New drugs in the treatment of gastric tumors

Clinical and Translational Oncology

Volumn 10, Issue 5, 2008, Pages 256-261

  Abad, Albert ^a  

^a HOSPITAL UNIVERSITARI GERMANS TRIAS I PUJOL   (Spain)

Author keywords

Gastric cancer; Hedgehog signaling pathway; Helicobacter pylori; Target therapy

Indexed keywords

ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; BEVACIZUMAB; CAGA PROTEIN; CAPECITABINE; CETUXIMAB; CISPLATIN; EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODY; EPIRUBICIN; ERLOTINIB; FLUOROURACIL; FOLINIC ACID; IRINOTECAN; LAPATINIB; MATUZUMAB; OXALIPLATIN; PACLITAXEL; SONIC HEDGEHOG PROTEIN; TRASTUZUMAB;

ABSENCE OF SIDE EFFECTS; ARTICLE; CANCER CHEMOTHERAPY; CANCER GENETICS; CLINICAL TRIAL; DISEASE MODEL; DRUG EFFICACY; DRUG FATALITY; DRUG POTENTIATION; DRUG TARGETING; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HUMAN; NEUTROPENIA; NONHUMAN; PROGNOSIS; SIGNAL TRANSDUCTION; STOMACH ADENOCARCINOMA; STOMACH CANCER; STOMACH CARCINOGENESIS; STOMACH MUCOSA; STOMACH TUMOR; UNSPECIFIED SIDE EFFECT; ANIMAL; METABOLISM; MICROBIOLOGY; PHYSIOLOGY; REVIEW;

ANIMALS; ANTINEOPLASTIC AGENTS; CLINICAL TRIALS AS TOPIC; HEDGEHOG PROTEINS; HELICOBACTER INFECTIONS; HUMANS; SIGNAL TRANSDUCTION; STOMACH NEOPLASMS;

EID: 51649127840     PISSN: 1699048X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12094-008-0194-9     Document Type: Article

References (20)

1. Schwartz GK, Shah MA (2005) Targeting the cell cycle: A new approach to cancer therapy. J Clin Oncol 23(36):9408-9421
2. Pinto C, Di Fabio F, Siena S et al (2007) Phase II study of cetuximab in combination with FOLFIRI in patients with untreated advanced gastric or gastroesophageal junction adenocarcinoma (FOLCETUX study). Ann Oncol 18(3): 510-517
3. Shah MA, Ramanathan RK, Ilson DH et al (2006) Multicenter phase II study of irinotecan, cisplatin, and bevacizumab in patients with metastatic gastric or gastroesophageal junction adenocarcinoma. J Clin Oncol 24(33):5201-5206
4. Dragovich T, McCoy S, Fenoglio-Preiser CM et al (2006) Phase II trial of erlotinib in gastroesophageal junction and gastric adenocarcinomas: SWOG 0127. J Clin Oncol 24(30):4922-4927
5. Rebischung C, Barnoud R, Stéfani L et al (2005) The effectiveness of trastuzumab (herceptin) combined with chemotherapy for gastric carcinoma with overexpression of the c-erbB-2 protein. Gastric Cancer 8(4):249-252
6. Kim SY, Kim HP, Kim YJ et al (2008) Trastuzumab inhibits the growth of human gastric cancer cell lines with HER2 amplification synergistically with cisplatin. Int J Oncol 32(1):89-95
7. Rao S, Starling N, Benson M et al (2005) Phase I study of the humanized epidermal grow factor receptor antibody EMD 72000 (matuzumab) in combination with ECX (epirubicin, cisplatin and capecitabine) as first line treatment for advanced oesophagogastric adenocarcinoma. J Clin Oncol 23(16S):314; 4028 abs
8. Uemura N, Okamoto S, Yamamoto S et al (2001) Helicobacter pylori infection and the development of gastric cancer. N Eng J Med 345(11):784-789
9. Tstsumi R, Higashi H, Higuchi M et al (2003) Attenuation of Helicobacter pylori CagA-SHP-2 signaling by interaction between CagA and C-terminal Src Kinase. J Biol Chem 278(6):3665-3670
10. Hatakeyama M (2006) Helicobacter pylori CagA-a bacterial intruder conspiring gastric carcinogenesis. Int J Cancer 119:1217-1223
11. Snider JS, Allison C, Bryan H et al (2008) The beta-1 integrin activates JNK independent of CagA, and JNK acication is requerid for Helicobacter pylori CagA+ induced motility of gastric cancer cells. J Biol Chem 2008, Mar 5
12. Nusslein-Volhard C, Wieschaus E (1980) Mutations affecting segment number and polarity in Drosophila. Nature 287:795-801
13. Cohen MM Jr (2003) The hedgehog signalling network. Am J Med Genet 123A:5-28
14. Hooper J, Scott M (2005) Communicating with hedgehogs. Nat Rev Mol Cell Biol 6:306-317
15. Osterlund T, Kogerman P (2006) Hedgehog signaling: How to get from Smo to Ci and Gli. Trens in Cell Biol 16:176-180
16. Mullor JL, Sánchez P, Altaba A (2002) Pathways and consequences: Hedgehog signaling in human disease. Trens Cell Biol 12:562-569
17. Katoh Y, Katoh M (2005) Hedgehog signaling pathway and gastric cancer. Cancer Biol Ther 4(10):1050-1054
18. Ma X, Chen K, Huang S et al (2005) Frequent activation of the hedgehog pathways in advanced gastric adenocarcinomas. Carcinogenesis 26(10):1698-1705
19. Yoo Y, Kang MH, Kim JS, Oh SC (2008) Sonic hedgehog signaling promotes motility and invasiveness of gastric cancer cells through TGF-beta-mediated activation of the ALK5-smad 3 pathway. Carcinogenesis 29(3):480-490
20. Xie J (2008) Hedgehog signaling pathway: Development of antagonists for cancer therapy. Curr Oncol Rep 10(2):107-113