메뉴 건너뛰기




Volumn 19, Issue 12, 2008, Pages 1187-1192

Th1 cytokines are upregulated by adenoviral vectors in the brains of primed mice

Author keywords

Cytokines; Demyelination; Dopamine transporter; Gene therapy; Interferon g; Primed animals; Th1; Th2; Tumour necrosis factor

Indexed keywords

ADENOVIRUS VECTOR; BETA GALACTOSIDASE; DOPAMINE TRANSPORTER; GAMMA INTERFERON; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GLYCOPROTEIN E1; INTERLEUKIN 12; INTERLEUKIN 4; INTERLEUKIN 6; MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; CYTOKINE;

EID: 51649087236     PISSN: 09594965     EISSN: None     Source Type: Journal    
DOI: 10.1097/WNR.0b013e3283088e3d     Document Type: Article
Times cited : (4)

References (26)
  • 1
    • 0029876694 scopus 로고    scopus 로고
    • Immunological instability of persistent adenovirus vectors in the brain: Peripheral exposure to vector leads to renewed inflammation, reduced gene expression, and demyelination
    • Byrnes AP, MacLaren RE, Charlton HM. Immunological instability of persistent adenovirus vectors in the brain: peripheral exposure to vector leads to renewed inflammation, reduced gene expression, and demyelination. J Neurosci 1996; 16:3045-3055.
    • (1996) J Neurosci , vol.16 , pp. 3045-3055
    • Byrnes, A.P.1    MacLaren, R.E.2    Charlton, H.M.3
  • 2
    • 0033557657 scopus 로고    scopus 로고
    • Interleukin-1 mediates a rapid inflammatory response after injection of adenoviral vectors into the brain
    • Cartmell T, Southgate T, Rees GS, Castro MG, Lowenstein PR, Luheshi GN. Interleukin-1 mediates a rapid inflammatory response after injection of adenoviral vectors into the brain. J Neurosci 1999; 19:1517-1523.
    • (1999) J Neurosci , vol.19 , pp. 1517-1523
    • Cartmell, T.1    Southgate, T.2    Rees, G.S.3    Castro, M.G.4    Lowenstein, P.R.5    Luheshi, G.N.6
  • 3
    • 0038128348 scopus 로고    scopus 로고
    • Inflammation and adaptive immune responses to adenoviral vectors injected into the brain: Peculiarities, mechanisms, and consequences
    • Lowenstein PR, Castro MG. Inflammation and adaptive immune responses to adenoviral vectors injected into the brain: peculiarities, mechanisms, and consequences. Gene Ther 2003; 10:946-954.
    • (2003) Gene Ther , vol.10 , pp. 946-954
    • Lowenstein, P.R.1    Castro, M.G.2
  • 4
    • 35348984094 scopus 로고    scopus 로고
    • Immune responses to adenovirus and adeno-associated vectors used for gene therapy of brain diseases: The role of immunological synapses in understanding the cell biology of neuroimmune interactions
    • Lowenstein PR, Mandel RJ, Xiong WD, Kroeger K, Castro MG. Immune responses to adenovirus and adeno-associated vectors used for gene therapy of brain diseases: the role of immunological synapses in understanding the cell biology of neuroimmune interactions. Curr Gene Ther 2007; 7:347-360.
    • (2007) Curr Gene Ther , vol.7 , pp. 347-360
    • Lowenstein, P.R.1    Mandel, R.J.2    Xiong, W.D.3    Kroeger, K.4    Castro, M.G.5
  • 6
    • 0031060168 scopus 로고    scopus 로고
    • Adenovirus infection stimulates the Raf/MAPK signaling pathway and induces interleukin-8 expression
    • Bruder JT, Kovesdi I. Adenovirus infection stimulates the Raf/MAPK signaling pathway and induces interleukin-8 expression. J Virol 1997; 71:398-404.
    • (1997) J Virol , vol.71 , pp. 398-404
    • Bruder, J.T.1    Kovesdi, I.2
  • 7
    • 0034691208 scopus 로고    scopus 로고
    • Peripheral infection with adenovirus causes unexpected long-term brain inflammation in animals injected intracranially with first-generation, but not with high-capacity, adenovirus vectors: Toward realistic long-term neurological gene therapy for chronic diseases
    • Thomas CE, Schiedner G, Kochanek S, Castro MG, Lowenstein PR. Peripheral infection with adenovirus causes unexpected long-term brain inflammation in animals injected intracranially with first-generation, but not with high-capacity, adenovirus vectors: toward realistic long-term neurological gene therapy for chronic diseases. Proc Natl Acad Sci U S A 2000; 97:7482-7487.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 7482-7487
    • Thomas, C.E.1    Schiedner, G.2    Kochanek, S.3    Castro, M.G.4    Lowenstein, P.R.5
  • 8
    • 0034926344 scopus 로고    scopus 로고
    • Preexisting antiadenoviral immunity is not a barrier to efficient and stable transduction of the brain, mediated by novel high-capacity adenovirus vectors
    • Thomas CE, Schiedner G, Kochanek S, Castro MG, Lowenstein PR. Preexisting antiadenoviral immunity is not a barrier to efficient and stable transduction of the brain, mediated by novel high-capacity adenovirus vectors. Hum Gene Ther 2001; 12:839-846.
    • (2001) Hum Gene Ther , vol.12 , pp. 839-846
    • Thomas, C.E.1    Schiedner, G.2    Kochanek, S.3    Castro, M.G.4    Lowenstein, P.R.5
  • 9
    • 0029760296 scopus 로고    scopus 로고
    • Role of T cells in inflammation caused by adenovirus vectors in the brain
    • Byrnes AP, Wood MJ, Charlton HM. Role of T cells in inflammation caused by adenovirus vectors in the brain. Gene Ther 1996; 3:644-651.
    • (1996) Gene Ther , vol.3 , pp. 644-651
    • Byrnes, A.P.1    Wood, M.J.2    Charlton, H.M.3
  • 10
    • 0000557447 scopus 로고    scopus 로고
    • The viruses and their replication
    • Fields B, Knipe DM, Howley PM, editors, Philadelphia: Lippincott-Raven;
    • Shenk T. The viruses and their replication. In: Fields B, Knipe DM, Howley PM, editors. Fundamental virology. Philadelphia: Lippincott-Raven; 1996.
    • (1996) Fundamental virology
    • Shenk, T.1
  • 11
    • 0029928417 scopus 로고    scopus 로고
    • The expanding universe of T-cell subsets: Th1, Th2 and more
    • Mosmann TR, Sad S. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol Today 1996; 17:138-146.
    • (1996) Immunol Today , vol.17 , pp. 138-146
    • Mosmann, T.R.1    Sad, S.2
  • 12
    • 5444266659 scopus 로고    scopus 로고
    • Local adenoviral expression of Fas ligand upregulates pro-inflammatory immune responses in the CNS
    • Regardsoe EL, McMenamin MM, Charlton HM, Wood MJ. Local adenoviral expression of Fas ligand upregulates pro-inflammatory immune responses in the CNS. Gene Ther 2004; 11:1462-1474.
    • (2004) Gene Ther , vol.11 , pp. 1462-1474
    • Regardsoe, E.L.1    McMenamin, M.M.2    Charlton, H.M.3    Wood, M.J.4
  • 13
    • 0029062270 scopus 로고
    • Adenovirus gene transfer causes inflammation in the brain
    • Byrnes AP, Rusby JE, Wood MJ, Charlton HM. Adenovirus gene transfer causes inflammation in the brain. Neuroscience 1995; 66:1015-1024.
    • (1995) Neuroscience , vol.66 , pp. 1015-1024
    • Byrnes, A.P.1    Rusby, J.E.2    Wood, M.J.3    Charlton, H.M.4
  • 14
    • 0028500549 scopus 로고
    • Inflammatory effects of gene transfer into the CNS with defective HSV-1 vectors
    • Wood MJ, Byrnes AP, Pfaff DW, Rabkin SD, Charlton HM. Inflammatory effects of gene transfer into the CNS with defective HSV-1 vectors. Gene Ther 1994; 1:283-291.
    • (1994) Gene Ther , vol.1 , pp. 283-291
    • Wood, M.J.1    Byrnes, A.P.2    Pfaff, D.W.3    Rabkin, S.D.4    Charlton, H.M.5
  • 17
    • 0028937785 scopus 로고
    • Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses
    • Yang Y, Li Q, Ertl HC, Wilson JM. Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses. J Virol 1995; 69:2004-2015.
    • (1995) J Virol , vol.69 , pp. 2004-2015
    • Yang, Y.1    Li, Q.2    Ertl, H.C.3    Wilson, J.M.4
  • 20
    • 0026771135 scopus 로고
    • Tumor necrosis factor (TNF-alpha) and lymphotoxin (TNF-beta)
    • Ruddle NH. Tumor necrosis factor (TNF-alpha) and lymphotoxin (TNF-beta). Curr Opin Immunol 1992; 4:327-332.
    • (1992) Curr Opin Immunol , vol.4 , pp. 327-332
    • Ruddle, N.H.1
  • 22
    • 0031581174 scopus 로고    scopus 로고
    • Promoter attenuation in gene therapy: Interferon-gamma and tumor necrosis factor-alpha inhibit transgene expression
    • Qin L, Ding Y, Pahud DR, Chang E, Imperiale MJ, Bromberg JS. Promoter attenuation in gene therapy: interferon-gamma and tumor necrosis factor-alpha inhibit transgene expression. Hum Gene Ther 1997; 8: 2019-2029.
    • (1997) Hum Gene Ther , vol.8 , pp. 2019-2029
    • Qin, L.1    Ding, Y.2    Pahud, D.R.3    Chang, E.4    Imperiale, M.J.5    Bromberg, J.S.6
  • 23
    • 33746724668 scopus 로고    scopus 로고
    • Effects of cytokines and infections on brain neurochemistry
    • Dunn AJ. Effects of cytokines and infections on brain neurochemistry. Clin Neurosci Res 2006; 6:52-68.
    • (2006) Clin Neurosci Res , vol.6 , pp. 52-68
    • Dunn, A.J.1
  • 24
    • 37349041351 scopus 로고    scopus 로고
    • Role of astrocytes and chemokine systems in acute TNFalpha induced demyelinating syndrome: CCR2-dependent signals promote astrocyte activation and survival via NF-kappaB and Akt
    • Quinones MP, Kalkonde Y, Estrada CA, Jimenez F, Ramirez R, Mahimainathan L, et al. Role of astrocytes and chemokine systems in acute TNFalpha induced demyelinating syndrome: CCR2-dependent signals promote astrocyte activation and survival via NF-kappaB and Akt. Mol Cell Neurosci 2008; 37:96-109.
    • (2008) Mol Cell Neurosci , vol.37 , pp. 96-109
    • Quinones, M.P.1    Kalkonde, Y.2    Estrada, C.A.3    Jimenez, F.4    Ramirez, R.5    Mahimainathan, L.6
  • 25
    • 35348828497 scopus 로고    scopus 로고
    • Th1 or Th2 balance regulated by interaction between dendritic cells and NKT cells
    • Onoe K, Yanagawa Y, Minami K, Iijima N, Iwabuchi K. Th1 or Th2 balance regulated by interaction between dendritic cells and NKT cells. Immunol Res 2007; 38:319-332.
    • (2007) Immunol Res , vol.38 , pp. 319-332
    • Onoe, K.1    Yanagawa, Y.2    Minami, K.3    Iijima, N.4    Iwabuchi, K.5
  • 26
    • 0028116618 scopus 로고
    • Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease
    • Racke MK, Bonomo A, Scott DE, Cannella B, Levine A, Raine CS, et al. Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease. J Exp Med 1994; 180:1961-1966.
    • (1994) J Exp Med , vol.180 , pp. 1961-1966
    • Racke, M.K.1    Bonomo, A.2    Scott, D.E.3    Cannella, B.4    Levine, A.5    Raine, C.S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.