CD14-159 and -260 gene polymorphisms are associated with HBV-related cirrhotic injury in Chinese Han patients

Chinese Journal of Physiology

Volumn 51, Issue 2, 2008, Pages 94-99

  Yan, Chun Gen ^a   Ren, Guang Yuan ^a   Wang, Feng ^b   Zhu, Dong Fang ^a   Zhuang, Yan ^c  

^a SHAOXING UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY AFFILIATED SIXTH PEOPLE S HOSPITAL   (China)

^c SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

CD14; Liver cirrhosis; Polymorphism; TolMike receptor 4

Indexed keywords

ASPARTIC ACID; CD14 ANTIGEN; GLYCINE; ISOLEUCINE; THREONINE; TOLL LIKE RECEPTOR 4; TLR4 PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; BASE PAIRING; CHINESE; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENE MUTATION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC DIFFERENCE; GENETIC POLYMORPHISM; GENOTYPE; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; ADOLESCENT; AMINO ACID SEQUENCE; CHINA; GENETICS; MIDDLE AGED;

ADOLESCENT; ADULT; AGED; AMINO ACID SEQUENCE; ANTIGENS, CD14; CHINA; FEMALE; GENE FREQUENCY; HEPATITIS B; HUMANS; LIVER CIRRHOSIS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; TOLL-LIKE RECEPTOR 4;

EID: 51049103845     PISSN: 03044920     EISSN: 26660059     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Arbour, N.C., Lorenz, E., Schutte, B.C., Zabner, J., Kline, J.N., Jones, M., Frees, K., Watt, J.L. and Schwartz, D.A. TLR4 mutationss are associated with endotoxin hyporesponsiveness in humans. Nat. Genet. 25: 187-191, 2000.
2. Che, F., Seokjoo, Y., Niclas, T., Harri, A., Jarvela, I., Kai, O.L. and Magnus, I.S. Hepatic expression of multiple acute phase proteins and down-regulation of nuclear receptors after acute endotoxin exposure. Biochem. Pharmacol. 67: 1389-1397, 2004.
3. Clett, E., John, S. and Ian, R.P. Monocytes heterozygous for the Asp299Gly and Thr399Ile mutations in the Toll-like receptor 4 gene show no deficit in lipopolysaccharide signalling. J. Exp. Med. 197: 1787-1791, 2003.
4. Doreen, M.A., Jacqueline, E., Calvano, S.J., Hahm, S.M., Coyle, S.A., Corbett, S.E. and Stephen, F.L. Human Toll-Like receptor 4 mutations but not CD14 polymorphisms are associated with an increased risk of gram-negative infections. J. Infect. Dis. 186: 1522-1525, 2002.
5. Gao, H.K., Zhou, Z.G., Li, Y. and Chen, Y.Q. Toll-like receptor 4 Asp299Gly polymorphism is associated with an increased risk of pancreatic necrotic infection in acute pancreatitis: a study in the Chinese population. Pancreas 34: 295-298, 2007.
6. Garza Gonzalez, E., Bosques-Padilla, F.J., Mendoza-Ibarra, S.I., Flores-Gutierrez, J.P., Maldonado-Garza, H.J. and Perez-Perez, G.I. Assessment of the toll-like receptor 4 Asp299gly, thr399Ile and interleukin-8 -251 polymorphisms in the risk for the development of distal gastric cancer. BMC. Cancer 7: 70, 2007.
7. Gonzalez-Quintela, A., Campos, J., Quinteiro, C. and Gude, F. Liver enzyme levels in relation to a common polymorphism in the CD14 promoter gene. Eur. J. Gastroenterol. Hepatol. 19:182-183, 2007.
8. Guo, Q.S., Zhu, J.B. and Xia, B. Polymorphism of CD14 gene but not the mutation of TLR4 gene is associated with colorectal cancer in Chinese patients. J. Gastroenterol, Hepatol. 21: 92-97, 2006.
9. Holla, L.I., Buckova, D., Fassmann, A., Halabala, T., Vasku, A. and Vacha, J. Promoter polymorphisms in the CD 14 receptor gene and their potential association with the severity of chronic periodontitis. J. Med. Genet. 39: 844-848, 2002.
10. Hubacek, J.A., Rothe, G. and Pit'ha, J. C(-260)→T polymorphism in the promoter of the CD14 monocyte receptor gene as a risk factor for myocardial infarction. Circulation 99: 3218-3220, 1999.
11. Keskin, O., Birben, E., Sackesen, C., Soyer, O.U., Alyamac, E., Karaaslan, C., Tokol, N., Ercan, H. and Kalayci, O. The effect of CD14-c159T genotypes on the cytokine response to endotoxin by peripheral blood mononuclear cells from asthmatic children. Ann. Allergy. Asthma. Immunol. 97: 321-328, 2006.
12. Klein, W., Tromm, A., Griga, T., Fricke, H., Folwaczny, C., Hocke, M., Eitner, K., Marx, M., Duerig, N. and Epplen, J.T. A polymorphism in the CD14 gene is associated with Crohn disease. Scand. J. Gastroenterol. 2: 189-191, 2002.
13. Laine, M,L., Morre, S.A., Murillo, L.S., van Winkelhoff, A.J. and Pena, A.S. CD14 and TLR4 gene polymorphisms in adult periodontitis. J. Dent. Res. 84: 1042-1046, 2005.
14. LeVan, T.D., Bloom, J.W. and Bailey, T.J. A common single nucleotide polymorphism in the CD14 promoter decreases the affinity of Sp protein binding and enhances transcriptional activity. J. Immunol. 167:5838 -5844, 2001.
15. Li, Y., Xiong, X.Q. and Zhang, P.A. Association of C-159-T polymorphism in promoter region of CD14 and coronary heart disease. Chinese J. Med. Genetics 22: 687-690, 2005.
16. Lichy, C., Meiser, H. and Grond-Ginsbach, C. Lipopolysaccharide receptor CD14 polymorphism and risk of stroke in a South-German population. J. Neurol. 249: 821-823, 2002.
17. Lorenz, E., Hallman, M., Marttila, R., Ataja, R. and Schwartz, D.A. Association between the Asp299Gly polymorphisms in the Toll-like receptor 4 and premature births in the Finnish population. Pediatric Res. 52: 373-376, 2002.
18. Manigold, T., Bocker, U., Hanck, C., Gundt, J., Traber, P., Antoni, C. and Rossol, S. Differential expression of toll-mike receptors 2 and 4 in patients with liver cirrhosis. Eur. J. Gastroenterol. Hepatol. 159: 275-282, 2003.
19. Matsumura, T., Ito, A., Takii, T., Hayashi, H. and Onozaki, K. Endotoxin and cytokine regulation of toll-like receptor (TLR) 2 and TLR4 gene expression in murine liver and hepatocytes. J. Interferon Cytokine Res. 20: 915-921, 2000.
20. Morre, S.A., Murillo, L.S., Bruggeman, C.A. and Pena, A.S. The role that the functional Asp299Gly polymorphism in the toll-like receptor-4 gene plays in susceptibility to Chlamydia trachomatis-associated tubal infertility. J. Infect. Dis. 187: 341-342, 2003.
21. Obana, N., Takahashi, S., Kinouchi, Y., Negoro, K., Takagi, S., Hiwatashi, N. and Shimosegawa, T. Ulcerative colitis is associated with a promoter polymorphism of lipopolysaccharide receptor gene, CD14. Scand. & Gastroenterol. 6: 699-704, 2002.
22. Okayama, N., Fujimura, K., Suehiro, Y., Hamanaka, Y., Fujiwara, M., Matsubara, T., Maekawa, T., Hazama, S., Oka, M., Nohara, H., Kayano, K., Okita, K. and Hinoda, Y. Simple genotype analysis of the Asp299Gly polymorphism of the Toll-like receptor-4 gene that is associated with lipopotysaccharide hyporesponsiveness. J. Clin. Lab. Anal. 16: 56-58, 2002.
23. O'Neill, L.A. How Toll-like receptors signal: what we know and what we don't know. Curr. Opin. Immunol. 18: 3-9, 2006.
24. Puthothu, B., Forster, J., Heinzmann, A. and Krueger, M. TLR-4 and CD14 polymorphisms in respiratory syncytial virus associated disease. Dis. Markers 22: 303-308, 2006.
25. Rechcinski, T., Grebowska, A., Kurpesa, M., Peruga, Z., Dziuba, M., Krzeminska-Pakula, M., Rudnicka, W. and Chmiela, M. CD14 gene polymorphism 159C/T in a group of patients with coronary artery disease from a population with high morbidity of cardiovascular diseases. Kardiol. Pol. 65: 237-244, 2007.
26. Riordan, S.M., Skinner, N., Nagree, A., McCallum, H., McIver, C.J., Kurtovic, J., Hamilton, J.A., Bengmark, S. and Williams, R.K. Peripheral blood mononuclear cell expression of toll-like receptors and relation to cytokine levels in cirrhosis. Hepatology 37: 1154-1164, 2003.
27. Schwabe, R,F., Seki, E. and Brenner, D.A. Toll-Like receptor signaling in the liver. Gastroenterology 130: 1886-1900, 2006.
28. Tomasz, R., Aneta, G., Magorzata, K., Zbigniew, P., Micha, D., Maria, K.P., Wiesawa, R. and Magdalena, Chmiela. CD14 gene polymorphism 159C/T in a group of patients with coronary artery disease from a population with high morbidity of cardiovascular diseases. Kardiol. Pol. 65: 237-244, 2007.
29. Wu, M.S., Cheng, T.Y., Shun, C.T., Lin, M.T., Chen, L.C. and Lin, J.T. Functional polymorphisms of CD14 and toll-like receptor 4 in Taiwanese Chinese with Helicobacter pylori-related gastric malignancies. Hepato-gastroenterology 53: 807-810, 2006.
30. Yamazaki, K., Ueki-Maruyama, K., Oda, T., Tabeta, K., Shimada, Y. and Tai, H. Single-nucleotide polymorphism in the CD14 promoter and periodontal disease expression in a Japanese population. J. Dent. Res. 82: 612-616, 2003.
31. Zarember, K.A. and Godowski, P.J. Tissue expression of human Toll like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines. J. Immunol. 168: 554-561, 2002.