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Volumn 68, Issue 15, 2008, Pages 6190-6198

Par-4 binds to topoisomerase 1 and attenuates its DNA relaxation activity

Author keywords

[No Author keywords available]

Indexed keywords

CAMPTOTHECIN; DNA; DNA TOPOISOMERASE; LEUCINE ZIPPER PROTEIN; PROTEINASE ACTIVATED RECEPTOR 4; PRIMER DNA; PROTEASE-ACTIVATED RECEPTOR 4; THROMBIN RECEPTOR;

EID: 51049094681     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-08-0831     Document Type: Article
Times cited : (37)

References (45)
  • 1
    • 0034923502 scopus 로고    scopus 로고
    • DNA topoisomerases: Structure, function, and mechanism
    • Champoux JJ. DNA topoisomerases: structure, function, and mechanism. Annu Rev Biochem 2001;70:369-413.
    • (2001) Annu Rev Biochem , vol.70 , pp. 369-413
    • Champoux, J.J.1
  • 2
    • 34447509295 scopus 로고    scopus 로고
    • Antitumour drugs impede DNA uncoiling by topoisomerase I
    • Koster DA, Palle K, Bot ES, et al. Antitumour drugs impede DNA uncoiling by topoisomerase I. Nature 2007;448:213-7.
    • (2007) Nature , vol.448 , pp. 213-217
    • Koster, D.A.1    Palle, K.2    Bot, E.S.3
  • 3
    • 33749034730 scopus 로고    scopus 로고
    • Topoisomerase I inhibitors: Camptothecins and beyond
    • Pommier Y. Topoisomerase I inhibitors: camptothecins and beyond. Nat Rev Cancer 2006;6:789-802.
    • (2006) Nat Rev Cancer , vol.6 , pp. 789-802
    • Pommier, Y.1
  • 4
    • 0036085460 scopus 로고    scopus 로고
    • Cellular roles of DNA topoisomerases: A molecular perspective
    • Wang JC. Cellular roles of DNA topoisomerases: a molecular perspective. Nat Rev Mol Cell Biol 2002;3:430-40.
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 430-440
    • Wang, J.C.1
  • 6
    • 0029912651 scopus 로고    scopus 로고
    • Targeted disruption of the mouse topoisomerase I gene by camptothecin selection
    • Morham SG, Kluckman KD, Voulomanos N, Smithies O. Targeted disruption of the mouse topoisomerase I gene by camptothecin selection. Mol Cell Biol 1996;16:6804-9.
    • (1996) Mol Cell Biol , vol.16 , pp. 6804-6809
    • Morham, S.G.1    Kluckman, K.D.2    Voulomanos, N.3    Smithies, O.4
  • 7
    • 0027235828 scopus 로고
    • Increased synthesis and degradation of DNA topoisomerase I during the initial phase of human T lymphocyte proliferation
    • Hwong CL, Chen CY, Shang HF, Hwang J. Increased synthesis and degradation of DNA topoisomerase I during the initial phase of human T lymphocyte proliferation. J Biol Chem 1993;268:18982-6.
    • (1993) J Biol Chem , vol.268 , pp. 18982-18986
    • Hwong, C.L.1    Chen, C.Y.2    Shang, H.F.3    Hwang, J.4
  • 8
    • 0021875410 scopus 로고
    • DNA topoisomerase I and II activities during cell proliferation and the cell cycle in cultured mouse embryo fibroblast (C3H 10T1/2) cells
    • Tricoli JV, Sahai BM, McCormick PJ, et al. DNA topoisomerase I and II activities during cell proliferation and the cell cycle in cultured mouse embryo fibroblast (C3H 10T1/2) cells. Exp Cell Res 1985;158:1-14.
    • (1985) Exp Cell Res , vol.158 , pp. 1-14
    • Tricoli, J.V.1    Sahai, B.M.2    McCormick, P.J.3
  • 9
    • 0032759443 scopus 로고    scopus 로고
    • DNA topoisomerase I in oncology: Dr. Jekyll or Mr. Hyde?
    • Larsen AK, Gobert C. DNA topoisomerase I in oncology: Dr. Jekyll or Mr. Hyde? Pathol Oncol Res 1999;5:171-8.
    • (1999) Pathol Oncol Res , vol.5 , pp. 171-178
    • Larsen, A.K.1    Gobert, C.2
  • 10
    • 0022340594 scopus 로고
    • Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I
    • Hsiang YH, Hertzberg R, Hecht S, Liu LF. Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. J Biol Chem 1985;260:14873-8.
    • (1985) J Biol Chem , vol.260 , pp. 14873-14878
    • Hsiang, Y.H.1    Hertzberg, R.2    Hecht, S.3    Liu, L.F.4
  • 11
    • 2342538318 scopus 로고    scopus 로고
    • Human topoisomerase I mediates illegitimate recombination leading to DNA insertion into the ribosomal DNA locus in Saccharomyces cerevisiae
    • Zhu J, Schiestl RH. Human topoisomerase I mediates illegitimate recombination leading to DNA insertion into the ribosomal DNA locus in Saccharomyces cerevisiae. Mol Genet Genom 2004;271:347-58.
    • (2004) Mol Genet Genom , vol.271 , pp. 347-358
    • Zhu, J.1    Schiestl, R.H.2
  • 12
    • 0242694944 scopus 로고    scopus 로고
    • Werner protein stimulates topoisomerase I DNA relaxation activity
    • Laine JP, Opresko PL, Indig FE, et al. Werner protein stimulates topoisomerase I DNA relaxation activity. Cancer Res 2003;63:7136-46.
    • (2003) Cancer Res , vol.63 , pp. 7136-7146
    • Laine, J.P.1    Opresko, P.L.2    Indig, F.E.3
  • 13
    • 0033621354 scopus 로고    scopus 로고
    • The Werner syndrome gene product co-purifies with the DNA replication complex and interacts with PCNA and topoisomerase I
    • Lebel M, Spillare EA, Harris CC, Leder P. The Werner syndrome gene product co-purifies with the DNA replication complex and interacts with PCNA and topoisomerase I. J Biol Chem 1999;274:37795-9.
    • (1999) J Biol Chem , vol.274 , pp. 37795-37799
    • Lebel, M.1    Spillare, E.A.2    Harris, C.C.3    Leder, P.4
  • 14
    • 0028015669 scopus 로고
    • Commonality of the gene programs induced by effectors of apoptosis in androgen-dependent and -independent prostate cells
    • Sells SF, Wood DP, Jr., Joshi-Barve SS, et al. Commonality of the gene programs induced by effectors of apoptosis in androgen-dependent and -independent prostate cells. Cell Growth Differ 1994;5:457-66.
    • (1994) Cell Growth Differ , vol.5 , pp. 457-466
    • Sells, S.F.1    Wood Jr., D.P.2    Joshi-Barve, S.S.3
  • 15
    • 0030824809 scopus 로고    scopus 로고
    • Immunohistochemical analysis of the proapoptotic protein Par-4 in normal rat tissues
    • Boghaert ER, Sells SF, Walid AJ, et al. Immunohistochemical analysis of the proapoptotic protein Par-4 in normal rat tissues. Cell Growth Differ 1997;8:881-90.
    • (1997) Cell Growth Differ , vol.8 , pp. 881-890
    • Boghaert, E.R.1    Sells, S.F.2    Walid, A.J.3
  • 16
    • 0033521923 scopus 로고    scopus 로고
    • Decreased expression of the pro-apoptotic protein Par-4 in renal cell carcinoma
    • Cook J, Krishnan S, Ananth S, et al. Decreased expression of the pro-apoptotic protein Par-4 in renal cell carcinoma. Oncogene 1999;18:1205-8.
    • (1999) Oncogene , vol.18 , pp. 1205-1208
    • Cook, J.1    Krishnan, S.2    Ananth, S.3
  • 17
    • 0043133881 scopus 로고    scopus 로고
    • Identification of a unique core domain of par-4 sufficient for selective apoptosis induction in cancer cells
    • El-Guendy N, Zhao Y, Gurumurthy S, et al. Identification of a unique core domain of par-4 sufficient for selective apoptosis induction in cancer cells. Mol Cell Biol 2003;23:5516-25.
    • (2003) Mol Cell Biol , vol.23 , pp. 5516-5525
    • El-Guendy, N.1    Zhao, Y.2    Gurumurthy, S.3
  • 18
    • 12844253808 scopus 로고    scopus 로고
    • Phosphorylation of Par-4 by protein kinase A is critical for apoptosis
    • Gurumurthy S, Goswami A, Vasudevan KM, Rangnekar VM. Phosphorylation of Par-4 by protein kinase A is critical for apoptosis. Mol Cell Biol 2005;25:1146-61.
    • (2005) Mol Cell Biol , vol.25 , pp. 1146-1161
    • Gurumurthy, S.1    Goswami, A.2    Vasudevan, K.M.3    Rangnekar, V.M.4
  • 19
    • 0008881181 scopus 로고    scopus 로고
    • Mutually exclusive expression patterns of Bcl-2 and Par-4 in human prostate tumors consistent with down-regulation of Bcl-2 by Par-4
    • Qiu G, Ahmed M, Sells SF, et al. Mutually exclusive expression patterns of Bcl-2 and Par-4 in human prostate tumors consistent with down-regulation of Bcl-2 by Par-4. Oncogene 1999;18:623-31.
    • (1999) Oncogene , vol.18 , pp. 623-631
    • Qiu, G.1    Ahmed, M.2    Sells, S.F.3
  • 20
    • 22144496103 scopus 로고    scopus 로고
    • Tumour-suppression activity of the proapoptotic regulator Par4
    • Garcia-Cao I, Duran A, Collado M, et al. Tumour-suppression activity of the proapoptotic regulator Par4. EMBO Rep 2005;6:577-83.
    • (2005) EMBO Rep , vol.6 , pp. 577-583
    • Garcia-Cao, I.1    Duran, A.2    Collado, M.3
  • 21
    • 33947196921 scopus 로고    scopus 로고
    • Inactivation of the candidate tumor suppressor par-4 in endometrial cancer
    • Moreno-Bueno G, Fernandez-Marcos PJ, Collado M, et al. Inactivation of the candidate tumor suppressor par-4 in endometrial cancer. Cancer Res 2007;67:1927-34.
    • (2007) Cancer Res , vol.67 , pp. 1927-1934
    • Moreno-Bueno, G.1    Fernandez-Marcos, P.J.2    Collado, M.3
  • 22
    • 25844454851 scopus 로고    scopus 로고
    • Binding and phosphorylation of par-4 by akt is essential for cancer cell survival
    • Goswami A, Burikhanov R, de Thonel A, et al. Binding and phosphorylation of par-4 by akt is essential for cancer cell survival. Mol Cell 2005;20:33-44.
    • (2005) Mol Cell , vol.20 , pp. 33-44
    • Goswami, A.1    Burikhanov, R.2    de Thonel, A.3
  • 23
    • 35148859307 scopus 로고    scopus 로고
    • Cancer resistance in transgenic mice expressing the SAC module of Par-4
    • Zhao Y, Burikhanov R, Qiu S, et al. Cancer resistance in transgenic mice expressing the SAC module of Par-4. Cancer Res 2007;67:9276-85.
    • (2007) Cancer Res , vol.67 , pp. 9276-9285
    • Zhao, Y.1    Burikhanov, R.2    Qiu, S.3
  • 24
    • 0033570123 scopus 로고    scopus 로고
    • Oncogenic Ras sensitizes cells to apoptosis by Par-4
    • Nalca A, Qiu SG, El-Guendy N, et al. Oncogenic Ras sensitizes cells to apoptosis by Par-4. J Biol Chem 1999;274:29976-83.
    • (1999) J Biol Chem , vol.274 , pp. 29976-29983
    • Nalca, A.1    Qiu, S.G.2    El-Guendy, N.3
  • 25
    • 0033604464 scopus 로고    scopus 로고
    • Negative regulation of Par-4 by oncogenic Ras is essential for cellular transformation
    • Qiu SG, Krishnan S, el-Guendy N, Rangnekar VM. Negative regulation of Par-4 by oncogenic Ras is essential for cellular transformation. Oncogene 1999;18:7115-23.
    • (1999) Oncogene , vol.18 , pp. 7115-7123
    • Qiu, S.G.1    Krishnan, S.2    el-Guendy, N.3    Rangnekar, V.M.4
  • 26
    • 0034731326 scopus 로고    scopus 로고
    • A novel nuclear localization signal in human DNA topoisomerase I
    • Mo YY, Wang C, Beck W T. A novel nuclear localization signal in human DNA topoisomerase I. J Biol Chem 2000;275:41107-13.
    • (2000) J Biol Chem , vol.275 , pp. 41107-41113
    • Mo, Y.Y.1    Wang, C.2    Beck, W.T.3
  • 27
    • 10544225383 scopus 로고    scopus 로고
    • A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1
    • Johnstone RW, See RH, Sells SF, et al. A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1. Mol Cell Biol 1996;16:6945-56.
    • (1996) Mol Cell Biol , vol.16 , pp. 6945-6956
    • Johnstone, R.W.1    See, R.H.2    Sells, S.F.3
  • 28
    • 34548510839 scopus 로고    scopus 로고
    • Nitrated indenoisoquinolines as topoisomerase I inhibitors: A systematic study and optimization
    • Morrell A, Placzek M, Parmley S, et al. Nitrated indenoisoquinolines as topoisomerase I inhibitors: a systematic study and optimization. J Med Chem 2007;50:4419-30.
    • (2007) J Med Chem , vol.50 , pp. 4419-4430
    • Morrell, A.1    Placzek, M.2    Parmley, S.3
  • 29
    • 0033047992 scopus 로고    scopus 로고
    • Synthesis of cytotoxic indenoisoquinoline topoisomerase I poisons
    • Strumberg D, Pommier Y, Paull K, et al. Synthesis of cytotoxic indenoisoquinoline topoisomerase I poisons. J Med Chem 1999;42:446-57.
    • (1999) J Med Chem , vol.42 , pp. 446-457
    • Strumberg, D.1    Pommier, Y.2    Paull, K.3
  • 30
    • 0027186443 scopus 로고
    • DNA topoisomerase I is involved in both repression and activation of transcription
    • Merino A, Madden KR, Lane WS, Champoux JJ, Reinberg D. DNA topoisomerase I is involved in both repression and activation of transcription. Nature 1993;365:227-32.
    • (1993) Nature , vol.365 , pp. 227-232
    • Merino, A.1    Madden, K.R.2    Lane, W.S.3    Champoux, J.J.4    Reinberg, D.5
  • 31
    • 34548763143 scopus 로고    scopus 로고
    • Nonclassic functions of human topoisomerase I: Genome-wide and pharmacologic analyses
    • Miao ZH, Player A, Shankavaram U, et al. Nonclassic functions of human topoisomerase I: genome-wide and pharmacologic analyses. Cancer Res 2007;67:8752-61.
    • (2007) Cancer Res , vol.67 , pp. 8752-8761
    • Miao, Z.H.1    Player, A.2    Shankavaram, U.3
  • 32
    • 0033538336 scopus 로고    scopus 로고
    • Inactivation of the inhibitory κB protein kinase/nuclear factor κB pathway by Par-4 expression potentiates tumor necrosis factor a-induced apoptosis
    • Diaz-Meco MT, Lallena MJ, Monjas A, et al. Inactivation of the inhibitory κB protein kinase/nuclear factor κB pathway by Par-4 expression potentiates tumor necrosis factor a-induced apoptosis. J Biol Chem 1999;274:19606-12.
    • (1999) J Biol Chem , vol.274 , pp. 19606-19612
    • Diaz-Meco, M.T.1    Lallena, M.J.2    Monjas, A.3
  • 33
    • 0030572696 scopus 로고    scopus 로고
    • The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C
    • Diaz-Meco MT, Municio MM, Frutos S, et al. The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C. Cell 1996;86:777-86.
    • (1996) Cell , vol.86 , pp. 777-786
    • Diaz-Meco, M.T.1    Municio, M.M.2    Frutos, S.3
  • 34
    • 0038504065 scopus 로고    scopus 로고
    • Par-4 transcriptionally regulates Bcl-2 through a WT1-binding site on the bcl-2 promoter
    • Cheema SK, Mishra SK, Rangnekar VM, et al. Par-4 transcriptionally regulates Bcl-2 through a WT1-binding site on the bcl-2 promoter. J Biol Chem 2003;278:19995-20005.
    • (2003) J Biol Chem , vol.278 , pp. 19995-20005
    • Cheema, S.K.1    Mishra, S.K.2    Rangnekar, V.M.3
  • 35
    • 33846682284 scopus 로고    scopus 로고
    • NKX3.1 homeodomain protein binds to topoisomerase I and enhances its activity
    • Bowen C, Stuart A, Ju JH, et al. NKX3.1 homeodomain protein binds to topoisomerase I and enhances its activity. Cancer Res 2007;67:455-64.
    • (2007) Cancer Res , vol.67 , pp. 455-464
    • Bowen, C.1    Stuart, A.2    Ju, J.H.3
  • 36
    • 0035864758 scopus 로고    scopus 로고
    • Human ARF protein interacts with topoisomerase I and stimulates its activity
    • Karayan L, Riou JF, Seite P, et al. Human ARF protein interacts with topoisomerase I and stimulates its activity. Oncogene 2001;20:836-48.
    • (2001) Oncogene , vol.20 , pp. 836-848
    • Karayan, L.1    Riou, J.F.2    Seite, P.3
  • 37
    • 0034662642 scopus 로고    scopus 로고
    • p53 dependence of topoisomerase I recruitment in vivo
    • Mao Y, Okada S, Chang LS, Muller MT. p53 dependence of topoisomerase I recruitment in vivo. Cancer Res 2000;60:4538-43.
    • (2000) Cancer Res , vol.60 , pp. 4538-4543
    • Mao, Y.1    Okada, S.2    Chang, L.S.3    Muller, M.T.4
  • 38
    • 0029133721 scopus 로고
    • DNA recombinase activity of eukaryotic DNA topoisomerase I; effects of camptothecin and other inhibitors
    • Pommier Y, Jenkins J, Kohlhagen G, Leteurtre F. DNA recombinase activity of eukaryotic DNA topoisomerase I; effects of camptothecin and other inhibitors. Mutat Res 1995;337:135-45.
    • (1995) Mutat Res , vol.337 , pp. 135-145
    • Pommier, Y.1    Jenkins, J.2    Kohlhagen, G.3    Leteurtre, F.4
  • 39
    • 0035477544 scopus 로고    scopus 로고
    • Par-4 drives trafficking and activation of Fas and Fasl to induce prostate cancer cell apoptosis and tumor regression
    • Chakraborty M, Qiu SG, Vasudevan KM, Rangnekar VM. Par-4 drives trafficking and activation of Fas and Fasl to induce prostate cancer cell apoptosis and tumor regression. Cancer Res 2001;61:7255-63.
    • (2001) Cancer Res , vol.61 , pp. 7255-7263
    • Chakraborty, M.1    Qiu, S.G.2    Vasudevan, K.M.3    Rangnekar, V.M.4
  • 40
    • 0037184095 scopus 로고    scopus 로고
    • The N-terminal domain anchors human topoisomerase I at fibrillar centers of nucleoli and nucleolar organizer regions of mitotic chromosomes
    • Christensen MO, Barthelmes HU, Boege F, Mielke C. The N-terminal domain anchors human topoisomerase I at fibrillar centers of nucleoli and nucleolar organizer regions of mitotic chromosomes. J Biol Chem 2002;277:35932-8.
    • (2002) J Biol Chem , vol.277 , pp. 35932-35938
    • Christensen, M.O.1    Barthelmes, H.U.2    Boege, F.3    Mielke, C.4
  • 41
    • 9644289374 scopus 로고    scopus 로고
    • Apoptotic topoisomerase I-DNA complexes induced by staurosporine-mediated oxygen radicals
    • Sordet O, Khan QA, Plo I, et al. Apoptotic topoisomerase I-DNA complexes induced by staurosporine-mediated oxygen radicals. J Biol Chem 2004;279:50499-504.
    • (2004) J Biol Chem , vol.279 , pp. 50499-50504
    • Sordet, O.1    Khan, Q.A.2    Plo, I.3
  • 42
    • 9644275563 scopus 로고    scopus 로고
    • Apoptotic topoisomerase I-DNA complexes induced by oxygen radicals and mitochondrial dysfunction
    • Sordet O, Khan QA, Pommier Y. Apoptotic topoisomerase I-DNA complexes induced by oxygen radicals and mitochondrial dysfunction. Cell Cycle 2004;3:1095-7.
    • (2004) Cell Cycle , vol.3 , pp. 1095-1097
    • Sordet, O.1    Khan, Q.A.2    Pommier, Y.3
  • 43
    • 4043064323 scopus 로고    scopus 로고
    • Topoisomerase I-DNA complexes contribute to arsenic trioxide-induced apoptosis
    • Sordet O, Liao Z, Liu H, et al. Topoisomerase I-DNA complexes contribute to arsenic trioxide-induced apoptosis. J Biol Chem 2004;279:33968-75.
    • (2004) J Biol Chem , vol.279 , pp. 33968-33975
    • Sordet, O.1    Liao, Z.2    Liu, H.3
  • 44
    • 20744447485 scopus 로고    scopus 로고
    • Ras-mediated loss of the pro-apoptotic response protein Par-4 is mediated by DNA hypermethylation through Raf-independent and Raf-dependent signaling cascades in epithelial cells
    • Pruitt K, Ulku AS, Frantz K, et al. Ras-mediated loss of the pro-apoptotic response protein Par-4 is mediated by DNA hypermethylation through Raf-independent and Raf-dependent signaling cascades in epithelial cells. J Biol Chem 2005;280:23363-70.
    • (2005) J Biol Chem , vol.280 , pp. 23363-23370
    • Pruitt, K.1    Ulku, A.S.2    Frantz, K.3
  • 45
    • 9544251502 scopus 로고    scopus 로고
    • Hypersensitivity of NIH3T3 cells transformed by H-ras gene to DNA-topoisomerase-I inhibitors
    • Ohira T, Nishio K, Kanzawa F, et al. Hypersensitivity of NIH3T3 cells transformed by H-ras gene to DNA-topoisomerase-I inhibitors. Int J Cancer 1996;67:702-8.
    • (1996) Int J Cancer , vol.67 , pp. 702-708
    • Ohira, T.1    Nishio, K.2    Kanzawa, F.3


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