Discovery of novel series of benzoic acid derivatives containing biphenyl ether moiety as potent and selective human β3-adrenergic receptor agonists: Part IV

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 18, 2008, Pages 5037-5040

  Nakajima, Yutaka ^a   Imanishi, Masashi ^a   Itou, Shinji ^a   Hamashima, Hitoshi ^a   Tomishima, Yasuyo ^a   Washizuka, Kenichi ^a   Sakurai, Minoru ^a   Matsui, Shigeo ^a   Imamura, Emiko ^a   Ueshima, Koji ^a   Yamamoto, Takao ^a   Yamamoto, Nobuhiro ^a   Ishikawa, Hirofumi ^a   Nakano, Keiko ^a   Unami, Naoko ^a   Hamada, Kaori ^a   Hattori, Kouji ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

3 Adrenergic receptor agonist; Overactive bladder

Indexed keywords

BENZOIC ACID DERIVATIVE; BETA 3 ADRENERGIC RECEPTOR STIMULATING AGENT; BIPHENYL ETHER; DIPHENYL ETHER DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DOG; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; IN VIVO STUDY; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; OVERACTIVE BLADDER; STRUCTURE ACTIVITY RELATION;

ADRENERGIC AGONISTS; ANIMALS; BENZOIC ACIDS; BIPHENYL COMPOUNDS; COMBINATORIAL CHEMISTRY TECHNIQUES; DISEASE MODELS, ANIMAL; DOGS; HUMANS; MOLECULAR STRUCTURE; RECEPTORS, ADRENERGIC, BETA-3; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

CANIS FAMILIARIS;

EID: 51349094588     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.08.009     Document Type: Article

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