Rottlerin induces calcium influx and protein degradation in cultured lenses independent of effects on protein kinase Cδ

Basic and Clinical Pharmacology and Toxicology

Volumn 101, Issue 6, 2007, Pages 459-464

  Xu, Shang Zhi ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CARBONYL CYANIDE 4 (TRIFLUOROMETHOXY)PHENYLHYDRAZONE; EGTAZIC ACID; GAP JUNCTION PROTEIN; PROTEIN KINASE C DELTA; ROTTLERIN; VERAPAMIL;

ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; DRUG EFFECT; GAP JUNCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN DEGRADATION; PROTEIN FUNCTION;

ACETOPHENONES; ADENOSINE TRIPHOSPHATE; ANIMALS; BENZOPYRANS; CALCIUM; CALCIUM CHANNELS, L-TYPE; CARBONYL CYANIDE P-TRIFLUOROMETHOXYPHENYLHYDRAZONE; CONNEXINS; ENZYME INHIBITORS; EYE PROTEINS; INTERMEDIATE FILAMENT PROTEINS; LENS, CRYSTALLINE; MICE; MICE, INBRED C57BL; MITOCHONDRIA; ORGAN CULTURE TECHNIQUES; ORGAN SIZE; PROTEIN KINASE C-DELTA; VIMENTIN;

EID: 36248947920     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/j.1742-7843.2007.00143.x     Document Type: Article

References (24)

1. Wilkinson SE, Hallam TJ. Protein kinase C: is its pivotal role in cellular activation over-stated? Trends Pharmacol Sci 1994 15 : 53 7.
2. Gschwendt M, Muller HJ, Kielbassa K et al. Rottlerin, a novel protein kinase inhibitor. Biochem Biophys Res Commun 1994 199 : 93 8.
3. Kim DC, Kim SH, Jeong MW, Baek N, Kim KT. Effect of rottlerin, a PKC-δ inhibitor, on TLR-4-dependent activation of murine microglia. Biochem Biophys Res Com 2005 337 : 110 5.
4. Ginnan R, Singer HA. PKC delta-dependent pathways contribute to PDGF-stimulated ERK1/2 activation in vascular smooth muscle. Am J Physiol Cell Physiol 2005 288 : 1193 1201.
5. Susarla BTS, Robinson MB. Rottlerin, an inhibitor of protein kinase Cδ (PKCδ), inhibits astrocytic glutamate transport activity and reduces GLAST immunoreactivity by a mechanism that appears to be PKCδ-independent. J Neurochem 2003 86 : 635 45.
6. Kayali AG, Austin DA, Webster NJ. Rottlerin inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes by uncoupling mitochondrial oxidative phosphorylation. Endocrinology 2002 143 : 3884 96.
7. Tapia JA, Jensen RT, Garcia-Marin LJ. Rottlerin inhibits stimulated enzymatic secretion and several intracellular signaling transduction pathways in pancreatic acinar cells by anon-PKC-δ-dependent mechanism. Biochim Biophys Acta 2006 1763 : 25 38.
8. Tillman DM, Izeradjene K, Szucs KS, Douglas L, Houghton JA. Rottlerin-sensitizes colon carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis via uncoupling of the mitochondria independent of protein kinase C1. Cancer Res 2003 63 : 5118 25.
9. Soltoff SP. Rottlerin is a mitochondrial uncoupler that decreases cellular ATP levels and indirectly blocks protein kinase C6 tyrosine phosphorylation. J Biol Chem 2001 276 : 37986 92.
10. i response to FCCP and acetate in carotid body glomus cells of adult rabbits. Brain Res 1997 768 : 37 42.
11. Lin D, Zhou J, Zelenka PS, Takemoto DJ. Protein kinase Cγ regulation of gap junction activity through caveolin-1-containing lipid rafts. Invest Ophthalmol Vis Sci 2003 44 : 52259 68.
12. Terada H. The interaction of highly active uncpuplers with mitochondria. Biochim Biophys Acta 1981 639 : 225.
13. Gao J, Sun X, Martinez-Wittinghan FJ, Gong X, White TW, Mathias RT. Connections between connexins, calcium, and cataracts in the lens. J Gen Physiol 2004 124 : 289 300.
14. 2+-induced reductions of NMDA receptor subunits in vitro. Neurotoxicology 2006 27 : 169 75.
15. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the folin phenol reagent. J Biol Chem 1951 193 : 265 75.
16. Lovicu FJ, Overbeek PA. Overlapping effects of different members of the FGF family on lens fiber differentiation in transgenic mice. Development 1998 125 : 3365 77.
17. Goll DE, Thompson VF, Li H, Wei W, Cong J. The calpain system. Physiol Rev 2003 83 : 731 801.
18. Kontny E, Kurowska M, Szczepanska K, Maslinski W. Rottlerin, a PKC isozyme-selective inhibitor, affects signaling events and cytokine production in human monocytes. J Leukoc Biol 2000 67 : 249 58.
19. Kikkawa U, Matsuzaki H, Yamamoto T. Protein kinase Cδ: activation mechanisms and functions. J Biochem 2002 132 : 831 9.
20. Li C, Chen X, Williams JA. Regulation of CCK-induced amylase release by PKC-delta in rat pancreatic acinar cells. Am J Physiol Gastrointest Liver Physiol 2004 287 : 764 71.
21. 2+ signaling and integrity of intestinal epithelial cells. Eur J Pharmacol 2005 518 : 1 9.
22. Marino F, Cosentino M, Ferrari M et al. Intracellular calcium changes induced by the endozepine triakontatetraneuropeptide in human polymorphonuclear leukocytes: role of protein kinase C and effect of calcium channel blockers. Cell Commun Signal 2004 2 : 1 8.
23. Liao YF, Hunag YC, Chang WH et al. The PKC delta inhibitor, rottlerin, induces apoptosis of haematopoietic cell lines through mitochondrial membrane depolarization and caspases' cascade. Life Sci 2005 77 : 707 19.
24. 2+-induced protein loss, vimentin cleavage and opacification. Invest Ophthalmol Vis Sci 2000 41 : 2255 61.