Evaluation of bone-to-implant contact and bone density adjacent to titanium implants using a stereological technique on ground sections

Image Analysis and Stereology

Volumn 25, Issue 1, 2006, Pages 13-24

  Balatsouka, Dimitra ^a   Gotfredsen, Klaus ^a   Gundersen, Hans Jørgen G ^b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Efficiency; Histomorphometric measurements; Stereology; Systematic sampling; Vertical sections

Indexed keywords

EID: 51149098857     PISSN: 15803139     EISSN: 18545165     Source Type: Journal    
DOI: 10.5566/ias.v25.p13-24     Document Type: Article

References (31)

1. Albrektsson T, Brânemark PI, Hansson H, Lindström J (1981). Osseointegrated titanium implants. Requirements for ensuring a long-lasting, direct bone-to-implant anchorage in man. Acta Orthopaedica Scandinavica 52:155-70.
2. Albrektsson T (1988). A multicenter report on osseo-integrated oral implants. J Prosthet Dent 60:75-84.
3. Baddeley AJ, Gundersen HJG, Cruz-Orive LM (1986). Estimation of surface area from vertical sections. J Microsc 142:259-76.
4. Balatsouka D, Gotfredsen K, Lindh CH, Berglundh T (2005). The impact of nicotine on bone healing and osseointegration. An experimental study in rabbits. Clin Oral Impl Res 16:268-76.
5. Cruz-Orive LM (1987). Stereology: recent solutions to old problems and a glimpse into the future. Proc. ICS VII Caen 1987. Acta Stereol 6(III):3-18.
6. Cruz-Orive LM, Weibel ER (1990). Recent stereological methods for cell biology: a brief survey. A J Physiol 258:L148-56.
7. Cruz-Orive LM, Roberts N (1993). Unbiased volume estimation with coaxial sections: an application to the human bladder. J Microsc 170:25-33.
8. Fini M, Gianluca G, Rimondini L, Giardino R (2002). Titanium Alloy Osseointegration in Cancellous and Cortical Bone of Ovariectomized Animals: Histomorpho-metric and Bone Hardness Measurements. Int J Oral Maxillofac Implants 17:28-37.
9. Gotfredsen K, Budtz-Jorgensen E, Jensen LN (1989). A method for preparing and staining histological sections containing titanium implants for light microscopy. Stain Technol 64:121-7.
10. Gotfredsen K, Rostrup E, Hjörting-Hansen E, Stoltze K, Jörgensen B (1991). Histological and histomorpho-metric evaluation of tissue reactions adjacent to endosteal implants in monkeys. Clin Oral Impl Res 2:30-7.
11. Gotfredsen K, Nimb L, Buser D, Hjorting-Hansen E (1993). Evaluation of guided bone regeneration around implants placed into fresh extraction sockets. An experimental study in dogs. Int J Oral Maxillofac Surg 51:879-84.
12. Gotfredsen K, Berghlund T, Lindhe J (2000). The anchorage of titanium implants with different surface characteristics. An experimental study in rabbits. Clin Impl Dent Rel Res 2:120-8.
13. Gotfredsen K, Berglundh, Lindhe J (2001). Bone reactions adjacent to titanium implants subjected to static load. A study in the dog (I). Clin Oral Impl Res 12:1-8.
14. Gundersen HJG, Osterby R (1981). Optimizing sampling efficiency of stereological studies in biology: or 'do more less well'. J Microsc 121:65-73.
15. Gundersen HJ, Bendtsen TF, Korbo L, Marcussen N, Moller A, Nielsen K et al. (1988). Some new, simple and efficient stereologics methods and their use in pathological research and diagnosis. APMIS 96:379-94.
16. Gundersen HJG, Jensen EB (1987). The efficiency of systematic sampling in stereology and its prediction. J Microsc 147:229-63.
17. Gundersen HJG, Jensen EB, Kieu K, Nielsen J (1999). The efficiency of systematic sampling in stereology-reconsidered. J Microsc 193:199-211.
18. Ivanoff CJ, Sennerby L, Johansson C, Rangert B, Lekholm U (1997). Influence of implant diameters on the integration of screw implants. An experimental study in rabbits. Int J Oral Maxillofac Surg 26:141-8.
19. Jensen EBV, Gundersen HJG (1993). The rotator. J Microsc 170:35-44.
20. Johansson CB (1991). On tissue reactions to metal implants. PhD dissertation, Götenborg, Sweden, ISBN: 91-628-0223-2.
21. Kolonidis S, Renvert S, Hämmerle CHF, Lang N, Harris D, Claffey N (2003). Osseointegraion on implant surfaces previously conamnated with plaque. An experimental study in the dog. Clin Oral Impl Res 14:373-80.
22. Miranov JrAA, Miranov AA (1998). Estimation of subcellular organelle volume from ultra-thin sections through centrioles with a discretized version of the vertical rotator. J Microsc 192:29-36.
23. Overgaard S, Bromose U, Lind M, Bunger C, Soballe K (1999). The influence of crystallinity of the hydroxyapatite coating on the fixation of implants. Mechanical and histomorphometric results. J Bone Joint Surgery Br 81:725-31.
24. Overgaard S (2000). Calcium phosphate coatings for fixation of bone implants evaluated mechanically and histologically by stereological methods. PhD dissertation. Acta Orthopaedica Scandinavica 71 (Suppl 297):1-74.
25. Overgaard S, Soballe K, Gundersen HJG (2000). Efficiency of systematic sampling in histomorhometric bone research illustrated by hydroxyapatite-coated implants: Optimizing the stereological vertical-section design. J Orthop Res 18:313-21.
26. Rahbek O (2002). The influence of hydroxyapatite coating on the peri-implant migration of polyethylene particles. PhD dissertation, Aarhus, Denmark.
27. Rasmusson L, Kahnberg KE, Tan A (2001). Effects of Implant Design and Surface on Bone Regeneration and Implant Stability: An Experimental Study in the Dog Mandible. Clin Impl Dent and Rel Res 3:2-8.
28. Romanos GE, Toh CG, Siar CH, Swaminathan D (2002). Histologic and Histomorphometric Evaluation of Periimplant Bone Subjected to Immediate Loading: An Experimental Study with Macaca Fascicularis. Int J Oral Maxillofac Implants 17:44-51.
29. Schou S, Holmstrup P, Skovgaard LT, Hjorting-Hansen E, Gundersen HJG (2003). Autogenous bone graft and ePTFE membrane in the treatment of peri-implantitis. II. Stereologic and histologic observations in cynomolgus monkeys. Clin Oral Impl Res 14:404-11.
30. Sennerby L, Ericson LE, Thomsen P, Lekholm U, Âstrand P (1991). Structure of the bone-titanium interface in retrieved clinical oral implants. Clin Oral Impl Res 2:103-11.
31. Vesterby A, Kragstrup J, Gundersen HJG, Melsen F (1987). Unbiased stereologic estimation of surface density in bone using vertical sections. Bone 8:13-7.