Threonine 66 in the death domain of IRAK-1 is critical for interaction with signaling molecules but is not a target site for autophosphorylation

Journal of Leukocyte Biology

Volumn 84, Issue 3, 2008, Pages 807-813

  Neumann, Detlef ^a   Kollewe, Christian ^a,c   Pich, Andreas ^a   Cao, Ping ^b   Resch, Klaus ^a   Martin, Michael U ^a,c  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b AMGEN INC   (United States)

^c JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

Inflammation; Interleukin 1; Kinases; Toll like receptor; Tollip

Indexed keywords

ADAPTOR PROTEIN; DEATH RECEPTOR; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1; THREONINE;

ANIMAL CELL; ARTICLE; AUTOPHOSPHORYLATION; EMBRYO; HUMAN; HUMAN CELL; MASS SPECTROMETRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION;

CELLS, CULTURED; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENETIC VECTORS; HUMANS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; INTERLEUKIN-2; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KIDNEY; MOLECULAR WEIGHT; MYELOID DIFFERENTIATION FACTOR 88; NF-KAPPA B; PHOSPHORYLATION; SIGNAL TRANSDUCTION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; THREONINE;

EID: 50849127162     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0507290     Document Type: Article

References (17)

1. Medzhitov, R., Janeway Jr., C. A. (1997) Innate immunity: impact on the adaptive immune response. Curr. Opin. Immunol. 9, 4-9.
2. Kirk, P., Bazan, J. F. (2005) Pathogen recognition: TLRs throw us a curve. Immunity 23, 347-350.
3. Martin, M. U., Wesche, H. (2002) Summary and comparison of the signaling mechanisms of the Toll/interleukin-1 receptor family. Biochim. Biophys. Acta 1592, 265-280.
4. O'Neill, L. A. (2002) Signal transduction pathways activated by the IL-1 receptor/Toll-like receptor superfamily. Curr. Top. Microbiol. Immunol. 270, 47-61.
5. Brikos, C., Wait, R., Begum, S., O'Neill, L. A., Saklatvala, J. (2007) Mass spectrometric analysis of the endogenous type I interleukin-1 (IL-1) receptor signaling complex formed after IL-1 binding identifies IL-1RAcP, MyD88, and IRAK-4 as the stable components. Mol. Cell. Proteomics 6, 1551-1559.
6. Burns, K., Clatworthy, J., Martin, L., Martinon, F., Plumpton, C., Maschera, B., Lewis, A., Ray, K., Tschopp, J., Volpe, F. (2000) Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor. Nat. Cell Biol. 2, 346-351.
7. Didierlaurent, A., Brissoni, B., Velin, D., Aebi, N., Tardivel, A., Kaslin, E., Sirard, J. C., Angelov, G., Tschopp, J., Burns, K. (2006) Tollip regulates proinflammatory responses to interleukin-1 and lipopolysaccharide. Mol. Cell. Biol. 26, 735-742.
8. Neumann, D., Kollewe, C., Resch, K., Martin, M. U. (2007) The death domain of IRAK-1: an oligomerization domain mediating interactions with MyD88, Tollip, IRAK-1, and IRAK-4. Biochem. Biophys. Res. Commun. 354, 1089-1094.
9. Ross, K., Yang, L., Dower, S., Volpe, F., Guesdon, F. (2002) Identification of threonine 66 as a functionally critical residue of the interleukin-1 receptor-associated kinase. J. Biol. Chem. 277, 37414-37421.
10. Mamidipudi, V., Lin, C., Seibenhener, M. L., Wooten, M. W. (2004) Regulation of interleukin receptor-associated kinase (IRAK) phosphorylation and signaling by ι protein kinase C. J. Biol. Chem. 279, 4161-4165.
11. Wesche, H., Henzel, W. J., Shillinglaw, W., Li, S., Cao, Z. (1997) MyD88: an adapter that recruits IRAK to the IL-1 receptor complex. Immunity 7, 837-847.
12. Knop, J., Martin, M. U. (1999) Effects of IL-1 receptor-associated kinase (IRAK) expression on IL-1 signaling are independent of its kinase activity. FEBS Lett. 448, 81-85.
13. Yang, X., Xu, P., Xu, T. (2005) A new pair for inter- and intra-molecular FRET measurement. Biochem. Biophys. Res. Commun. 330, 914-920.
14. Kollewe, C., Mackensen, A. C., Neumann, D., Knop, J., Cao, P., Li, S., Wesche, H., Martin, M. U. (2004) Sequential autophosphorylation steps in the interleukin-1 receptor-associated kinase-1 regulate its availability as an adapter in interleukin-1 signaling. J. Biol. Chem. 279, 5227-5236.
15. Wesche, H., Gao, X., Li, X., Kirschning, C. J., Stark, G. R., Cao, Z. (1999) IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family. J. Biol. Chem. 274, 19403-19410.
16. Lasker, M. V., Gajjar, M. M., Nair, S. K. (2005) Cutting edge: molecular structure of the IL-1R-associated kinase-4 death domain and its implications for TLR signaling. J. Immunol. 175, 4175-4179.
17. Anthonsen, M. W., Andersen, S., Solhaug, A., Johansen, B. (2001) A typical λ/ι PKC conveys 5-lipoxygenase/leukotriene B4-mediated crosstalk between phospholipase A2s regulating NF-κ B activation in response to tumor necrosis factor-α and interleukin-1β. J. Biol. Chem. 276, 35344-35351.