Titanium Alloy Osseointegration in Cancellous and Cortical Bone of Ovariectomized Animals: Histomorphometric and Bone Hardness Measurements

International Journal of Oral and Maxillofacial Implants

Volumn 17, Issue 1, 2002, Pages 28-37

  Fini, Milena ^a   Giavaresi, Gianluca ^a   Rimondini, Lia ^b   Giardino, Roberto ^a,c  

^a RIZZOLI ORTHOPAEDIC INSTITUTE   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Bone biomaterial interface; Implant; Microhardness; Osseointegration; Osteoporosis; Titanium alloy

Indexed keywords

DENTAL ALLOY; TITANIUM; TITANIUM ALLOY (TIAL6V4);

ANIMAL; ARTICLE; BONE; BONE DENSITY; BONE REGENERATION; FEMALE; HARDNESS; IMPLANT; OSTEOPOROSIS; OVARIECTOMY; OVARY; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RAT; SHEEP; TIBIA;

ANIMALS; BONE AND BONES; BONE DENSITY; DENTAL ALLOYS; FEMALE; HARDNESS; IMPLANTS, EXPERIMENTAL; OSSEOINTEGRATION; OSTEOPOROSIS; OVARIECTOMY; OVARY; RATS; SHEEP; TIBIA; TITANIUM;

EID: 0036365395     PISSN: 08822786     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (61)

1. Kleerekoper M, Avioli LV. Osteoporosis pathogenesis and therapy. In: Avioli LV, Krane SM (eds). Metabolic bone disease. San Diego: Academic Press, 1998:387-409.
2. Dao TTT, Andersen JD, Zarb GA. Is osteoporosis a risk factor for osseointegration of dental implants? Int J Oral Maxillofac Implants 1993;8:137-144.
3. Cheng S, Toivanen JA, Suominen H, Toivanen JT, Timonen J. Estimation of structural and geometrical properties of cortical bone by computerized tomography in 78-year-old women. J Bone Miner Res 1995;10:139-148.
4. Ruff CB, Hayes WC. Sex differences in age-related remodeling of the femur and tibia. J Orthop Res 1988;6:886-896.
5. Krall EA, Garcia RI, Dawson-Hughes B. Increased risk of tooth loss is related to bone loss at the whole body, hip, and spine. Calcif Tissue Int 1996;59:433-437.
6. Kannus P, Niemi S, Palvanen M, Parkkari J. Continuously increasing number and incidence of fall-induced, fracture-associated, spinal cord injuries in elderly persons. Arch Intern Med 2000;160:2145-2149.
7. Miller SC, Hunziker J, Mechman M, Wronsky TJ. Intermittent parathyroid hormone administration stimulus bone formation in the mandibles of aged ovariectomized rats. J Dent Res 2000;76:1471-1476.
8. Von Wowern N, Klausen B, Kollerup G. Osteoporosis: A risk factor in periodontal disease. J Periodontol 1994;65: 1134-1138.
9. Miller SC, Bowman BM, Miller MA, Bagi CM. Calcium absorption and osseous organ-, tissue-, and envelope-specific changes following ovariectomy in rats. Bone 1992;12: 439-446.
10. Nishimura I, Hosokawa R, Atwood DA. The knife-edge tendency in mandibular residual ridges in women. J Prosthet Dent 1992;67:820-826.
11. Bollen AM, Taguchi A, Hujoel PP, Hollender LG. Case-control study on self-reported osteoporotic fractures and mandibular cortical bone. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2000;90:518-524.
12. Kribbs PJ. Comparison of mandibular bone in normal and osteoporotic women. J Prosthet Dent 1990;63:218-222.
13. Becker W, Hujoel PP, Becker BE, Willingham H. Osteoporosis and implant failure: An exploratory case-control study. J Periodontol 2000;71:625-631.
14. Fujimoto T, Niimi A, Nakai H, Ueda M. Osseointegrated implants in a patient with osteoporosis: A case report. Int J Oral Maxillofac Implants 1996;11:539-542.
15. Barrios C, Brostrom LA, Stark A, Walheim G. Healing complications after internal fixation of trochanteric hip fractures: The prognostic value of osteoporosis. J Orthop Trauma 1993;7:438-442.
16. Blomqvist JE, Alberius P, Isaksson S, Linde A, Hansson BG. Factors in implant osteointegration failure after bone grafting. An osteometric and endocrinologic matched analysis. Int J Oral Maxillofac Surg 1996;25:63-68.
17. Roberts WE, Simmons KE, Garetto LP, DeCastro RA. Bone physiology and metabolism in dental implantology: Risk factors for osteoporosis and other metabolic bone diseases. Implant Dent 1992;1:11-21.
18. Weber RL, Wiesen MJ, Iacono VJ, Baer PN. Osteoporosis: A risk factor for dental implants and in the prognosis of periodontal therapy. Periodontal Clin Investig 1997;19:5-8.
19. Celiker R, Arslan S. IGF-I levels were found to be lower in women with osteoporosis. Rheumatol Int 2000;19:205-208.
20. Marie PJ. Cellular and molecular alterations of osteoblasts in human disorders of bone formation. Histol Histopathol 1999;14:525-538.
21. Linkhart TA, Mohan S, Baylink KDJ. Growth factors for bone growth and repair: IGF, TGF beta and BMP. Bone 1996;19:1S-12S.
22. Jilka RL. Cytokines, bone remodeling, and estrogen deficiency: A 1998 update. Bone 1998;23:75-81.
23. Raltson SH. Role of cytokines in clinical disorders of bone metabolism. In: Gowen M (ed). Cytokine and Bone Metabolism. Boca Raton: CRC, 1992:362-367.
24. Fini M, Nicoli Aldini N, Gandolfi MG, et al. Biomaterials for orthopaedic surgery in osteoporotic bone: A comparative study in osteopenic rats. Int J Artif Organs 1997;20:291-297.
25. Fini M, Giavaresi G, Nicoli Aldini N, et al. The effect of osteopenia on the osteointegration of different biomaterials: Histomorphometric study in rats. J Mat Sci Mat Med 2000; 11:579-585.
26. Fini M, Giavaresi G, Torricelli P, et al. Biocompatibility and osseointegration in osteoporotic bone. A preliminary in vitro and in vivo study. J Bone Joint Surg Br 2001;83:139-143.
27. Hara T, Hayashi K, Nakashima Y, Kanemaru T, Iwamoto Y. The effect of hydroxyapatite coating on the bonding of bone to titanium implants in the femora of ovariectomised rats. J Bone Joint Surg Br 1999;81:705-709.
28. Yamazaki M, Shirota T, Tokugawa Y, et al. Bone reactions to titanium screw implants in ovariectomized animals. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1999;87: 411-418.
29. Pan J, Shirota T, Ohno K, Michi K. Effect of ovariectomy on bone remodeling adjacent to hydroxyapatite-coated implants in the tibia of mature rats. J Oral Maxillofac Surg 2000;58:877-882.
30. Mori H, Manabe M, Kurachi Y, Nagumo M. Osseointegration of dental implants in rabbit bone with low mineral density. J Oral Maxillofac Surg 1997;55:351-361.
31. Fujimoto T, Niimi A, Sawai T, Ueda M. Effects of steroid-induced osteoporosis on osseointegration of titanium implants. IntJ Oral Maxillofac Implants 1998;13:183-189.
32. Hayashi K, Uenoyama K, Mashima T, Sugioka Y. Remodeling of bone around hydroxyapatite and titanium in experimental osteoporosis. Biomaterials 1994;15:11-16.
33. Takeshita F, Iyama S, Ayukawa Y, Kido MA, Murai K, Suetsugu T. The effects of diabetes on the interface between hydroxyapatite implants and bone rat tibia. J Periodontol 1997;68:180-185.
34. Oleksik A, Lips P, Dawson A, et al. Health-related quality of life in postmenopausal women with low BMD with or without prevalent vertebral fractures. J Bone Miner Res 2000;15: 1384-1392.
35. Giavaresi G, De Terlizzi F, Gnudi S, et al. Discriminant capacity of quantitative ultrasound versus dual-X-ray absorptiometry to determine cancellous bone loss in ovariectomized rats. Bone 2000;26:297-303.
36. Fini M, Pierini G, Giavaresi G, et al. The ovariectomised sheep as a model for testing biomaterials and prosthetic devices in osteopenic bone: a preliminary study on iliac crest biopsies. Int J Artif Organs 2000;23:275-281.
37. Parfitt AM, Drezner MK, Glorieux FH, et al. Bone histomorphometry: Standardization of nomenclature, symbols and units. J Bone Miner Res 1987;2:595-610.
38. Huja SS, Katona TR, Roberts WE. Microhardness testing of bone. In: An YH, Draughin RA (eds). Mechanical testing of bone and the bone-implant interface. Boca Raton: CRC, 1999:247-256.
39. Wiktorowicz ME, Goeree R, Papaioannou A, Adachi JD, Papadimitropoulos E. Economic implications of hip fracture: Health service use, institutional care and cost in Canada. Osteoporos Int 2001;12:271-278.
40. Wheeler DL, Eschbach EJ, Montfort MJ, Maleshwari P, McLoughlin SW. Mechanical strength of fracture callus in osteopenic bone at different phases of healing. J Orthop Trauma 2000;2:86-92.
41. Soballe K. Hydroxyapatite ceramic coating for bone implant fixation. Acta Orthop Scand 1993;255:1-57.
42. Glowachki J, Spector M. Tissue responses to bone-derived and synthetic materials. In: Davies JE (ed). The Bone Biomaterial Interface. Toronto: Toronto Press, 1991:265-274.
43. Walsh WR, Sherman P, Howlett CR, Sonnabend DH, Ehrlich MG. Fracture healing in a rat osteopenia model. Clin Orthop 1997;342:218-227.
44. Muschler GF, Lane JM. Orthopaedic surgery. In: Habal MB, Hari Reddi A (eds). Bone Grafts and Bone Substitutes. Philadelphia: WB Saunders, 1992:375-407.
45. Kubo T, Shiga T, Hashimoto J, et al. Osteoporosis influences the late period of fracture healing in a rat model by ovariectomy and low calcium diet. J Steroid Biochem Mol Biol 1999;68:197-202.
46. Namkung-Matthal H, Appleyard R, Jansen J, et al. Osteoporosis influences the early period of fracture healing in a rat osteoporotic model. Bone 2001;28:80-86.
47. Chappard D, Aguado E, Hurè G, Grizon F, Basle MF. The early remodeling phases around titanium implants: A histomorphometric assessment of bone quality in a 3-and 6-month study in sheep. IntJ Oral Maxillofac Implants 1999;14:189-196.
48. Yamazaki I, Yamaguchi H. Characteristics of an ovariectomized osteopenic rat model. J Bone Miner Res 1989;4: 13-22.
49. Frost HM, Jee WSS. On the rat model of human osteopenias and osteoporoses. Bone Miner 1992;18:227-236.
50. Martin RB, Paul HA, Bargar WL, Dannucci GA, Sharkey NA. Effects of estrogen deficiency on the growth of tissue into porous titanium implants. J Bone Joint Surg Am 1988; 70:540-547.
51. ISO 10993:1994, Biological evaluation of medical devices-Part 6: Tests for local effects after implantation.
52. Newman E, Turner AS, WarkJD. The potential of sheep for the study of osteopenia: Current status and comparison with other animal models. Bone 1995;4:277S-284S.
53. Bellino FL. Nonprimate animal models of menopause: Workshop report. Menopause 2000;7:14-24.
54. Thorndike EA, Turner AS. In search of an animal model for postmenopausal diseases. Front Biosci 1998;3:17-26.
55. Thompson DD, Simmons HA, Pirie CM, Ke HZ. FDA guidelines and models for osteoporosis. Bone 1995;17: 125-133.
56. Stea S, Visentin M, Savarino L, et al. Microhardness of bone at the interface with ceramic-coated metal implants. J Biomed Mater Res 1995;29:695-699.
57. Moroni A, Caja VL, Maltarello MC, et al. Biochemical, scanning electron microscopy, and microhardness analyses of the bone pin interface in hydroxyapatite coated vs uncoated pins. J Orthop Trauma 1997;11:154-161.
58. Savarino S, Stea S, Ciapetti G, et al. Microstructural investigation of bone cement interface. J Biomed Mater Res 1995; 29:701-705.
59. Huja SS, Katona TR, Moore BK, Roberts WE. Microhardness and anisotropy of the vital osseous interface and endosseous implants supporting bone. J Orthop Res 1998; 16:54-60.
60. Hämmerle CHF, Lang NP. Tissue integration of oral implants. In: Lang NP, Karring T (eds). Proceedings of the 1st European Workshop on Periodontology. London: Quintessence, 1994:297-316.
61. Buser D. Effects of various titanium surface configurations on osseointegration and clinical implant stability. In: Lang NP, Karring T, Lindhe LJ (eds). Proceedings of the 3rd European Workshop on Periodontology-Implant Dentistry. London: Quintessence, 1999:88-101.