Aerosolized STAT1 antisense oligodeoxynucleotides decrease the concentrations of inflammatory mediators in bronchoalveolar lavage fluid in bleomycin-induced rat pulmonary fibrosis

Cellular and Molecular Immunology

Volumn 5, Issue 3, 2008, Pages 219-224

  Zeng, Ming ^a   Liao, Bin ^a   Zhu, Chen ^a   Wang, Wenjun ^a   Zhan, Xiaoqin ^a   Fan, Xianming ^a  

^a SOUTHWEST MEDICAL UNIVERSITY   (China)

Author keywords

aerosolization; ASON; inflammatory mediator; Pulmonary fibrosis; STAT1

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; AUTACOID; BLEOMYCIN; INTERCELLULAR ADHESION MOLECULE 1; LIPOSOME; PLATELET DERIVED GROWTH FACTOR; STAT1 PROTEIN; STAT1 PROTEIN, RAT; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

AEROSOL; ANIMAL; ARTICLE; CHEMICALLY INDUCED DISORDER; CHEMISTRY; CYTOLOGY; FEMALE; GENETIC TRANSFECTION; GENETICS; IMMUNOLOGY; LUNG; LUNG ALVEOLUS MACROPHAGE; LUNG FIBROSIS; LUNG LAVAGE; METABOLISM; RAT; WISTAR RAT;

AEROSOLS; ANIMALS; BLEOMYCIN; BRONCHOALVEOLAR LAVAGE FLUID; FEMALE; INFLAMMATION MEDIATORS; INTERCELLULAR ADHESION MOLECULE-1; LIPOSOMES; LUNG; MACROPHAGES, ALVEOLAR; OLIGONUCLEOTIDES, ANTISENSE; PLATELET-DERIVED GROWTH FACTOR; PULMONARY FIBROSIS; RATS; RATS, WISTAR; STAT1 TRANSCRIPTION FACTOR; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 51049109902     PISSN: 16727681     EISSN: None     Source Type: Journal    
DOI: 10.1038/cmi.2008.27     Document Type: Article

References (24)

1. Gharaee-kermani M, Hu B, Thannickal VJ, Phan SH, Gyetko MR. Current and emerging drugs for idiopathic pulmonary fibrosis. Expert Opin Emerg Drugs. 2007;12:627-646. (Pubitemid 350189128)
2. Scotton CJ, Chambers RC. Molecular targets in pulmonary fibrosis. The myofibroblast in focus. Chest. 2007;132:1311-1321. (Pubitemid 47621009)
3. Scheule RK, Perkins RC, Hamilton R, Holian A. Bleomycin stimulation of cytokine secretion by the human alveolar macrophages. Am J Physiol. 1992;262: L386-L391.
4. Prasse A, Pechkovsky DV, Toews GB, et al. A vicious circle of alveolar macrophages and fibroblasts perpetuates pulmonary fibrosis via CCL18. Am J Respir Crit Care Med. 2006;173:781-792.
5. Baker SJ, Rane SG, Reddy EP. Hematopoietic cytokine receptor signalling. Oncogene. 2007;26:6724-6737.
6. Mertens C, Darnell Jr JE. Snapshot: JAK/STAT signaling. Cell. 2007;131:612.
7. Ramana CV, Chatterjee-Kishore M, Nguyen H, Stark GR. Complex roles of stat1 in regulating gene expression. Oncogene. 2000;19:2619-2627. (Pubitemid 30339218)
8. Gharavi NM, Alva JA, Mouillesseaux KP, et al. Role of the JAK/STAT pathway in the regulation of interleukin-8 transcription by oxidized phospholipids in vitro and in atherosclerosis in vivo. J Biol Chem. 2007;282:31460-31468. (Pubitemid 350044874)
9. Fan XM, Wang ZL, Li ZH. STAT1 activation and STAT1-dependent immune-response gene ICAM-1 expression in alveolar macrophages of rats suffered from interstitial pulmonary fibrosis. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2003;19:3-6.
10. Fan XM, Wang ZL. STAT1 antisense oligonucleotides attenuate the proinflammatory cytokines release by alveolar macrophages in bleomycin-induced fibrosis. Cell Mol Immunol. 2005;2:211-217.
11. Fan XM, Liu CT, Zhan XQ, et al. The effect of STAT1 antisense oligonucleotides on lung fibroblast proliferation and hydroxyproline secretion. Zhonghua Jie He He Hu Xi Za Zhi. 2005;28:709-713.
12. Carpenter M, Epperly MW, Agarwal A, et al. Inhalation delivery of manganese superoxide dismutase-plasmid/liposomes protects the murine lung from irradiation damage. Gene Ther. 2005;12:685-693. (Pubitemid 40561507)
13. Balamugesh T, Behera D. Idiopathic pulmonary fibrosis. J Assoc Physicians India. 2007;55:363-370.
14. Tabata C, Tabata R, Kadokawa Y, et al. Thalidomide prevents bleomycin-induced pulmonary fibrosis in mice. J Immunol. 2007;179:708-714. (Pubitemid 46986590)
15. Stenton GR, Ulanova M, Dery RE, et al. Inhibition of allergic inflammation in the airways using aerosolized antisense to Syk kinase. J Immunol. 2002;169:1028-1036. (Pubitemid 34753463)
16. Duan W, Chan JH, Mckay K, et al. Inhaled p38α mitogenactivated protein kinase antisense oligonucleotide attenuates asthma in mice. Am J Respir Crit Care Med. 2005;171:571-578. (Pubitemid 40365411)
17. + γδT cells. Immunology. 2007;122:230-238. (Pubitemid 47389951)
18. Ali S, Leonard SA, Kukoly CA, et al. Absorption, distribution, metabolism, and excretion of a respirable antisense oligonucleotide for asthma. Am J Respir Crit Care Med. 2001;163:989-993. (Pubitemid 32275876)
19. Bringardner BD, Baran CP, Eubank TD, Marsh CB. The role of inflammation in the pathogenesis of idiopathic pulmonary fibrosis. Antioxid Redox Signal. 2008;10:287-301.
20. Coker RK, Laurent GJ, Shahzeidi S, et al. Transforming growth factors-β1,-β2, and-β3 stimulate fibroblast procollagen production in vitro but are differentially expressed during bleomycin-induced lung fibrosis. Am J Pathol. 1997;150:981-991.
21. Nagano J, Iyonaga K, Kawamura K, et al. Use of tacrolimus, a potent antifibrotic agent, in bleomycin-induced lung fibrosis. Eur Respir J. 2006;27:460-469. (Pubitemid 43372519)
22. Li YJ, Azuma A, Usuki J, et al. EM703 improves bleomycininduced pulmonary fibrosis in mice by the inhibition of TGF-β signaling in lung fibroblasts. Respir Res. 2006;7:16.
23. Selman M, Thannickal VJ, Pardo A, Zisman DA, Martinez FJ, Lynch JP. Idiopathic pulmonary fibrosis: pathogenesis and therapeutic approaches. Drugs. 2004;64:405-430. (Pubitemid 38337436)
24. Bonner JC. Regulation of PDGF and its receptors in fibrotic diseases. Cytokine Growth Factor Rev. 2004;15:255-273. (Pubitemid 38781050)