A blend of small molecules regulates both mating and development in Caenorhabditis elegans

Nature

Volumn 454, Issue 7208, 2008, Pages 1115-1118

  Srinivasan, Jagan ^a   Kaplan, Fatma ^b   Ajredini, Ramadan ^b   Zachariah, Cherian ^b   Alborn, Hans T ^c   Teal, Peter E A ^c   Malik, Rabia U ^d   Edison, Arthur S ^b   Sternberg, Paul W ^a   Schroeder, Frank C ^d  

^a CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c CENTER FOR MEDICAL   (United States)

^d United States Department of Agriculture Agricultural Research Service and Boyce Thompson Institute for Plant Research   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SEX PHEROMONE;

CONCENTRATION (COMPOSITION); LARVAL DEVELOPMENT; MATING BEHAVIOR; NEMATODE; POPULATION DENSITY; SYNERGISM;

ARTICLE; CAENORHABDITIS ELEGANS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; MATING; NERVE CELL; NONHUMAN; PHYSICAL DEVELOPMENT; PRIORITY JOURNAL; REPRODUCTION; SENSORY NERVE; SEXUAL BEHAVIOR;

ANIMALS; CAENORHABDITIS ELEGANS; ESCHERICHIA COLI; GLYCOLIPIDS; HERMAPHRODITISM; HEXOSES; MALE; NEURONS; POPULATION DENSITY; SEX ATTRACTANTS; SEXUAL BEHAVIOR, ANIMAL;

CAENORHABDITIS ELEGANS;

EID: 50649118316     PISSN: 00280836     EISSN: 14764679     Source Type: Journal    
DOI: 10.1038/nature07168     Document Type: Article

References (23)

1. Camilli, A. & Bassler, B. L. Bacterial small-molecule signaling pathways. Science 311, 1113-1116 (2006).
2. Dulac, C. & Torello, A. T. Molecular detection of pheromone signals in mammals: from genes to behaviour. Nature Rev. Neurosci. 4, 551-562 (2003).
3. Golden, J. W. & Riddle, D. L. A pheromone influences larval development in the nematode Caenorhabditis elegans. Science 218, 578-580 (1982).
4. Golden, J. W. & Riddle, D. L. A pheromone-induced developmental switch in Caenorhabditis elegans: Temperature-sensitive mutants reveal a wild-type temperature-dependent process. Proc. Natl Acad. Sci. USA 81, 819-823 (1984).
5. Simon, J. M. & Sternberg, P. W. Evidence of a mate-finding cue in the hermaphrodite nematode Caenorhabditis elegans. Proc. Natl Acad. Sci. USA 99, 1598-1603 (2002).
6. White, J. Q. et al. The sensory circuitry for sexual attraction in C. elegans males. Curr. Biol. 17, 1847-1857 (2007).
7. Butcher, R. A., Fujita, M., Schroeder, F. C. & Clardy, J. Small-molecule pheromones that control dauer development in Caenorhabditis elegans. Nature Chem. Biol. 3, 420-422 (2007).
8. Hirsh, D., Oppenheim, D. & Klass, M. Development of the reproductive system of Caenorhabditis elegans. Dev. Biol. 49, 200-219 (1976).
9. Brey, W. W. et al. Design, construction, and validation of a 1-mm triple-resonance high-temperature-superconducting probe for NMR. J. Magn. Reson. 179, 290-293 (2006).
10. Carde, R. T. & Elkinton, J. S. Field Trapping with Attractants: Methods and Interpretation (eds Hummel, H. E. & Miller, T. A.) 111-129 (Springer, 1984).
11. Chasnov, J. R., So, W. K., Chan, C. M. & Chow, K. L. The species, sex, and stage specificity of a Caenorhabditis sex pheromone. Proc. Natl Acad. Sci. USA 104, 6730-6735 (2007).
12. Jeong, P. Y. et al. Chemical structure and biological activity of the Caenorhabditis elegans dauer-inducing pheromone. Nature 433, 541-545 (2005).
13. Gershenzon, J. & Dudareva, N. The function of terpene natural products in the natural world. Nature Chem. Biol. 3, 408-414 (2007).
14. Lehar, J. et al. Chemical combination effects predict connectivity in biological systems. Mol. Syst. Biol. 3, doi:10.1038/msb4100116 (2007).
15. Golden, J. W. & Riddle, D. L. A gene affecting production of the Caenorhabditis elegans dauer-inducing pheromone. Mol. Gen. Genet. 198, 534-536 (1985).
16. Cronin, C. J. et al. An automated system for measuring parameters of nematode sinusoidal movement. BMC Genet. 6, doi:10.1186/1471-2156-6-5 (2005).
17. Collet, J., Spike, C. A., Lundquist, E. A., Shaw, J. E. & Herman, R. K. Analysis of osm-6, a gene that affects sensory cilium structure and sensory neuron function in Caenorhabditis elegans. Genetics 148, 187-200 (1998).
18. Bae, Y. K. et al. General and cell-type specific mechanisms target TRPP2/PKD-2 to cilia. Development 133, 3859-3870 (2006).
19. Tabish, M., Siddiqui, Z. K., Nishikawa, K. & Siddiqui, S. S. Exclusive expression of C. elegans osm-3 kinesin gene in chemosensory neurons open to the external environment. J. Mol. Biol. 247, 377-389 (1995).
20. Zwaal, R. R., Mendel, J. E., Sternberg, P. W. & Plasterk, R. H. Two neuronal G proteins are involved in chemosensation of the Caenorhabditis elegans Dauer-inducing pheromone. Genetics 145, 715-727 (1997).
21. Gems, D. & Riddle, D. L. Longevity in Caenorhabditis elegans reduced by mating but not gamete production. Nature 379, 723-725 (1996).
22. Partridge, L., Gems, D. & Withers, D. J. Sex and death: what is the connection? Cell 120, 461-472 (2005).
23. Tissenbaum, H. A. & Ruvkun, G. An insulin-like signaling pathway affects both longevity and reproduction in Caenorhabditis elegans. Genetics 148, 703-717 (1998).