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Volumn , Issue 12, 2002, Pages 1663-1668

Synthesis of isoxazolines and isoxazoles using poly(ethylene glycol) as support

Author keywords

Cycloaddition; Isoxazoles; Isoxazolines; Liquid phase; Poly(ethylene glycol)

Indexed keywords

ADDITION REACTIONS; SYNTHESIS (CHEMICAL);

EID: 0036992625     PISSN: 00397881     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2002-33655     Document Type: Article
Times cited : (38)

References (20)
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    • Reviews on liquid-phase organic synthesis (LPOS): (a) Gravert, D. J.; Janda, K. D. Chem. Rev. 1997, 97, 489. (b) Harwig, C. W.; Gravert, D. J.; Janda, K. D. Chemtracts: Org. Chem. 1999, 12, 1. (c) Gravert, D. J.; Janda, K. D. In Molecular Diversity and Combinatorial Synthesis: Libraries and Drug Discovery, ACS Symposium Series; Chaiken, I. M.; Janda, K. D., Eds.; American Chemical Society: Washington DC, 1996, 118-127. (d) Vandersteen, A. M.; Han, H.; Janda, K. D. Mol. Diversity 1996, 2, 89. (e) For a recent example of LPOS, see: Annunziata, R; Benaglia, M.; Cinquini, M.; Cozzi, F. Chem.-Eur. J. 2000, 6, 133.
    • (1997) Chem. Rev. , vol.97 , pp. 489
    • Gravert, D.J.1    Janda, K.D.2
  • 7
    • 0032848810 scopus 로고    scopus 로고
    • Reviews on liquid-phase organic synthesis (LPOS): (a) Gravert, D. J.; Janda, K. D. Chem. Rev. 1997, 97, 489. (b) Harwig, C. W.; Gravert, D. J.; Janda, K. D. Chemtracts: Org. Chem. 1999, 12, 1. (c) Gravert, D. J.; Janda, K. D. In Molecular Diversity and Combinatorial Synthesis: Libraries and Drug Discovery, ACS Symposium Series; Chaiken, I. M.; Janda, K. D., Eds.; American Chemical Society: Washington DC, 1996, 118-127. (d) Vandersteen, A. M.; Han, H.; Janda, K. D. Mol. Diversity 1996, 2, 89. (e) For a recent example of LPOS, see: Annunziata, R; Benaglia, M.; Cinquini, M.; Cozzi, F. Chem.-Eur. J. 2000, 6, 133.
    • (1999) Chemtracts: Org. Chem. , vol.12 , pp. 1
    • Harwig, C.W.1    Gravert, D.J.2    Janda, K.D.3
  • 8
    • 3142538092 scopus 로고    scopus 로고
    • Chaiken, I. M.; Janda, K. D., Eds.; American Chemical Society: Washington DC
    • Reviews on liquid-phase organic synthesis (LPOS): (a) Gravert, D. J.; Janda, K. D. Chem. Rev. 1997, 97, 489. (b) Harwig, C. W.; Gravert, D. J.; Janda, K. D. Chemtracts: Org. Chem. 1999, 12, 1. (c) Gravert, D. J.; Janda, K. D. In Molecular Diversity and Combinatorial Synthesis: Libraries and Drug Discovery, ACS Symposium Series; Chaiken, I. M.; Janda, K. D., Eds.; American Chemical Society: Washington DC, 1996, 118-127. (d) Vandersteen, A. M.; Han, H.; Janda, K. D. Mol. Diversity 1996, 2, 89. (e) For a recent example of LPOS, see: Annunziata, R; Benaglia, M.; Cinquini, M.; Cozzi, F. Chem.-Eur. J. 2000, 6, 133.
    • (1996) Molecular Diversity and Combinatorial Synthesis: Libraries and Drug Discovery, ACS Symposium Series , pp. 118-127
    • Gravert, D.J.1    Janda, K.D.2
  • 9
    • 0030252431 scopus 로고    scopus 로고
    • Reviews on liquid-phase organic synthesis (LPOS): (a) Gravert, D. J.; Janda, K. D. Chem. Rev. 1997, 97, 489. (b) Harwig, C. W.; Gravert, D. J.; Janda, K. D. Chemtracts: Org. Chem. 1999, 12, 1. (c) Gravert, D. J.; Janda, K. D. In Molecular Diversity and Combinatorial Synthesis: Libraries and Drug Discovery, ACS Symposium Series; Chaiken, I. M.; Janda, K. D., Eds.; American Chemical Society: Washington DC, 1996, 118-127. (d) Vandersteen, A. M.; Han, H.; Janda, K. D. Mol. Diversity 1996, 2, 89. (e) For a recent example of LPOS, see: Annunziata, R; Benaglia, M.; Cinquini, M.; Cozzi, F. Chem.-Eur. J. 2000, 6, 133.
    • (1996) Mol. Diversity , vol.2 , pp. 89
    • Vandersteen, A.M.1    Han, H.2    Janda, K.D.3
  • 10
    • 0033985668 scopus 로고    scopus 로고
    • Reviews on liquid-phase organic synthesis (LPOS): (a) Gravert, D. J.; Janda, K. D. Chem. Rev. 1997, 97, 489. (b) Harwig, C. W.; Gravert, D. J.; Janda, K. D. Chemtracts: Org. Chem. 1999, 12, 1. (c) Gravert, D. J.; Janda, K. D. In Molecular Diversity and Combinatorial Synthesis: Libraries and Drug Discovery, ACS Symposium Series; Chaiken, I. M.; Janda, K. D., Eds.; American Chemical Society: Washington DC, 1996, 118-127. (d) Vandersteen, A. M.; Han, H.; Janda, K. D. Mol. Diversity 1996, 2, 89. (e) For a recent example of LPOS, see: Annunziata, R; Benaglia, M.; Cinquini, M.; Cozzi, F. Chem.-Eur. J. 2000, 6, 133.
    • (2000) Chem.-Eur. J. , vol.6 , pp. 133
    • Annunziata, R.1    Benaglia, M.2    Cinquini, M.3    Cozzi, F.4
  • 11
    • 0030883333 scopus 로고    scopus 로고
    • 2 at -78 °C. To circumvent this problem Janda et al. have successfully used noncross-linked chloromethylated polystyrene (NCPS) as a soluble polymer support: Chen, S.; Janda, K. D. J. Am. Chem. Soc. 1997, 119, 8724.
    • (1997) J. Am. Chem. Soc. , vol.119 , pp. 8724
    • Chen, S.1    Janda, K.D.2
  • 15
    • 0345764879 scopus 로고    scopus 로고
    • note
    • A search in MDDR (MDL data base) revealed the presence of more than 250 structures based on the isoxazole scaffold and endowed with several pharmacological activities used for analgesia, inflammation, immunology and CNS diseases (such as anxiety, memory impairment, depression, Parkinson's and stroke).
  • 16
    • 0032563904 scopus 로고    scopus 로고
    • The first example of a liquid-phase 1,3-dipolar cycloaddition reaction was reported by Norris et al.: Moore, M.; Norris, P. Tetrahedron Lett. 1998, 39, 7027.
    • (1998) Tetrahedron Lett. , vol.39 , pp. 7027
    • Moore, M.1    Norris, P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.