Bauhinia Kunitz-type proteinase inhibitors: Structural characteristics and biological properties

Biological Chemistry

Volumn 389, Issue 8, 2008, Pages 1007-1013

  Vilela Oliva, Maria Luiza ^a   Sampaio, Misako Uemura ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Cathepsin; Inflammation; Kallikrein; Kunitz; Plant proteinase inhibitors; Trypsin

Indexed keywords

BLOOD CLOTTING FACTOR 10A INHIBITOR; CYSTEINE PROTEINASE INHIBITOR; ELASTASE INHIBITOR; KALLIKREIN; KALLIKREIN INHIBITOR; KININ; SERINE PROTEINASE INHIBITOR; TRYPSIN INHIBITOR;

AMINO ACID SEQUENCE; BAUHINIA; BAUHINIA BAUHINIOIDES; BAUHINIA RUFA; BAUHINIA UNGULATA; BAUHINIA VARIEGATA; BAUHINIA VARIEGATA CANDIDA; BLOOD CLOTTING; CONFERENCE PAPER; DRUG ACTIVITY; DRUG MECHANISM; DRUG SPECIFICITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME SUBSTRATE; KALLIKREIN KININ SYSTEM; NEOPLASM; PRIORITY JOURNAL; SOYBEAN; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANIMALS; BAUHINIA; BIOLOGY; BLOOD COAGULATION; HUMANS; PROTEASE INHIBITORS; PROTEIN BINDING; SUBSTRATE SPECIFICITY;

BAUHINIA;

EID: 50849124784     PISSN: 14316730     EISSN: 14374315     Source Type: Journal    
DOI: 10.1515/BC.2008.119     Document Type: Conference Paper

References (55)

1. Andrade, S.A., Santomauro-Vaz, E.M., Lopes, A.R., Chudzinski-Tavassi, A.M., Juliano, M.A., Terra, W.R., Sampaio, M.U., Sampaio, C.A.M., and Oliva, M.L.V. (2003). Bauhinia proteinase inhibitors-based synthetic fluorogenic substrates for enzymes isolated from insect midgut and caterpillar bristles. Biol. Chem. 384, 489-492.
2. Araújo, A.P.U., Hansen, D., Vieira, D.F., Oliveira, C., Santana, L.A., Beltramini, L.M., Sampaio, C.A.M., Sampaio, M.U., and Oliva, M.L.V. (2005). Kunitz type Bauhinia bauhinioides inhibitors devoid of disulfide bridges: isolation of the cDNAs, heterologous expression and structural studies. Biol. Chem. 386, 561-568.
3. Azarkan, M., Dibiani, R., Goormaghtigh, E., Raussens, V., and Baeyens-Volant, D. (2006). The papaya Kunitz-type trypsin inhibitor is a highly stable β-sheet glycoprotein. Biochim. Biophys. Acta 1764, 1063-1072.
4. Baker, C., Belbin, O., Kalsheker, N., and Morgan, K. (2007). SERPINA (aka α-1-antichymotrypsin). Front. Biosci. 12, 2821-2835.
5. Batista, I.F., Nonato, M.C., Bonfadini, M.R., Beltramini, L.M., Oliva, M.L.V., Sampaio, M.U., Sampaio, C.A.M., and Garratt, R.C. (2001). Preliminary crystallographic studies of EcTI, a serine proteinase inhibitor from Enterolobium contortisiliquum seeds. Acta Crystallogr. D Biol. Crystallogr, 57, 602-604.
6. Bhandari, P., Kumar, N., Gupta, A.P., Singh, B., and Kaul, V.K. (2007). A rapid RP-HPTLC densitometry method for simultaneous determination of major flavonoids in important medicinal plants. J. Sep. Sci. 13, 2092-2096.
7. Birk, Y. (2003). In: Plant Protease inhibitors: Significance in Nutrition, Plant Protection, Cancer Prevention and Genetic Engineering (Berlin: Springer-Verlag), pp. 1-126.
8. Cagliari, C.I., De Caroli, F.P., Nakahata, A.M., Araújo, M.S., Nakaie, C.R., Sampaio, M.U., Sampaio, C.A., and Oliva, M.L. (2003). Action of Bauhinia bauhinioides synthetic peptides on serine proteinases. Biochem. Biophys. Res. Commun. 311, 241-245.
9. Chen, Y.W., Huang, S.C., Lin-Shiau, S.Y., and Lin, J.K. (2005). Bowman-Birk inhibitor abates proteasome function and suppresses the proliferation of MCF7 breast cancer cells through accumulation of MAP kinase phosphatase-1. Carcinogenesis 26, 1296-1306.
10. Christeller, J. and Laing, W. (2005). Plant serine proteinase inhibitors. Protein Pept. Lett. 12, 439-447.
11. Conners, R., Konarev, A.V., Forsyth, J., Lovegrove, A., Marsh, J., Joseph-Horne, T., Shewry, P., and Brady, R.L. (2007). An unusual helix-turn-helix protease inhibitory motif in a novel trypsin inhibitor from seeds of Veronica (Veronica hederifolia L.). J. Biol. Chem. 282, 27760-27768.
12. De Leo, F., Volpicella, M., Licciulli, F., Liuni, S., Gallerani, R., and Ceci, L.R. (2002). PLANT-PIs: a database for plant protease inhibitors and their genes. Nucleic Acids Res. 30, 347-348.
13. de Oliveira, C., Santana, L.A., Carmona, A.K., Cezari, M.H., Sampaio, M.U., Sampaio, C.A.M., and Oliva, M.L.V. (2001). Structure of cruzipain/cruzain inhibitors isolated from Bauhinia bauhinioides seeds. Biol. Chem. 382, 847-852.
14. de Souza, A.F., Torquato, R.J., Tanaka, A.S., and Sampaio, C.A. (2005). Cloning, expression and characterization of Bauhinia variegata trypsin inhibitor BvTI. Biol. Chem. 386, 1185-1189.
15. Di Ciero, L., Oliva, M.L.V., Torquato, R., Kokler, P., Weder, J.P., Novello, J.C., Sampaio, C.A.M., Oliveira, B., and Marangoni, S. (1998). The complete amino acid sequence of a trypsin inhibitor from Bauhinia variegata var. candida seeds. J. Protein Chem. 17, 827-834.
16. do Socorro, M.C.M., Oliva, M.L.V., Fritz, H., Jochum, M., Mentele, R., Sampaio, M.U., Coelho, L.C., Batista, I.F., and Sampaio, C.A.M. (2002). Characterization of a kunitz trypsin inhibitor with one disulfide bridge purified from Swartzia pickellii. Biochem. Biophys. Res. Commun. 1, 635-639.
17. Faria, R.A., Andrade-Neto, M., Pinto, L.S., Castellon, R.R., Calvete, J.J., and Cavada, B.S. (2004). Biochemical and chemical partial characterization of Bauhinia forficata link seeds. Arch. Latinoam. Nutr. 54, 349-353.
18. Fuentes, O., Arancibia-Avila, P., and Alarcon, J. (2004). Hypoglycemic activity of Bauhinia candicans in diabetic induced rabbits. Fitoterapia 75, 527-532.
19. Grudkowska, M. and Zagdanska, B. (2004). Multifunctional role of plant cysteine proteinases. Acta Biochim. Pol. 51, 609-624.
20. Hansen, D., Macedo-Ribeiro, S., Verissimo, P., Yoo Im, S., Sampaio, M.U., and Oliva, M.L. (2007). Crystal structure of a novel cysteinless plant Kunitz-type protease inhibitor. Biochem. Biophys. Res. Commun. 360, 735-740.
21. He, S.H., Xie, H., and Fu, Y.L. (2005). Activation of human tonsil and skin mast cells by agonists of proteinase activated receptor-2. Acta Pharmacol. Sin. 26, 568-574.
22. Jung, H.I., Kim, S.I., Ha, K.S., Joe, C.O., and Kang, K.W. (1995). Isolation and characterization of guamerin, a new human leukocyte elastase inhibitor from Hirudo nipponia. J. Biol. Chem. 270, 13879-13884.
23. Kawalec, M., Potempa, J., Moon, J.L., Travis, J., and Murray, B.E. (2005). Molecular diversity of a putative virulence factor: purification and characterization of isoforms of an extracellular serine glutamyl endopeptidase of Enterococcus faecalis with different enzymatic activities. J. Bacteriol. 187, 266-275.
24. Kennedy, A.R. and Wan, X.S. (2002). Effects of the Bowman-Birk inhibitor on growth, invasion, and clonogenic survival of human prostate epithelial cells and prostate cancer cells. Prostate 50, 125-133.
25. Knight, C.G. (1986). The characterization of enzymes inhibition. In: Proteinase Inhibitors, A.J. Barrett and G. Salvesen, eds. (Amsterdam, The Netherlands: Elsevier Science), pp. 23-51.
26. Knox, D.P. (2007). Proteinase inhibitors and helminth parasite infection. Parasite Immunol. 29, 57-71.
27. Macedo, M.L.R., De Matos, D.G., Machado, O.L., Marangoni, S., and Novello, J.C. (2000). Trypsin inhibitor from Dimorphandra mollis seeds: purification and properties. Phytochemistry 54, 553-558.
28. Mello, G.C., Oliva, M.L., Sumikawa, J.T., Machado, O.L., Marangoni, S., Novello, J.C., and Macedo, M.L. (2001). Purification and characterization of a new trypsin inhibitor from Dimorphandra mollis seeds. J. Protein Chem. 20, 625-632.
29. Nakahata, A.M., Bueno, N.R., Rocha, H.A., Franco, C.R., Chammas, R., Nakaie, C.R., Jasiulionis, M.G., Nader, H.B., Santana, L.A., Sampaio, M.U., and Oliva, M.L. (2006). Structural and inhibitory properties of a plant proteinase inhibitor containing the RGD motif. Int. J. Biol. Macromol. 40, 22-29.
30. Neuhof, C., Oliva, M.L., Maybauer, D., Maybauer, M., de Oliveira, C., Sampaio, M.U., Sampaio, C.A., and Neuhof, H. (2003). Effect of plant Kunitz inhibitors from Bauhinia bauhinioides and Bauhinia rufa on pulmonary edema caused by activated neutrophils. Biol. Chem. 384, 939-944.
31. Oliva, M.L., Sampaio, M.U., and Sampaio, C.A. (1988). Purification and partial characterization of a thiol proteinase inhibitor from Enterolobium contortisiliquum beans. Biol. Chem. Hoppe-Seyler 369 (Suppl.), 229-232.
32. Oliva, M.L., Mendes, C.R., Juliano, M.A., Chagas, J.R., Rosa, J.C., Greene, L.J., Sampaio, M.U., and Sampaio, C.A.M. (1999). Characterization of a tissue kallikrein inhibitor isolated from Bauhinia bauhinioides seeds: inhibition of the hydrolysis of kininogen related substrates. Immunopharmacology 45, 163-169.
33. Oliva, M.L., Souza-Pinto, J.C., Batista, I.F., Araujo, M.S., Silveira, V.F., Auerswald, E.A., Mentele, R., Eckerskorn, C., Sampaio, M.U., and Sampaio, C.A. (2000). Leucaena leucocephala serine proteinase inhibitor: primary structure and action on blood coagulation, kinin release and rat paw edema. Biochim. Biophys. Acta 7, 64-74.
34. Oliva, M.L., Mendes, C.R., Santomauro-Vaz, E.M., Juliano, M.A., Mentele, R., Auerswald, E.A., Sampaio, M.U., and Sampaio, C.A.M. (2001a). Bauhinia bauhinioides plasma kallikrein inhibitor: interaction with synthetic peptides and fluorogenic peptide substrates related to the reactive site sequence. Curr. Med. Chem. 8, 977-984.
35. Oliva, M.L., Santomauro-Vaz, E.M., Andrade, S.A., Juliano, M.A., Pott, V.J., Sampaio, M.U., and Sampaio, C.A.M. (2001b). Synthetic peptides and fluorogenic substrates related to the reactive site sequence of Kunitz-type inhibitors isolated from Bauhinia: interaction with human plasma kallikrein. Biol. Chem. 382, 109-113.
36. Oliva, M.L., Andrade, S.A., Juliano, M.A., Sallai, R.C., Torquato, R.J., Sampaio, M.U., Pott, V.J., and Sampaio, C.A. (2003). Kinetic characterization of factor Xa binding using a quenched fluorescent substrate based on the reactive site of factor Xa inhibitor from Bauhinia ungulata seeds. Curr. Med. Chem. 10, 1085-1093.
37. Oliveira, A.S., Migliolo, L., Aquino, R.O., Ribeiro, J.K., Macedo, L.L., Andrade, L.B., Bemquerer, M.P., Santos, E.A., Kiyota, S., and Sales, M.P. (2007). Identification of a Kunitz-type proteinase inhibitor from Pithecellobium dumosum seeds with insecticidal properties and double activity. J. Agric. Food Chem. 55, 7342-7349.
38. Pando, S.C., Oliva, M.L., Sampaio, C.A., Di Ciero, L., Novello, J.C., and Marangoni, S. (2001). Primary sequence determination of a Kunitz inhibitor isolated from Delonix regia seeds. Phytochemistry 57, 625-631.
39. Pepato, M.T., Keller, E.H., Baviera, A.M., Kettelhut, I.C., Vendramini, R.C., and Brunetti, I.L. (2002). Anti-diabetic activity of Bauhinia forficata decoction in streptozotocin-diabetic rats. J. Ethnopharmacol. 81, 191-197.
40. Qi, R.F., Song, Z.W., and Chi, C.W. (2005) Structural features and molecular evolution of Bowman-Birk protease inhibitors and their potential application. Acta Biochim. Biophys. Sin. (Shanghai) 37, 283-292.
41. Rau, J.C., Beaulieu, L.M., Huntington, J.A., and Church, F.C. (2007). Serpins in thrombosis, hemostasis and fibrinolysis. J. Thromb. Haemost. 5, 102-115.
42. Reis, C.V., Farsky, S., Fernandes, B.L., Santoro, M.L., Oliva, M.L.V., Mariano, M., and Chudzinski-Tavassi, A.M. (2001). In vivo characterization of LOPAP, a prothrombin activator serine protease from the Lonomia obliqua caterpillar venom. Thromb. Res. 102, 437-443.
43. Richardson, M. (1991). Seed storage proteins: the enzyme inhibitors. Methods Plant Biochem. 5, 259-305.
44. Sampaio, C.A., Motta, G., Sampaio, M.U., Oliva, M.L., Araújo, M.S., Stella, R.C., Tanaka, A.S., and Batista, I.F. (1992). Action of plant proteinase inhibitors on enzymes of the kallikrein kinin system. Agents Actions 36, 191-199.
45. Schmaier, A.H. (2004). The physiologic basis of assembly and activation of the plasma kallikrein/kinin system. Thromb. Haemost. 91, 1-3.
46. Silva, F.C., Alcazar, A., Macedo, L.L., Oliveira, A.S., Macedo, F.P., Abreu, L.R., Santos, E.A., and Sales, M.P. (2006). Digestive enzymes during development of Ceratitis capitata (Diptera: Tephritidae) and effects of SBTI on its digestive serine proteinase targets. Insect Biochem. Mol. Biol. 36, 561-569.
47. Silva, J.A., Damico D.C., Baldasso, P.A., Mattioli, M.A., Winck, F.V., Fraceto, L.F., Novello, J.C., and Marangoni, S. (2007). Isolation and biochemical characterization of a galactoside binding lectin from Bauhinia variegata Candida (BvcL) seeds. Protein J. 3, 193-201.
48. Souza Pinto, J.C., Remacle-Volon, G., Sampaio, C.A., and Damas, J. (1995). Collagenase-induced oedema in the rat paw and the kinin system. Eur. J. Pharmacol. 274, 101-107.
49. Sumikawa, J.T., Nakahata, A.M., Fritz, H., Mentele, R., Sampaio, M.U., and Oliva, M.L. (2006). A Kunitz-type glycosylated elastase inhibitor with one disulfide bridge. Planta Med. 72, 393-397.
50. Travis, J. and Salvesen, G.S. (1983). Human plasma proteinase inhibitors. Annu. Rev. Biochem. 52, 655-709.
51. Travis, J. and Potempa, J. (2000). Bacterial proteinases as targets for the development of second-generation antibiotics. Biochim. Biophys. Acta 7, 35-50.
52. Ueda, H. and Ogawa, H. (1999). Glycobiology of the plant glycoprotein epitope: structure, immunogenicity and allergenicity of plant glycotopes. Trends Glycosci. Glycotechn. 11, 413-428.
53. Valueva, T.A. and Mosolov, V.V. (2004). Role of inhibitors of proteolytic enzymes in plant defense against phytopathogenic microorganisms. Biochemistry 69, 1305-1309.
54. Wu, J.X., Zhao, X.Y., Pan, R., and He, R.Q. (2007). Glycosylated trypsin-like proteases from earthworm Eisenia fetida. Int. J. Biol. Macromol. 40, 399-406.
55. Yadava, R.N. and Reddy, V.M. (2001). A new flavone glycoside, 5-hydroxy 7,3′,4′,5′-tetra-methoxyflavone5-O-β-D- xylopyranosyl-(1 → 2)-α-L-rhamnopyranoside from Bauhinia variegata Linn. J. Asian Nat. Prod. Res. 3, 341-346.