How drugs interact with transporters: SGLT1 as a model

Journal of Membrane Biology

Volumn 223, Issue 2, 2008, Pages 87-106

  Loo, Donald D F ^a   Hirayama, Bruce A ^a   Sala Rabanal, Monica ^a   Wright, Ernest M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Competitive inhibition of sugar transport; Conformational change; Drug cotransporter interactions; Fluorescence; Na+ glucose cotransport turnover; Steady state and pre steady state kinetics

Indexed keywords

ALPHA METHYLGLUCOSIDE; GLUCOPYRANOSIDE; GLUCOSE; INDICAN; RHODAMINE; SODIUM GLUCOSE COTRANSPORTER 1; SUGAR;

ANIMAL CELL; ARTICLE; BINDING SITE; CARBOHYDRATE TRANSPORT; CONTROLLED STUDY; DEPOLARIZATION; DISSOCIATION; DRUG DELIVERY SYSTEM; ELECTRIC ACTIVITY; ELECTRIC POTENTIAL; FEMALE; FLUORESCENCE; HYPERPOLARIZATION; KINETICS; MEMBRANE; MODEL; MUTANT; NONHUMAN; OOCYTE; PROTEIN CONFORMATION; PROTEIN EXPRESSION; STEADY STATE; TIME; WILD TYPE; XENOPUS;

ANIMALS; BIOLOGICAL TRANSPORT, ACTIVE; FLUORESCENCE; GLUCOSE; GLUCOSIDES; HUMANS; INDICAN; KINETICS; METHYLGLUCOSIDES; MODELS, BIOLOGICAL; OOCYTES; PROTEIN CONFORMATION; SODIUM-GLUCOSE TRANSPORTER 1; XENOPUS LAEVIS;

EID: 51649125643     PISSN: 00222631     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00232-008-9116-6     Document Type: Article

References (35)

1. F Bezanilla 2000 The voltage sensor in voltage-dependent ion channels Physiol Rev 80 555 592
2. +/glucose cotransporter cloned from rabbit small intestine Pfluegers Arch 418 79 85
3. E Briasoulis I Judson N Pavlidis P Beale J Wanders Y Groot G Veerman M Schuessler G Niebch K Siamopoulos E Tzamakou D Rammou L Wolf R Walker A Hanauske 2000 Phase I trial of 6-hour infusion of glufosfamide, a new alkylating agent with potentially enhanced selectivity for tumors that overexpress transmembrane glucose transporters: a study of the European Organization for Research and Treatment of Cancer Early Clinical Studies Group J Clin Oncol 18 3535 3544
4. +-dependent glucose cotransporters: comparison of SGLT1 and SGLT3 J Membr Biol 176 111 117
5. +/glucose cotransporter J Biol Chem 276 49188 49194
6. +/glucose cotransporter J Membr Biol 204 23 32
7. S Falk A Guay C Chenu SD Patil A Berteloot 1998 Reduction of an eight-state mechanism of cotransport to a six-state model using a new computer program Biophys J 74 816 830
8. +/glucose cotransporter (SGLT1) J Membr Biol 155 175 186
9. -/GABA (hGAT1) cotransporters Br J Pharmacol 134 484 495
10. BA Hirayama DDF Loo A Díez-Sampedro DW Leung A-K Meinild M Lai-Bing E Turk EM Wright 2007 Na-dependent reorganization of the sugar-binding site of SGLT1 Biochemistry 46 13391 13406
11. +/glucose cotransporter J Biol Chem 272 2110 2115
12. +-glucose transporter (SGLT-1) Am J Physiol 270 G919 G926
13. AE King MA Ackley CE Cass JD Young SA Baldwin 2006 Nucleoside transporters: from scavengers to novel therapeutic targets Trends Pharmacol Sci 27 416 425
14. +/peptide cotransporters FEBS J 274 5905 5914
15. +/nucleoside cotransporter 1 (hCNT1) and role of adenosine on hCNT1 function J Biol Chem 279 8999 9007
16. + cotransporter (NupC) produced in Xenopus laevis oocytes Mol Membr Biol 21 1 10
17. +/glucose cotransporter Proc Natl Acad Sci USA 90 5767 5771
18. + and glucose transport Proc Natl Acad Sci USA 95 7789 7794
19. Loo DDF, Eskandari S, Hirayama BA, Wright EM (2002) A kinetic model for secondary active transport. In: Layton HE, Weinstein AM (eds), Membrane transport and renal physiology, the IMA volumes in mathematics and its applications, vol 129, Springer-Verlag, New York, pp 65-83
20. +/glucose cotransporter J Gen Physiol 125 13 36
21. +/glucose cotransport J Gen Physiol 128 701 720
22. DDF Loo BA Hirayama A-K Meinild G Chandy T Zeuthen EM Wright 1999 Passive water and ion transport by cotransporters J Physiol 518 195 202
23. +/glucose cotransporter (SGLT1): analysis of interactions J Membr Biol 142 161 170
24. +/glucose cotransporter (SGLT1) currents and fluxes J Membr Biol 162 101 106
25. JR Mackey SYM Yao KM Smith E Karpinski SA Baldwin CE Cass JD Young 1999 Gemcitabine transport in Xenopus oocytes expressing recombinant plasma membrane mammalian nucleoside transporters J Natl Cancer Inst 91 1876 1881
26. +/glucose cotransporter Biochemistry 41 1250 1258
27. +/glucose cotransporter: II. A transport model under nonrapid equilibrium conditions J Membr Biol 125 63 79
28. + channel J Biol Chem 276 1728 1734
29. +-oligopeptide cotransporter hPEPT1 J Physiol 574 149 166
30. M Sala-Rabanal DDF Loo BA Hirayama EM Wright 2008 Molecular mechanism of dipeptide and drug transport by the human renal H+/oliopeptide cotransporter, hPEPT2 Am J Physiol 294 F1422 F1432
31. +-coupled nucleoside transporter (hCNT1) produced in Xenopus oocytes J Physiol 558 807 823
32. +/galactose cotransporter Biochemistry 43 3620 3627
33. +-d-glucose cotransporter SAAT1 Proc Natl Acad Sci USA 95 2914 2919
34. SYM Yao AML Ng MWL Ritzel WP Gati CE Cass JD Young 1996 Transport of adenosine by recombinant purine- and pyrimidine-selective sodium/nucleoside cotransporters from rat jejunum expressed in Xenopus laevis oocytes Mol Pharmacol 50 1529 1535
35. GA Zampighi M Kreman KJ Boorer DDF Loo F Bezanilla G Chandy EM Wright 1995 A method for determining the unitary functional capacity of cloned channels and transporters in Xenopus laevis oocytes J Membr Biol 148 65 78