Novel polymorphisms in the GCKR gene and their influence on glucose and insulin levels in a Danish twin population

Diabetic Medicine

Volumn 22, Issue 12, 2005, Pages 1677-1682

  Køster, Brian ^a   Fenger, M ^a   Poulsen, P ^b   Vaag, A ^b   Bentzen, J ^a  

^a HVIDOVRE HOSPITAL   (Denmark)

^b STENO DIABETES CENTER   (Denmark)

Author keywords

Beta cell function; Glucokinase regulatory protein; Insulin; Polymorphism; Type 2 diabetes

Indexed keywords

GLUCOKINASE REGULATORY PROTEIN; GLUCOSE; INSULIN; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; ALLELE; ARTICLE; CONTROLLED STUDY; FEMALE; GENETIC ASSOCIATION; GENOTYPE PHENOTYPE CORRELATION; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; HUMAN; IMPAIRED GLUCOSE TOLERANCE; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; MONOZYGOTIC TWINS; NON INSULIN DEPENDENT DIABETES MELLITUS; ORAL GLUCOSE TOLERANCE TEST; PANCREAS ISLET BETA CELL; RECEPTOR GENE; SINGLE NUCLEOTIDE POLYMORPHISM; TWIN DISCORDANCE;

AGED; BLOOD GLUCOSE; DENMARK; DIABETES MELLITUS, TYPE 2; FEMALE; GLUCOKINASE; GLUCOSE TOLERANCE TEST; HUMANS; INSULIN; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 30044448287     PISSN: 07423071     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1464-5491.2005.01700.x     Document Type: Article

References (20)

1. World Health Organization. Report of a WHO consultation. Definition, Diagnosis and Classification of Diabetes Mellitus and its Complications. Geneva, Switzerland: World Health Organization, Department of Non-Communicable Disease Surveillance, 1999.
2. Froguel P, Velho G. Medical genetics of MODYs. Front Diabetes 2000; 15: 35-43.
3. De la Iglesia N, Mukhtar M, Seoane J, Guinovart, JJ. The role of the regulatory protein of glucokinase in the glucose sensory mechanism of the hepatocyte. J Biol Chem 2000; 275: 10597-10603.
4. Hayward BE, Fantes JA, Warner JP, Intody S, Leek JP, Markham AF et al. Co-localization of the ketohexokinase and glucokinase regulator genes to a 500-kb region of chromosome 2p23. Mammalian Genome 1996; 7: 454-458.
5. Hayward BE, Warner JP, Dunlop N, Fantes JA, Intody S, Leek JP et al. Molecular genetics of the human glucokinase regulatory-fructokinase (GCKR-KHK) region of chromosome 2p23. Biochem Soc Trans 1997; 25: 140-145.
6. Veiga-da-Cunha M, Delplanque J, Gillain A, Bonthron DT, Boutin P, Van Schaftingen E et al. Mutations in the glucokinase regulatory protein gene in 2p23 in obese French Caucasians. Diabetologia 2003; 46: 704-711.
7. Hayward BE, Dunlop N, Intody S, Leek JP, Markham AF, Warner JP et al. Organization of the human glucokinase regulator gene GCKR. Genomics 1998; 49: 137-142.
8. Warner JP, Leek JP, Intody S, Markham AF, Bonthron DT. Human glucokinase regulatory protein (GCKR): cDNA and genomic cloning, complete primary structure, and chromosomal localization. Mammalian Genome 1995; 6: 532-536.
9. Poulsen P, Kyvik KO, Vaag A, Beck-Nielsen H. Heritability of type II (non-insulin dependent) diabetes mellitus and abnormal glucose tolerance - a population-based twin study. Diabetologia 1999; 42: 139-145.
10. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412-419.
11. Genbank Data Libraries. Accession no. 13644097. Available from: http://www.ncbi.nlm.nih.gov/cgi-bin/Entrez/getfeat?gi=13644097&id =7&entity=1.
12. Lynch M, Walsh B. Properties of Single Loci in Genetics and Analysis of Quantitative Traits, 1st edn. Sunderland: Sinauer Associates Inc, 1998: 51-76.
13. Christiansen FB, Feldman MW. Population distribution of alleles and genotypes. In: Population Genetics. Oxford: Blackwell Scientific Publications, 1986: 73-103.
14. Altman DG. Comparing Groups - Continuous Data. Practical Statistics for Medical Research, 1st edn. London: Chapman & Hall, 1992: 179-228.
15. Veiga-da-cunha M, Van Schaftingen E. Identification of fructose 6-phosphate and fructose 1-phosphate binding residues in the regulatory protein of glucokinase. J Biol Chem 2002; 277: 8466-8473.
16. Moukil MA, Veiga-da-cunha M, Van Schaftingen E. Study of the regulatory properties of glucokinase by site-directed mutagenesis-conversion of glucokinase to an enzyme with high affinity for glucose. Diabetes 2000; 49: 195-201.
17. Veiga-da-cunha M, Courtois S, Michel A, Gosselain E, Van Schaftingen E. Amino acid conservation in animal glucokinases - identification of residues implicated in the interaction with the regulatory protein. J Biol Chem 1996; 271: 6292-6297.
18. Farrelly D, Brown KS, Tieman A, Ren J, Lira SA, Hagan D et al. Mice mutant for glucokinase regulatory protein exhibit decreased liver glucokinase: a sequestration mechanism in metabolic regulation. Proc Natl Acad Sci 1999; 96: 14511-14516.
19. Shiota C, Coffey JW, Grimsby J, Grippo JF, Magnuson MA. Nuclear import of hepatic glucokinase depends upon glucokinase regulatory protein, whereas export is due to a nuclear export signal sequence in glucokinase. J Biol Chem 1999; 274: 37125-37130.
20. Grimsby J, Coffey JW, Dvorozniak MT, Magram J, Li G, Matschinsky FM et al. Characterization of glucokinase regulatory protein-deficient mice. J Biol Chem 2000; 275: 7826-7831.