Inverse relationship between E-cadherin and p27Kip1 expression in renal cell carcinoma

International Journal of Oncology

Volumn 33, Issue 1, 2008, Pages 41-47

  Migita, Toshiro ^a,c   Oda, Yoshinao ^a   Masuda, Katsuaki ^a   Hirata, Akira ^a   Kuwano, Michihiko ^a   Naito, Seiji ^b   Tsuneyoshi, Masazumi ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c CANCER INSTITUTE   (Japan)

Author keywords

E cadherin; P27; Renal carcinoma

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1B; EPIDERMAL GROWTH FACTOR RECEPTOR; UVOMORULIN; CADHERIN; CDKN1B PROTEIN, HUMAN; CYCLIN E; SIGNAL PEPTIDE;

ARTICLE; BREAST CANCER; CANCER CELL; CELL ADHESION; CELL LEVEL; CELL PROLIFERATION; COLON CANCER; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KIDNEY CARCINOMA; LIVER CANCER; MONOLAYER CULTURE; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; CELL COMMUNICATION; DRUG ANTAGONISM; KIDNEY TUMOR; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

CADHERINS; CARCINOMA, RENAL CELL; CELL COMMUNICATION; CELL LINE, TUMOR; CYCLIN E; HUMANS; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KIDNEY NEOPLASMS; RECEPTOR, EPIDERMAL GROWTH FACTOR;

EID: 51049094705     PISSN: 10196439     EISSN: None     Source Type: Journal    
DOI: 10.3892/ijo.33.1.41     Document Type: Article

References (30)

1. Takeichi M: Cadherin cell adhesion receptors as a morphogenetic regulator. Science 251: 1451-1455, 1991.
2. Pece S and Gutkind JS: Signaling from E-cadherins to the MAPK pathway by the recruitment and activation of epidermal growth factor receptors upon cell-cell contact formation. J Biol Chem 275: 41227-41233, 2000.
3. Pece S, Chiariello M, Murga C and Gutkind JS: Activation of the protein kinase Akt/PKB by the formation of E-cadherin-mediated cell-cell junctions. Evidence for the association of phosphatidylinositol 3-kinase with the E-cadherin adhesion complex. J Biol Chem 274: 19347-19351, 1999.
4. Steinberg MS and McNutt PM: Cadherins and their connections: adhesion junctions have broader functions. Curr Opin Cell Biol 11: 554-560, 1999.
5. Knudsen KA, Frankowski C, Johnson KR and Wheelock MJ: A role for cadherins in cellular signaling and differentiation. J Cell Biochem 72 (Suppl 30-31): 168-176, 1998.
6. Day ML, Zhao X, Vallorosi CJ, Putzi M, Powell CT, Lin C and Day KC: E-cadherin mediates aggregation-dependent survival of prostate and mammary epithelial cells through the retinoblastoma cell cycle control pathway. J Biol Chem 274: 9656-9664, 1999.
7. Polyak K, Lee MH, Erdjument-Bromage H, Koff A, Roberts JM, Tempst P and Massague J: Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell 78: 59-66, 1994.
8. Lloyd RV, Erickson LA, Jin L, Kulig E, Qian X, Cheville JC and Scheithauer BW: p27kip1: a multifunctional cyclin-dependent kinase inhibitor with prognostic significance in human cancers. Am J Pathol 154: 313-323, 1999.
9. Sgambato A, Cittadini A, Faraglia B and Weinstein IB: Multiple functions of p27(Kip1) and its alterations in tumor cells: a review: J Cell Physiol 183: 18-27, 2000.
10. Kandikonda S, Oda D, Niederman R and Sorkin BC: Cadherin-mediated adhesion is required for normal growth regulation of human gingival epithelial cells. Cell Adhes Commun 4: 13-24, 1996.
11. Migita T, Oda Y, Naito S and Tsuneyoshi M: Low expression of p27(Kip1) is associated with tumor size and poor prognosis in patients with renal cell carcinoma. Cancer 94: 973-979, 2002.
12. Shiozaki H, Tahara H, Oka H, Miyata M, Kobayashi K, Tamura S, Iihara K, Doki Y, Hirano S, Takeichi M and Mori T: Expression of immunoreactive E-cadherin adhesion molecules in human cancers. Am J Pathol 139: 17-23, 1991.
13. Nagafuchi A, Shirayoshi Y, Okazaki K, Yasuda K and Takeichi M: Transformation of cell adhesion properties by exogenously introduced E-cadherin cDNA. Nature 329: 341-343, 1987.
14. St Croix B, Sheehan C, Rak JW, Florenes VA, Slingerland JM and Kerbel RS: E-Cadherin-dependent growth suppression is mediated by the cyclin-dependent kinase inhibitor p27(KIP1). J Cell Biol 142: 557-571, 1998.
15. Pagano M, Tam SW, Theodoras AM, Beer-Romero P, Del Sal G, Chau V, Yew PR, Draetta GF and Rolfe M: Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27. Science 269: 682-685, 1995.
16. Shirane M, Harumiya Y, Ishida N, Hirai A, Miyamoto C, Hatakeyama S, Nakayama K and Kitagawa M: Down-regulation of p27(Kip1) by two mechanisms, ubiquitin-mediated degradation and proteolytic processing. J Biol Chem 274: 13886-13893, 1999.
17. Loda M, Cukor B, Tam SW, Lavin P, Fiorentino M, Draetta GF, Jessup JM and Pagano M: Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas. Nat Med 3: 231-234, 1997.
18. Benaud CM and Dickson RB: Adhesion-regulated G1 cell cycle arrest in epithelial cells requires the downregulation of c-Myc. Oncogene 20: 4554-4567, 2001.
19. Polyak K, Kato JY, Solomon MJ, Sherr CJ, Massague J, Roberts JM and Koff A: p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest. Genes Dev 8: 9-22, 1994.
20. Takahashi K and Suzuki K: Density-dependent inhibition of growth involves prevention of EGF receptor activation by E-cadherin-mediated cell-cell adhesion. Exp Cell Res 226: 214-222, 1996.
21. Kinch MS, Petch L, Zhong C and Burridge K: E-cadherin engagement stimulates tyrosine phosphorylation. Cell Adhes Commun 4: 425-437, 1997.
22. Kawada M, Yamagoe S, Murakami Y, Suzuki K, Mizuno S and Uehara Y: Induction of p27Kip1 degradation and anchorage independence by Ras through the MAP kinase signaling pathway. Oncogene 15: 629-637, 1997.
23. Busse D, Doughty RS, Ramsey TT, Russell WE, Price JO, Flanagan WM, Shawver LK and Arteaga CL: Reversible G(1) arrest induced by inhibition of the epidermal growth factor receptor tyrosine kinase requires up-regulation of p27(KIP1) independent of MAPK activity. J Biol Chem 275: 6987-6995, 2000.
24. Fashena SJ and Thomas SM: Signalling by adhesion receptors. Nat Cell Biol 2: E225-E229, 2000.
25. Fredersdorf S, Burns J, Milne AM, Packharn G, Fallis L, Gillett CE, Royds JA, Peston D, Hall PA, Hanby AM, Barnes DM, Shousha S, O'Hare MJ and Lu X: High level expression of p27(kip1) and cyclin D1 in some human breast cancer cells: inverse correlation between the expression of p27(kip1) and degree of malignancy in human breast and colorectal cancers. Proc Natl Acad Sci USA 94: 6380-6385, 1997.
26. Doki Y, Imoto M, Han EK, Sgambato A and Weinstein IB: Increased expression of the P27KIP1 protein in human esophageal cancer cell lines that over-express cyclin D1. Carcinogenesis 18: 1139-1148, 1997.
27. Kouvaraki M, Gorgoulis VG, Rassidakis GZ, Liodis P, Markopoulos C, Gogas J and Kittas C: High expression levels of p27 correlate with lymph node status in a subset of advanced invasive breast carcinomas: relation to E-cadherin alterations, proliferative activity, and ploidy of the tumors. Cancer 94: 2454-2465, 2002.
28. Besson A, Hwang HC, Cicero S, Donovan SL, Gurian-West M, Johnson D, Clurman BE, Dyer MA and Roberts JM: Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype. Genes Dev 21: 1731-1746, 2007.
29. Sicinski P, Zacharek S and Kim C: Duality of p27Kip1 function in tumorigenesis. Genes Dev 21: 1703-1706, 2007.
30. Pentimalli F: Tumour suppressors: The dark side of p27. Nat Rev Cancer 7: 637, 2007.