Effect of ibuprofen on neutrophil migration in vivo in cystic fibrosis and healthy subjects

Journal of Pharmacology and Experimental Therapeutics

Volumn 306, Issue 3, 2003, Pages 1086-1091

  Konstan, Michael W ^a,b   Krenicky, Jeanne E ^a,b   Finney, Marcie R ^a,c   Kirchner, H Lester ^a,b   Hilliard, Kathleen A ^a,b   Hilliard, Jay B ^a,b   Davis, Pamela B ^a,b   Hoppel, Charles L ^a,c  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

^c LOUIS STOKES CLEVELAND VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IBUPROFEN;

ADULT; ARTICLE; CELL MIGRATION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DRUG BLOOD LEVEL; DRUG DOSE REGIMEN; DRUG EFFECT; FEMALE; HUMAN; HUMAN CELL; IN VIVO STUDY; INFLAMMATION; LONG TERM CARE; LUNG DISEASE; LUNG FIBROSIS; MALE; MOUTH MUCOSA; NEUTROPHIL; PRIORITY JOURNAL;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; AREA UNDER CURVE; CELL MOVEMENT; CYSTIC FIBROSIS; HUMANS; IBUPROFEN; MOUTH MUCOSA; NEUTROPHILS;

EID: 0042934009     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.052449     Document Type: Article

References (21)

1. Albert KS and Gernaat CM (1984) Pharmacokinetics of ibuprofen. Am J Med 77:40-46.
2. Brown KA and Collins AJ (1977) Action of nonsteroidal anti-inflammatory drugs on human and rat peripheral leukocyte migration in vitro. Ann Rheum Dis 36:239-243.
3. Cleveland WS, Devlin SJ, and Grosse E (1988) Regression by local fitting. J Econometrics 37:87-114.
4. Flynn PJ, Becker WK, Vercellotti GM, Weisdorf DJ, Craddock PR, Hammerschmidt DE, Lillehei RC, and Jacob HS (1984) Ibuprofen inhibits granulocyte responses to inflammatory mediators. A proposed mechanism for reduction of experimental myocardial infarct size. Inflammation 8:33-44.
5. Higgs GA, Eakins KE, Mugridge KG, and Moncada S (1980) The effects of nonsteroid anti-inflammatory drugs on leukocyte migration in carrageenin-induced inflammation. Eur J Pharmacol 66:81-86.
6. Hurvich CM and Simonoff JS (1998) Smoothing parameter selection in nonparametric regression using an improved Akaike_Information Criterion. J R Stat Soc B 60:271-293.
7. Ingalls ST, Schwerkoske JF, Forman WB, and Hoppel CL (1983) Rapid and sensitive method for the determination of salicylic acid in serum by reversed-phase ion-pair high-performance liquid chromatography. J Chromatogr 274:366-371.
8. Kaplan HB, Edelson HS, Korchak HM, Given WP, Abramson S, and Weissman G (1984) Effects of non-steroidal anti-inflammatory agents on human neutrophil functions in vitro and in vivo. Biochem Pharmacol 33:371-378.
9. Konstan MW (1996) Treatment of airway inflammation in cystic fibrosis. Curr Opin Pulm Med 2:452-456.
10. Konstan MW and Berger M (1993) Infection and inflammation of the lung in cystic fibrosis, in Cystic Fibrosis (Davis PB ed) pp 219-76, Marcel Dekker, Inc., New York.
11. Konstan MW and Berger M (1997) Current understanding of the inflammatory process in cystic fibrosis - onset and etiology. Pediatr Pulmonol 24:137-142.
12. Konstan MW, Byard PJ, Hoppel CL, and Davis PB (1995) Effect of high-dose ibuprofen in patients with cystic fibrosis. N Engl J Med 332:848-854.
13. Konstan MW, Hoppel CL, Chai B, and Davis PB (1991) Ibuprofen in children with cystic fibrosis: pharmacokinetics and adverse effects. J Pediatr 118:956-964.
14. Maderazo EG, Breaux SP, and Woronick CL (1984) Inhibition of human polymorphonuclear leukocyte cell responses by ibuprofen. J Pharmacol Sci 73:1403-1406.
15. Minkler PE and Hoppel CL (1988) Determination of ibuprofen in human plasma by high performance liquid chromatography. J Chromatogr 428:388-394.
16. Rinaldo JE and Pennock B (1986) Effects of ibuprofen on endotoxin-induced alveolitis: biphasic dose response and dissociation between inflammation and hypoxemia. Am J Med Sci 291:29-38.
17. Shimanuki T, Nakamura RM, and Dizerega GS (1985) Modulation of leukotaxis by ibuprofen: a quantitative determination in vivo. Inflammation 9:285-295.
18. Sordelli DO, Cerquetti MC, El-Tawil G, Ramwell PW, Hooke AM, and Bellanti JA (1985) Ibuprofen modifies the inflammatory response of the murine lung to Pseudomonas aeruginosa. Eur J Resp Dis 67:118-127.
19. Spisani S, Vanzini G, and Traniello S (1978) Inhibition of human leucocytes locomotion by anti-inflammatory drugs. Experientia 35:803-804.
20. Venezio FR, DiVincenzo C, Pearlman F, and Phair JP (1985) Effects of the newer nonsteroidal anti-inflammatory agents ibuprofen, fenoprofen and sulindac on neutrophil adherence. J Infect Dis 152:690-694.
21. Wright DG, Meierovics AI, and Foxley JM (1986) Assessing the delivery of neutrophils to tissues in neutropenia. Blood 67:1023-1030.