Native polycystin 2 functions as a plasma membrane Ca2+-permeable cation channel in renal epithelia

Molecular and Cellular Biology

Volumn 23, Issue 7, 2003, Pages 2600-2607

  Luo, Ying ^a   Vassilev, Peter M ^a   Li, Xiaogang ^a   Kawanabe, Yoshifumi ^a   Zhou, Jing ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CATION CHANNEL; CELL SURFACE PROTEIN; CHAPERONE; POLYCLONAL ANTIBODY; POLYCYSTIN;

ANIMAL CELL; ARTICLE; BIOTINYLATION; CALCIUM TRANSPORT; CELL MEMBRANE; CELL STRAIN; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; KIDNEY EPITHELIUM; KIDNEY POLYCYSTIC DISEASE; MOUSE; MUTATION; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; SWINE;

ANIMALS; ANTIBODY SPECIFICITY; BIOTINYLATION; CALCIUM; CATIONS; CELL MEMBRANE; CELLS, CULTURED; DOGS; EPITHELIAL CELLS; FLUORESCENT ANTIBODY TECHNIQUE; ION CHANNELS; KIDNEY; MEMBRANE PROTEINS; MICE; POTASSIUM; PRECIPITIN TESTS; SUBCELLULAR FRACTIONS; TRANSFECTION; TRPP CATION CHANNELS;

ANIMALIA; SUS SCROFA; XENOPUS LAEVIS;

EID: 0037378484     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.23.7.2600-2607.2003     Document Type: Article

References (40)

1. Anonymous. 1995. Polycystic kidney disease: the complete structure of the PKD1 gene and its protein. The International Polycystic Kidney Disease Consortium. Cell 81:289-298.
2. Brown, C. R., L. Q. Hong-Brown, and W. J. Welch. 1997. Correcting temperature-sensitive protein folding defects. J. Clin. Investig. 99:1432-1444.
3. Cai, Y., Y. Maeda, A. Cedzich, V. E. Torres, G. Wu, T. Hayashi, T. Mochizuki, J. H. Park, R. Witzgall, and S. Somlo. 1999. Identification and characterization of polycystin-2, the PKD2 gene product. J. Biol. Chem. 274:28557-28565.
4. Chen, X. Z., P. M. Vassilev, N. Basora, J. B. Peng, H. Nomura, Y. Segal, E. M. Brown, S. T. Reeders, M. A. Hediger, and J. Zhou. 1999. Polycystin-L is a calcium-regulated cation channel permeable to calcium ions. Nature 401:383-386.
5. Delmas, P., H. Nomura, X. Li, M. Lakkis, Y. Luo, Y. Segal, J. M. Fernandez-Fernandez, P. Harris, A. M. Frischauf, D. A. Brown, and J. Zhou. 2002. Constitutive activation of G-proteins by polycystin-1 is antagonized by polycystin-2. J. Biol. Chem. 277:11276-11283.
6. Denning, G. M., M. P. Anderson, J. F. Amara, J. Marshall, A. E. Smith, and M. J. Welsh. 1992. Processing of mutant cystic fibrosis transmembrane conductance regulator is temperature-sensitive. Nature 358:761-764.
7. Foggensteiner, L., A. P. Bevan, R. Thomas, N. Coleman, C. Boulter, J. Bradley, O. Ibraghimov-Beskrovnaya, K. Klinger, and R. Sandford. 2000. Cellular and subcellular distribution of polycystin-2, the protein product of the PKD2 gene. J. Am. Soc. Nephrol. 11:814-827.
8. Geng, L., Y. Segal, B. Peissel, N. Deng, Y. Pei, F. Carone, H. G. Rennke, A. M. Glucksmann-Kuis, M. C. Schneider, M. Ericsson, S. T. Reeders, and J. Zhou. 1996. Identification and localization of polycystin, the PKD1 gene product. J. Clin. Investig. 98:2674-2682.
9. 2+-permeable nonselective cation channel. Proc. Natl. Acad. Sci. USA 98:1182-1187.
10. Gonzalez-Perrett, S., M. Batelli, K. Kim, M. Essafi, G. Timpanaro, N. Moltabetti, I. L. Reisin, M. A. Arnaout, and H. F. Cantiello. 2002. Voltage dependence and pH regulation of human polycystin-2 mediated cation channel activity. J. Biol. Chem. 277:24959-24966.
11. Guo, L., T. H. Schreiber, S. Weremowicz, C. C. Morton, C. Lee, and J. Zhou. 2000. Identification and characterization of a novel polycystin family member, polycystin-L2, in mouse and human: sequence, expression, alternative splicing, and chromosomal localization. Genomics 64:241-251.
12. Hamill, O. P., A. Marty, E. Neher, B. Sakmann, and F. J. Sigworth. 1981. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch. 391:85-100.
13. Hanaoka, K., F. Qian, A. Boletta, A. K. Bhunia, K. Piontek, L. Tsiokas, V. P. Sukhatme, W. B. Guggino, and G. G. Germino. 2000. Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents. Nature 408:990-994.
14. Hou, X., M. Mrug, B. K. Yoder, E. J. Lefkowitz, G. Kremmidiotis, P. D'Eustachio, D. R. Beier, and L. M. Guay-Woodford. 2002. Cystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney disease. J. Clin. Investig. 109:533-540.
15. Hughes, J., C. J. Ward, R. Aspinwall, R. Butler, and P. C. Harris. 1999. Identification of a human homologue of the sea urchin receptor for eggjelly: a polycystic kidney disease-like protein. Hum. Mol. Genet. 8:543-549.
16. Hughes, J., C. J. Ward, B. Peral, R. Aspinwall, K. Clark, J. L. San Millan, V. Gamble, and P. C. Harris. 1995. The polycystic kidney disease 1 (PKD1) gene encodes a novel protein with multiple cell recognition domains. Nat. Genet. 10:151-160.
17. Ibraghimov-Beskrovnaya, O., W. R. Dackowski, L. Foggensteiner, N. Coleman, S. Thiru, L. R. Petry, T. C. Burn, T. D. Connors, T. Van Raay, J. Bradley, F. Qian, L. F. Onuchic, T. J. Watnick, K. Piontek, R. M. Hakim, G. M. Landes, G. G. Germino, R. Sandford, and K. W. Klinger. 1997. Polycystin: in vitro synthesis, in vivo tissue expression, and subcellular localization identifies a large membrane-associated protein. Proc. Natl. Acad. Sci. USA 94:6397-6402.
18. Jensen, T. J., M. A. Loo, S. Pind, D. B. Williams, A. L. Goldberg, and J. R. Riordan. 1995. Multiple proteolytic systems, including the proteasome, contribute to CFTR processing. Cell 83:129-135.
19. Koulen, P., Y. Cai, L. Geng, Y. Maeda, S. Nishimura, R. Witzgall, B. E. Ehrlich, and S. Somlo. 2002. Polycystin-2 is an intracellular calcium release channel. Nat. Cell Biol. 4:191-197.
20. Mochizuki, T., G. Wu, T. Hayashi, S. L. Xenophontos, B. Veldhuisen, J. J. Saris, D. M. Reynolds, Y. Cai, P. A. Gabow, A. Pierides, W. J. Kimberling, M. H. Breuning, C. C. Deltas, D. J. Peters, and S. Somlo. 1996. PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein. Science 272:1339-1342.
21. Nauli, S. M., F. J. Alenghat, Y. Luo, E. Williams, P. Vassilev, X. Li, A. E. H. Elia, W. Lu, E. M. Brown, S. J. Quinn, D. E. Ingber, and J. Zhou. 2003. Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat. Genet. 33:129-137.
22. Newby, L. J., A. J. Streets, Y. Zhao, P. C. Harris, C. J. Ward, and A. C. Ong. 2002. Identification, characterization, and localization of a novel kidney polycystin-1-polycystin-2 complex. J. Biol. Chem. 277:20763-20773.
23. Nomura, H., A. E. Turco, Y. Pei, L. Kalaydjieva, T. Schiavello, S. Weremowicz, W. Ji, C. C. Morton, M. Meisler, S. T. Reeders, and J. Zhou. 1998. Identification of PKDL, a novel polycystic kidney disease 2-like gene whose murine homologue is deleted in mice with kidney and retinal defects. J. Biol. Chem. 273:25967-25973.
24. Parnell, S. C., B. S. Magenheimer, R. L. Maser, C. A. Zien, A. M. Frischauf, and J. P. Calvet. 2002. Polycystin-1 activation of c-Jun N-terminal kinase and AP-1 is mediated by heterotrimeric G proteins. J. Biol. Chem. 277:19566-19572.
25. Pazour, G. J., S. A. Baker, J. A. Deane, D. G. Cole, B. L. Dickert, J. L. Rosenbaum, G. B. Witman, and J. C. Besharse. 2002. The intraflagellar transport protein, IFT88, is essential for vertebrate photoreceptor assembly and maintenance. J. Cell Biol. 157:103-113.
26. Pazour, G. J., J. T. San Agustin, J. A. Follit, J. L. Rosenbaum, and G. B. Witman. 2002. Polycystin-2 localizes to kidney cilia and the ciliary level is elevated in orpk mice with polycystic kidney disease. Curr. Biol. 12:R378-R380.
27. Peters, D. J., A. van de Wal, L. Spruit, J. J. Saris, M. H. Breuning, J. A. Bruijn, and E. de Heer. 1999. Cellular localization and tissue distribution of polycystin-1. J. Pathol. 188:439-446.
28. Qian, F., F. J. Germino, Y. Cai, X. Zhang, S. Somlo, and G. G. Germino. 1997. PKD1 interacts with PKD2 through a probable coiled-coil domain. Nat. Genet. 16:179-183.
29. Sato, S., C. L. Ward, M. E. Krouse, J. J. Wine, and R. R. Kopito. 1996. Glycerol reverses the misfolding phenotype of the most common cystic fibrosis mutation. J. Biol. Chem. 271:635-638.
30. Scheffers, M. S., H. Le, P. van der Bent, W. Leonhard, F. Prins, L. Spruit, M. H. Breuning, E. de Heer, and D. J. Peters. 2002. Distinct subcellular expression of endogenous polycystin-2 in the plasma membrane and Golgi apparatus of MDCK cells. Hum. Mol. Genet. 11:59-67.
31. Taulman, P. D., C. J. Haycraft, D. F. Balkovetz, and B. K. Yoder. 2001. Polaris, a protein involved in left-right axis patterning, localizes to basal bodies and cilia. Mol. Biol. Cell 12:589-599.
32. 2+ with quin2. Methods Enzymol. 172:230-262.
33. Tsiokas, L., T. Arnould, C. Zhu, E. Kim, G. Walz, and V. P. Sukhatme. 1999. Specific association of the gene product of PKD2 with the TRPC1 channel. Proc. Natl. Acad. Sci. USA 96:3934-3939.
34. Tsiokas, L., E. Kim, T. Arnould, V. P. Sukhatme, and G. Walz. 1997. Homo- and heterodimeric interactions between the gene products of PKD1 and PKD2. Proc. Natl. Acad. Sci. USA 94:6965-6970.
35. Valentijn, J. A., G. K. Fyfe, and C. M. Canessa. 1998. Biosynthesis and processing of epithelial sodium channels in Xenopus oocytes. J. Biol. Chem. 273:30344-30351.
36. 2+ homeostasis in polycystic kidney disease. Biochem. Biophys. Res. Commun. 282:341-350.
37. Ward, C. L., S. Omura, and R. R. Kopito. 1995. Degradation of CFTR by the ubiquitin-proteasome pathway. Cell 83:121-127.
38. Wu, G., T. Hayashi, J. H. Park, M. Dixit, D. M. Reynolds, L. Li, Y. Maeda, Y. Cai, M. Coca-Prados, and S. Somlo. 1998. Identification of PKD2L, a human PKD2-related gene: tissue-specific expression and mapping to chromosome 10q25. Genomics 54:564-568.
39. Yoder, B. K., A. Tousson, L. Millican, J. H. Wu, C. E. Bugg, Jr., J. A. Schafer, and D. F. Balkovetz. 2002. Polaris, a protein disrupted in orpk mutant mice, is required for assembly of renal cilium. Am. J. Physiol. Renal Physiol. 282:F541-F552.
40. Yuasa, T., B. Venugopal, S. Weremowicz, C. C. Morton, L. Guo, and J. Zhou. 2002. The sequence, expression, and chromosomal localization of a novel polycystic kidney disease 1-like gene, PKD1L1, in human. Genomics 79:376-386.