Mutation of Trp29 of human equilibrative nucleoside transporter 1 alters affinity for coronary vasodilator drugs and nucleoside selectivity

Biochemical Journal

Volumn 414, Issue 2, 2008, Pages 291-300

  Paproski, Robert J ^a   Visser, Frank ^a   Zhang, Jing ^a   Tackaberry, Tracey ^a   Damaraju, Vijaya ^a   Baldwin, Stephen A ^b   Young, James D ^a   Cass, Carol E ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

Dilazep; Draflazine; Human equilibrative nucleoside transporter 1 (hENT1); Nitrobenzylmercaptopurine ribonucleoside (NBMPR); Nucleoside transporter; Soluflazine

Indexed keywords

DILAZEP; DRAFLAZINE; HUMAN EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1 (HENT1); NITROBENZYLMERCAPTOPURINE RIBONUCLEOSIDE (NBMPR); NUCLEOSIDE TRANSPORTER; SOLUFLAZINE;

ANIMAL CELL CULTURE;

ADENOSINE; COMPLEMENTARY DNA; CORONARY VASODILATING AGENT; CYTIDINE; DILAZEP; DIPYRIDAMOLE; DRAFLAZINE; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1; GUANOSINE; INOSINE; METHIONINE; MUTANT PROTEIN; NITROBENZYLTHIOINOSINE; NUCLEOSIDE; PURINE NUCLEOSIDE; PYRIMIDINE NUCLEOSIDE; SOLUFLAZINE; THYMIDINE; TRYPTOPHAN; URIDINE; 4-NITROBENZYLTHIOINOSINE; DRUG DERIVATIVE; MERCAPTOPURINE RIBOSIDE; PIPERAZINE DERIVATIVE; VASODILATOR AGENT;

ARTICLE; BINDING AFFINITY; BINDING SITE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG SENSITIVITY; GENETIC COMPLEMENTATION; GENETIC SCREENING; IC 50; MUTAGENESIS; MUTATIONAL ANALYSIS; NUCLEOSIDE TRANSPORT; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SEQUENCE ALIGNMENT; TRANSPORT KINETICS; BIOLOGICAL MODEL; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVATION; GENETICS; HUMAN; KINETICS; METABOLISM; MUTATION; PROTEIN BINDING; TRANSPORT AT THE CELLULAR LEVEL;

ADENOSINE; BIOLOGICAL TRANSPORT; DILAZEP; DIPYRIDAMOLE; ENZYME ACTIVATION; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1; HUMANS; KINETICS; MODELS, BIOLOGICAL; MUTATION; NUCLEOSIDES; PIPERAZINES; PROTEIN BINDING; THIOINOSINE; TRYPTOPHAN; VASODILATOR AGENTS;

EID: 50949087105     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20080074     Document Type: Article

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