16:245-249. 16012756
29. Oguri T Achiwa H Bessho Y Muramatsu H Maeda H Niimi T Sato S Ueda R The role of thymidylate synthase and dihydropyrimidine dehydrogenase in resistance to 5-fluorouracil in human lung cancer cells Lung Cancer 2005, 49:345-351. 15993511
30. Kamoshida S Shiogama K Shimomura R Inada K Sakurai Y Ochiai M Matuoka H Maeda K Tsutsumi Y Immunohistochemical demonstration of fluoropyrimidine-metabolizing enzymes in various types of cancer Oncol Rep 2005, 14:1223-1230. 16211289
31. Peters G Groeningen C Laurensse E Pinedo HM A Comparison of 5-fluorouracil metabolism in human colorectal cancer and colon mucosa Cancer 1991, 68:1903-1909. 1717130
32. Maehara Y Moriguchi S Emi Y Watanabe A Kohnoe S Tsujitani S Sugimachi K Comparison of pyrimidine nucleotide synthetic enzymes involved in 5-fluoroyracil metabolism between human adnocarcinomas and squamous cell carcinomas Cancer 1990, 66:156-161. 2162241
33. Ichikawa W Takahashi T Suto K Nihei Z Shirota Y Shimizu M Sasaki Y Hirayama R Thymidylate synthase and dihydropyrimidine dehydrogenase gene expression in relation to differentiation of gastric cancer Int J Cancer 2004, 112:967-973. 15316940
34. Lassmann S Hennig M Rosenberg R Nährig J Schreglmann J Krause F Poignee-Heger M Nekarda H Höfler H Werner M Thymidine phosphorylase, dihydropyrimidine dehydrogenase and thymidylate synthase mRNA expression in primary colorectal tumors-correlation to tumor histopathology and clinical follow up Int J Colorectal Dis 2006, 21:238-247. 16132996
35. Johnston S Ridge S Cassidy J McLeod H Reguration of dihydropyrimidine dehydrogenase in colorectal cancer Clin Cancer Res 1999, 5:2566-2570. 10499634
36. Takebayashi Y Yamada K Miyadera K Sumizawa T Furukawa T Kinoshita F Aoki D Okumura H Yamada Y Akiyama S Aikou T The activity and expression of thymidine phosphorylase in human solid tumours Eur J Cancer 1996, 32A:1227-1232. 8758258
37. Maeda K Kang SM Ogawa M Onoda N Sawada T Nakata B Kato Y Chung YS Sowa M Combined analysis of vascular endothelial growth factor and platelet-derived endothelial cell growth factor expression in gastric carcinoma Int J Cancer 1997, 74:545-550. 9355979
38. Toi M Ueno T Matsumoto H Saji H Funata N Koike M Tominaga T Significance of thymidine phosphorylase as a marker of protumor monocytes in breast cancer Clin Cancer Res 1999, 5:1131-1137. 10353748
39. Takebayashi Y Akiyama S Akiba S Yamada K Miyadera K Sumizawa T Yamada Y Murata F Aikou T Clinicopathologic and prognostic significance of an angiogenic factor, thymidine phosphorylase, in human colorectal carcinoma J Natl Cancer Inst 1996, 88:1110-1117. 8757190
40. Amaya H Tanigawa N Lu C Matsumura M Shimomatsuya T Horiuchi T Muraoka R Association of vascular endothelial growth factor expression with tumor angiogenesis, survival and thymidine phosphorylase/platelet-derived endothelial cell growth factor expression in human colorectal cancer Cancer Lett 1997, 119:227-235. 9570376
41. Haba A Monden T Sekimoto M Ikeda K Izawa H Kanou T Amano M Kanayama H Monden M PyNPase expression in human colon cancer Cancer Lett 1998, 122:85-92. 9464495
42. Matsumura M Chiba Y Lu C Amaya H Shimomatsuya T Horiuchi T Muraoka R Tanigawa N Platelet-derived endothelial cell growth factor/thymidine phosphorylase expression correlated with tumor angiogenesis and macrophage infiltration in colorectal cancer Cancer Lett 1998, 128:55-63. 9652793
43. Emmert-Buck MR Bonner RF Smith PD Chuaqui RF Zhuang Z Godstein SR Weiss RA Liotta LA Laser capture microdissection Science 1996, 274:998-1001. 8875945
44. Farrugia DC Ford HE Cunningham D Danenberg KD Danenberg PV Brabender J McVicar AD Aherne GW Hardcastle A McCarthy K Jackman AL Thymidylate synthase expression in advanced colo-rectal cancer predicts for response to raltitrexed Clin Cancer Res 2003, 9:792-801. 12576452